A blasting bead toothbrush

Abstract

This invention belongs to the field of pharmaceutical preparations containing organic active ingredients, specifically relating to the manufacture of pharmaceutical excipients. It relates to a toothbrush with burst beads, comprising: a toothbrush handle and a brush head, the toothbrush handle being connected to the brush head. The brush head has a burst bead storage cavity, which is filled with functional burst beads. Each functional burst bead comprises: a shell and contents, the contents being composed of the following raw materials in parts by weight: 1-2 parts of the above-mentioned fig polyphenol extract, 0.3-0.5 parts of vitamin C, 1-3 parts of propylene glycol, 88-90 parts of glycerin, and 1.5-2 parts of water. This invention uses a natural eutectic solvent composed of glycerin / fructose / lysine to extract fig polyphenols as the core functional ingredient of the burst beads, possessing both strong antioxidant, broad-spectrum antibacterial, and adjunctive therapeutic effects on oral ulcers. Furthermore, the ingredients are natural, non-irritating, convenient to use, and highly hygienic, solving the problems of traditional oral care products having limited functionality and leaving artificial solvent residues.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical preparations containing organic active ingredients, and relates to the manufacture of pharmaceutical excipients, specifically to a fig polyphenol extract for adjuvant treatment of oral ulcers, a beaded toothbrush, and their preparation and application. Background Technology

[0002] Oral ulcers are a common oral mucosal disease in clinical practice. Their pathogenesis is closely related to the imbalance of local oxidative stress in the oral cavity, damage to mucosal epithelial cells, pathogenic bacterial infection, and immune dysfunction. Traditional oral care products mostly only have a cleaning function. Although some medicated mouthwashes and gels can relieve oral ulcers, they have problems such as inconvenience of use, strong irritation of ingredients, and easy to cause secondary pollution.

[0003] As a novel oral care product, the burst bead toothbrush encapsulates functional ingredients within burst beads. When used, the bead is popped to release the ingredients, offering both convenience and hygiene. For example, patent CN118526416A discloses an antibacterial burst bead toothbrush that effectively inhibits the growth and reproduction of bacteria in the mouth, thereby reducing plaque and tartar formation. Patent CN117771318A discloses a medicinal polysaccharide functional burst bead toothbrush, which, through optimized extraction of areca polyphenols, exhibits a certain effect in lowering blood sugar levels.

[0004] However, the core material of the aforementioned toothbrushes lacks functional ingredients that target oral oxidative stress and oral ulcers, and some products use synthetic solvents to extract functional ingredients, posing a risk of residue and failing to meet the demand for green and natural products.

[0005] Therefore, there is an urgent need to develop a toothbrush with popping beads that has both antioxidant and adjunctive therapeutic effects on oral ulcers. Summary of the Invention

[0006] To address the aforementioned issues, this invention provides a bursting bead toothbrush. This invention uses fig polyphenols extracted from a natural eutectic solvent composed of glycerol / fructose / lysine as the core functional ingredient of the bursting beads. It possesses strong antioxidant, broad-spectrum antibacterial, and adjunctive therapeutic effects on oral ulcers. Furthermore, the ingredients are natural, non-irritating, convenient to use, and highly hygienic, thus solving the problems of traditional oral care products having limited functions and leaving artificial solvent residues.

[0007] To achieve the above technical objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides a fig polyphenol extract for adjunctive treatment of oral ulcers, the preparation method comprising: Glycerin, fructose, lysine and water are mixed evenly at 40~50℃ and cooled to room temperature to obtain a natural eutectic solvent, wherein the molar ratio of glycerin, fructose and lysine is 4-6:2-4:1-1.5; Wash, dry, and crush the figs to obtain fig powder; The natural eutectic solvent was mixed with fig powder, and ultrasonic-assisted extraction was performed. The extract was collected, filtered, and a crude extract was obtained. The crude extract was concentrated, washed, and freeze-dried to obtain fig polyphenol extract.

[0008] In a second aspect, the present invention provides a toothbrush with burst beads, comprising: a toothbrush handle and a brush head, wherein the toothbrush handle is connected to the brush head, and the brush head is provided with a burst bead storage cavity, wherein the burst bead storage cavity is filled with functional burst beads, the functional burst beads comprising: a shell and contents, the contents being composed of the following raw materials in parts by weight: 1-2 parts of the above-mentioned fig polyphenol extract, 0.3-0.5 parts of vitamin C, 1-3 parts of propylene glycol, 88-90 parts of glycerin, and 1.5-2 parts of water.

[0009] A third aspect of the present invention provides a method for preparing the above-mentioned explosive bead toothbrush, comprising: Preparation of fig polyphenol extract; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. After the gelatin swells in water at 40°C for 30 minutes, it is slowly heated to 70°C to completely dissolve it. Then, tragacanth gum, guar gum, and dextrin are added, and the mixture is kept warm and stirred until it is evenly mixed. Glycerin is then added, and the mixture is evenly mixed. The mixture is then degassed under vacuum to obtain the capsule sol. The contents solution is dripped into the capsule shell sol to form burst beads, which are then filtered out and dried to obtain functional burst beads. The functional popping beads are installed inside the popping bead storage cavity of the toothbrush.

[0010] In a fourth aspect, the present invention provides the application of the above-mentioned fig polyphenol extract and the above-mentioned popping bead toothbrush in the preparation of oral medical devices with antioxidant, antibacterial and adjunctive therapeutic effects on oral ulcers.

[0011] The beneficial effects of this invention are as follows: (1) The fig polyphenol extract prepared in this invention is rich in a variety of phenolic acids, flavonoids, coumarins and triterpenoids, which have a target synergistic effect on oral ulcers (antibacterial + anti-inflammatory + healing + antioxidant), and can gently and effectively improve the condition of oral ulcers.

[0012] (2) The present invention uses glycerol / fructose / lysine as a natural eutectic solvent to extract fig polyphenols as the core functional ingredient of popping beads. It has the effects of strong antioxidant and adjuvant treatment of oral ulcers. Moreover, the ingredients are natural, non-irritating, convenient to use and highly hygienic, which solves the problems of single function and artificial solvent residue in traditional oral care products.

[0013] (3) In this invention, vitamin C acts as an antioxidant, which can effectively inhibit the oxidative degradation of fig polyphenols. At the same time, it has the function of assisting anti-inflammatory and promoting mucosal repair. It works synergistically with polyphenols to enhance the effect of assisting in the treatment of oral ulcers.

[0014] (4) The method of the present invention is simple, easy to operate, highly practical, and easy to promote. Attached Figure Description

[0015] The accompanying drawings, which form part of this invention, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an improper limitation of the invention.

[0016] Figure 1 The figures show the antioxidant performance test results of the embodiments and comparative examples of the present invention; Figure 2 This is a graph showing the test results of the adjunctive treatment effect of oral ulcers in an experimental example of the present invention. Detailed Implementation

[0017] It should be noted that the following detailed descriptions are exemplary and intended to provide further illustration of the invention. Unless otherwise specified, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0019] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0020] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this invention is in use. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention. In addition, the terms "first," "second," "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0021] As described in the background section, addressing the current lack of toothbrushes with popping beads for adjuvant treatment of oral ulcers, this invention studies existing natural extracts and their extraction methods. It was found that fig polyphenol extract is rich in various phenolic acids, flavonoids, coumarins, and triterpenoids, exhibiting a synergistic effect on oral ulcers (antibacterial + anti-inflammatory + healing-promoting + antioxidant), and can gently and effectively improve oral ulcer conditions. Therefore, this invention provides a fig polyphenol extract for adjuvant treatment of oral ulcers, prepared by a method comprising: Glycerin, fructose, lysine and water are mixed evenly at 40~50℃ and cooled to room temperature to obtain a natural eutectic solvent, wherein the molar ratio of glycerin, fructose and lysine is 4-6:2-4:1-1.5; Wash, dry, and crush the figs to obtain fig powder; The natural eutectic solvent was mixed with fig powder, and ultrasonic-assisted extraction was performed. The extract was collected, filtered, and a crude extract was obtained. The crude extract was concentrated, washed, and freeze-dried to obtain fig polyphenol extract.

[0022] To avoid the problem of organic residues, this invention uses a natural eutectic solvent. The composition of the natural eutectic solvent affects the composition and content of active substances in fig polyphenol extract. Therefore, this invention studies the composition of the natural eutectic solvent. Preferably, fig polyphenol extract prepared with glycerol and fructose as hydrogen bond donors and lysine as hydrogen bond acceptor has better antioxidant properties and a good adjunctive therapeutic effect on oral ulcers.

[0023] The addition of water can improve the viscosity and polarity of DES, thereby improving the extraction effect of fig polyphenols. Therefore, this invention has studied the amount of water used. Preferably, the amount of water used is 20%-25% of the total mass of glycerol, fructose, and lysine to obtain better antioxidant properties and adjuvant therapeutic effects on oral ulcers. The liquid-to-solid ratio affects the extraction rate, cost, and subsequent concentration difficulty of fig polyphenols. Therefore, this invention studies the liquid-to-solid ratio of natural eutectic solvent and fig powder. Preferably, the liquid-to-solid ratio of the natural eutectic solvent to fig powder is 25-30:1.

[0024] The power, temperature, and time of ultrasound-assisted extraction affect the extraction efficiency of fig polyphenols. Therefore, this invention studies the power, temperature, and time of ultrasound-assisted extraction. Preferably, the conditions for ultrasound-assisted extraction are 350W-400W, extraction temperature 30℃-35℃, and extraction time 35min-40min, in order to obtain a better extraction rate of fig polyphenols.

[0025] The solution after ultrasonic extraction still contains a large amount of solids and impurities, which need to be separated to improve the purity and activity of fig polyphenols. Preferably, after ultrasonic-assisted extraction, the extract is centrifuged, collected, and filtered through a membrane to obtain a crude extract, so as to effectively remove solids and other impurities and increase the content of fig polyphenols in the extract.

[0026] To increase the content of fig polyphenols per unit dosage, it is necessary to remove the solvent and water from the crude extract. Therefore, the present invention concentrates and freeze-dries the crude extract. Preferably, the concentration method is vacuum distillation to improve the concentration efficiency and reduce the destruction of fig polyphenols.

[0027] Based on the fig polyphenol extract obtained above, this invention further develops a toothbrush with a bursting bead effect that can be used as an adjunct treatment for oral ulcers. The toothbrush includes a toothbrush handle and a brush head, the handle being connected to the brush head. The brush head has a bursting bead storage cavity, which is filled with functional bursting beads. Each functional bursting bead comprises a shell and contents, the contents being composed of the following parts by weight: 1-2 parts of the fig polyphenol extract, 0.3-0.5 parts of vitamin C, 1-3 parts of propylene glycol, 88-90 parts of glycerin, and 1.5-2 parts of water.

[0028] Experimental results show that the fig polyphenol extract prepared by the above method can relieve the redness, swelling and pain symptoms of oral ulcers, significantly shorten the ulcer healing time, and has a good adjuvant therapeutic effect.

[0029] The present invention does not impose any special limitations on the structure of the toothbrush handle and brush head. The structure of the toothbrush handle and brush head of commercially available granulation toothbrushes can be adopted. In some embodiments, a brush head with grooves can be used to install the functional granulation beads on the granulation toothbrush by snapping them together.

[0030] The present invention does not impose any special limitations on the specific composition of the capsule shell, as long as it can meet the encapsulation requirements of the burst beads. Preferably, the capsule shell is composed of the following raw materials in parts by weight: 2-4 parts of tragacanth gum, 1.5-3 parts of gelatin, 1.5-3 parts of guar gum, 7.5-10 parts of glycerin, 3-4 parts of dextrin, and 75-85 parts of water, in order to obtain better film-forming properties, moldability, and mechanical strength.

[0031] The present invention will be further described in detail below with reference to specific embodiments. It should be noted that the specific embodiments are explanations of the present invention and not limitations thereof.

[0032] Example 1 (1) Preparation of natural eutectic solvents Weigh out glycerol, fructose, and lysine (the molar ratio of glycerol:fructose:lysine is 5:3:1.2), add deionized water (23% of the total mass of the three), and stir well in a water bath at 48°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0033] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 360 W and an extraction temperature of 35 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0034] (3) Preparation of functional burst beads Take 1.5 parts of fig polyphenol extract, 0.4 parts of vitamin C, 2 parts of propylene glycol, 89 parts of glycerin, and 1.75 parts of water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 3 parts tragacanth gum, 2 parts gelatin, 2 parts guar gum, 8.5 parts glycerin, 4.5 parts dextrin, and 80 parts water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0035] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0036] Example 2 (1) Preparation of natural eutectic solvents Weigh out glycerol, fructose, and lysine (the molar ratio of glycerol:fructose:lysine is 4:2:1), add deionized water (20% of the total mass of the three), and stir well in a water bath at 50°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0037] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 25:1. Place it in an ultrasonic extractor and extract for 40 min at an ultrasonic power of 400 W and an extraction temperature of 30 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0038] (3) Preparation of functional burst beads Take 1 part fig polyphenol extract, 0.3 parts vitamin C, 1 part propylene glycol, 88 parts glycerin, and 1.5 parts water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 2 parts of tragacanth gum, 1.5 parts of gelatin, 1.5 parts of guar gum, 7.5 parts of glycerin, 3 parts of dextrin, and 75 parts of water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0039] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0040] Example 3 (1) Preparation of natural eutectic solvents Weigh out glycerol, fructose, and lysine (the molar ratio of glycerol:fructose:lysine is 6:4:1.5), add deionized water (25% of the total mass of the three), and stir evenly in a water bath at 40°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0041] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 350 W and an extraction temperature of 40 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0042] (3) Preparation of functional burst beads Take 2 parts fig polyphenol extract, 0.5 parts vitamin C, 3 parts propylene glycol, 90 parts glycerin, and 2 parts water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. Mix the first and second mixtures evenly, and degas under vacuum to obtain the contents solution; take 4 parts of tragacanth gum, 3 parts of gelatin, 3 parts of guar gum, 10 parts of glycerin, 4 parts of dextrin, and 85 parts of water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed, then add glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0043] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0044] Comparative Example 1 The difference from Example 1 is that lysine was not added in step (1), which specifically includes: (1) Preparation of natural eutectic solvents Weigh out glycerol and fructose separately (the molar ratio of glycerol to fructose is 5:3), add deionized water (the amount used is 23% of the total mass of the two), stir evenly under a water bath at 48°C to obtain a homogeneous and transparent solution, cool to room temperature to obtain a natural eutectic solvent.

[0045] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 360 W and an extraction temperature of 35 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0046] (3) Preparation of functional burst beads Take 1.5 parts of fig polyphenol extract, 0.4 parts of vitamin C, 2 parts of propylene glycol, 89 parts of glycerin, and 1.75 parts of water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 3 parts tragacanth gum, 2 parts gelatin, 2 parts guar gum, 8.5 parts glycerin, 4.5 parts dextrin, and 80 parts water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0047] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0048] Comparative Example 2 The difference from Example 1 is that glycerol was not added in step (1), which specifically includes: (1) Preparation of natural eutectic solvents Weigh out fructose and lysine (the molar ratio of fructose to lysine is 3:1.2), add deionized water (23% of the total mass of the two), and stir evenly in a water bath at 48°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0049] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 360 W and an extraction temperature of 35 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0050] (3) Preparation of functional burst beads Take 1.5 parts of fig polyphenol extract, 0.4 parts of vitamin C, 2 parts of propylene glycol, 89 parts of glycerin, and 1.75 parts of water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 3 parts tragacanth gum, 2 parts gelatin, 2 parts guar gum, 8.5 parts glycerin, 4.5 parts dextrin, and 80 parts water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0051] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0052] Comparative Example 3 The difference from Example 1 is that in step (1), L-proline is used instead of lysine, specifically including: (1) Preparation of natural eutectic solvents Weigh out glycerol, fructose, and L-proline (the molar ratio of glycerol:fructose:L-proline is 5:3:1.2), add deionized water (23% of the total mass of the three), and stir well in a water bath at 48°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0053] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 360 W and an extraction temperature of 35 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0054] (3) Preparation of functional burst beads Take 1.5 parts of fig polyphenol extract, 0.4 parts of vitamin C, 2 parts of propylene glycol, 89 parts of glycerin, and 1.75 parts of water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 3 parts tragacanth gum, 2 parts gelatin, 2 parts guar gum, 8.5 parts glycerin, 4.5 parts dextrin, and 80 parts water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0055] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0056] Comparative Example 4 The difference from Example 1 is that in step (1), glycine is used instead of lysine, specifically including: (1) Preparation of natural eutectic solvents Weigh out glycerol, fructose, and glycine (the molar ratio of glycerol:fructose:glycine is 5:3:1.2), add deionized water (23% of the total mass of the three), and stir evenly in a water bath at 48°C to obtain a homogeneous and transparent solution. Cool to room temperature to obtain a natural eutectic solvent.

[0057] (2) Preparation of fig polyphenol extract Wash, dry, and crush fresh figs to obtain fig powder; Take the natural eutectic solvent from step (1) and mix it with fig powder at a mass ratio of 30:1. Place it in an ultrasonic extractor and extract for 35 min at an ultrasonic power of 360 W and an extraction temperature of 35 °C. Centrifuge and collect the supernatant. Filter the supernatant through a 0.22 μm microporous membrane to obtain a crude extract. Remove the solvent from the crude extract by vacuum distillation and freeze-dry to obtain fig polyphenol extract.

[0058] (3) Preparation of functional burst beads Take 1.5 parts of fig polyphenol extract, 0.4 parts of vitamin C, 2 parts of propylene glycol, 89 parts of glycerin, and 1.75 parts of water; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. Take 3 parts tragacanth gum, 2 parts gelatin, 2 parts guar gum, 8.5 parts glycerin, 4.5 parts dextrin, and 80 parts water. Soak the gelatin in water at 40°C for 30 minutes, then slowly heat it to 70°C to completely dissolve it. Add the tragacanth gum, guar gum, and dextrin, keep warm and stir until evenly mixed. Add the glycerin, mix evenly, and degas under vacuum to obtain the capsule sol. Functional burst beads were made by concentric dripping of the contents solution and the capsule shell sol.

[0059] (4) Assembly of the beaded toothbrush The functional popping beads prepared in step (3) are installed in the popping bead storage cavity of the toothbrush and fixed by a snap-fit ​​method.

[0060] Experiment Example 1 Antioxidant Performance Test The antioxidant activity of the fig polyphenol extract prepared in step (2) of the examples and comparative examples was determined by the DPPH free radical scavenging method. The scavenging rate was calculated. The test conditions were the same as those in the paper "The role of polyphenols in Camellia in scavenging DPPH and the test of total antioxidant capacity" by Sun Jiangshan, September 2017.

[0061] Table 1. DPPH free radical scavenging rate of fig polyphenol extract of the present invention

[0062] The comparison of Examples 1-3 shows that the ratio of hydrogen bond donors to hydrogen bond acceptors, ultrasonic conditions, etc., affect the extraction effect of fig polyphenols. Among them, the extraction effect of Example 1 is the best.

[0063] As can be seen from the comparison of Example 1 and Comparative Examples 1 and 2, compared with the binary eutectic solvent, the ternary eutectic solvent composed of glycerol, fructose and lysine has a better extraction effect on fig polyphenols and the DPPH free radical scavenging rate is significantly enhanced.

[0064] As can be seen from the comparison of Example 1 and Comparative Examples 3 and 4, compared with glycine and L-proline, the extraction effect of fig polyphenols by using lysine as hydrogen bond acceptor and a ternary eutectic solvent composed of glycerol and fructose is better, and the DPPH free radical scavenging rate is significantly enhanced.

[0065] Experiment Example 2: Test of the Adjunctive Treatment Effect of Oral Ulcers 1. Subjects: Sixty patients with oral ulcers (aged 18-60 years, ulcer duration approximately 3 days, ulcer diameter 2-4 mm, excluding patients with severe oral ulcers, other oral diseases, or those currently using other anti-inflammatory drugs) were randomly divided into an experimental group, a blank control group, and a positive control group, with 20 patients in each group. There were no significant differences between the two groups in terms of age, gender, and ulcer severity (P>0.05).

[0066] 2. Experimental Methods: The experimental group used the fig polyphenol bursting bead toothbrush of this invention, brushing twice daily for 3-5 minutes each time. The bursting bead was popped during use to ensure the contents fully contacted the ulcer site. The blank control group used a regular toothbrush, using the same method as the experimental group. The positive control group used watermelon frost spray, applying it twice daily (morning and evening) and brushing twice daily (morning and evening) with a regular toothbrush. All three groups used the product continuously for 7 days. Ulcer healing time, time to relief of redness, swelling, and pain were recorded, and the treatment effect was evaluated.

[0067] 3. Efficacy Evaluation Criteria Complete recovery: The ulcer has completely healed, the mucous membrane has returned to normal, and there is no redness, swelling, or pain; Effective: Ulcer diameter reduced by ≥50%, redness, swelling, and pain significantly relieved; Ineffective: Ulcer diameter shrinks by less than 50%, redness, swelling, and pain are not relieved or even worsen.

[0068] Overall effective rate = (number of cured cases + number of effective cases) / total number of cases × 100%.

[0069] 4. Experimental Results Table 2. Adjunctive therapeutic effect of the bead-filled toothbrush of the present invention on oral ulcers.

[0070] Experimental conclusion: After using the explosive bead toothbrush of the present invention, the experimental group achieved a total effective rate of 90%, which was significantly better than the blank control group (P<0.01). This indicates that the explosive bead toothbrush of the present invention can relieve the redness, swelling and pain symptoms of oral ulcers, significantly shorten the ulcer healing time, and has a good adjuvant therapeutic effect.

[0071] While the specific embodiments of the present invention have been described above, they are not intended to limit the scope of protection of the present invention. Those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art without creative effort based on the technical solutions of the present invention are still within the scope of protection of the present invention.

Claims

1. A ficus polyphenol extract for the adjuvant treatment of oral ulcers, characterized in that, Preparation methods include: Glycerin, fructose, lysine and water are mixed evenly at 40~50℃ and cooled to room temperature to obtain a natural eutectic solvent, wherein the molar ratio of glycerin, fructose and lysine is 4-6:2-4:1-1.5; Wash, dry, and crush the figs to obtain fig powder; The natural eutectic solvent was mixed with fig powder, and ultrasonic extraction was performed. The extract was collected, filtered, and a crude extract was obtained. The crude extract was concentrated, washed, and freeze-dried to obtain fig polyphenol extract.

2. The fig polyphenol extract for adjunctive treatment of oral ulcers as described in claim 1, characterized in that, The amount of water used is 20%-25% of the total mass of glycerol, fructose, and lysine.

3. The fig polyphenol extract for adjunctive treatment of oral ulcers as described in claim 1, characterized in that, The liquid-to-solid ratio of the natural eutectic solvent to the fig powder is 25-30:

1.

4. The fig polyphenol extract for adjunctive treatment of oral ulcers as described in claim 1, characterized in that, The conditions for ultrasound-assisted extraction are 350W-400W, extraction temperature 30℃-35℃, and extraction time 35min-40min.

5. The fig polyphenol extract for adjunctive treatment of oral ulcers as described in claim 1, characterized in that, After ultrasonic-assisted extraction, the extract is centrifuged, collected, and filtered through a membrane to obtain a crude extract.

6. The fig polyphenol extract for adjunctive treatment of oral ulcers as described in claim 1, characterized in that, The concentration method is vacuum distillation.

7. A toothbrush with exploding beads, characterized in that, include: A toothbrush handle and a brush head, wherein the toothbrush handle is connected to the brush head, and the brush head is provided with a capsule storage cavity, wherein the capsule storage cavity is filled with functional capsules, and the functional capsules comprise: a shell and contents, wherein the contents are composed of the following raw materials in parts by weight: 1-2 parts of fig polyphenol extract as described in any one of claims 1-6, 0.3-0.5 parts of vitamin C, 1-3 parts of propylene glycol, 88-90 parts of glycerin, and 1.5-2 parts of water.

8. The toothbrush with bursting beads as described in claim 7, characterized in that, The capsule is composed of the following raw materials in parts by weight: 2-4 parts tragacanth gum, 1.5-3 parts gelatin, 1.5-3 parts guar gum, 7.5-10 parts glycerin, 3-4 parts dextrin, and 75-85 parts water.

9. A method for preparing a toothbrush with bursting beads as described in claim 7 or 8, characterized in that, include: Preparation of fig polyphenol extract; Glycerin and propylene glycol were mixed evenly at 40°C to obtain the first mixture. Dissolve vitamin C in water and mix well. Then add fig polyphenol extract and mix well to obtain a second mixture. The first and second mixtures were mixed evenly and then degassed under vacuum to obtain the contents solution. After the gelatin swells in water at 40°C for 30 minutes, it is slowly heated to 70°C to completely dissolve it. Then, tragacanth gum, guar gum, and dextrin are added, and the mixture is kept warm and stirred until it is evenly mixed. Glycerin is then added, and the mixture is evenly mixed. The mixture is then degassed under vacuum to obtain the capsule sol. The contents solution is dripped into the capsule shell sol to form burst beads, which are then filtered out and dried to obtain functional burst beads. The functional popping beads are installed inside the popping bead storage cavity of the toothbrush.

10. The use of the fig polyphenol extract according to any one of claims 1-6 and the beaded toothbrush according to claim 7 or 8 in the preparation of oral medical devices with antioxidant, antibacterial, and adjunctive therapeutic effects on oral ulcers.

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