Mouthwash for preventing and treating oral ulcer and preparation method thereof

Abstract

The invention provides mouthwash for preventing and treating oral ulcer and a preparation method thereof, and belongs to the technical field of oral care. The mouthwash is prepared from the following components in percentage by weight: 0.01 to 0.5 percent of dipotassium glycyrrhizinate, 0.05 to 0.5 percent of beta glucan, 0.01 to 0.3 percent of hyaluronic acid, 0.05 to 1 percent of honeysuckle flower extract, 0.5 to 5 percent of a solubilizer, 1.001 to 10.1 percent of a sweetening agent, 2 to 20 percent of a humectant, 0.01 to 0.5 percent of a chelating agent, 0.1 to 0.6 percent of a preservative, 0.01 to 0.5 percent of a flavoring agent, 1 to 10 percent of a solvent, 0.01 to 0.2 percent of a coloring agent and the balance of water. According to the mouthwash disclosed by the invention, all the components are combined together, the synergistic effect of '1 + 1gt, 2' can be exerted instead of simple effect addition, the oral ulcer can be effectively prevented and treated, and the effect is far better than that of existing commercially available products.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of oral care, and particularly relates to a mouthwash for preventing and treating oral ulcer and a preparation method thereof. BACKGROUND

[0002] According to the investigation, about 10%-25% of people suffer from recurrent oral ulcer. The main pain points of oral ulcer are pain, slow healing and easy recurrence. The ulcer site is burning pain, which is aggravated when brushing teeth, eating, drinking and speaking. When it is serious, it affects daily life. Long-term recurrent oral ulcer leads to anxiety, sleep disorders and even social avoidance. Oral ulcer patients need a mild and non-irritating special mouthwash which can quickly relieve pain and promote the repair and healing of ulcer surface. The existing mouthwash on the market has the following problems: 1. Single function, lack of mucosa repair function, and no demand for oral ulcer patients; 2. Strong irritation (such as containing alcohol and high-concentration bactericides), which aggravates ulcer pain and destroys oral mucosa in long-term use; 3. Bitter taste, poor user experience. SUMMARY

[0003] Therefore, the present application aims to provide a mouthwash for preventing and treating oral ulcer and a preparation method thereof. By compounding honeysuckle extract (heat-clearing and fire-eliminating), dipotassium glycyrrhizinate (anti-inflammatory), beta-glucan (mucosa repair) and hyaluronic acid (moisturizing), combined with poloxamer 407 solubilization technology, a mild and efficient mouthwash for treating oral ulcer is developed, which meets the triple needs of anti-inflammatory, repair and taste.

[0004] In order to achieve the above-mentioned application purposes, the present application provides the following technical solutions:

[0005] The present application provides a mouthwash for preventing and treating oral ulcer, which comprises the following ingredients in percentage by weight: 0.01-0.5% dipotassium glycyrrhizinate, 0.05-0.5% beta-glucan, 0.01-0.3% hyaluronic acid, 0.05-1% honeysuckle extract, 0.5-5% solubilizer, 1.001-10.1% sweetener, 2-20% humectant, 0.01-0.5% chelating agent, 0.1-0.6% preservative, 0.01-0.5% flavoring agent, 1-10% solvent, 0.01-0.2% colorant and the balance of water.

[0006] The solubilizer comprises poloxamer 407 and PEG-40 hydrogenated castor oil.

[0007] The sweetener comprises one or more of xylitol, sucralose, mannitol, stevia, aspartame and sodium saccharin. When the sweetener is xylitol and sucralose, the amount of xylitol is 1-10%, and the amount of sucralose is 0.001-0.1%.

[0008] The moisturizing agent comprises one or more of glycerin and sorbitol, when the moisturizing agent is glycerin and sorbitol, the amount of glycerin is 1-15%, and the amount of sorbitol is 1-5%;

[0009] The chelating agent comprises EDTA-2Na;

[0010] The preservative comprises one or more of sodium benzoate, potassium sorbate, phenoxyethanol and ethylhexylglycerin, when the preservative is sodium benzoate and potassium sorbate, the amount of sodium benzoate is 0.05-0.3%, and the amount of potassium sorbate is 0.05-0.3%;

[0011] The flavoring agent comprises essence;

[0012] The solvent comprises edible propylene glycol;

[0013] The coloring agent comprises water-soluble food colorant.

[0014] Preferably, the ingredients comprise the following weight percentages: 0.1% dipotassium glycyrrhizinate, 0.1% beta glucan, 0.05% hyaluronic acid, 0.1% honeysuckle extract, 2% poloxamer 407, 5% xylitol, 0.01% sucralose, 8% glycerin, 3% sorbitol, 0.05% EDTA-2Na, 0.1% sodium benzoate, 0.1% potassium sorbate, 0.1% essence, 3% edible propylene glycol, 0.1% coloring agent, and the balance water.

[0015] The application also provides a preparation method of the mouthwash, comprising the following steps:

[0016] 1) Take part of water and add EDTA-2Na, sodium benzoate and potassium sorbate, sorbitol and xylitol, glycerin in sequence to completely dissolve to obtain solution A;

[0017] 2) Mix edible propylene glycol and hyaluronic acid to obtain a slurry, and add poloxamer 407 into solution A, continue to stir for 20-40 min after adding, cool to 4-8℃, then continuously stir for 2-4 h, and add the slurry to obtain solution B;

[0018] 3) Restore solution B to 20-25℃, and add dipotassium glycyrrhizinate, beta glucan and honeysuckle extract in sequence to obtain solution C;

[0019] 4) Add sucralose, essence and water-soluble food colorant in sequence into solution C to obtain solution D;

[0020] 5) Use the remaining water to set the volume of solution D, stir, and filter to obtain the mouthwash for preventing and treating oral ulcer.

[0021] Preferably, the pH is 5.5-6.5, the stirring time is 15-30 min, and the filtration uses a 0.45 μm microporous filter membrane.

[0022] Compared with the prior art, the present application has the following beneficial effects:

[0023] The honeysuckle extract contains active ingredients such as chlorogenic acid and luteoloside, has the effects of clearing heat and resolving toxins, antibacterial and anti-inflammatory, and antiviral, can inhibit the growth of various oral pathogenic bacteria (such as bacteria causing secondary infection), has inhibitory effect on some viruses (such as herpes simplex virus, which may induce some oral ulcers), can also reduce local inflammatory reaction, reduce the risk of infection of the ulcer surface, control the development of inflammation, and relieve redness, heat and pain. Licorice acid is a recognized natural anti-inflammatory agent that can inhibit the release of inflammatory mediators (such as prostaglandins and leukotrienes) and reduce inflammatory reactions. It also has a corticosteroid-like anti-inflammatory effect (but is milder), can quickly relieve pain and discomfort, and can promote the repair of oral mucosal cells, quickly reduce pain and inflammation, is one of the key ingredients for relieving ulcer discomfort, and creates conditions for healing. Beta-glucan can activate immune cells such as macrophages, enhance local immune defense ability, and remove necrotic tissue and pathogens. More importantly, it can stimulate fibroblast proliferation and collagen synthesis, accelerate mucosal tissue repair and regeneration, and help rebuild the damaged mucosal barrier. It is a core "wound healing" ingredient that directly accelerates the repair process of ulcer wounds and shortens healing time. Hyaluronic acid has strong hydrophilicity and water retention capacity, and can form a breathable, water-rich protective film on the surface of the ulcer. This film can isolate food, bacteria and other external stimuli, significantly reduce pain (especially contact pain), keep the wound moist, provide an ideal microenvironment (moisture environment is more conducive to wound healing than dry environment) for cell migration and proliferation, and also has certain anti-inflammatory and tissue repair-promoting effects, providing immediate protection and comfort, creating a moist healing environment, and assisting the repair process.

[0024] The components of the present application are combined together, and are not simply additive effects, but can exert a synergistic effect of "1+1>2". Anti-inflammatory analgesic synergistic effect: honeysuckle extract (broad-spectrum antibacterial anti-inflammatory) + glycyrrhizin (strong anti-inflammatory, rapid analgesic) = significantly control ulcer and surrounding inflammatory reaction, quickly relieve redness and pain, honeysuckle reduce the pathogen of inducing and aggravating inflammation, glycyrrhizin directly inhibit the inflammatory pathway. Immune regulation and repair synergy: beta-glucan (activate immunity, promote fibroblasts and collagen) + honeysuckle extract (control infection, reduce immune system burden) = more effectively clear local potential infection source, optimize the immune environment, and strongly drive tissue regeneration and repair process, beta-glucan is the main force of repair, and honeysuckle removes obstacles. Create and maintain an ideal healing environment: hyaluronic acid (form a hydrated protective film, moisturizing) + beta-glucan (promote repair) = create and maintain a moist, lubricated, protected microenvironment on the ulcer surface. This environment greatly reduces the pain caused by external stimuli (food friction, acidic substances, etc.), while significantly accelerating the crawling of epithelial cells and re-epithelialization of the wound. The barrier effect of hyaluronic acid allows beta-glucan to focus on repair work. Comprehensive protection and comfort enhancement: the lubricating protective film of hyaluronic acid can immediately reduce the severe pain during gargling and eating, and the rapid relief effect of glycyrrhizin further relieves the burning pain. This immediate sense of comfort is very important, as it makes people more willing to adhere to use and eat normally, indirectly promoting recovery, especially in the early stages of ulcer pain, the relief brought by this protective film is very obvious. Covering the whole stage of ulcer management: early stage (redness and pain): honeysuckle + glycyrrhizin strongly anti-inflammatory analgesic; hyaluronic acid provides immediate protection and comfort; middle stage (repair initiation): beta-glucan + honeysuckle synergistically promote immune clearance and repair initiation; hyaluronic acid maintains a moist environment; glycyrrhizin continues to anti-inflammatory; later stage (healing closure): beta-glucan continues to drive tissue regeneration and barrier reconstruction; hyaluronic acid protects the newly formed tissue. DETAILED DESCRIPTION

[0025] The present application provides a mouthwash for preventing and treating oral ulcer, comprising the following ingredients by weight percentage: 0.01-0.5% glycyrrhizin, 0.05-0.5% beta-glucan, 0.01-0.3% hyaluronic acid, 0.05-1% honeysuckle extract, 0.5-5% solubilizer, 1.001-10.1% sweetener, 2-20% humectant, 0.01-0.5% chelating agent, 0.1-0.6% preservative, 0.01-0.5% flavoring agent, 1-10% solvent, 0.01-0.2% colorant and the balance of water.

[0026] The glycyrrhizic acid dipotassium has the effects of anti-inflammatory and anti-allergy, the dosage of the glycyrrhizic acid dipotassium is preferably 0.03-0.3%, further preferably 0.1%; the β-glucan has the effects of mucosa repair and immune regulation, the dosage of the β-glucan is preferably 0.08-0.3%, further preferably 0.1%; the hyaluronic acid has the effects of moisturizing and film forming, the dosage of the hyaluronic acid is preferably 0.03-0.2%, further preferably 0.05%; the honeysuckle extract has the effects of antibacterial and antiviral, the dosage of the honeysuckle extract is preferably 0.08-0.3%, further preferably 0.1%; the solubilizer includes poloxamer 407 and PEG-40 hydrogenated castor oil, the dosage of the solubilizer is preferably 1-3%, further preferably 2%; the sweetener includes one or more of xylitol, sucralose, xylitol, rebaudioside, aspartame and sodium saccharin, when the sweetener is xylitol and sucralose, the dosage of the xylitol is preferably 1-10%, further preferably 2-8%, more preferably 5%; the dosage of the sucralose is preferably 0.001-0.1%, further preferably 0.005-0.08%, more preferably 0.01%; the humectant includes one or more of glycerol and sorbitol, when the humectant is glycerol and sorbitol, the dosage of the glycerol is preferably 1-15%, further preferably 3-12%, more preferably 8%; the dosage of the sorbitol is preferably 1-5%, further preferably 3%; the chelating agent includes EDTA-2Na, the dosage of the chelating agent is preferably 0.03-0.3%, further preferably 0.05%; the preservative includes one or more of sodium benzoate, potassium sorbate, phenoxyethanol and ethylhexylglycerin, when the preservative is sodium benzoate and potassium sorbate, the dosage of the sodium benzoate is preferably 0.05-0.3%, further preferably 0.08-0.2%, more preferably 0.1%; the dosage of the potassium sorbate is preferably 0.05-0.3%, further preferably 0.08-0.2%, more preferably 0.1%; the flavoring agent includes essence, the dosage of the flavoring agent is preferably 0.05-0.4%, further preferably 0.1%; the solvent includes edible propylene glycol, the dosage of the solvent is preferably 2-8%, further preferably 3%; the pH regulator includes citric acid and sodium citrate, the coloring agent includes water-soluble food colorant, the dosage of the coloring agent is preferably 0.05-0.15%, further preferably 0.1%.

[0027] The application further provides a preparation method of the mouthwash, comprising the following steps:

[0028] 1) take part of water and add EDTA-2Na, sodium benzoate and potassium sorbate, sorbitol and xylitol, glycerol in sequence to completely dissolve to obtain solution A;

[0029] 2) Mix edible propylene glycol and hyaluronic acid to obtain a slurry, add poloxamer 407 into solution A, continue stirring for 20-40 min after adding, cool to 4-8℃, then continue stirring for 2-4 h, add the slurry to obtain solution B;

[0030] 3) Recover solution B to 20-25℃, add dipotassium glycyrrhizinate, beta glucan and honeysuckle extract into solution B in sequence to obtain solution C;

[0031] 4) Add sucralose, essence and water-soluble edible pigment into solution C in sequence to obtain solution D;

[0032] 5) Use the remaining water to set the volume of solution D, stir and filter to obtain the mouthwash for preventing and treating oral ulcer.

[0033] In the present application, the time of the continuous stirring in step 2) is preferably 30 min; the temperature of the cooling is preferably 6℃; the time of the continuous stirring is preferably 3 h; the temperature of the recovering in step 3) is preferably 23℃; the pH in step 5) is preferably 5.5-6.5, further preferably 6.0; the time of the stirring is preferably 15-30 min, further preferably 25 min; the filtering adopts a microporous filter membrane with a pore size of 0.45 μm.

[0034] The technical solutions provided by the present application are described in detail below in combination with examples, but they should not be understood as limiting the scope of protection of the present application.

[0035] Example 1

[0036] A mouthwash for preventing and treating oral ulcer is composed of the following ingredients in percentage by weight: 0.1% dipotassium glycyrrhizinate, 0.1% beta glucan, 0.05% hyaluronic acid, 0.1% honeysuckle extract, 2% poloxamer 407, 5% xylitol, 0.01% sucralose, 8% glycerol, 3% sorbitol, 0.05% EDTA-2Na, 0.1% sodium benzoate, 0.1% potassium sorbate, 0.1% essence, 3% edible propylene glycol, 0.1% water-soluble edible pigment and the balance of water.

[0037] The preparation method of the mouthwash for preventing and treating oral ulcer is as follows:

[0038] First step: preparation of water phase (phase A)

[0039] Add 80% of the formula amount of purified water into a preparation tank. Start stirring (medium speed), and slowly and evenly add the following raw materials in sequence, making sure that the previous one is completely dissolved before adding the next one: EDTA-2Na, sodium benzoate and potassium sorbate, xylitol and sorbitol, glycerol, and stir until all the ingredients are completely dissolved to obtain a clear solution.

[0040] Second Step: Solubilizing Phase Preparation (Phase B - Key Step)

[0041] Dissolution of Poloxamer 407: This is a temperature sensitive process. Slowly and evenly sprinkle the poloxamer 407 into the surface of the Phase A solution under stirring (high speed shear is better). After the addition is complete, continue stirring for 30 minutes to ensure complete dispersion. Cool the preparation vessel to 6°C (or place in a refrigerator) and continue stirring for at least 3 hours, or even overnight, to ensure complete hydration and formation of a clear, gel-like solution. This step is critical to avoid poloxamer clumping.

[0042] Dispersion of Hyaluronic Acid: Take a separate container and pre-wet the hyaluronic acid powder with propylene glycol and stir to a uniform slurry. Slowly add this slurry to the hydrated poloxamer solution (Phase B) under stirring (moderate speed). Continue stirring until the hyaluronic acid is completely dissolved and dispersed. The solution may appear slightly viscous.

[0043] Third Step: Active Ingredient Addition (Phase C)

[0044] Return the Phase B solution to room temperature (23°C). Under stirring (moderate speed), add the following active ingredients one at a time: dipotassium glycyrrhizinate, beta-glucan, honeysuckle extract (if in powder form, pre-dissolve in a small amount of warm water). Each ingredient must be completely dissolved before adding the next.

[0045] Fourth Step: Flavoring and Color Adjustment (Phase D)

[0046] Add sucralose and stir until dissolved. Add flavoring and stir until dissolved. Add water-soluble food coloring and stir until the color is uniform.

[0047] Fifth Step: Volume Adjustment and Filtration

[0048] Adjust the volume with the remaining purified water and stir slowly for 25 minutes to ensure uniformity. Filter using a 0.45 μm microporous filter to remove any small particulate impurities and ensure clarity.

[0049] Sixth Step: Filling and Packaging

[0050] Transfer the filtered, clear solution to a holding tank and fill into containers. Label, box, and store.

[0051] Example 2

[0052] A mouthwash for preventing and treating oral ulcer, which is composed of the following ingredients in percentage by weight: 0.01% dipotassium glycyrrhizinate, 0.05% beta glucan, 0.01% hyaluronic acid, 0.05% honeysuckle extract, 0.5% poloxamer 407, 1% xylitol, 0.001% sucralose, 1% glycerol, 1% sorbitol, 0.01% EDTA-2Na, 0.05% sodium benzoate, 0.05% potassium sorbate, 0.01% essence, 1% edible propylene glycol, 0.01% colorant and the balance of water.

[0053] The preparation method of the mouthwash for preventing and treating oral ulcer is as follows:

[0054] First step: preparation of water phase (A phase)

[0055] Add 80% of the formula amount of purified water to the preparation tank. Start stirring (medium speed), and slowly and evenly add the following raw materials one by one: EDTA-2Na, sodium benzoate and potassium sorbate, xylitol and sorbitol, glycerol, and stir until all the ingredients are completely dissolved to obtain a clear solution.

[0056] Second step: preparation of solubilization phase (B phase - key step)

[0057] Dissolution of poloxamer 407: This is a temperature-sensitive process. Slowly and evenly sprinkle poloxamer 407 onto the surface of A phase under stirring (high-speed shearing is better). After adding, continue stirring for 20 min to ensure complete dispersion. Reduce the temperature of the preparation tank to 4°C (or place it in a refrigerator) and continue stirring for at least 2 h or even overnight to ensure complete hydration and form a clear gelatinous solution. This step is crucial to prevent poloxamer from clumping.

[0058] Dispersion of hyaluronic acid: Take a separate container and pre-wet the hyaluronic acid powder with propylene glycol, stirring to form a uniform slurry. Slowly add the slurry to the hydrated poloxamer solution (B phase) under stirring (medium speed). Continue stirring until the hyaluronic acid is completely dissolved and dispersed, and the solution may be slightly viscous.

[0059] Third step: addition of active ingredients (C phase)

[0060] Restore the B phase solution to room temperature (20°C). Under stirring (medium speed), add the following active ingredients one by one: dipotassium glycyrrhizinate, beta-glucan, honeysuckle extract (if it is a powder, it can be pre-dissolved with a small amount of warm water), and each ingredient needs to be completely dissolved before adding the next one.

[0061] Fourth step: flavoring and coloring (D phase)

[0062] Add sucralose, stir to dissolve, add essence, stir to dissolve, and add water-soluble food colorant, and stir until the color is uniform.

[0063] Fifth Step: Make up volume and filtration

[0064] Make up volume with the remaining purified water, stir slowly for 15 minutes to ensure homogeneity. Filter through a 0.45 μm microfiltration membrane to remove possible small particulate impurities and ensure product clarity.

[0065] Sixth Step: Filling and packaging

[0066] Transfer the filtered and clear solution to the storage tank for filling. Label, box and store.

[0067] Example 3

[0068] A mouthwash for preventing and treating oral ulcer, which is composed of the following ingredients by weight percentage: 0.5% dipotassium glycyrrhizinate, 0.5% beta glucan, 0.3% hyaluronic acid, 1% honeysuckle extract, 5% poloxamer 407, 10% xylitol, 0.1% sucralose, 15% glycerol, 5% sorbitol, 0.5% EDTA-2Na, 0.3% sodium benzoate, 0.3% potassium sorbate, 0.5% essence, 10% edible propylene glycol, 0.2% colorant and the balance of water.

[0069] The preparation method of the mouthwash for preventing and treating oral ulcer is as follows:

[0070] First Step: Preparation of water phase (phase A)

[0071] Add 80% of the formula amount of purified water to the preparation tank. Start stirring (medium speed), and slowly and evenly add the following raw materials one by one, making sure that the previous one is completely dissolved before adding the next one: EDTA-2Na, sodium benzoate and potassium sorbate, xylitol and sorbitol, glycerol, and stir until all the ingredients are completely dissolved to obtain a clear solution.

[0072] Second Step: Preparation of solubilization phase (phase B - key step)

[0073] Dissolution of poloxamer 407: This is a temperature-sensitive process. Slowly and evenly sprinkle poloxamer 407 onto the surface of phase A under stirring (high-speed shear is better). After adding, continue stirring for 40 minutes to ensure complete dispersion. Reduce the temperature of the preparation tank to 8°C (or put it in the refrigerator) and continue stirring for at least 4 hours or even overnight to ensure complete hydration and form a clear gelatinous solution. This step is the key to avoiding poloxamer clumping.

[0074] Dispersion of hyaluronic acid: Take a separate container and pre-wet the hyaluronic acid powder with propylene glycol, stirring to form a uniform slurry. Slowly add the slurry to the hydrated poloxamer solution (phase B) under stirring (medium speed). Continue stirring until the hyaluronic acid is completely dissolved and dispersed, and the solution may be slightly viscous.

[0075] Third step: active ingredient addition (C phase)

[0076] The B phase solution is returned to room temperature (25°C). Under stirring (medium speed), the following active ingredients are added in sequence: dipotassium glycyrrhizinate, beta-glucan, honeysuckle extract (if in powder, it can be pre-dissolved with a small amount of warm water first), each ingredient needs to be completely dissolved before adding the next one.

[0077] Fourth step: flavoring and color adjustment (D phase)

[0078] Add sucralose, stir to dissolve, add flavoring, stir to dissolve, add water-soluble food colorant, and stir until the color is uniform.

[0079] Fifth step: volume adjustment and filtration

[0080] Adjust the volume with the remaining purified water, stir slowly for 30 minutes to ensure uniformity of the entire system. Use a 0.45 μm microporous filter to remove possible small particle impurities and ensure product clarity.

[0081] Sixth step: filling and packaging

[0082] The filtered and clear solution is transferred to a storage tank for filling. Labeling, boxing, and warehousing are performed.

[0083] Comparative Example 1

[0084] A certain refreshing mint mouthwash (containing stannsoporane) sold in supermarkets.

[0085] Experimental Example 1

[0086] Recruit 90 volunteers with common mild oral ulcers (ulcer diameter about 3-5 mm), and randomly divide them into 3 groups, 30 people in each group. Divide them into Example 1, Comparative Example 1 and control group, Example 1 and Comparative Example 1 use the mouthwash of Example 1 and Comparative Example 1 respectively, and the control group uses normal saline (0.9% sodium chloride solution).

[0087] Usage: all volunteers gargle 6 times a day, take 10 mL of mouthwash each time, gargle for 2 minutes and then spit it out. Continuous use for 5 days.

[0088] For the convenience of volunteers to understand and record, we use the following two very intuitive indicators:

[0089] (1) Pain score: let the volunteers evaluate the degree of pain with 0-10 points according to their own feelings.

[0090] 0 points: completely painless.

[0091] 10 points: unbearable severe pain.

[0092] The scores before use, on the first day of use, on the third day, and on the fifth day are recorded.

[0093] (2) The number of days required for complete healing of the ulcer: the total number of days from the start of use to the complete healing of the ulcer surface, where no trace can be seen or felt, is recorded.

[0094] (3) A comprehensive feeling satisfaction survey is conducted after 5 days of use.

[0095] Experimental results: as shown in Tables 1-3.

[0096] Table 1: Changes in average pain scores of three groups of volunteers (0-10 points)

[0097]

[0098]

[0099] As shown in Table 1, the pain score of the mouthwash of Example 1 of the present application decreased significantly on the first day of use, indicating that the analgesic effect was very fast. By the fifth day, the pain had basically disappeared, and the effect was much better than that of the other groups.

[0100] Table 2: Average healing time of ulcers of three groups of volunteers

[0101] Group Average healing days required (days) Example 1 4.5 days Comparative Example 1 7.0 days Control group 9.0 days

[0102] As shown in Table 2, the volunteers using the mouthwash of Example 1 of the present application had the fastest healing rate of oral ulcers, with an average healing time of only 4.5 days, which was more than 2 days faster than that of the commercially available products, and more than half the time of the control group.

[0103] Table 3: Comprehensive feeling satisfaction survey after 5 days of use (% represents the proportion of satisfied people)

[0104]

[0105] As shown in Table 3, the mouthwash of Example 1 of the present application was significantly ahead of the commercially available products and the control group in terms of each satisfaction index, proving that it had the best overall experience.

[0106] As shown in the above examples and experimental examples, the mouthwash of the present application can quickly relieve the pain caused by oral ulcers, significantly shorten the healing period of oral ulcers, and has a much better healing effect than existing commercially available products, and has high taste acceptance, no tooth discoloration, no taste change, and other side effects.

[0107] The above is only a preferred embodiment of the present application, and it should be noted that those skilled in the art can make several improvements and refinements without departing from the principles of the present application, and these improvements and refinements should also be considered within the scope of protection of the present application.

Claims

1. A mouthwash for preventing and treating oral ulcers, characterized in that, It includes the following ingredients by weight percentage: 0.01–0.5% dipotassium glycyrrhizate, 0.05–0.5% β-glucan, 0.01–0.3% hyaluronic acid, 0.05–1% honeysuckle extract, 0.5–5% solubilizer, 1.001–10.1% sweetener, 2–20% humectant, 0.01–0.5% chelating agent, 0.1–0.6% preservative, 0.01–0.5% flavoring agent, 1–10% solvent, 0.01–0.2% colorant, and the balance being water; The solubilizers include poloxamer 407 and PEG-40 hydrogenated castor oil; The sweetener includes one or more of xylitol, sucralose, sucralose, stevia, aspartame, and sodium saccharin. When the sweetener is xylitol and sucralose, the amount of xylitol used is 1-10%, and the amount of sucralose used is 0.001-0.1%. The moisturizer includes one or more of glycerin and sorbitol. When the moisturizer is glycerin and sorbitol, the amount of glycerin is 1-15% and the amount of sorbitol is 1-5%. The chelating agent includes EDTA-2Na; The preservative includes one or more of sodium benzoate, potassium sorbate, phenoxyethanol and ethylhexylglycerin. When the preservative is sodium benzoate and potassium sorbate, the amount of sodium benzoate is 0.05-0.3% and the amount of potassium sorbate is 0.05-0.3%. The flavoring agent includes flavoring; The solvent includes food-grade propylene glycol; The colorant includes water-soluble food coloring.

2. The mouthwash for preventing and treating oral ulcers according to claim 1, characterized in that, The ingredients include the following ingredients by weight percentage: 0.1% dipotassium glycyrrhizate, 0.1% beta-glucan, 0.05% hyaluronic acid, 0.1% honeysuckle extract, 2% poloxamer 407, 5% xylitol, 0.01% sucralose, 8% glycerin, 3% sorbitol, 0.05% EDTA-2Na, 0.1% sodium benzoate, 0.1% potassium sorbate, 0.1% flavoring, 3% edible propylene glycol, 0.1% water-soluble food coloring, and the balance being water.

3. The method for preparing the mouthwash according to claim 1 or 2, characterized in that, Includes the following steps: 1) Take a portion of water and add EDTA-2Na, sodium benzoate and potassium sorbate, sorbitol and xylitol, and glycerol in sequence until completely dissolved to obtain solution A; 2) Mix edible propylene glycol and hyaluronic acid to obtain a slurry. Add poloxamer 407 to solution A. After adding all the slurry, continue stirring for 20-40 minutes. Cool the solution to 4-8°C and continue stirring for 2-4 hours. Add the slurry to obtain solution B. 3) Restore solution B to 20-25℃, and add dipotassium glycyrrhizate, β-glucan and honeysuckle extract in sequence to obtain solution C; 4) Add sucralose, flavoring, and water-soluble food coloring to solution C in sequence to obtain solution D; 5) Dilute solution D with the remaining water, stir, and filter to obtain a mouthwash for preventing and treating oral ulcers.

4. The preparation method according to claim 3, characterized in that, Step 5) The pH is 5.5 to 6.5, the stirring time is 15 to 30 minutes, and the filtration uses a 0.45 μm microporous membrane.

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