156results about How to "Short peak time" patented technology

The invention relates to an oral preparation containing andrographolide and a preparation method thereof, belonging to the field of medicines. The oral preparation containing andrographolide is in dosage forms of enteric-coated granules, enteric-coated tablets, enteric-coated capsules and enteric-coated dispersible tablets which are prepared by mixing andrographolide and pharmaceutically acceptable auxiliary materials. The prepared oral preparation can reduce incidence of adverse reactions and side effects thereof and improve the medication safety while ensuring the therapeutic effect, and uses the andrographolide more widely.

The invention provides a method for detecting trace phosphine gas in a water sample by a gas chromatograph (GC)-cooperating pre-column twice cold trap enrichment method, and aims to overcome the shortcomings of the existing various measurement methods. The method mainly comprises the following steps of: (1) cooling and enriching the phosphine gas and establishing a GC/NPD (nitrogen phosphorous detector) detection device; (2) extracting and dissolving the phosphine gas in lake water by a gas-liquid two-phase phase equilibrium method, and preparing a gas sample to be detected; (3) preprocessingthe gas sample; (4) extracting a certain volume of the gas sample into a gas absorption tube; (5) performing primary enrichment of the processed gas sample in a cold trap I, and removing the impuritygas with a relatively low boiling point; (6) heating the cold trap I so that the gas enters a cold trap II for secondary enrichment; (7) detecting the final enrichment product by a nitrogen phosphorous detector in a gas chromatograph through a chromatographic column; and (8) converting the measured area of a characteristic peak of the phosphine according to a certain formula to obtain the concentration of the phosphine in the water sample to be detected.

A medicine Leibeilazuona for injection contains Leibeilazuona, excipient, pH regulator and antioxidizing agent. It can be used for treating stomach ulcer, duodenal ulcer, erosive gastroesophageal reverse flor disease, pyloric halicobacterium, and zollinger-ellison syndrome. Its advantages are high biological utilization rate and quickly taking its effect.

The invention relates to the method for detecting the quality of senile cough and cough tablets. The method comprises the following steps: qualitatively distinguishing the active ingredients including radix astragaliseuhedysari, bighead atractylodes rhizome, radix saposhnikoviae, licoriceroot,herbaepimedii andfructuspsoralea in asenile cough and cough tabletpreparation by using a thin layer chromatography, and determining the contents of icariin, psoralen and isopsoralenin the preparation by a UPLC method. The detection method provided by the invention has the advantages of simplifying the sampling steps, having simple operation and high specificity, shortening the content determination time, simultaneously detecting multi-index components, having stabledetection baseline, good resolution, high detection accuracy and good stability, improving efficiency, and being relatively economic and environmentally friendly.

The invention discloses a research for realizing quick classification and identification of chemical components in an ixeris sonchifolia hance injection based on a UPLC-Q-TOF-MS technology, and aims to take flavonoids, organic acids, amino acids and nucleosides in the ixeris sonchifolia hance injection as research objects to realize quick classification and identification of the chemical components in the ixeris sonchifolia hance injection based on a UPLC-Q-TOF-MS technical platform. The research comprises the following steps: firstly, performing information integration on components of flavonoids, organic acids, amino acids and nucleosides in the ixeris sonchifolia hance injection to discover and summarize a rule for diagnosing fragments and neutral losses of the four types of substances; meanwhile, performing mass spectrographic analysis on reference substances of different types of compounds by adopting the UPLC-Q-TOF-MS technology, and performing verification; and constructing a method for realizing quick classification and identification of chemical components in the ixeris sonchifolia hance injection by using a method for diagnosing fragments and neutral losses as a screening and identifying tool.

The invention provides a pharmaceutical composition for the prevention and treatment of ischemic cerebrovascular diseases and the preparation method thereof, which contains active ingredients and carriers, wherein the active ingredients consist of fumalic acid or the pharmaceutically acceptable salt and borneol with the weight ratio of 100: 0.5 to 10. The invention can be prepared into the pharmaceutical formulations which are applicable to the clinical application, and the formulations include: granules, capsules, tablets, dropping pills, suppositories and injections. The invention reveals the neuro-protective effect of the composition of fumalic acid or the salt and borneol for transient total cerebral ischemia, and the synergy of the two drugs is played by the combination of the two; compared with single fumalic acid, the absorption half-life is prolonged, the time for reaching peak is faster, the dosage of fumalic acid is reduced and the safety of the drugs is increased. The invention has the advantages of the complementary and synergy of pharmacological effects, instant effects, prolonged effective time, small dosage and precise efficacy when being taken as the drug for the prevention and treatment of ischemic cerebrovascular diseases.

The invention relates to a separation and detection method for astaxanthin in a haematococcus pluvialis extract. The separation and detection method comprises the following steps of 1 extraction of carotenoid in the haematococcus pluvialis extract; 2 enzymolysis of the carotenoid; 3 astaxanthin separation and detection through a normal-phase high performance liquid analysis method, wherein the liquid-phase on-device conditions comprise the detection wavelength is 474 nm, a chromatographic column is Luna 3micro Silica(2), the chromatographic column temperature ranges from 20 DEG C to 25 DEG C, the flow speed is 1-1.2 ml/min, a flow phase is prepared from n-hexane and acetone according to the volume ratio of 75%:25%-90%:10%, and isocratic elution is conducted. According to the separation and detection method, the pretreatment efficiency is high, the intersolubility between the extracting reagent acetone and the astaxanthin is good, the enzymolysis time is shorter than the saponification time, and the efficiency is high; the high performance liquid chromatography on-device conditions are good; isocratic elution is achieved, a base line is easier to stabilize, the peak shape is good, the separation degree is high, and more isomers can be separated out; the peak flowing time is short, and the method is not prone to be influenced by outside light and heat and more suitable for large-scale detection.

The invention discloses a content determination method of sanguisorbin I. The method comprises the following steps of: (1) respectively dissolving a standard product of sanguisorbin I and a sample containing sanguisorbin I into an ethanol aqueous solution to respectively prepare a standard solution and a sample solution; and (2) respectively injecting the standard solution and the sample solution which have equal volumes into a high-efficiency liquid-phase chromatograph, and then measuring and calculating the peak area of the standard solution and the sample solution to acquire the content of sanguisorbin I in the sample. The invention provides a rapid and accurate method for measuring the content of sanguisorbin I in a medical herb of garden burnet and extractives or preparations thereof.

The invention relates to an flatoxin and sulfanilamide drug light derivatization device. An array ultraviolet LED is taken as an excitation light source, and an excitation wavelength is between 280 nmand 380 nm. A fine internal-diameter pipeline which allows ultraviolet light to pass is taken as a derivatization reaction tank, the derivatization reaction tubes are arranged in a linear mode, the internal diameter of the derivatization reaction tube is 0.15-0.5 millimeters, a length is 0.5-12 meters, and the volume of the derivatization reaction tank is 100-1000 [mu]L. The fluorescence intensity of flatoxin B1 is increased by 6.5 times by the light derivatization device, and the light derivatization device is suitable for requirements of derivatization after high performance liquid chromatography columns and flow injection analysis derivatization.

The invention provides a method for detecting the content of beta-lactoglobulin in a dairy product. The method comprises the following steps of: extracting beta-lactoglobulin from the dairy product; and measuring the content of the beta-lactoglobulin by adopting a high performance liquid chromatography method. According to the high performance liquid chromatography method, a C18 chromatographic column is adopted, gradient elution is performed, and the detection wavelength is 210-230 nanometers; an elution solution consists of a mobile phase A and a mobile phase B; the mobile phase A is an ultrapure aqueous solution of trifluoroacetic acid with a volume fraction of 0.05 to 0.15, and the mobile phase B is a mixed solution of acetonitrile, ultrapure water and trifluoroacetic acid; the volume ratio of the mobile phase A to the mobile phase B is 80: 20 to 82: 18; and in the mobile phase B, the volume ratio of the acetonitrile to the ultrapure water is 320: 100 to 480: 100, and the volume of the ultrapure water to trifluoroacetic acid is 100: 0.4 to 100: 0.6. The method is low in cost, short in target peak apperance time, high in separation degree and accuracy, and is favorable for detection of the content of beta-lactoglobulin in the dairy product; the peak shape is acute and symmetric; and the influence from environment change is low.

The invention relates to dispersible tablets containing diabetosan and glibenclamide. The dissolving rate of glibenclamide is improved by making colloidal powder or solid dispersion powder of glibenclamide before making tablets. The dispersible tablets can disintegrate quickly, and the dissolving rates of diabetosan and glibenclamide of the dispersible tablets are significantly faster than that of common preparation.

The invention relates to a method for preparing norfloxacin capsules, which comprises the following steps: (1) evenly stirring norfloxacin and beta-cyclodextrin by the substance ratio of norfloxacin to Beta-cyclodextrin being 1:1, then, adding water and evenly grinding the mixture into paste for 6 to 10 hours at the temperature of 20 to 35 DEG C until the norfloxacin/Beta-cyclodextrin inclusion compound is formed; (2) tiling and drying the inclusion compound at the temperature of 45 to 60 DEG C; (3) pulverizing the dried inclusion compound, granulating the ground medicine through a 80-mesh sieve and drying at the temperature of 45 to 60 DEG C until the water content is lower than 9%; and (4) measuring the norfloxacin content of the granules, converting and filling a No.0 empty capsule with the granules to ensure that each granule contains 0.1g of norfloxacin, and finally packaging to obtain the norfloxacin capsules. The product of the invention has good water-solubility and improves the bioavailability and the stability.

The invention discloses a method of preparing a high-purity polypeptide or an analogue thereof. The method includes the steps of: preparing a purified AMP416 water solution through high performance liquid chromatography, and collecting a fraction of a target peak. Chromatographic conditions are described as follows: a stationary phase is C18, a mobile phase A is a phosphate, a formate or an acetate water solution and a mobile B is methanol or acetonitrile, wherein volume ratio of the mobile phase A to the mobile phase B is (80-100) : (0-20). The method can high-effectively separate and purifythe AMG416 at high yield and high product purity, so that the method has excellent industrial application potential.

The invention discloses a method for determining the content of chloroethanol in a gelatin hollow capsule, which comprises the following steps: step 1, preparing a test solution, taking a proper amount of gelatin hollow capsule, cutting into pieces, weighing, placing in a headspace bottle, precisely adding n-hexane, sealing, dipping overnight, taking the subsequent filtrate as the test solution, and preparing a blank sample by using the n-hexane to perform a blank test; step 2, preparing a reference substance solution, taking a proper amount of a chloroethanol reference substance, precisely weighing, dissolving with n-hexane, and quantitatively diluting chloroethanol to prepare a solution; and step 3, determination: taking the test solution, the blank sample and the reference solution prepared in the step 1 and the step 2, and carrying out gas chromatograph detection on the test solution, the blank sample and the reference solution. The detection method provided by the invention is verified by a test, and a result shows that the method is strong in specificity, good in precision and high in accuracy, and the content of chloroethanol can be rapidly measured.

The invention discloses an enrofloxacin quick-release pellet and relates to the field of veterinary medicines. The enrofloxacin quick-release pellet comprises the following components by weight percent: 10%-45% of enrofloxacin, 18%-86% of excipient, 1%-5% of disintegrating agent, 1%-2% of adhesive and 2%-30% of coating solution. The invention also relates to a preparation method for the enrofloxacin quick-release pellet. The enrofloxacin quick-release pellet is capable of covering the bitter taste of enrofloxacin and guaranteeing quick disintegration release of the preparation in gastrointestinal tracts. Compared with the preparation sold in the market, the enrofloxacin quick-release pellet has the advantages that the prescription is simplified, few sorts of ingredients are used, the quality problem of the preparation caused by uneven mixing of raw materials and ingredients in the preparation process is reduced, the preparation process is simple, the quality is stable and reliable andthe bioavailability of drugs in animal body is obviously increased.

The invention relates to a method for detecting the pesticide residue quantity in radix ophiopogonis. The method comprises the following steps of (1) weighing radix ophiopogonis to be tested; performing treatment by using a QuEChERS pretreatment technology; preparing a first test product solution; (2) weighing a proper amount of ribonolactone and sorbitol; adding acetonitrile and water for dissolution; using the materials as an analysis protection agent; (3) measuring the first test product solution; blowing the solution to the near dry state by nitrogen; adding acetone for dissolution; addingthe analysis protection agent; performing uniform mixing; using the materials as a second test product solution; (4) weighing a pesticide reference product solution; respectively adding acetonitrileto prepare a first reference product solution; measuring and taking the first reference product solution; respectively adding acetone to prepare a second reference product solution; (5) using a testing method; (6) calculating the content of pesticide in the first test product solution and the second test product solution according to an outer standard method. The method has the characteristics ofhigh repeatability, high accuracy, low utilization cost and the like. The pesticide residue quantity in the radix ophiopogonis can be fast, effectively, simply and conveniently detected.

The invention discloses a method for simultaneously detecting the content of four components in Huangqi Guizhi Wuwu Granule. The four components are paeoniflorin, calycosin-7-glucoside, cinnamaldehydeand 6-gingerol. The method comprises the steps of extracting a to-be-detected sample by using an extraction solvent: 30-80% methanol, filtering extract and directly detecting by using a high-performance liquid chromatograph. Through the method disclosed by the invention, the content of the four components in the Huangzhi Guizhi Wuwu Granule can be simultaneously detected and the method has the advantages of high efficiency and accuracy and the like, so that the quality of the Huangqi Guizhi Wuwu Granule is more controllable.