Composition for preventing and treating bone arthritis and application thereof

An osteoarthritis and composition technology, which is applied in the field of compositions containing non-denatured type II collagen and cartilage collagen peptides, can solve the problems of increased bone-to-bone friction, only palliative treatment, fracture, etc., and achieves improvement and treatment. Arthritis and joint degeneration prevention effect

Active Publication Date: 2019-01-01
安徽盛美诺生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the increase of age, the synthesis rate of collagen gradually decreases, the loss of collagen increases, and the network structure relaxes or even breaks, which accelerates the loss of proteoglycan and other components, degeneration of articular cartilage, and intensified friction between bones , causing inflammation in the joints
[0004] The drugs currently used for osteoarthritis are mainly non-steroidal anti-inflammatory drugs, which have anti-inflammatory and analgesic effects, and are suitable for inflammatory pain; however, these drugs can cause nausea, vomiting and other gastrointestinal discomfort, and long-term use will also increase digestion. risk of tract bleeding
Moreover, such traditional treatment methods such as detumescence and pain relief can only treat the symptoms, but are difficult to cure the root cause.
[0005] The products for osteoarthritis appearing in the health care products market are mainly glucosamine and chondroitin sulfate. These health products have a certain degree of nutritional supplement effect, but the effect is also very limited; moreover, because these health products do not have anti-inflammatory effects , in order to relieve pain caused by inflammation, additional anti-inflammatory drugs are required
[0006] At present, there is still a lack of effective food or medicine for the prevention and treatment of osteoarthritis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Crushing: Grinding and crushing each component of the candy flakes, and filtering through 80 mesh sieves;

[0052] (2) Mixing: Weigh each component: fructooligosaccharide 31g (Shandong Bailong Chuangyuan Biotechnology Co., Ltd.), cartilage collagen peptide 13g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), non-denatured type II collagen 6g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), 9.5g of microcrystalline cellulose (Henan Jianjiu Industrial Co., Ltd.), 0.5g of magnesium stearate (Henan Jianjiu Industrial Co., Ltd.), placed in a three-dimensional mixer, mixed and stirred for about 10 minutes;

[0053] (3) Tablet compression: at a relative humidity below 60% and a temperature of 40 degrees Celsius, adjust the filling wheel so that the weight of each piece of candy is about 600 mg, the rotary speed of the tablet machine is 25 revolutions per minute, and the positive pressure of the pressure wheel is 280N. The lateral pressure was 240N, and a total of 100 tablet...

Embodiment 2

[0055] (1) Pulverization: the components of the candy slices are ground and broken, and filtered through a 100-mesh sieve;

[0056] (2) Mixing: weighing each component: fructooligosaccharide 31g (Shandong Bailong Chuangyuan Biotechnology Co., Ltd.), cartilage collagen peptide 18g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), non-denatured type II collagen 1g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), 9.5g of microcrystalline cellulose (Henan Jianjiu Industrial Co., Ltd.), 0.5g of magnesium stearate (Henan Jianjiu Industrial Co., Ltd.), placed in a three-dimensional mixer, mixed and stirred for about 10 minutes;

[0057] (3) Tablet compression: When the relative humidity is below 60%, the temperature is below 40 degrees Celsius, adjust the filling wheel so that the weight of each piece of candy is about 600 mg, the rotary table speed of the tablet machine is 25 revolutions per minute, and the positive pressure of the pressure wheel is 280N. The lateral pressure was 240N...

Embodiment 3

[0059] (1) Crushing: Grinding and crushing each component of the candy flakes, and filtering through 80 mesh sieves;

[0060] (2) Mixing: Weigh each component: fructooligosaccharide 31g (Shandong Bailong Chuangyuan Biotechnology Co., Ltd.), cartilage collagen peptide 10g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), non-denatured type II collagen 6g (Beijing Shengmei Nuo Biotechnology Co., Ltd.), turmeric 1g (Sabinsa Corporation, Curcumin C3Complex), licorice extract 1g (Norevo Suzhou Food Co., Ltd.), vitamin C 1g (CSPC, food grade), microcrystalline Cellulose 9.5g (Henan Jianjiu Industrial Co., Ltd.), magnesium stearate 0.5g (Henan Jianjiu Industrial Co., Ltd.), placed in a three-dimensional mixer, mixed for about 10 minutes;

[0061] (3) Tablet compression: When the relative humidity is below 60%, the temperature is below 40 degrees Celsius, adjust the filling wheel so that the weight of each piece of candy is about 600 mg, the rotary table speed of the tablet machine is 2...

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PUM

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Abstract

The invention provides a composition for preventing and treating bone arthritis. The composition is characterized by comprising non-denaturing type II collagen and cartilage collagen peptide accordingto a weight ratio of 1:(0.5 to 30), preferably 1:(1 to 20), more preferably 1:(1.5 to 10), and most preferably 1:(1.5 to 6). The invention also provides application of the composition in preparationof a product for preventing and treating the bone arthritis, wherein the product is a medicine or health-care food. The composition for preventing and treating bone arthritis has the advantages that the cartilage collagen peptide can be used as a raw material needed for synthesizing cartilage tissues, the degradation of joints is prevented, and the repair function is realized on the injured joints; the non-denaturing type II collagen can inhibit the generation of inflammation, so as to relieve and treat the arthritis; proved by experiment results, the combination of the cartilage collagen peptide and the non-denaturing type II collagen can achieve a synergistic effect on the preventing and treatment of arthritis.

Description

technical field [0001] The invention relates to a composition for preventing and treating osteoarthritis and its application, in particular to a composition containing non-denatured type II collagen and cartilage collagen peptide and its application. Background technique [0002] In the past 20 years, the incidence of joint diseases in my country has been increasing, and osteoarthritis is the most common joint disease. At present, more than half of the elderly over 60 years old in my country suffer from osteoarthritis. At the same time, osteoarthritis caused by young people's improper exercise and trauma is becoming more and more common, and osteoarthritis has shown a trend of younger age. In fact, the disability rate of osteoarthritis can be as high as 53%, and the severity of pain and dysfunction caused by osteoarthritis is comparable or even greater than that of cardiovascular and cerebrovascular diseases. [0003] Articular cartilage is mainly composed of collagen (59%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P19/02A61P29/00A23L33/00A61K38/01A61K36/9066A61K36/78A61K36/484A61K31/375
CPCA23V2002/00A61K31/375A61K36/484A61K36/78A61K36/9066A61K38/014A61K38/39A23L33/00A61P19/02A61P29/00A61K2300/00A23V2200/30
Inventor 刘爽王海燕刘爱青
Owner 安徽盛美诺生物技术有限公司
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