46results about How to "Low related substances" patented technology

The present invention discloses a display device and a manufacturing method thereof by which a manufacturing process can be simplified. Further, the present invention discloses technique for manufacturing a pattern such as a wiring into a desired shape with good controllability. A method for forming a pattern for constituting the display device according to the present invention comprises the steps of forming a first region and a second region; discharging a composition containing a pattern formation material to a region across the second region and the first region; and flowing a part of the composition discharged to the first region into the second region; wherein wettability with respect to the composition of the first region is lower than that of the second composition.

Azacitidine for injection and a preparation method thereof are disclosed. Main components of the azacitidine for injection contain main drugs of azacitidine and mannitol. Mainly by controlling pH value of an azacitidine aqueous solution, hydrolysis of azacitidine is effectively inhibited, related substances of freeze-dried product are minimized, and product quality of the azacitidine freeze-drying preparation is raised.

The invention relates to an Edaravone crystal form and a preparation method thereof. The Edaravone crystal form is characterized by X-ray diffractogram of powder. The crystal form can obviously improve the water solubility of Edaravone, thereby being more beneficial to preparation of injections. Besides, related substances are further decreased, and the safety of the preparation is improved.

The invention relates to bicontinuous microemulsions and to the use thereof as a fuel, combustion or heating fluid. Said fuels permit an increased efficiency of internal combustion systems and heating installations of any type and, simultaneously, a minimized emission of pollutants, associated with combustion, to be obtained.

This invention concerns a method for absorbing acrylic acid, characterized by supplying an acrylic acid-containing reaction gas component obtained by the reaction of catalytic gas phase oxidation to an acrylic acid absorption column and advancing a high boiling inert hydrophobic organic liquid into counter-flow contact with said reaction gas in said acrylic acid absorption column with the mass flow rate of the organic liquid fixed in the range of 0.2-7.0 times the mass flow rate of the acrylic acid in the reaction gas thereby absorbing acrylic acid in said organic liquid and obtaining an acrylic acid-containing solution including a low boiling substance in the range of 0.7-7.5 wt % based on the weight of bottom liquid of absorption column.

The invention provides a process for preparing naloxone hydrochloride injection. The pH of the naloxone hydrochloride injection can be unchangeable during placing by strictly controlling the pH range in production; and simultaneously, a method for inert gas protection adopted in the production reduces the oxygen content in liquid medicine and an ampoule to the minimum so as to prevent oxidative deterioration of the naloxone hydrochloride injection to reduce related substances. The technology greatly ensures the product quality.

A freeze-dried powder injection of spartase for supplementing electrolyte and treating arrhythmia, myocarditis sequelae, congestive heart failure, myocardial infarction, etc is prepared through reaction between L-aminobutanedioic acid and magnesium oxide, ultrasonic treating, cold storage, ultrafiltration, adding the filtered liquid prepared from potassium hydroxide and mannitol, filling in containers in dark condition, freeze drying and sealing.

A medical rubber closure according to the present invention includes a disc-shaped flange portion and a leg portion formed to be continuous to a lower surface side of the flange portion, and a region at the lower surface side of the flange portion and the leg portion are made of a nitrile based rubber, a region at a top surface side of the flange portion is made of a butyl based rubber, and the leg portion is laminated with a coating layer made of a fluorine based resin film.

The invention provides an oral liquid preparation of pidotimod, which can promote immunoreaction of a human body, effectively reduces times and degree of treating acute attack of bacteria or virus induced infection, shortens the course of the disease, can serve as an auxiliary medicine of antibiotic during acute infection and belongs to the field of medicines. The oral liquid preparation comprises the pidotimod, a chemical stabilizer, a pH regulator, a flavoring agent and the like, wherein trihytdroxy methyl-aminomethane serves as the pH regulator; and stability of the solution can be effectively improved through quantitative proportion and synergistic effect of each ingredient. The oral liquid preparation has stable quality, is convenient to store for a long time and is particularly suitable for old people or children to take.

The invention relates to a method and device for controlling an internal combustion engine comprising an inlet pipe leading to a cylinder input where a gas input valve is placed. Said engine also comprises a drive for the gas input valve which makes it possible to adjust a gas input valve lift for at least two values. The engine also comprises an injection valve for metering fuel and a spark plug which controls the crankshaft angle of air-fuel mixture ignition. Said internal combustion engine is controlled in a following manner: a fuel is metered at least once during the intake stroke of a cylinder when the valve lift (VL) passes from one value to the other and at least one final injection is carried out in a dosing manner only when the valve lift (VL) is really carried out.

The present invention discloses a display device and a manufacturing method thereof by which a manufacturing process can be simplified. Further, the present invention discloses technique for manufacturing a pattern such as a wiring into a desired shape with good controllability. A method for forming a pattern for constituting the display device according to the present invention comprises the steps of forming a first region and a second region; discharging a composition containing a pattern formation material to a region across the second region and the first region; and flowing a part of the composition discharged to the first region into the second region; wherein wettability with respect to the composition of the first region is lower than that of the second composition.

An acetylglutamide injection for improving brain function and treating coma, palsy, hypointelligence, dysmnesia, etc is prepared through mixing acetylglutamide and phosphate buffering liquid, ultrasonic treating, cold storage, ultrafiltration, mixing with Na2EDTA solution in dark condition, pouring in containers, sterilizing and lamp examining.

An injection of trace elements for providing external nutrients is prepared through depositing in water, cold storage, ultrasonic treating, ultrafiltration, adding filtered sorbitol in dark condition and N2 atmosphere, pouring in containers, sterilizing and lamp examining.

A freeze-dried powder injection of clindamycin hydrochloride for treating various infectious diseases, tonsillitis, tympanitis, acute bronchitis, pneumonia, etc is prepared from clindamycin hydrochloride through ultrafiltration, mixing with filtered mannitol in dark condition and N2 atmosphere, pouring in containers, freeze drying, and sealing.

The invention relates to a method and device for controlling an internal combustion engine comprising an inlet pipe leading to a cylinder input where a gas input valve is placed. Said engine also comprises a drive for the gas input valve which makes it possible to adjust a gas input valve lift for at least two values. The engine also comprises an injection valve for metering fuel and a spark plug which controls the crankshaft angle of air-fuel mixture ignition. Said internal combustion engine is controlled in a following manner: a fuel is metered at least once during the intake stroke of a cylinder when the valve lift (VL) passes from one value to the other and at least one final injection is carried out in a dosing manner only when the valve lift (VL) is really carried out.

The invention provides an alprostadil injection. Every 1000ml of alprostadil injection comprises the following raw materials: 5mg of alprostadil, 90-110g of soybean oil, 15-20g of phosphatide, 2-3g of oleic acid, 22.1-25g of isoosmotic agent, and appropriate pH modifier, wherein the content of the pH modifier is enough to regulate the pH of the injection to be 5.0-6.0. The invention also provides a preparation method for the alprostadil injection. Compared with the prior art, the alprostadil injection prepared by the method has higher encapsulation efficiency and content of main drug, contains fewer related substances, has good stability, and provides safety guarantee for clinical medication.

A freeze-dried powder injection of VC for preventing and treating scurvy, acute and chronic infectious diseases, purpura, Keshan disease, etc is prepared from VC, sodium hydrogen sulfate, and disodium versenate through ultrasonic treating, adding CO2 saturated water for injection in dark condition and N2 atmosphere, regulating pH value and temp, etc.

The invention belongs to the technical field of medicines, and particularly relates to cefoperazone sodium and tazobactam sodium pharmaceutical composition for injection and a preparation method of the cefoperazone sodium and tazobactam sodium pharmaceutical composition. The pharmaceutical composition is a freeze-dried powder preparation. The mass ratio of cefoperazone sodium to tazobactam sodium in the pharmaceutical composition is 4:1. The preparation method comprises the steps as follows: firstly, tazobactam is refined; then, tazobactam sodium is prepared from refined tazobactam and sodium bicarbonate; finally, cefoperazone sodium and prepared tazobactam sodium are uniformly mixed for preparation of freeze-dried powder. Compared with like products sold in the market, the pharmaceutical composition has the advantages of good solubility, light color, few related substances, small polymer content and low adverse reaction rate; besides, effective constituents in the pharmaceutical composition are stable, and when the pharmaceutical composition is preserved for a long term, few effective constituents are degraded, the content of impurities is low, the quality performance of products is relatively good, and the medication safety of patients is guaranteed accordingly.

The invention provides a topiramate granule and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The preparation method comprises the steps of firstly, preparing a cyclodextrin inclusion compound from topiramate serving as an active drug; then, screening the inclusion compound, and next, uniformly mixing the screened inclusion compound and pharmaceutically-acceptable auxiliary materials; and granulating by using a wet process or dry process to obtain the granule. The granule is good in uniformity and stability and is easily dissolved into water; the bitter taste of topiramate is completely covered; the taste of the topiramate granule is remarkably improved; the dosage of the topiramate granule can be conveniently selected according to the age and bodyweight of a patient; and the compliance of the old, children and patients having difficulty in swallowing during drug use is improved.

A garlicin injection for preventing and treating acute and chronic bacillary dysentery and enteritis, pertussis, fungus infection of lung and digestive tract, etc is prepared through ultrasonic treating to garlicin and tween-80, mixing with alcohol, ultrafiltration, pouring it in containers containing N2 in dark condition, sterilizing, and lamp examining.

The invention provides a process for refining bendazac lysine and analogs thereof, belonging to the technical field of chemical drug preparation. The process comprises the steps of adopting bendazac or bendazac analogs and L-lysine or L-histidine as raw materials; reacting the raw and salifying the materials in an aqueous solution of a polar aprotic solvent so as to obtain a crude product; and then recrystallizing the crude product in an aqueous solution of a polar protic solvent, wherein the polar aprotic solvent preferably selected from acetonitrile while the polar protic solvent is preferably selected from ethanol. The bendazac lysine and the analogs thereof which are finally prepared by using the invention are both white crystalline powders with yield of more than 80% and content of 99.6-101%, wherein the content of 3-hydroxyl-1-benzyl indazole is lower than 0.1%; or even no 3-hydroxyl-1-benzyl indazole is detected; and the total content of impurities does not exceed 0.2%. The refining process provided by the invention has the advantages of simple method, mild condition, short reaction time, low product cost, high purity and high yield, is beneficial for large-scale production and can be also can be used for refining commercial bendazac lysine raw materials.

The invention relates to bicontinuous microemulsions and to the use thereof as a fuel, combustion or heating fluid. Said fuels permit an increased efficiency of internal combustion systems and heating installations of any type and, simultaneously, a minimized emission of pollutants, associated with combustion, to be obtained.

The invention relates to a thiamphenicol glycinate hydrochloride freeze-dried powder injection and a preparation method thereof, belonging to the technical field of medicines. The proper pH value range and the proper freeze-drying conditions of an intermediate solution are screened out by researching the thiamphenicol glycinate formulation technology, therefore, the obtained freeze-dried powder injection has the advantages of low related substances, stable quality, easy transportation and storage and high safety.

A low-dosage injection of tanshinone IIA-sodium sulfonate for treating coronary heart disease, angina pectoris, myocardial infarction and ventricular premature contraction is prepared from the tanshinone IIA-sodium sulfonate through depositing in water, cold storage, ultrafiltration, adding additives in dark condition, pouring in containers in Na atmosphere, sterilizing and lamp examining.

The invention relates to the technical field of the pharmacy, and especially relates to a preparation method of a compound paracetamol and amantadine hydrochloride capsule. The method is characterized in that smaller amounts of components comprising dextrin, calculus bovis factitious, chlorphenamine maleate and caffeine in a prescription are uniformly mixed to obtain mixed powder I, and larger amounts of compounds comprising viregyt hydrochloride and paracetamol in the prescription are uniformly mixed with the mixed powder I to realize uniform mixing and the uniformity of the content of the chlorphenamine maleate in the whole capsule. Double-tapered rotary vacuum drying is adopted, the physical and chemical properties of a material are not changed after the drying of the material, and the content of relevant substances in a finally finished product is low.

The invention relates to the technical field of medicines and discloses a mezlocillin sodium and sulbactam sodium compound drug composition for injection. The mezlocillin sodium and sulbactam sodium compound drug composition comprises mezlocillin sodium, sulbactam sodium and sodium benzoate. The mezlocillin sodium and sulbactam sodium compound drug composition realizes higher product performance by less auxiliary materials, has the advantages of being good in solubility, shallow in color, uniform in main drug mixing, low in related substance, low in polymer content, low in incidence rate of adverse reactions and the like and ensures that patients are safer in the clinical use, and the treatment effect is more reliable.