46results about How to "Low related substances" patented technology

Azacitidine for injection and a preparation method thereof are disclosed. Main components of the azacitidine for injection contain main drugs of azacitidine and mannitol. Mainly by controlling pH value of an azacitidine aqueous solution, hydrolysis of azacitidine is effectively inhibited, related substances of freeze-dried product are minimized, and product quality of the azacitidine freeze-drying preparation is raised.

The invention relates to an Edaravone crystal form and a preparation method thereof. The Edaravone crystal form is characterized by X-ray diffractogram of powder. The crystal form can obviously improve the water solubility of Edaravone, thereby being more beneficial to preparation of injections. Besides, related substances are further decreased, and the safety of the preparation is improved.

The invention relates to bicontinuous microemulsions and to the use thereof as a fuel, combustion or heating fluid. Said fuels permit an increased efficiency of internal combustion systems and heating installations of any type and, simultaneously, a minimized emission of pollutants, associated with combustion, to be obtained.

The invention provides a process for preparing naloxone hydrochloride injection. The pH of the naloxone hydrochloride injection can be unchangeable during placing by strictly controlling the pH range in production; and simultaneously, a method for inert gas protection adopted in the production reduces the oxygen content in liquid medicine and an ampoule to the minimum so as to prevent oxidative deterioration of the naloxone hydrochloride injection to reduce related substances. The technology greatly ensures the product quality.

A freeze-dried powder injection of spartase for supplementing electrolyte and treating arrhythmia, myocarditis sequelae, congestive heart failure, myocardial infarction, etc is prepared through reaction between L-aminobutanedioic acid and magnesium oxide, ultrasonic treating, cold storage, ultrafiltration, adding the filtered liquid prepared from potassium hydroxide and mannitol, filling in containers in dark condition, freeze drying and sealing.

The invention provides an oral liquid preparation of pidotimod, which can promote immunoreaction of a human body, effectively reduces times and degree of treating acute attack of bacteria or virus induced infection, shortens the course of the disease, can serve as an auxiliary medicine of antibiotic during acute infection and belongs to the field of medicines. The oral liquid preparation comprises the pidotimod, a chemical stabilizer, a pH regulator, a flavoring agent and the like, wherein trihytdroxy methyl-aminomethane serves as the pH regulator; and stability of the solution can be effectively improved through quantitative proportion and synergistic effect of each ingredient. The oral liquid preparation has stable quality, is convenient to store for a long time and is particularly suitable for old people or children to take.

An acetylglutamide injection for improving brain function and treating coma, palsy, hypointelligence, dysmnesia, etc is prepared through mixing acetylglutamide and phosphate buffering liquid, ultrasonic treating, cold storage, ultrafiltration, mixing with Na2EDTA solution in dark condition, pouring in containers, sterilizing and lamp examining.

The invention provides an alprostadil injection. Every 1000ml of alprostadil injection comprises the following raw materials: 5mg of alprostadil, 90-110g of soybean oil, 15-20g of phosphatide, 2-3g of oleic acid, 22.1-25g of isoosmotic agent, and appropriate pH modifier, wherein the content of the pH modifier is enough to regulate the pH of the injection to be 5.0-6.0. The invention also provides a preparation method for the alprostadil injection. Compared with the prior art, the alprostadil injection prepared by the method has higher encapsulation efficiency and content of main drug, contains fewer related substances, has good stability, and provides safety guarantee for clinical medication.

The invention provides a topiramate granule and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The preparation method comprises the steps of firstly, preparing a cyclodextrin inclusion compound from topiramate serving as an active drug; then, screening the inclusion compound, and next, uniformly mixing the screened inclusion compound and pharmaceutically-acceptable auxiliary materials; and granulating by using a wet process or dry process to obtain the granule. The granule is good in uniformity and stability and is easily dissolved into water; the bitter taste of topiramate is completely covered; the taste of the topiramate granule is remarkably improved; the dosage of the topiramate granule can be conveniently selected according to the age and bodyweight of a patient; and the compliance of the old, children and patients having difficulty in swallowing during drug use is improved.

A garlicin injection for preventing and treating acute and chronic bacillary dysentery and enteritis, pertussis, fungus infection of lung and digestive tract, etc is prepared through ultrasonic treating to garlicin and tween-80, mixing with alcohol, ultrafiltration, pouring it in containers containing N2 in dark condition, sterilizing, and lamp examining.

A biological substance related article includes a coating formed by causing a biological substance adsorption preventive coating composition to come in contact with a surface of the biological substance related article and heating the composition, the biological substance adsorption preventive coating composition including: (A) a copolymer obtained by copolymerizing raw material monomers including a monomer A1 shown by the following general formula (1) and an active hydrogen group-containing monomer A2; (B) a crosslinking agent reactive with an active hydrogen group; and (C) a solvent.

CH₂═CR³COOR¹OR²  (1)

(R¹ represents an alkylene group having 1 to 4 carbon atoms, R² represents an alkyl group having 1 to 4 carbon atoms, and R³ represents a hydrogen atom or a methyl group).

The invention relates to a thiamphenicol glycinate hydrochloride freeze-dried powder injection and a preparation method thereof, belonging to the technical field of medicines. The proper pH value range and the proper freeze-drying conditions of an intermediate solution are screened out by researching the thiamphenicol glycinate formulation technology, therefore, the obtained freeze-dried powder injection has the advantages of low related substances, stable quality, easy transportation and storage and high safety.

A low-dosage injection of tanshinone IIA-sodium sulfonate for treating coronary heart disease, angina pectoris, myocardial infarction and ventricular premature contraction is prepared from the tanshinone IIA-sodium sulfonate through depositing in water, cold storage, ultrafiltration, adding additives in dark condition, pouring in containers in Na atmosphere, sterilizing and lamp examining.