20results about How to "Mask bitterness" patented technology

The invention relates to the technical field of medicine preparation, and discloses a rebamipide tablet and a preparation method and application thereof, the rebamipide tablet comprises 40-60 parts of rebamipide, 3-6 parts of polyethylene glycol, 20-30 parts of beta-cyclodextrin, 5-8 parts of an adhesive, 10-20 parts of a filler, 2-5 parts of a disintegrating agent, 0.1-1 part of a flow aid, and 1-3 parts of a lubricant. According to the rebamipide tablet, beta-cyclodextrin and PEG are combined for use, so that the electrostatic adsorption phenomenon of rebamipide is weakened, agglomeration among rebamipide molecules is prevented, the flowability of rebamipide particles is improved, and the prepared rebamipide tablet is higher in particle uniformity and faster and higher in dissolution rate. In the preparation method, the beta-cyclodextrin is firstly added, stirred and sheared, the PEG solution is sprayed, then the adhesive, the filler, the disintegrating agent and the glidant are added, and the lubricant is added, so that the preparation process is relatively smooth, the yield is increased, the content uniformity of the rebamipide tablet is improved, the tablet weight difference is reduced, the dissolution rate is accelerated, and the bitter taste of the rebamipide is covered.

The invention discloses a coating preparation and a preparation method thereof. The coating preparation comprises a quick-release layer, a slow-release layer and a coating material, wherein the quick-release layer and the slow-release layer are coated with the coating material; the coating preparation is prepared by the following steps: S1, preparing the quick release layer; s2, preparing a sustained-release layer; s3, preparing a coating material; and S4, preparing the coating preparation. The coating preparation provided by the invention can improve the position and speed of drug release, increase the stability of the drug, prevent the compatibility change of the drug, control the position of drug release, cover the bitter taste and bad smell of the drug, and improve the appearance of the drug. According to the method for preparing the coating preparation, the problems of migration of active pharmaceutical ingredients in the tabletting process, breakage of a coating film and crushing of the medicine in the transportation and storage processes can be avoided, the stability of the active pharmaceutical ingredients is further guaranteed, the production efficiency of the medicine can be improved, the product quality is guaranteed, and the production cost is reduced. The production cost is reduced; meanwhile, the environment-friendly requirement is met.

The invention discloses a silybin meglumine oral liquid and a preparation method thereof. The method comprises the following steps: preparing silybin meglumine powder, a sweetening agent, an acidulant and purified water as raw materials; under the conditions that the stirring speed is 250 rpm and the water temperature is 25-30 DEG C, silybin meglumine powder is slowly scattered into the purified water to be stirred for 45 minutes until the silybin meglumine powder is completely dissolved; adding a sweetening agent and an acidulant, continuously stirring for 10 minutes, and then filtering through a 0.22 mu m microfiltration membrane to obtain a sterile and transparent solution; and subpackaging the solution into sterile oral liquid bottles, and sealing and packaging. The silybin meglumine oral liquid prepared by the method has the advantages of high dissolution efficiency, optimized taste, sterility, safety, stable quality and the like, is suitable for industrial large-scale production, and can remarkably improve the medication compliance of patients. The method is simple in process, easy to operate and low in cost, and has wide popularization and application values.

The present invention belongs to the technical field of feed additives, and specifically relates to a coated tannic acid preparation for weaned piglets, and a preparation method and use thereof. In view of the existing problems that weaned piglets are prone to high diarrhea rate, low feed intake, reduced immune function, and poor growth, the present invention provides a coated tannic acid preparation for weaned piglets. The coated tannic acid preparation for weaned piglets described in the present invention comprises: by weight percentage, 70-80% of the main material and 20-30% of the auxiliary material; the main material is a mixture of tannic acid, chlorogenic acid and hesperidin; the auxiliary material is a mixture of corn starch, β-cyclodextrin, sodium alginate, palm oil, acrylic resin and hydroxypropyl methylcellulose acetate succinate. The present invention also provides a preparation method and use of the above-mentioned preparation. The preparation of the present invention can improve the palatability of feed, reduce the diarrhea rate of weaned piglets, repair damaged intestines of weaned piglets, maintain the balance of intestinal microbial cells, and improve the disease resistance of weaned piglets.

A method for separating and purifying high-purity soybean active peptides comprises the following steps: (1) extreme enzymatic hydrolysis pretreatment: taking defatted soybean powder, adding 15-25 times the amount of water, then adding 1.0-2.0% of oligosaccharides and 0.5-1.5% of hemicellulase preparation, treating at 105-125°C and 0.12-0.18MPa for 20-30min, then cooling to 45-55°C, adjusting the pH to 7.0-8.0, and obtaining a pretreated soybean protein suspension; (2) dual enzyme synergistic enzymatic hydrolysis: first adding 30% of the pretreated soybean protein suspension to the pretreated soybean protein suspension; 00-7000U / g protein neutral protease, then add 3000-7000U / g protein alkaline protease, enzymolysis at 50-60℃ for 2-4h, during which the pH of the system is maintained at 7.5-8.5 by adding sodium hydroxide solution, and after the enzymolysis is completed, the enzyme is inactivated at 90-100℃ for 10-20min to obtain an enzymolysis solution; (3) ultrafiltration-activated carbon adsorption coupling separation; (4) reverse phase chromatography separation and purification; (5) excipient and packaging: take the active peptide freeze-dried powder, add 15-25% oligofructose, mix well and then package to obtain the soybean active peptide product.

The application discloses low-bitter rice residue peptide micelles, a rice residue protein hydrolysate and a preparation method and application thereof, and relates to the technical field of protein processing. The preparation method comprises the following steps: performing step-by-step enzymolysis on rice residue protein to perform directional cutting on the hydrophilic region and the hydrophobic region of the rice residue protein, so as to obtain an amphiphilic polypeptide mixture; adjusting the pH and the temperature, so that the amphiphilic polypeptide mixture is self-assembled to form rice residue peptide micelles, and low-bitter rice residue peptide micelles are obtained. The application aims to solve the technical problems that the existing rice residue protein enzymolysis product has significant bitterness, and traditional debittering technologies have the problems of nutrient loss or the need for external addition. A new mechanism of realizing physical debittering by constructing a supramolecular micelle structure is innovatively proposed and verified. The rice residue protein peptides after enzymolysis are self-assembled to form stable nanometer micelles through step-by-step enzymolysis and directional cutting, so that the hydrophobic groups causing bitterness are selectively embedded in the core of the micelles, and the contact of the hydrophobic groups with taste receptors is physically blocked.

The invention provides a stomach-strengthening and digestion-promoting oral gel and a preparation method thereof, and relates to the field of medical technology. The stomach-strengthening and digestion-promoting oral gel of the invention comprises components by weight fraction: 0.5-2% compound glue, 0.05-0.2% potassium chloride, 5-20% sucrose, 0.05-0.25% citric acid, 0.025-0.075% antibacterial agent, 2.5-4% fruit powder and 73.475-91.875% liquid; in the liquid, the concentration of the Chinese medicine extract is 0.19-0.51g crude drug / mL; in the compound glue, the mass ratio of carrageenan, locust bean gum and xanthan gum is 1-5:0.3-3:0.5-2.5; the prepared stomach-strengthening and digestion-promoting oral gel has moderate elasticity and hardness, is convenient to chew, has a good taste, can meet the needs of different groups of people, improve the compliance of people with chewing and swallowing difficulties, can also significantly reduce the relative residual rate of pigment in the stomach, and significantly accelerate the pigment propulsion movement in the small intestine.

The invention discloses a pentoxyverine citrate sustained-release dry suspension with a taste-masking effect and a preparation method thereof, and relates to the technical field of medicines, the sustained-release dry suspension comprises pentoxyverine citrate taste-masking sustained-release pellets, a suspending aid, a sweetening agent, a bacteriostatic agent and an aromatic; the preparation method comprises the following steps: firstly, preparing the pentoxyverine citrate taste-masking sustained-release pellets, and then uniformly mixing the pentoxyverine citrate taste-masking sustained-release pellets, the suspending aid, the sweetening agent, the bacteriostatic agent and the aromatic. By adopting the sustained-release framework material, the sustained-release effect is achieved, the medicine taking frequency is reduced, and the medicine taking compliance of a patient is improved.

The invention provides a high-stability erythromycin cyclic ester dry suspension and a preparation method thereof. The preparation method comprises the following steps: S1, adding hydroxypropyl-beta-cyclodextrin, mannitol, sucrose and lactose into a polyvinyl alcohol solution, and uniformly stirring and mixing to prepare a mixture A; s2, adding low-substituted hydroxypropyl cellulose, lauryl sodium sulfate, acesulfame potassium and vanillin into the xanthan gum solution, and uniformly stirring and mixing to prepare a mixture B; s3, uniformly stirring and mixing erythromycin cydocarbonate with the mixture A and the mixture B to prepare a mixture; and S4, preparing a soft material from the mixture, sieving and granulating to obtain wet particles, drying, finishing the particles, and sub-packaging to obtain the high-stability erythromycin cydocarbonate dry suspension. According to the method disclosed by the invention, the erythromycin cyclamate, the mixture A and the mixture B are stably adsorbed to form a stable medicine mixture, the stable medicine mixture is easy to disperse and stabilize in water, meanwhile, rapid degradation of the erythromycin cyclamate in the later storage process is also effectively avoided, the storage stability is improved, and the bioavailability is also high.

The invention discloses animal-derived low-sodium seasoning salt and a preparation method thereof, belongs to the technical field of salt substitutes, and provides the animal-derived low-sodium seasoning salt which comprises the following components in parts by weight: 10-12 parts of animal-derived Maillard powder, 50-60 parts of NaCl, 30-40 parts of KCl, 3-6 parts of a bitterness inhibitor and 2 parts of maltodextrin. The animal-derived low-sodium seasoning salt provided by the invention contains rich flavor amino acids, flavor nucleotides and small molecule peptides, avoids bad flavors such as bitter taste and metallic taste brought by KCl, further reduces the use amount of NaCl in daily life, is a novel healthy nutritional seasoning, and can be widely used in families and catering industries.

The invention belongs to the technical field of veterinary drugs, and discloses a preparation method and application of pH response type enrofloxacin granules for treating porcine respiratory bacterial mixed infection. The invention provides the enrofloxacin coated particle, the enrofloxacin coated particle has pH response capability, is not released in a stomach pH environment and can be quickly released in a near small intestine pH environment, so that the stomach irritation of enrofloxacin is reduced, and the enrofloxacin is ensured to be absorbed at an optimal part. According to the enrofloxacin coated granules, the bitter taste of the medicine is effectively covered, the administration frequency is reduced, and the effective plasma concentration maintaining time is prolonged. Meanwhile, the enrofloxacin coated granules have a good treatment effect on porcine respiratory diseases caused by mixed infection of various bacteria.

The present invention provides a sildenafil citrate orodisintegrating tablet and a preparation method thereof, and belongs to the field of medical technology. Icariin, tribulus saponin and sildenafil citrate are mixed to prepare liposomes, added to a hydrogel prepared from modified maltodextrin and earthworm protein, mixed evenly, dried, ground to obtain a mixed powder, added to an auxiliary material, and tableted to obtain a sildenafil citrate orodisintegrating tablet. The sildenafil citrate orodisintegrating tablet prepared by the present invention adopts a direct tableting method, has a simple preparation method, does not require coating, has good palatability, good stability, good therapeutic effect, has a good sustained-release effect, prolongs the drug effect time, improves the patient's compliance, and has broad application prospects.

The present invention relates to a pharmaceutical composition, advantageously a ready-to-use liquid composition or a dry powder for redissolution, comprising: sinocarbamate or a salt, hydrate or solvate thereof, where the pharmaceutical composition for administration is preferably an oral suspension; a kit for precise metering and administration of pharmaceutical compositions. In addition, the present composition has at least one surface modifier for controlling the solid state of the sinocarbamate in the suspension; and a method for treating focal seizures in a human patient comprising administering a therapeutically effective amount of the pharmaceutical composition.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a Qi-invigorating and blood-activating granule for heart pain and its preparation method, comprising the following raw materials in parts by weight: 25-35 parts of raw Astragalus membranaceus, 10-20 parts of Angelica sinensis, 5-15 parts of ginseng, 4-8 parts of Panax notoginseng, 10-20 parts of Ligusticum chuanxiong, 8-12 parts of earthworm, and 2-4 parts of leech. This invention precisely targets the core pathogenesis of Qi deficiency and blood stasis syndrome, which is "Qi deficiency as the root and blood stasis as the manifestation," selecting raw Astragalus membranaceus and ginseng as the core Qi-invigorating components, and Panax notoginseng, leech, Ligusticum chuanxiong, Angelica sinensis, and earthworm as the core blood-activating components. The formulation follows the traditional Chinese medicine principle of "invigorating Qi to promote blood circulation without harming the body's vital energy." The dosage of each raw material has been optimized through systematic experiments to form a specific range of parts by weight, solving the technical problems of poor targeting and insufficient synergy in existing formulations.

The invention discloses empagliflozin and metformin compound sustained-release granules and a preparation method thereof.The empagliflozin and metformin compound sustained-release granules comprise empagliflozin quick-release granules and metformin sustained-release coating granules, each metformin sustained-release coating granule comprises a core layer and a coating layer, the core layer is a mixture of metformin hydrochloride, an adhesive and sodium polystyrene sulfonate, and the coating layer is a mixture of metformin hydrochloride, an adhesive and sodium polystyrene sulfonate. The sodium polystyrenesulfonate accounts for 10%-30% of the total weight of the metformin sustained-release coated granules; the coating layer is a mixed material of polyvinyl acetate, triacetin and Tween 80, and the mass ratio of polyvinyl acetate to triacetin to Tween 80 is (75-85): (10-15): (5-10). Sodium polystyrenesulfonate and metformin hydrochloride are mixed and then coated with the coating layer, so that the bitter taste of metformin hydrochloride can be completely covered.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an amisulpride pharmaceutical composition, an oral suspension prepared from the amisulpride pharmaceutical composition and a corresponding preparation method. The composition disclosed by the invention is mainly composed of amisulpride and polyvinyl alcohol, other pharmaceutical auxiliary materials can be added to prepare an oral suspension, polyvinyl alcohol has the dual effects of modifying taste and assisting suspension, the composition has excellent stability, the bitter taste of amisulpride in a preparation is remarkably improved, and the medication compliance of a patient is improved.

The invention discloses a ginsenoside-containing flash release agent as well as a preparation method and application thereof. The flash release agent is prepared from red ginseng, dwarf lilyturf tuber, Chinese magnoliavine fruit and specific auxiliary materials, and does not contain any sweetening agent or flavoring agent. The preparation method comprises the steps of superfine grinding, clathration and taste masking and direct tabletting. According to the invention, by optimizing the ratio of auxiliary materials and a tabletting process, the preparation is rapidly disintegrated within 3 seconds under the tongue, active ingredients are directly absorbed by sublingual mucous membrane, the first-pass effect is effectively avoided, and the preparation rapidly takes effect within 3 minutes; meanwhile, a sugar-free formula and a cyclodextrin inclusion technology are adopted, so that the beverage tastes good and is suitable for diabetics. The preparation method is simple and convenient in process and excellent in stability, and can be used for preparing medicines or health-care products for improving learning and memory, relieving fatigue or assisting sedation.

The trimebutine maleate resin compound slow-release suspension is prepared from the following raw materials in parts by weight: 190 to 210 parts of trimebutine maleate resin compound, 18 to 22 parts of xanthan gum, 0 to 20 parts of tragacanth gum, 15 to 17 parts of citric acid, 4 to 6 parts of propylene glycol and 240 to 260 parts of water. The invention also discloses a preparation method of the trimebutine maleate resin compound slow-release suspension, which comprises the following steps: dissolving xanthan gum and tragacanth gum in water, then sequentially adding citric acid and propylene glycol, uniformly mixing, then adding the trimebutine maleate resin compound, uniformly stirring and mixing to obtain the trimebutine maleate resin compound slow-release suspension. The trimebutine maleate resin compound slow-release suspension is obtained. The trimebutine maleate resin compound sustained-release suspension disclosed by the invention can realize positioned sustained release in the intestinal tract of a human body and continuously exert the drug effect, has good stability and no bitter taste, and improves the taking compliance of a patient.

The present invention belongs to the field of medical technology, and relates to a lumiperone orodispersible film taste-masking composition, a preparation method and application thereof. The composition of the present invention comprises: an active ingredient, an alkaline excipient and an inclusion compound; the active ingredient comprises one or more of lumiperone and a pharmaceutically acceptable salt of lumiperone; the composition further comprises: one or more of a film-forming material, a plasticizer, a sweetener, a disintegrant and a colorant. The lumiperone orodispersible film obtained by the present invention has good taste, good instant solubility and high stability, and can effectively improve the problems of poor medication compliance, drug hiding and drug vomiting in patients with mental illness, and has high clinical application value.

The invention provides an erythromycin stearate nano-micelle oral liquid preparation and a preparation method thereof, and belongs to the technical field of medicine preparation, the erythromycin stearate nano-micelle oral liquid preparation comprises the following components: erythromycin stearate, ethanol, polyoxyethylene 40 hydrogenated castor oil and vitamin E succinic acid polyethylene glycol ester. The preparation method comprises the following steps: S1, stirring and mixing polyoxyethylene 40 hydrogenated castor oil and vitamin E succinic acid polyethylene glycol ester, adding ethanol, and continuously stirring; s2, keeping the temperature, adding erythromycin stearate, and stirring until erythromycin stearate is dissolved; s3, water is added under the stirring condition, and stirring is kept; s4, citric acid is added and stirred, and the pH value is adjusted; and S5, adding water to a batch, stirring, sterilizing, filtering, and canning. According to the erythromycin stearate nano-micelle oral liquid disclosed by the invention, the bitter taste can be greatly reduced, the medication compliance of old people and children with dysphagia can be improved, the stability of erythromycin in the stomach can be improved due to the fact that erythromycin is wrapped in the nano-micelle, and the micelle also has the effect of promoting body absorption and increasing the bioavailability at the same time.