The invention discloses preparation methods of mineralized hydrogel and a biomimetic mineralized bone
repair material. The mineralized hydrogel is prepared by using a photoactivated biomacromoleculesand a photoactivated
phosphatase as raw materials; hydrogel is formed by initiating cross-linking by means of
light irradiation or initiating
polymerization cross-linking by means of a
radical initiator; when the hydrogel is put into mineralized liquid,
phosphatase can promote the uniform deposition of
phosphate in the gel, so that the uniformly mineralized hydrogel is obtained.
Phosphoprotein-like molecules are added during the preparation of the hydrogel; the
phosphoprotein-like molecules can promote the uniform deposition of
phosphate along a
molecular network of biomacromolecules, so thatthe high-strength mineralized hydrogel can be obtained. When the
phosphoprotein-like molecules and cells are added during the preparation of the hydrogel, the in-situ loading of the cells can be realized, and the
enzyme in a process of bone physiological mineralization can be simulated so as to promote a
phosphate mineralization process, so that the biomimetic mineralized bone
repair material withhigh strength can be obtained, and the personalized customization of the bionic mineralized bone
repair material can be realized; therefore, the preparation methods have a broad application prospectin the field of
bone tissue engineering.