Method for detecting quality of senile coughand asthmatablets

A quality inspection method, the technology of Kechuan Tablets, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of complex operation, inability to scientifically control the quality of the Elderly Kechuan Tablets, and the inability to qualitatively identify the Elderly Kechuan Tablets.

Inactive Publication Date: 2016-12-07
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The identification and content determination methods of the active ingredients in Older Kechuan Tablets are reported in the existing literature, but the identification and determination methods involved are complex in operation, not strong in specificity, unstable

Method used

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  • Method for detecting quality of senile coughand asthmatablets
  • Method for detecting quality of senile coughand asthmatablets
  • Method for detecting quality of senile coughand asthmatablets

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0098] Example 1 The active ingredients in the old Kechuan tablets were identified according to the following methods

[0099] A. Identification of the active ingredient Fangfeng:

[0100] S1. Preparation of test solution: Take 3g of the old cough tablet powder without film coating, grind it, add 20mL of acetone, sonicate for 30 minutes, filter, evaporate the filtrate to dryness, add 1mL of ethanol to the residue to dissolve, as the test Product solution

[0101] S2. Preparation of control medicinal material solution: take 1g of the windproof control medicinal material, and prepare the control medicinal material solution in the same way as the test solution;

[0102] S3. Preparation of reference substance solution: take the reference substance of cimicifuga glycoside and 5-O-methylvisamidol glycoside, add methanol to make a mixed solution containing 1mg per 1mL, as the reference substance solution;

[0103] S4. Preparation of the negative control solution: Take 3g of the negative sampl...

Example Embodiment

[0133] Example 2 According to the following methods, the active ingredients in the elderly Kechuan tablets were identified

[0134] A. Identification of the active ingredient Fangfeng:

[0135] S1. Preparation of the test solution: Take 1g of the old cough tablet powder with the film coating removed, grind it, add 10mL of acetone, sonicate for 10 minutes, filter, evaporate the filtrate to dryness, add 2mL of ethanol to the residue to dissolve, as the test Product solution

[0136] S2. Preparation of control medicinal material solution: take 2g of the windproof control medicinal material and prepare the control medicinal material solution in the same way as the test solution;

[0137] S3. Preparation of reference substance solution: take the reference substance of cimicifuga glycoside and 5-O-methylvisamidol glycoside, add methanol to make a mixed solution containing 1mg per 1mL, as the reference substance solution;

[0138] S4. Preparation of Negative Control Solution: Take 1g of the n...

Example Embodiment

[0167] Example 3 According to the following methods, the active ingredients in the elderly Kechuan tablets were identified

[0168] A. Identification of the active ingredient Fangfeng:

[0169] S1. Preparation of test solution: Take 6g of the old cough tablet powder without film coating, grind it, add 40mL of acetone, sonicate for 50 minutes, filter, evaporate the filtrate to dryness, add 3mL of ethanol to the residue to dissolve it, as the test Product solution

[0170] S2. Preparation of control medicinal material solution: take 3g of the windproof control medicinal material and prepare the control medicinal material solution in the same way as the test solution;

[0171] S3. Preparation of reference substance solution: take the reference substance of cimicifuga glycoside and 5-O-methylvisamidol glycoside, add methanol to make a mixed solution containing 1mg per 1mL, as the reference substance solution;

[0172] S4. Preparation of the negative control solution: Take 6g of the negativ...

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Abstract

The invention relates to the method for detecting the quality of senile cough and cough tablets. The method comprises the following steps: qualitatively distinguishing the active ingredients including radix astragaliseuhedysari, bighead atractylodes rhizome, radix saposhnikoviae, licoriceroot,herbaepimedii andfructuspsoralea in asenile cough and cough tabletpreparation by using a thin layer chromatography, and determining the contents of icariin, psoralen and isopsoralenin the preparation by a UPLC method. The detection method provided by the invention has the advantages of simplifying the sampling steps, having simple operation and high specificity, shortening the content determination time, simultaneously detecting multi-index components, having stabledetection baseline, good resolution, high detection accuracy and good stability, improving efficiency, and being relatively economic and environmentally friendly.

Description

technical field [0001] The quality detection of the Chinese patent medicine of the present invention, more specifically, relates to the quality detection method of the Old Kechuan Tablet. Background technique [0002] Elderly cough and asthma tablets are made from Chinese herbal medicines such as Fangfeng, Licorice, Epimedium, Psoraleae, Astragalus, Atractylodes Rhizoma, Polygonatum and other multi-flavored Chinese herbal medicines. Rehabilitation of the sick body, used for chronic bronchitis in the elderly and various physical deficiency syndromes. Among them, epimedium and psoraleae are the important drugs used in larger amounts in the prescription. There are currently more than 70 kinds of chemical constituents of Epimedium plants, mainly flavonoids, such as icariin. In addition to the effects of tonifying kidney yang, strengthening bones and bones, and dispelling rheumatism, icariin also has antitussive, anti-inflammatory and anti-inflammatory effects. Phlegm and anti-...

Claims

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Application Information

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IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 白璐凌勇根刘逆夫龚云
Owner ZHUZHOU QIANJIN PHARMA
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