Arbidol dry suspension and preparation method thereof

A technology of arbidol hydrochloride and suspension, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of unwell children, poor patient compliance, etc. Short peak time, the effect of improving compliance

Active Publication Date: 2011-04-06
SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Arbidol itself tastes bitter, and the patient's compliance with taking it is poor, so it is not suitable for children to take

Method used

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  • Arbidol dry suspension and preparation method thereof
  • Arbidol dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1: A dry suspension of Arbidol, 100 g Arbidol hydrochloride, 100 g gum arabic, 50 g hydroxypropyl cellulose, 15 g xanthan gum, 2.0 g sodium lauryl sulfate, and citric Acid 20g, aspartame 50g, sucrose 656g, orange flavor 0.005g; Arbidol hydrochloride through a 100 mesh sieve, gum arabic, hydroxypropyl cellulose, xanthan gum, sodium lauryl sulfate, citric The acid, sucrose, and strawberry flavor were crushed and passed through a 100-mesh sieve; except for sucrose, the remaining components were thoroughly mixed, and then sucrose was added to mix evenly; then the soft material was moistened with 90% ethanol and passed through a 32-mesh sieve for granulation. Dry it at ℃, pass through a 38-mesh sieve and sizing. After passing the inspection, put it into an aluminum-plastic composite film bag to make 1000 bags, 1g each.

Embodiment 2

[0010] Example two, a dry suspension of Arbidol, 100 g of Arbidol hydrochloride, 100 g of gum arabic, 50 g of hydroxypropyl cellulose, 15 g of xanthan gum, 2 g of sodium lauryl sulfate, and citric acid 20g, sucrose 713g, orange flavor 0.005g; Arbidol hydrochloride through a 100 mesh sieve, gum arabic, hydroxypropyl cellulose, xanthan gum, sodium lauryl sulfate, citric acid, sucrose, orange flavor respectively After crushing, pass through a 100-mesh sieve; except for sucrose, the remaining components are thoroughly mixed, and then sucrose is added and mixed uniformly; then the soft material is wetted with 80% ethanol, granulated through a 20-mesh sieve, dried at 40°C, and passed through a 40-mesh sieve Whole grains, after passing the inspection, put them into aluminum-plastic composite film bags to make 1000 bags, 1g per bag.

[0011] Example two, a dry arbidol suspension, taking 100g arbidol hydrochloride, 90g hydroxypropyl cellulose, 30g tragacanth, 2.5g sodium laurate, 2.5g tar...

Embodiment 3

[0012] Example three, a dry arbidol suspension, taking 100 g arbidol hydrochloride, 120 g acacia, 55 g povidone, 2.5 g sodium lauryl sulfate, 19.5 g citric acid, 680 g sucrose, Microcrystalline cellulose 20g, aspartame 3g, banana flavor 0.005g; Arbidol hydrochloride through a 100 mesh sieve, acacia, povidone, sodium lauryl sulfate, citric acid, sucrose, microcrystalline Cellulose, aspartame and banana essence were crushed and passed through a 100-mesh sieve; except for sucrose and microcrystalline cellulose, the remaining components were thoroughly mixed, then sucrose and microcrystalline cellulose were added and mixed uniformly; then 90% ethanol Wet the soft material, pass through a 32-mesh sieve, granulate, dry at 45°C, and pass through a 38-mesh sieve for granulation. After passing the inspection, put it into an aluminum-plastic composite film bag to make 1000 bags, 1g each.

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Abstract

The invention discloses an arbidol dry suspension and a preparation method thereof, and belongs to the medical industry. The arbidol dry suspension comprises Arbidol hydrochloride, a suspending aid, a diluent, a lubricating agent, a flavoring agent and a pH regulator, wherein the suspending aid is one or more of Arabic gum, tragacanth, sodium alga acid, povidone, hydroxy propyl cellulose and xanthan gum; the diluent is saccharose, mannitol and microcrystalline cellulose; the lubricating agent is lauryl sodium sulfate and sodium lauryl sulphate; the flavoring agent comprises a sweetener and an aromatizer, the sweetener is mannitol, saccharose, sodium cyclamate and aspartame, and the aromatizer is orange essence, banana essence, strawberry essence, and pineapple essence; and the pH regulator is citric acid and tartaric acid. The preparation method comprises the following steps of: sieving the arbidol hydrochloride, and respectively crushing and sieving the suspending aid, the diluent, and the lubricating agent; fully mixing the components except the diluent, and then adding the diluent for uniform mixing; and wetting by using ethanol to prepare a soft material, drying, and packaging into an aluminum-plastic composite membrane bag. After the arbidol is prepared into the dry suspension, the bitter of the arbidol is effectively masked, and the compliance of the patient is greatly improved.

Description

Technical field: [0001] The invention relates to an Arbidol dry suspension in the medical and health industry and a preparation method thereof. Background technique: [0002] Arbidol is a broad-spectrum antiviral drug, which can enter the nucleus to directly inhibit the synthesis of viral DNA and RNA, and at the same time enhance immunity, induce interferon, and has a triple effect. Arbidol inhibits influenza A, B and C viruses and is the only drug against influenza C. Studies at home and abroad have shown that Arbidol has an inhibitory effect on H1N1, H2N2, H3N2, H9N2, H6N1, and H5N1. Arbidol can treat upper respiratory tract infections caused by influenza A and B viruses, and influenza A (H1N1) is included in this indication. Arbidol can reduce the incidence of complications and slow aggravation rates of influenza patients, and can treat influenza complications and other acute respiratory infections. Arbidol can also prevent influenza A and B. The effective rate of Arbidol t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/404A61P31/12
Inventor 汲涌李显林苏显英马大中
Owner SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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