639results about How to "Mask bitterness" patented technology

The present invention discloses coating compositions with taste masking property, comprising a blend of pH sensitive polymers and optionally a pH independent polymer or a blend of the pH sensitive polymer and pH independent polymer used for taste masking of highly bitter drugs. The pH sensitive polymers used comprise the acid soluble polymers and the enteric polymers. The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said coating compositions is disclosed. The concomitant use of the polymers inhibits the release of the bitter drug at the pH of saliva. The said coating compositions deliver substantial amount of the bitter drug immediately with improved palatability.

The invention relates to a cyclodextrin-included florfenicol quick-release water-soluble powder preparation and a preparation method thereof. The preparation is prepared by stirring florfenicol, cyclodextrin and water at a uniform speed and including by using an inclusion technology. The preparation can be directly dissolved in water to be taken by livestock, and has the characteristics of high medicine dissolution rate, high dissolubility, high bioavailability, good absorption and the like; and the medicine (florfenicol) is included in a carrier material, the bitterness of the florfenicol can be masked, and the intake or drinking of animals cannot be influenced by the bitterness of the medicine.

The invention provides a stable and rapidly disintegrable aqueous oral preparation (liquid or jelly preparation) of amlodipine. The liquid preparation comprises an anionic surfactant having a sulfuric acid group or a sulfonic acid group as a stabilizer in an aqueous solution of amlodipine, at pH 5-7, while the jelly preparation further comprises a gelling agent, a fine powder solid, and a gelling regulator.

The present invention relates to food production, is especially the production process of sour and hot bitter bamboo shoot, and solves the technological problem of utilizing the resource of bitter bamboo shoot to produce delicious food product in simple process and low cost. The production process of sour and hot bitter bamboo shoot includes the following steps: slicing bitter bamboo shoot into shreds or slices; boiling in water with salt for 40-60 min; draining and cooling; mixing with sugar and pressurizing for 1-2 days; mixing with chicken bouillon, pickled chili chip and vinegar, sealing in can; sterilizing; etc.

The invention discloses a preparing method for pomelo wine. According to the method, water, sugar, honey, acid, pectinase, yeast cell wall, nutrimental agents and yeast are added into a crushed pomelo and mixed uniformly to be fermented at the temperature of about 18 DEG C, an odor absorber is added when the alcoholic strength is about 6% vol, after fermentation is finished, wine liquid is taken and stored in the environment with the temperature of about 2 DEG C, wine sediment is removed after 60 days, then the wine liquid is stored for about 90 days, then the wine liquid is placed in the environment with the temperature of about minus 4 DEG C for 3 days, clarification is carried out, and the wine liquid is filtered and sterilized after being placed in the environment with the temperature of about minus 4 DEG C for 4 days. According to the method, the skin can also be fermented for generating the pomelo wine, the inhibiting effect on the fermenting effect from special ingredients in the pomelo skin is overcome, and the pomelo wine with the special taste can be brewed, and has the dense lemon scent; the way of adding the odor absorber to the special fermenting process is fished out, bitterness of the pomelo can be covered up, flavor compounds in the pomelo wine are effectively preserved, the scent of the pomelo wine is more complex, and the mouthfeel is enhanced.

The invention discloses an anti-hypelipidemic powder mainly for diabetes patient and the preparing method. The raw material essentially comprises balsam pear powder, union powder, black soybean powder, duck wheat powder and pumpkin powder. The early stage curative effect of this product is apparent and the medium-long term curative effect is stable.

The invention provides a preparation method of a buckwheat flavone microcapsule, which comprises the following steps: 1) pretreating: drying buckwheat grain, buckwheat shell, buckwheat husk or buckwheat stem leaf, sieving after crushing for standby to obtain buckwheat powder; 2) extracting; 3) separating and purifying; 4) preparing a capsule emulsion: uniformly mixing a core material, a wall material and an emulsifier to prepare a buckwheat flavone microcapsule emulsion; 5) spray drying to obtain the buckwheat flavone microcapsule. The invention has the advantages that: 1, the activity of an active component flavone substance in buckwheat is protected; 2, the buckwheat flavone is prevented from damage of gastric acid, has certain targeting after microencapsulation, and has good enteric solubility but insolublility in stomach; 3, the bitter taste of buckwheat is covered; 4, the release speed is controlled, the flavone substance can not be stored in vivo, and the concentration of the flavone substance is rapidly increased in vivo after taking and rapidly decreasing due to metabolism degradation effect, the microencapsulation enables a slow release function and releases functional factors in certain time and scope.

The invention relates to a tilmicosin micro-capsule preparation, and in particular relates to a tilmicosin micro-capsule preparation and a preparation method of the tilmicosin micro-capsule preparation, belonging to the technical field of veterinary medicine. The tilmicosin micro-capsule preparation comprises an inner core layer and a coating layer, wherein the inner core layer comprises a tilmicosin raw material and macromolecule auxiliary materials, the macromolecule auxiliary materials are selected from one or more than one of 12-carbon fatty acid-18-carbon fatty acid, paraffins and vegetable wax; and the coating layer comprises an inner coating layer and an outer coating layer, wherein the material of the inner coating layer is one or more than one of starch, calcium carbonate and calcium hydrophosphate, and the material of the outer coating layer is acrylic resin. The tilmicosin micro-capsule preparation disclosed by the invention is tasteless, enteric, and good in palatability. According to the invention, the tilmicosin is packed by the macromolecule auxiliary materials, a layer of enteric coating layer is sprayed on the surfaces of the tilmicosin grains in the process of rolling circle when the materials are prepared, and the strong bitter taste and odor of the tilmicosin can be completely covered due to the double-layer package, and the preparation method is simple in technology, and low in cost.

The invention relates to the field of medicinal preparations, and particularly relates to racecadotril granules and a preparation method thereof. The racecadotril granules are prepared from the following raw materials by weight: 0.1-2 parts of racecadotril, 93-99 parts of an excipient, 0.02-2 parts of a corrigent, 0.01-0.1 part of an adhesive and 0.05-1 part of a suspending agent. The racecadotril granules are prepared by suspending racecadotril in the adhesive and dissolving partial sucrose in the adhesive, so that bitter taste of a drug can be covered. The prepared racecadotril granules have relatively good granulation effect, and increase compliance of children.

The invention relates to an azithromycin enteric dry suspension and a preparation method thereof. The dry suspension comprises the following components in percentage by weight: 4 to 10 percent of azithromycin, 0.3 to 0.5 percent of isolated coating material, 1.6 to 3.2 percent of enteric coating material, 75 to 90 percent of flavoring agent and 3 to 6 percent of suspending agent. The azithromycin enteric dry suspension solves the problem that the azithromycin stimulates gastric mucosa in the background art, and provides an azithromycin preparation which is dissolved, released and absorbed in intestinal tracks. The azithromycin enteric dry suspension also solves the problem that the basic remedy and a capsule shell in an azithromycin enteric capsule generate cross-linking reaction, and masks the bitterness of the azithromycin through a taste masking technique, so the azithromycin enteric dry suspension is suitable for medicaments for children.

The invention discloses a green tea-bitter gourd slices, and a preparation method and application thereof. The preparation method comprises the following steps of: pre-treating, debitterizing and hardening bitter gourds, and maintaining the bitter gourds green; crushing and sieving green tea, heating and digesting the green tea with deionized water, filtering the green tea, adding xylitol and high fructose syrup in filtrate, and adjusting the pH value of the filtrate to be 6-7, thus obtaining green tea soup; soaking the treated bitter gourd slices in the green tea soup to enable ingredients such as tea polyphenol, the xylitol and the high fructose syrup in the tea soup to permeate in the bitter gourd slices; and draining and drying the soaked bitter gourd slices which are fished out, thusobtaining the green tea-bitter gourd slices. The green tea-bitter gourd slices prepared by the preparation method disclosed by the invention are 0.2cm to 0.8 cm thick, brownish green, semi-ring-shaped, full in appearance, and free from crystals on the surface; the taste of the tea-bitter gourd slices is slightly bitter and then sweet, rich in tea aroma, and mild in bitter gourd flavour; and the total content of the tea polyphenol is 8840-11510 mg/kg. The green tea-bitter gourd slices are convenient to store, and can be eaten by chewing or drunk by being mixed with warm water or boiling water.

The invention provides a medicinal micro-capsule taking corn cob flour as a core material and a preparation method of the medicinal micro-capsule. The preparation method comprises the following steps that 1, a core substance is prepared: a medicinal solvent is dissolved to prepare a medicinal solution, or a medicine and assistants such as an emulsifier are combined to prepare an emulsion; the medicinal solution or the emulsion and the corn cob flour are mixed, sufficiently stirred and dried to obtain the core substance taking the corn cob flour as a medicinal carrier; 2, bonding and fixing are performed: a bonding agent is dissolved by a solvent to obtain a bonding agent solution; the bonding agent solution and the core substance are mixed, sufficiently stirred, dried and sieved to obtain the secure core substance containing the bonding agent; 3, coating is performed: the core substance is coated with the core material to prepare the medicinal micro-capsule taking the corn cob flour as the core material, wherein coating methods include an air suspension method, a spray drying method, a pan coating method and a painting method; the painting coating method is preferable.

The invention relates to a spill-resistant pharmaceutical composition, comprising a spill-resistant formulation with taste masking concentrations of polyethylene glycol (PEG) and diphenhydramine, which is less bitter, sweeter and has better overall flavor than current pharmaceutical compositions, while maintaining advantageous spill-resistant properties.

The invention relates to a novel Olanzapine orally disintegrating tablet. The tablet comprises (I) a stabilizing Olanzapine coating particulate and (II) an additive, wherein the stabilizing Olanzapine coating particulate contains: (i) a neutral core; (ii) an active layer surrounding the neutral core; and (iii) a protective layer surrounding the active layer. The invention also relates to a preparation method of the stabilizing Olanzapine coating particulate and the novel Olanzapine orally disintegrating tablet containing the stabilizing Olanzapine coating particulate.

The invention discloses a cefuroxime axetil composition which comprises the following components in parts by weight: 1 part of cefuroxime axetil, 1-15 parts of a low-melting-point wax material, 5-8 parts of filler, 0-0.6 part of a disintegrating agent, 0-0.15 part of a binder and 0-0.08 part of a corrigent. The invention further discloses a preparation method of the cefuroxime axetil composition. The cefuroxime axetil composition obtained can better cover bitter taste of the medicine and is good in dissolution rate, so that the medication compliance of patients is further improved.

The invention discloses common perilla and brown sugar stuffing sweet dumplings and a production method thereof. The common perilla and brown sugar stuffing sweet dumplings consist of sweet dumpling stuffing and sweet dumpling wrappers, wherein the sweet dumpling stuffing comprises the components of white granulated sugar powder, plant oil, drinking water, wheat flour, brown sugar, common perilla powder, black sesame powder, peanut powder and soybean meal; and the sweet dumpling wrappers comprise the components of water-containing water-milled glutinous rice flour, cooked sticky rice roll, drinking water and konjaku flour. The production method of the common perilla and brown sugar stuffing sweet dumplings comprises the following steps: making the aqueous water-milled glutinous rice flour; preparing a sweet dumpling wrapper dough; preparing the stuffing; and making the sweet dumplings. If the prepared sweet dumplings are frozen quickly and preserved in a freezing manner, the preservation time of the sweet dumplings can be prolonged. Compared with the prior art, the common perilla and brown sugar stuffing sweet dumplings are rich and balanced in nutrition, have the effects of improving health, are good in color and mouthfeel, and are fine and smooth in taste. Moreover, the production method of the common perilla and brown sugar stuffing sweet dumplings is convenient and is easy in operation. The produced sweet dumplings are safer and more sanitary by means of inhibition of the breeding of microorganisms.

The invention relates to an oral preparation containing amisulpride. The amisulpride which is active medicine is prepared into cyclodextrin inclusion compound, is sieved, is uniformly mixed with pharmaceutically acceptable auxiliary materials, and is granulated by a wet method or a dry method, obtained granules are squashed to form tablets, filled into capsules to form a capsule preparation or is directly separately packaged to obtain a granule preparation. The water solubility and the stability of the oral preparation containing the amisulpride can be strengthened, bitter taste of the amisulpride is covered, medication compliances of patients are improved, and bioavailability of the oral preparation is improved to a great extent.

A compound medicine taken orally is prepared from famotidine, cyclodextrin and antiacid through including the famotidine particles by cyclodextrin, and mixing the inclusion compound with antiacid.

The invention relates to a low-sodium and low-phosphate meat product which comprises a main material and auxiliary materials, wherein the main material is fresh minced meat and fresh meat loaves, and the auxiliary materials comprise lysine, arginine, potassium chloride, magnesium chloride, sodium chloride, water, monosodium glutamate, ginger powder, white granulated sugar, white pepper powder and sodium nitrite. The raw materials in the formula are used for making sausage, stewed meat or fried products respectively; sodium salt is partially replaced with sylvite and magnesium salt, so that the addition quantity of sodium chloride is reduced to lower than 1.75%, addition of sodium salt and phosphate is lower than corresponding national standard; astringency and bitter caused by addition of sylvite and magnesium salt can be hidden effectively through collaborative application of lysine and arginine, and the flavor and water conservation of products can be improved; and indexes including the color and luster, flavor, tissue state, taste and the like of the meat product are close to or better than like products in the market.

The invention discloses a production method for orange wine. The method comprises the following steps: 1, squeezing quantitative oranges to obtain orange juice (A), carrying out enzymolysis on pomace to prepare orange juice (B), and mixing the orange juice (A) with the orange juice (B) to obtain orange juice (C); 2, adding the orange juice (C) into glutinous rice flour, and carrying out gelatinization, liquefaction and saccharification on the obtained product to obtain mash (D) containing 200.00g/L-220.00g/L reducing sugar, wherein the amount of the orange juice (C) is 4 times of the amount of the glutinous rice flour; 3, adding fruit wine yeast into the mash (D), fermenting for 7-8 days to obtain unblended wine (E) the alcoholic strength of which is 10.0-12.0%Vol, and filtering and agingthe unblended wine to obtain base wine (F); and 4, blending the base wine (F) to produce the finished product of the orange wine. The method disclosed by the invention is simple, is low in productioncost and has the advantage of improving the utilization ratio of oranges by 10-15%; and the prepared orange wine has orange color, is transparent, is agreeable to the taste and mellow, and has the specific incense of orange fruit wine.