Dispersible tablet containing metformin and glibenclamide and preparation method thereof

Abstract

The invention relates to dispersible tablets containing diabetosan and glibenclamide. The dissolving rate of glibenclamide is improved by making colloidal powder or solid dispersion powder of glibenclamide before making tablets. The dispersible tablets can disintegrate quickly, and the dissolving rates of diabetosan and glibenclamide of the dispersible tablets are significantly faster than that of common preparation.

Description

Technical field:

[0001] The invention relates to a pharmaceutical composition containing metformin hydrochloride and glibenclamide, and relates to an improved technology for an oral solid preparation of metformin glibenclamide compound preparation. Background technique:

[0002] Today, worldwide, with the continuous improvement of people's living standards, changes in diet structure, improvement in labor intensity, and increased stress, the incidence of diabetes in the world is increasing at an alarming rate. According to the prediction of international authoritative diabetes epidemiology experts, the number of diabetic patients in the world will increase to 239 million by 2010, and will reach 300 million by 2025, of which more than 90% are type 2 diabetes. The situation in our country is no exception. According to the latest epidemiological survey, the incidence of diabetes in our country has risen from 0.67% 15 years ago to 3.21% in recent years, and it is increasing rapid...