6 results about "Stomach ulcers" patented technology

The present application relates to the field of medicine synthesis, disclose a long-acting dual agonist compound. The tirzepatide derivative described in the application is used for preparing a pharmaceutical composition for treating diseases, the use of the pharmaceutical composition in the preparation of a medicine for treating at least one of the following diseases, the diseases include type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or indigestion or gastric ulcer, liver fibrosis disease and pulmonary fibrosis disease.

The present invention provides a preparation method for a licoflavone multi-component supramolecular inclusion complex and a gastric retention sustained-release formulation thereof and use thereof, and belongs to the technical field of biopharmaceuticals. The licoflavone multi-component supramolecular inclusion complex provided by the present invention is prepared from 10 parts by weight of licoflavone, 10-30 parts by weight of poloxamer, 10-100 parts by weight of cyclodextrin, and 1-10 parts by weight of hypromellose. The licoflavone multi-component supramolecular inclusion complex and the gastric retention sustained-release formulation thereof of the present invention can significantly improve the solubility of licoflavone in water and the solubility of licoflavone in gastric juice, increase the retention time of licoflavone in the stomach, enable sustained release of the drug, increase the absorption of the drug by the stomach or duodenum, improve the bioavailability, reduce the dosage level and the frequency of administration, and have a significant therapeutic effect on stomach ulcers, etc.

The invention relates to the field of traditional Chinese medicine formulas, and particularly discloses a traditional Chinese medicine formula for treating stomach diseases and a preparation method and application thereof. The invention discloses a traditional Chinese medicine formula for treating stomach diseases. The traditional Chinese medicine formula comprises the following components by weight: 5-15g of deep-fried bighead atractylodes rhizome, 3-10g of cassia twig, 10-15g of rice sprout, 1.5-5g of coptis chinensis, 3-15g of fructus forsythiae, 15-30g of dandelion, 3-10g of mangnolia officinalis, 1-3g of agilawood, 15-30g of astragalus membranaceus, 3-9g of poria cocos, 3-9g of elecampane, 3-9g of fingered citron, 3-10g of octopus, 10-15g of pearl, 3-10g of pericarpium citri reticulatae, 3-9g of frankincense, 3-9g of myrrh, 5-10g of trogopterus dung, 3-9g of stigma croci, 10-15g of red yeast rice, 2-10g of liquorice, 3-9g The traditional Chinese medicine is prepared from 0.5-1.0 g of benzoin, 0.03-1 g of borneol, 6-15 g of radix salviae miltiorrhizae, 3-9 g of radix curcumae, 1-3 g of clove, 3-6 g of amomum cardamomum, 3-10 g of rhizoma nardostachyos, 3-9 g of Chinese yam, 5-10 g of radix paeoniae alba, 3-9 g of curcuma zedoary and a small amount The preparation method of the Sanwei capsule comprises the following steps: S1, preparing thick paste; s2, grinding into powder; s3, performing granulation; and S4, preparing the capsule. The Sanwei powder and the Sanwei capsule can be used for treating various types of gastritis, gastric ulcer and gastric erosion, and have the advantages of good effect and small side effect.

The invention relates to a herbal preparation that supports the treatment of gastric and duodenal ulcers and gastroesophageal reflux, along with a process for preparing this preparation, which involves a rational combination of natural herbal ingredients, optimal extraction techniques, and strict control of product content and quality. Specifically, the preparation is made from a mixture of herbs including White Peony (Radix Paeoniae lactiflorae), Ginger-processed Pinellia (Rhizoma Pinelliae praeparatum), Tangerine Peel (Pericarpium Citri reticulatae perenne), Chinese Yam (Tuber Dioscoreae persimilis), Saussurea lappae (Radix Saussureae lappae), and Gardenia Fruit (Fructus Gardeniae), with the ratio adjusted within an optimal range to maximize synergistic effects, combined with safe pharmaceutical additives to stabilize the dosage form and increase absorption.Preclinical trial results showed that the preparation significantly reduced the degree of gastric mucosal damage in an experimental ulcer model, while also reducing damage and improving esophageal morphology in a reflux model, with observed effects better than the untreated model and comparable to the control group Nexium 10 mg. These results demonstrate the preparation's ability to protect the mucosa, support damage recovery, and reduce inflammation. Furthermore, the optimized manufacturing process in terms of solvent, extraction conditions, and impurity removal resulted in a pure, stable herbal extract with good bioavailability, thus providing high therapeutic efficacy and safety.

The present invention relates to the field of pharmaceutical synthesis. A GLP-1 / Gcg dual-agonist compound is disclosed. The GLP-1 / Gcg dual-agonist compound is used for preparing a pharmaceutical composition for treating disease. Use of the pharmaceutical composition in the preparation of a drug for treating at least one of the following diseases: type-II diabetes, impaired glucose tolerance, type-I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive disorders, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, strokes, inflammatory bowel syndrome and / or dyspepsia or gastric ulcers, hepatic fibrosis disease, and pulmonary fibrosis disease.

The invention relates to a composition which comprises glycosaminoglycans, a polysaccharide and a monosaccharide derivative of glucose. The invention also relates to its use as a medicament and, particularly, to its use as a gastroprotector for the treatment of gastric irritation, stomach ulcers, gastroesophageal reflux disease (GERD), radiation proctitis and stomach inflammation and for the prevention of stress ulcers and to the use of composition as food supplement of complementary feed.