Preparation method of clindamycin hydrochloride freeze dried powder injection

A technology of clindamycin hydrochloride and freeze-dried powder injection, which is applied in the field of preparation of clindamycin hydrochloride freeze-dried powder injection, which can solve the problems of content reduction, high failure rate of clarity, and strong irritation of liquid medicine, etc.
CN1830452AInactive Publication Date: 2006-09-13巴里莫尔制药(通化)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
巴里莫尔制药(通化)有限公司
Publication Date
2006-09-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

A freeze-dried powder injection of clindamycin hydrochloride for treating various infectious diseases, tonsillitis, tympanitis, acute bronchitis, pneumonia, etc is prepared from clindamycin hydrochloride through ultrafiltration, mixing with filtered mannitol in dark condition and N2 atmosphere, pouring in containers, freeze drying, and sealing.
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Description

technical field

[0001] The invention relates to a preparation method of clindamycin hydrochloride freeze-dried powder injection for antibiotic drug injection. Specifically, it relates to a freeze-dried powder injection with clindamycin hydrochloride as the main component. After clindamycin hydrochloride is processed by ultrafiltration technology, clindamycin hydrochloride ultrafiltrate is obtained, and mannitol filtrate is used to avoid It is prepared under light and nitrogen conditions, filled, freeze-dried, capped and packaged to make the finished product of clindamycin hydrochloride freeze-dried powder for injection. It has been proved by clinical experiments that it can be infused intravenously, and has high antibacterial activity against Gram-positive bacteria such as Staphylococcus (including penicillin-resistant strains), Streptococcus, Bacillus diphtheria, and Bacillus anthracis. It also has good antibacterial activity against Gram-negative anaerobic bacteria. Most of...

Claims

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