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Method for detecting quality of senile coughand asthmatablets

A quality inspection method, the technology of Kechuan Tablets, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of complex operation, inability to scientifically control the quality of the Elderly Kechuan Tablets, and the inability to qualitatively identify the Elderly Kechuan Tablets.

Inactive Publication Date: 2016-12-07
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The identification and content determination methods of the active ingredients in Older Kechuan Tablets are reported in the existing literature, but the identification and determination methods involved are complex in operation, not strong in specificity, unstable in method, and cannot be comprehensively tested for Older Kechuan Tablets. Qualitative identification, and simultaneous multi-component index detection cannot be realized, so the quality of the elderly cough and asthma tablets cannot be scientifically controlled

Method used

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  • Method for detecting quality of senile coughand asthmatablets
  • Method for detecting quality of senile coughand asthmatablets
  • Method for detecting quality of senile coughand asthmatablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Example 1 Identify the active ingredients in the Old Kechuan Tablets according to the following method

[0099] A. Identification of the active ingredient Fangfeng:

[0100] S1. Preparation of the test solution: take 3 g of the old cough and asthma tablet powder with the film coat removed, grind it finely, add 20 mL of acetone, ultrasonicate for 30 minutes, filter, evaporate the filtrate to dryness, add 1 mL of ethanol to the residue to dissolve, and use it as the test product product solution;

[0101] S2. Preparation of contrasting medicinal material solution: get 1g of Radix Fangfeng contrasting medicinal material, make contrasting medicinal material solution with the method for need testing solution;

[0102] S3. Preparation of reference substance solution: take acteoside reference substance and 5-O-methylvisamigoside reference substance, add methanol to make a mixed solution containing 1 mg per 1 mL, as the reference substance solution;

[0103] S4. Preparation o...

Embodiment 2

[0133] Example 2 Identify the active ingredients in the Old Kechuan Tablets according to the following method

[0134] A. Identification of the active ingredient Fangfeng:

[0135] S1. Preparation of the test solution: take 1 g of the old cough and asthma tablet powder with the film coat removed, grind it finely, add 10 mL of acetone, ultrasonicate for 10 minutes, filter, evaporate the filtrate to dryness, add 2 mL of ethanol to the residue to dissolve, and use it as the test product product solution;

[0136] S2. the preparation of contrast medicinal material solution: get Radix Fangfeng contrast medicinal material 2g, make contrast medicinal material solution with the method for need testing solution;

[0137] S3. Preparation of reference substance solution: take acteoside reference substance and 5-O-methylvisamigoside reference substance, add methanol to make a mixed solution containing 1 mg per 1 mL, as the reference substance solution;

[0138] S4. Preparation of negati...

Embodiment 3

[0167] Example 3 According to the following method, the active ingredients in the Old Kechuan Tablets are identified

[0168] A. Identification of the active ingredient Fangfeng:

[0169] S1. Preparation of the test solution: take 6 g of old cough and asthma tablet powder with film coating removed, grind it finely, add 40 mL of acetone, ultrasonicate for 50 minutes, filter, evaporate the filtrate to dryness, add 3 mL of ethanol to the residue to dissolve, and use as test product solution;

[0170] S2. the preparation of contrast medicinal material solution: get the windproof contrast medicinal material 3g, make contrast medicinal material solution with the method for need testing solution;

[0171] S3. Preparation of reference substance solution: take acteoside reference substance and 5-O-methylvisamigoside reference substance, add methanol to make a mixed solution containing 1 mg per 1 mL, as the reference substance solution;

[0172] S4. Preparation of Negative Control Sol...

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Abstract

The invention relates to the method for detecting the quality of senile cough and cough tablets. The method comprises the following steps: qualitatively distinguishing the active ingredients including radix astragaliseuhedysari, bighead atractylodes rhizome, radix saposhnikoviae, licoriceroot,herbaepimedii andfructuspsoralea in asenile cough and cough tabletpreparation by using a thin layer chromatography, and determining the contents of icariin, psoralen and isopsoralenin the preparation by a UPLC method. The detection method provided by the invention has the advantages of simplifying the sampling steps, having simple operation and high specificity, shortening the content determination time, simultaneously detecting multi-index components, having stabledetection baseline, good resolution, high detection accuracy and good stability, improving efficiency, and being relatively economic and environmentally friendly.

Description

technical field [0001] The quality detection of the Chinese patent medicine of the present invention, more specifically, relates to the quality detection method of the Old Kechuan Tablet. Background technique [0002] Elderly cough and asthma tablets are made from Chinese herbal medicines such as Fangfeng, Licorice, Epimedium, Psoraleae, Astragalus, Atractylodes Rhizoma, Polygonatum and other multi-flavored Chinese herbal medicines. Rehabilitation of the sick body, used for chronic bronchitis in the elderly and various physical deficiency syndromes. Among them, epimedium and psoraleae are the important drugs used in larger amounts in the prescription. There are currently more than 70 kinds of chemical constituents of Epimedium plants, mainly flavonoids, such as icariin. In addition to the effects of tonifying kidney yang, strengthening bones and bones, and dispelling rheumatism, icariin also has antitussive, anti-inflammatory and anti-inflammatory effects. Phlegm and anti-...

Claims

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Application Information

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IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 白璐凌勇根刘逆夫龚云
Owner ZHUZHOU QIANJIN PHARMA
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