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Dispersible tablet containing metformin and glibenclamide and preparation method thereof

A technology of metformin and glibenclamide, applied in the technical field of improving oral solid preparations

Inactive Publication Date: 2008-04-30
林海平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since a single hypoglycemic agent can only correct some of this, initial administration of a single agent is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of glibenclamide superfine powder: add glibenclamide sodium lauryl sulfate powder (the weight ratio of sodium lauryl sulfate to glibenclamide is 0.6%) and mix, place in the micropowder equipment , Grinding, and observing the micro-ultrafine powder of glibenclamide under a microscope, more than 90% of the particles are distributed in the range of 2-3 μm.

[0037] prescription:

[0038] Metformin Hydrochloride 250g

[0039] Glibenclamide micro-superfine powder 2.5g

[0040] Sodium carboxymethyl starch (additional) 15g

[0041] Sodium carboxymethyl starch (additional) 15g

[0042] Microcrystalline Cellulose PH101 95g

[0043] Magnesium Stearate 3.0g

[0044] 30% Povidone K 30 Aqueous solution 102ml

[0045] 3% sodium lauryl sulfate aqueous solution 102ml

[0046] Makes 1000 pieces

[0047] Preparation method of dispersible tablets: Metformin hydrochloride, sodium carboxymethyl starch, microcrystalline cellulose, and magnesium stearate are respectiv...

Embodiment 2

[0055] Preparation of glibenclamide superfine powder:

[0056] Dissolve sodium lauryl sulfate (0.6% by weight to glibenclamide) in water to make an aqueous solution, add glibenclamide, stir evenly, dry at 40°C, and grind in a ball mill to make glibenclamide The micro-ultrafine powder of this urea is observed under a microscope, and more than 90% of the particles are distributed in the range of 2-3 μm.

[0057] prescription:

[0058] Metformin Hydrochloride 500g

[0059] Glibenclamide Superfine Powder 5g

[0060] Sodium carboxymethyl starch (internal addition) 25.9g

[0061] Sodium carboxymethyl starch (additional) 17.3g

[0062] Microcrystalline Cellulose PH102 215.9g

[0063] Magnesium Stearate 4.3g

[0064] 30% Povidone K 30 Aqueous solution 288ml

[0065] 3% sodium lauryl sulfate aqueous solution 288ml

[0066] Makes 1000 pieces

[0067] Preparation method of dispersible tablets: Metformin hydrochloride, sodium carboxymethyl starch, microcrystalline cellulose, and...

Embodiment 3

[0070] Preparation of glibenclamide solid dispersion:

[0071] Glibenclamide was first dissolved in ethanol, then polyethylene glycol 4000 was added, and the ratio of polyethylene glycol 4000 and glibenclamide was 4:1, mixed evenly, rotatively evaporated, dried, and pulverized to obtain Glibenclamide Solid dispersion powder of urea.

[0072] prescription:

[0073] Metformin Hydrochloride 250g

[0074] Glibenclamide solid dispersion powder 6.25g (contains glibenclamide 1.25g)

[0075] Sodium carboxymethyl starch (internal addition) 29.5g

[0076] Sodium carboxymethyl starch (additional) 10.0g

[0077] Microcrystalline Cellulose PH102 71.5g

[0078] Magnesium Stearate 2.4g

[0079] 25% Povidone K 30 Aqueous solution 94.8ml

[0080] 2.5% sodium lauryl sulfate aqueous solution 94.8ml

[0081] Makes 1000 pieces

[0082] Preparation method of dispersible tablets: Metformin hydrochloride, sodium carboxymethyl starch, microcrystalline cellulose, and magnesium stearate are resp...

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Abstract

The invention relates to dispersible tablets containing diabetosan and glibenclamide. The dissolving rate of glibenclamide is improved by making colloidal powder or solid dispersion powder of glibenclamide before making tablets. The dispersible tablets can disintegrate quickly, and the dissolving rates of diabetosan and glibenclamide of the dispersible tablets are significantly faster than that of common preparation.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing metformin hydrochloride and glibenclamide, and relates to an improved technology for an oral solid preparation of metformin glibenclamide compound preparation. Background technique: [0002] Today, worldwide, with the continuous improvement of people's living standards, changes in diet structure, improvement in labor intensity, and increased stress, the incidence of diabetes in the world is increasing at an alarming rate. According to the prediction of international authoritative diabetes epidemiology experts, the number of diabetic patients in the world will increase to 239 million by 2010, and will reach 300 million by 2025, of which more than 90% are type 2 diabetes. The situation in our country is no exception. According to the latest epidemiological survey, the incidence of diabetes in our country has risen from 0.67% 15 years ago to 3.21% in recent years, and it is increasing rapid...

Claims

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Application Information

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IPC IPC(8): A61K31/64A61K9/20A61K47/38A61P3/10A61K31/155
Inventor 林海平
Owner 林海平
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