18 results about "Oral ulcerations" patented technology

The invention provides a nanocrystalline composite oral ulcer film agent as well as a preparation method and application thereof. The nanocrystalline composite oral ulcer film agent comprises a waterproof backing layer and a drug-loading adhesion layer coated on the waterproof backing layer, the drug-loaded adhesion layer comprises a macromolecular hydrogen bond compound formed by a weakly acidic polymer and a nonionic proton receptor polymer, and a nanocrystalline drug. Compared with the prior art, the preparation method has the advantages that the polyacrylic acid polymer and the nonionic cellulose polymer interact to form IPC serving as an adhesion layer film-forming material, the nanocrystals are loaded into the adhesion layer film-forming material, the waterproof backing layer is coated with the adhesion layer film-forming material, and the oral ulcer film agent is prepared after drying and cutting. The obtained film agent has good comfort and adhesive power, shows good drug stability and permeation promotion performance, can be used as a carrier of an oral administration route, prolongs the drug action time and improves the curative effect. The preparation method of the film agent is simple and easy for industrial mass production.

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The invention discloses an oral ulcer medicine application device, which belongs to the field of medical instruments, and comprises a device shell, a disinfection assembly is located in the device shell, and oral ulcer of a patient is disinfected by using saline water; the suction assembly is located in the device shell and used for sucking disinfected saline water, the disinfection assembly is switched to the working position through the switching assembly, it is ensured that the disinfection assembly communicates with an internal pipeline of the device through the connecting assembly, and the disinfection assembly is used for spraying saline water to the dental ulcer position to complete disinfection. After disinfection, the switching assembly is switched to the suction assembly, the connecting assembly is synchronously switched to be communicated with the suction assembly, residual saline water in the oral cavity is sucked and discharged, and the ulcers are rapidly dried; finally, the medicine applying assembly is switched through the switching assembly, the connecting assembly is communicated with the medicine applying assembly, medicine is applied to the dried ulcer, the integrated operation of disinfection, drying and medicine applying in oral ulcer treatment is achieved, and the treatment efficiency and convenience are improved.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine oral ulcer patch and a preparation method thereof. The application provides a traditional Chinese medicine oral ulcer patch, wherein the patch comprises a drug-containing layer and an isolation layer which are sequentially arranged in layers; according to mass fractions, the drug-containing layer comprises 4-8 parts of bletilla striata polysaccharide, 7-14 parts of bletilla striata powder or 14-28 parts of bletilla striata decoction, 16-32 parts of indigo extract, 8-16 parts of cimicifuga foetida extract, 8-16 parts of mentha extract, 0.5-2 parts of tea polyphenol, 10-15 parts of glycerol and 1-2 parts of sodium carboxymethyl cellulose; and the isolation layer comprises 10-15 parts of glycerol and 20-30 parts of polyvinyl alcohol. The oral ulcer double-layer patch prepared from pure traditional Chinese medicine is mild, safe and reliable, has good healing effect, long-acting effect, simple preparation and low cost, and has a wide application prospect.

The utility model provides a hydrogel adhesion testing device for an oral ulcer patch. The hydrogel adhesion testing device comprises a base, a placement seat is fixed on the base, a patch body is placed on the placement seat, a positioning mechanism is arranged on the side of the placement seat, and a testing mechanism is connected above the placement seat in a lifting and sliding manner. The patch body is moved and positioned to the position under the testing mechanism through the positioning mechanism, alignment of the testing mechanism during testing is facilitated, meanwhile, the probe makes contact with hydrogel on the surface of the patch body through downward movement of the moving block, and certain pressure is applied. The pressure sensor starts to record the contact pressure and feeds back the numerical value of the contact pressure to the controller, the controller processes and stores the fed-back pressure, then the moving block moves upwards, the probe is separated upwards at a constant speed, and at the moment, the pressure sensor records the maximum pulling force in the separation process, namely the adhesive force; and the controller also processes and stores the adhesive force, so that the effect of testing the adhesion of the patch body is achieved.

The invention relates to a toothpaste composition, in particular to a synergistic toothpaste composition containing lipidosome vitamin C and ascorbyl palmitate, which remarkably enhances the effects of improving gingival health and repairing oral cavity through the synergistic effect of lipidosome VC and L-AP. The toothpaste comprises the following components in percentage by mass: 45%-60% of a humectant, 10%-20% of a friction agent, 2%-3% of a cleaning agent, 0.5%-1.5% of an adhesive, 0.1%-0.2% of a sweetening agent, 0.1%-0.2% of a preservative, 0.5%-1.5% of L-ascorbyl palmitate, 1%-3% of liposome vitamin C, 0.3%-0.7% of vitamin E, 5%-10% of vitamin B, 2%-5% of zinc gluconate and the balance of water. Cell experiments and clinical data prove that the composition can remarkably promote gingival fibroblast proliferation, enhance I-type collagen expression and effectively improve the problems of gingival bleeding, swelling and pain, oral ulcer and the like.

The invention relates to the technical field of oral ulcer gel grinding, and discloses a colloid mill for oral ulcer gel bacteriostatic preparation production, which comprises a cooling mechanism, the cooling mechanism comprises a support frame, the outer surface of the support frame is fixedly sleeved with a fixing frame, the outer wall of one end, far away from the support frame, of the fixing frame is fixedly connected with a support leg, and the support leg is fixedly connected with the cooling mechanism. A groove is formed in the outer surface of the top of the supporting frame, the grinding mechanism comprises a motor fixedly connected with the supporting frame, the top output end of the motor penetrates through the supporting frame and is fixedly connected with a rotating shaft, the outer surface of the rotating shaft is fixedly sleeved with a fixing block, and the bottom output end of the motor is fixedly connected with a fan. When the colloid is ground, heat is generated, at the moment, the temperature of the supporting frame is reduced by means of the cooling mechanism and the auxiliary assembly, then the temperature of the material is reduced, therefore, the adverse effect on the gel stability and the drug activity caused by temperature rise in the grinding process can be reduced, and the product quality is guaranteed.

The invention relates to the technical field of oral care, and provides Chinese herbal medicine plant toothpaste and a preparation method thereof.The toothpaste is composed of wild mint, paris polyphylla roots, pseudo-ginseng roots, dandelion, radix paeoniae alba, moutan bark, honeysuckle, wild chrysanthemum flowers, gentiana rigescens, verbena, herba lycopi, gypsum, calculus bovis and matrix auxiliary materials, and core raw materials are Yunnan genuine medicinal materials. The preparation process combining segmented extraction and nitrogen protection superfine grinding is adopted, effective components of Chinese herbal medicines are fully released, all the components have a synergistic effect, and the toothpaste has the comprehensive effects of preventing oral ulcer, whitening, removing halitosis, strengthening teeth, diminishing inflammation, killing bacteria, reducing stomach fire, stopping bleeding and strengthening the oral cavity; particularly, the effects of inhibiting oral pathogenic bacteria, repairing gingival injury and removing dental plaque are obvious. The product is controllable in process, high in stability, mild and non-irritant, can comprehensively solve various potential oral problems, and meets the high-quality oral care requirements of consumers.

This invention belongs to the field of pharmaceutical preparations containing organic active ingredients, specifically relating to the manufacture of pharmaceutical excipients. It relates to a toothbrush with burst beads, comprising: a toothbrush handle and a brush head, the toothbrush handle being connected to the brush head. The brush head has a burst bead storage cavity, which is filled with functional burst beads. Each functional burst bead comprises: a shell and contents, the contents being composed of the following raw materials in parts by weight: 1-2 parts of the above-mentioned fig polyphenol extract, 0.3-0.5 parts of vitamin C, 1-3 parts of propylene glycol, 88-90 parts of glycerin, and 1.5-2 parts of water. This invention uses a natural eutectic solvent composed of glycerin / fructose / lysine to extract fig polyphenols as the core functional ingredient of the burst beads, possessing both strong antioxidant, broad-spectrum antibacterial, and adjunctive therapeutic effects on oral ulcers. Furthermore, the ingredients are natural, non-irritating, convenient to use, and highly hygienic, solving the problems of traditional oral care products having limited functionality and leaving artificial solvent residues.

The invention provides mouthwash for preventing and treating oral ulcer and a preparation method thereof, and belongs to the technical field of oral care. The mouthwash is prepared from the following components in percentage by weight: 0.01 to 0.5 percent of dipotassium glycyrrhizinate, 0.05 to 0.5 percent of beta glucan, 0.01 to 0.3 percent of hyaluronic acid, 0.05 to 1 percent of honeysuckle flower extract, 0.5 to 5 percent of a solubilizer, 1.001 to 10.1 percent of a sweetening agent, 2 to 20 percent of a humectant, 0.01 to 0.5 percent of a chelating agent, 0.1 to 0.6 percent of a preservative, 0.01 to 0.5 percent of a flavoring agent, 1 to 10 percent of a solvent, 0.01 to 0.2 percent of a coloring agent and the balance of water. According to the mouthwash disclosed by the invention, all the components are combined together, the synergistic effect of '1 + 1gt, 2' can be exerted instead of simple effect addition, the oral ulcer can be effectively prevented and treated, and the effect is far better than that of existing commercially available products.

The invention discloses an oral ulcer pasting film and a preparation method thereof, and belongs to the field of medicine, the oral ulcer pasting film comprises a double-layer film layer and a carrier layer loading the film layer; the double-layer film layer comprises an outer film layer and an inner film layer which are tightly attached to each other; the outer film layer is attached to the carrier layer; the inner membrane layer is prepared from the following components in parts by weight: 20 to 25 parts of phosphorylated chitosan, 15 to 20 parts of polyvinyl alcohol, 10 to 12 parts of glutin and 3 to 5 parts of a TG enzyme-aprotinin compound; the outer film layer is prepared from the following components in parts by weight: 35 to 40 parts of temperature-sensitive salt shrinkage polymer, 20 to 25 parts of carboxylated protein and 8 to 10 parts of glyceryl monostearate; the carrier layer is prepared from the following components in parts by weight: 70 to 80 parts of hydrophilic fiber-gelatin modifier, 6 to 8 parts of saliva stimulating factor and 15 to 20 parts of glycerol. The film of the present invention can maintain good structural flatness.

The utility model belongs to the technical field of respiratory apparatus, specifically relates to an oral cavity pasting formula breathing pipe, including the mutual connection of mouth bite device and pharyngeal cavity air duct, wherein, mouth bite device includes front end mouth, lip stop, tooth socket pipe and tooth stop, and front end mouth and lip stop are connected, and front end mouth and lip stop are connected, and lip stop is oval thin ring, and tooth stop is irregular oval ring, and lip stop and tooth stop are connected through tooth socket pipe, and tooth stop is arranged in the front end of pharyngeal cavity air duct, and front end mouth, tooth socket pipe and pharyngeal cavity air duct are all partial oval pipe body structure, and the front end surface of tooth stop, tooth socket pipe and the rear end surface of lip stop constitute tooth socket, and mouth bite device and pharyngeal cavity air duct are integrally formed.The utility model reduces even eliminates the symptom generation of lip part chapped, tongue front area mucous membrane dry and oral cavity ulcer, reduces the number of night awakening, alleviates snore frequency, improves sleep quality and daytime work efficiency, has the effective prevention of oral cavity pasting formula breathing pipe frequent drop out of the body, and can improve the comfort of wearing.

This application discloses a traditional Chinese medicine oral ulcer patch containing camellia oil and its preparation method, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine oral ulcer patch containing camellia oil, by weight fraction, comprises: 7.1-9.1 parts camellia oil, 5-7 parts propolis, 2-4 parts Bletilla striata extract, 2-4 parts honeysuckle extract, 2-4 parts Artemisia argyi volatile oil, 4.4-6.4 parts collagen peptides, 14-16 parts polyvinyl alcohol, 4-6 parts hydroxypropyl methylcellulose, 4-6 parts glycerin, 1-3 parts polyethylene glycol, 0.2-0.4 parts benzoate, 0.1-0.3 parts menthol, and 0.5-1.5 parts vitamin E. This traditional Chinese medicine oral ulcer patch not only has anti-inflammatory effects, relieves oral ulcer pain, and promotes ulcer healing, but also forms a stable protective film layer in the oral cavity, effectively isolating external stimuli such as food friction and saliva erosion, providing a stable microenvironment for mucosal repair.

The invention provides a method for constructing an animal model based on X-ray induced radiation oral ulceration, which comprises the following steps: selecting SPF-level SD (Sprague Dawley) rats, adaptively feeding the rats for 7 days, and randomly grouping the rats; the method comprises the following steps: locally irradiating oral mucosa by adopting X rays for 15 Gy single time, taking oral mucosa tissues 14 days after irradiation, and carrying out HE staining to observe epithelial exfoliation and inflammatory cell infiltration conditions, TUNEL apoptosis detection and inflammatory factor detection. Through local X-ray irradiation, clinical characteristics such as mucous membrane erosion and inflammatory factor increase caused by radiotherapy are reproduced, the drug curative effect is comprehensively evaluated in combination with multiple indexes (behavioristics, histology and molecular biology), and compared with a small animal precise radiotherapy instrument (SARRP), the method is low in equipment requirement and suitable for laboratory popularization.

The invention relates to zinc silicate loaded lysozyme multifunctional toothpaste and a preparation method thereof. The zinc silicate loaded lysozyme multifunctional toothpaste is prepared from the following components in percentage by mass: 40 to 50 weight percent of abrasive, 18 to 25 weight percent of humectant, 2.0 to 2.9 weight percent of surfactant, 1.0 to 1.5 weight percent of adhesive, 0.1 to 0.5 weight percent of preservative, 0.1 to 0.4 weight percent of sweetening agent, 1 to 20 weight percent of lysozyme loaded zinc silicate and the balance of water. The zinc silicate loaded lysozyme multi-effect toothpaste disclosed by the invention has various effects of well preventing and treating decayed teeth, oral ulcers and the like, not only has a good mineralization promoting effect, but also has excellent antibacterial, anti-inflammatory and repair promoting effects, and has a very wide application prospect. The preparation method disclosed by the invention has the advantages of low cost, simplicity and convenience in operation, controllable process, mild reaction conditions and the like.

The invention relates to an external traditional Chinese medicine composition for treating oral ulcer and a preparation method thereof. The composition comprises the following components in parts by weight: 1-60 parts of coptis chinensis, 1-60 parts of bombyx batryticatus, 1-30 parts of gallnut, 1-60 parts of raw liquorice and the balance of auxiliary materials required by common solid or liquid preparations. The traditional Chinese medicine composition can be prepared into solid preparations such as powder, cream, paste and oral patches. The traditional Chinese medicine composition can be prepared into liquid preparations such as linimentum, paste, film, liniment, spray and decocted extract. The traditional Chinese medicine composition is prepared under the guidance of traditional Chinese medicine theory, has the effects of astringing dampness and sores, removing toxicity for detumescence, dispelling wind and removing stasis, clearing away heart-fire and purging spleen, has the pharmacological effects of inhibiting bacteria and diminishing inflammation and promoting ulcer surface healing, and is externally used for treating oral ulcer. The symptoms and characteristics of the treated crowd include local scorching heat and pain of aphtha, obvious red and swollen wounds, yellow secretions on the surface, dry mouth and halitosis, vexation and insomnia, dry stool and dark urine, red tongue tip, yellow coating and new or repeated attack of dental ulcer.

The invention relates to the technical field of oral cavity laser therapeutic instruments, and particularly discloses a medical oral ulcer treatment device which comprises an oral cavity laser therapeutic instrument body. The oral cavity laser therapeutic instrument comprises an oral cavity laser therapeutic instrument body and further comprises limb monitoring mechanisms, the limb monitoring mechanisms are arranged on the two sides of the oral cavity laser therapeutic instrument body, and the limb monitoring mechanisms are used for being bound to the hands of a patient and monitoring the limb shaking strength when the patient pains. Through cooperation of the vibration sensor and the noise sensor, when oral ulcer treatment is carried out on a patient, shaking of limbs of the patient caused by pain and mouth sound generated by monitoring the pain are carried out in a matched mode, if pain response signals generated when the patient is treated can be monitored in a double-matched mode, the pain response signals can be fed back to the intensity adjusting mechanism, and the patient can be treated more accurately. The method is used for self-adaptive adjustment of laser energy intensity in real time, so that stimulation to treatment of a patient can be effectively reduced.

The application discloses an oral ulcer film and a preparation method thereof, and belongs to the medical field. The oral ulcer film comprises a double-layer film layer and a carrier layer of a loaded film layer. The double-layer film layer comprises a tightly adhered outer film layer and an inner film layer. The outer film layer is adhered to the carrier layer. The inner film layer comprises the following components in weight fractions: 20-25 parts of phosphorylated chitosan, 15-20 parts of polyvinyl alcohol, 10-12 parts of gelatin protein and 3-5 parts of a TG enzyme-antipain complex. The outer film layer comprises the following components in weight fractions: 35-40 parts of a temperature-sensitive salt condensation polymer, 20-25 parts of a carboxylated protein and 8-10 parts of glycerol monostearate. The carrier layer comprises the following components in weight fractions: 70-80 parts of a hydrophilic fiber-gelatin modifier, 6-8 parts of a saliva stimulating factor and 15-20 parts of glycerol. The film can maintain good structural flatness.