The invention discloses an integrated treatment process for clindamycin hydrochloride production wastewater. The process comprises the following steps: performing triple-effect evaporation and concentration on the clindamycin hydrochloride production wastewater, performing centrifugal separation, feeding coarse salts produced by centrifugal separation into a salt refining workshop, collecting the mother solution to be used for extracting phosphate, and repeatedly performing dissolution, evaporation and centrifugal separation on the coarse salts in the salt refining workshop, thereby obtaining high-purity chlorine salts; washing by ethanol, thereby obtaining the finished chlorine salts; collecting the produced mother solution to be used for extracting phosphate; performing evaporation and concentration on the phosphate mother solution, centrifuging and washing, thereby obtaining the phosphate; rectifying the scrubbing solution, recycling the methanol, feeding the distillation residues into a hazardous waste treatment center, merging the foul condensate produced by multiple-effect evaporation and crystallization mother liquor produced by centrifugal separation, homogenizing, and performing anaerobic and aerobic biological treatment and advanced treatment. The method provided by the invention is an integrated method for combining multiple-effect evaporation, methanol rectification and biological treatment and has the characteristics of reasonable resource utilization, low cost, simplicity and convenience in operation, stable operation and the like.