Tilmicosin micro-capsule preparation and preparation method thereof

Abstract

The invention relates to a tilmicosin micro-capsule preparation, and in particular relates to a tilmicosin micro-capsule preparation and a preparation method of the tilmicosin micro-capsule preparation, belonging to the technical field of veterinary medicine. The tilmicosin micro-capsule preparation comprises an inner core layer and a coating layer, wherein the inner core layer comprises a tilmicosin raw material and macromolecule auxiliary materials, the macromolecule auxiliary materials are selected from one or more than one of 12-carbon fatty acid-18-carbon fatty acid, paraffins and vegetable wax; and the coating layer comprises an inner coating layer and an outer coating layer, wherein the material of the inner coating layer is one or more than one of starch, calcium carbonate and calcium hydrophosphate, and the material of the outer coating layer is acrylic resin. The tilmicosin micro-capsule preparation disclosed by the invention is tasteless, enteric, and good in palatability. According to the invention, the tilmicosin is packed by the macromolecule auxiliary materials, a layer of enteric coating layer is sprayed on the surfaces of the tilmicosin grains in the process of rolling circle when the materials are prepared, and the strong bitter taste and odor of the tilmicosin can be completely covered due to the double-layer package, and the preparation method is simple in technology, and low in cost.

Description

technical field

[0001] The invention relates to a tilmicosin preparation, in particular to a tilmicosin microcapsule preparation and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique

[0002] Timicosin is a semi-synthetic macrolide antibiotic for livestock and poultry developed in the 1980s, which has inhibitory effects on Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, and spirochetes; It has stronger antibacterial activity than tylosin against Actinomyces pleuropneumoniae and Pasteurella. It is mainly used for the prevention and treatment of livestock pneumonia (caused by Actinobacillus pleuropneumoniae, Pasteurella, Mycoplasma, etc.), avian mycoplasmosis and mastitis of lactating animals. In recent years, studies have found that it has a certain inhibitory effect on PRRS, so tilmicosin has a broad market space. However, because tilmicosin is very bitter and has an odor, when fed with the mixture,...

Examples

Embodiment 1

[0039] First take by weighing 30kg tilmicosin, 50kg dodecyl fatty acid, under the molten state of 65 ℃, shear and stir evenly, cool to room temperature, make the mixture of tilmicosin and above-mentioned auxiliary material. The above mixture was added to 15kg of starch for granulation and spheronization. During the spheronization process, 10kg of methyl methacrylate solution with a solid content of 50% was sprayed on the surface of the granules to obtain approximately spherical microcapsule particles. Dry the obtained semi-finished product of tasteless enteric-coated tilmicosin microcapsules to obtain the final product, the diameter of the microcapsules is 200 μm, and the moisture content is 2%.

[0040]

Embodiment 2

[0042] First take by weighing 40kg tilmicosin, 30kg 15-carbon fatty acid, under 100 ℃ molten state, shear and stir evenly, cool to room temperature, make the mixture of tilmicosin and auxiliary material 15-carbon fatty acid. Add the above mixture to 20kg of starch for granulation and spheronization. During the spheronization process, spray 25kg of butyl acrylate solution with a solid content of 40% on the surface of the granules to obtain approximately spherical microcapsule particles. The obtained tasteless enteric-coated substitute The semi-finished product of micosin microcapsule particles is dried to obtain the final product. The diameter of the microcapsule particles is 500 μm and the moisture content is 4%.

[0043]

Embodiment 3

[0045] First weigh 50kg of tilmicosin and 20kg of octadecyl fatty acid, in a molten state at 120°C, shear and stir evenly, cool to room temperature, and make a mixture of tilmicosin and the above-mentioned auxiliary materials. The above mixture was added to 20kg of calcium carbonate for granulation and spheronization. During the spheronization process, 22.2kg of stearyl acrylate solution with a solid content of 45% was sprayed on the surface of the particles to obtain approximately spherical microcapsule particles. The obtained semi-finished product of tasteless enteric-coated tilmicosin microcapsule particles was dried to obtain the final product, the diameter of the microcapsule particles was 650 μm, and the moisture content was 3%.

[0046]

technical field

[0001] The invention relates to a tilmicosin preparation, in particular to a tilmicosin microcapsule preparation and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique

[0002] Timicosin is a semi-synthetic macrolide antibiotic for livestock and poultry developed in the 1980s, which has inhibitory effects on Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, and spirochetes; It has stronger antibacterial activity than tylosin against Actinomyces pleuropneumoniae and Pasteurella. It is mainly used for the prevention and treatment of livestock pneumonia (caused by Actinobacillus pleuropneumoniae, Pasteurella, Mycoplasma, etc.), avian mycoplasmosis and mastitis of lactating animals. In recent years, studies have found that it has a certain inhibitory effect on PRRS, so tilmicosin has a broad market space. However, because tilmicosin is very bitter and has an odor, when fed with the mixture,...

Examples

Embodiment 1

[0039] First take by weighing 30kg tilmicosin, 50kg dodecyl fatty acid, under the molten state of 65 ℃, shear and stir evenly, cool to room temperature, make the mixture of tilmicosin and above-mentioned auxiliary material. The above mixture was added to 15kg of starch for granulation and spheronization. During the spheronization process, 10kg of methyl methacrylate solution with a solid content of 50% was sprayed on the surface of the granules to obtain approximately spherical microcapsule particles. Dry the obtained semi-finished product of tasteless enteric-coated tilmicosin microcapsules to obtain the final product, the diameter of the microcapsules is 200 μm, and the moisture content is 2%.

[0040]

Embodiment 2

[0042] First take by weighing 40kg tilmicosin, 30kg 15-carbon fatty acid, under 100 ℃ molten state, shear and stir evenly, cool to room temperature, make the mixture of tilmicosin and auxiliary material 15-carbon fatty acid. Add the above mixture to 20kg of starch for granulation and spheronization. During the spheronization process, spray 25kg of butyl acrylate solution with a solid content of 40% on the surface of the granules to obtain approximately spherical microcapsule particles. The obtained tasteless enteric-coated substitute The semi-finished product of micosin microcapsule particles is dried to obtain the final product. The diameter of the microcapsule particles is 500 μm and the moisture content is 4%.

[0043]

Embodiment 3

[0045] First weigh 50kg of tilmicosin and 20kg of octadecyl fatty acid, in a molten state at 120°C, shear and stir evenly, cool to room temperature, and make a mixture of tilmicosin and the above-mentioned auxiliary materials. The above mixture was added to 20kg of calcium carbonate for granulation and spheronization. During the spheronization process, 22.2kg of stearyl acrylate solution with a solid content of 45% was sprayed on the surface of the particles to obtain approximately spherical microcapsule particles. The obtained semi-finished product of tasteless enteric-coated tilmicosin microcapsule particles was dried to obtain the final product, the diameter of the microcapsule particles was 650 μm, and the moisture content was 3%.

[0046]

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