5results about How to "Mask bitterness" patented technology

The application discloses low-bitter rice residue peptide micelles, a rice residue protein hydrolysate and a preparation method and application thereof, and relates to the technical field of protein processing. The preparation method comprises the following steps: performing step-by-step enzymolysis on rice residue protein to perform directional cutting on the hydrophilic region and the hydrophobic region of the rice residue protein, so as to obtain an amphiphilic polypeptide mixture; adjusting the pH and the temperature, so that the amphiphilic polypeptide mixture is self-assembled to form rice residue peptide micelles, and low-bitter rice residue peptide micelles are obtained. The application aims to solve the technical problems that the existing rice residue protein enzymolysis product has significant bitterness, and traditional debittering technologies have the problems of nutrient loss or the need for external addition. A new mechanism of realizing physical debittering by constructing a supramolecular micelle structure is innovatively proposed and verified. The rice residue protein peptides after enzymolysis are self-assembled to form stable nanometer micelles through step-by-step enzymolysis and directional cutting, so that the hydrophobic groups causing bitterness are selectively embedded in the core of the micelles, and the contact of the hydrophobic groups with taste receptors is physically blocked.

The invention belongs to the technical field of veterinary drugs, and discloses a preparation method and application of pH response type enrofloxacin granules for treating porcine respiratory bacterial mixed infection. The invention provides the enrofloxacin coated particle, the enrofloxacin coated particle has pH response capability, is not released in a stomach pH environment and can be quickly released in a near small intestine pH environment, so that the stomach irritation of enrofloxacin is reduced, and the enrofloxacin is ensured to be absorbed at an optimal part. According to the enrofloxacin coated granules, the bitter taste of the medicine is effectively covered, the administration frequency is reduced, and the effective plasma concentration maintaining time is prolonged. Meanwhile, the enrofloxacin coated granules have a good treatment effect on porcine respiratory diseases caused by mixed infection of various bacteria.

The present invention relates to a pharmaceutical composition, advantageously a ready-to-use liquid composition or a dry powder for redissolution, comprising: sinocarbamate or a salt, hydrate or solvate thereof, where the pharmaceutical composition for administration is preferably an oral suspension; a kit for precise metering and administration of pharmaceutical compositions. In addition, the present composition has at least one surface modifier for controlling the solid state of the sinocarbamate in the suspension; and a method for treating focal seizures in a human patient comprising administering a therapeutically effective amount of the pharmaceutical composition.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a Qi-invigorating and blood-activating granule for heart pain and its preparation method, comprising the following raw materials in parts by weight: 25-35 parts of raw Astragalus membranaceus, 10-20 parts of Angelica sinensis, 5-15 parts of ginseng, 4-8 parts of Panax notoginseng, 10-20 parts of Ligusticum chuanxiong, 8-12 parts of earthworm, and 2-4 parts of leech. This invention precisely targets the core pathogenesis of Qi deficiency and blood stasis syndrome, which is "Qi deficiency as the root and blood stasis as the manifestation," selecting raw Astragalus membranaceus and ginseng as the core Qi-invigorating components, and Panax notoginseng, leech, Ligusticum chuanxiong, Angelica sinensis, and earthworm as the core blood-activating components. The formulation follows the traditional Chinese medicine principle of "invigorating Qi to promote blood circulation without harming the body's vital energy." The dosage of each raw material has been optimized through systematic experiments to form a specific range of parts by weight, solving the technical problems of poor targeting and insufficient synergy in existing formulations.

The invention discloses a ginsenoside-containing flash release agent as well as a preparation method and application thereof. The flash release agent is prepared from red ginseng, dwarf lilyturf tuber, Chinese magnoliavine fruit and specific auxiliary materials, and does not contain any sweetening agent or flavoring agent. The preparation method comprises the steps of superfine grinding, clathration and taste masking and direct tabletting. According to the invention, by optimizing the ratio of auxiliary materials and a tabletting process, the preparation is rapidly disintegrated within 3 seconds under the tongue, active ingredients are directly absorbed by sublingual mucous membrane, the first-pass effect is effectively avoided, and the preparation rapidly takes effect within 3 minutes; meanwhile, a sugar-free formula and a cyclodextrin inclusion technology are adopted, so that the beverage tastes good and is suitable for diabetics. The preparation method is simple and convenient in process and excellent in stability, and can be used for preparing medicines or health-care products for improving learning and memory, relieving fatigue or assisting sedation.