Sodium rebeilazole for injection use

A technology for rabeprazole sodium and injection, which is applied in the field of preparations containing rabeprazole sodium, can solve the problems of rabeprazole sodium instability, low bioavailability, and easy destruction, and improve bioavailability high degree of bioavailability and avoid damage

Inactive Publication Date: 2003-04-16
黄振华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Rabeprazole sodium is unstable under acidic conditions and is easily destroyed in gastric acid. After being made into enteric-coated tablets or enteric-coated capsules, the onset of oral absorption is slow and the bioavailability is low

Method used

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Embodiment Construction

[0055] Now illustrate the specific implementation of the present invention with embodiment, see table 1 for details:

[0056] serial number

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Abstract

A medicine Leibeilazuona for injection contains Leibeilazuona, excipient, pH regulator and antioxidizing agent. It can be used for treating stomach ulcer, duodenal ulcer, erosive gastroesophageal reverse flor disease, pyloric halicobacterium, and zollinger-ellison syndrome. Its advantages are high biological utilization rate and quickly taking its effect.

Description

Technical field: [0001] The invention relates to the field of preparation processing, in particular to a preparation containing rabeprazole sodium. Background technique: [0002] The chemical structure of rabeprazole sodium is: [0003] Chemical name: 2-[[[4-(3-methoxypropoxy)-3-methyl-α-pyridyl]methyl]sulfinyl-1H-benzimidazole sodium] [0004] Rabeprazole sodium (sodium rabeprazole) is the latest benzimidazole substitute after omeprazole and lansoprazole, and it is a strong inhibitor of the proton pump in the secretory membrane of the parietal cell tip. Rabeprazole sodium is specific It can effectively inhibit the activity of H+-K+-ATPase, which is the key enzyme of gastric acid production, and has inhibitory effect on basic gastric acid and gastric acid secretion caused by stimulation. Rabeprazole sodium is suitable for gastric ulcer, duodenal ulcer, erosive gastroesophageal reflux disease, Helicobacter pylori, and Zollinger-ellison syndrome. The current clinical appl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61P1/04A61P31/04
Inventor 黄振华
Owner 黄振华
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