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Research for realizing quick classification and identification of chemical components in ixeris sonchifolia hance injection based on UPLC-Q-TOF-MS technology

A UPLC-Q-TOF-MS, chemical composition technology, applied in scientific instruments, material separation, analysis of materials, etc., can solve the problems of analysis, classification and identification difficulties, and achieve the effect of moderate retention time and short peak time.

Active Publication Date: 2015-02-18
TONGHUA HUAXIA PHARMA
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Problems solved by technology

By establishing a diagnostic debris filtering strategy and a neutral loss filtering strategy, and using them for the rapid screening of the attributable component groups in the fingerprint of Kudiezi injection, the technical problems of analysis, classification and identification difficulties caused by complex components of traditional Chinese medicine injections are effectively solved.

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  • Research for realizing quick classification and identification of chemical components in ixeris sonchifolia hance injection based on UPLC-Q-TOF-MS technology
  • Research for realizing quick classification and identification of chemical components in ixeris sonchifolia hance injection based on UPLC-Q-TOF-MS technology
  • Research for realizing quick classification and identification of chemical components in ixeris sonchifolia hance injection based on UPLC-Q-TOF-MS technology

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Embodiment Construction

[0023] Rapid classification and identification of ingredients in Kudiezi injection based on UPLC-Q-TOF-MS technology:

[0024] 1 Introduction

[0025] Kudiezi injection is a plant of the genus Kudiezi in the family Asteraceae, Kudiezi. Ixeris sonchifolia Hance ] The whole plant is made by extracting and processing. According to the chemical substance group to which the identified compounds belong, a database including chemical name, molecular formula, structural formula, and accurate mass number is established, and the characteristic fragments and neutral loss of a certain type of compound with a corresponding public skeleton are summarized, which is applied to the original data of the fingerprint Analysis, and strive to achieve the purpose of rapid and accurate classification and identification. Nowadays, with the continuous development of data post-processing technology, Diagnostic fragments filter (PIF) and neutral loss filter (Neutral loss, NIF) have shown unique advant...

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Abstract

The invention discloses a research for realizing quick classification and identification of chemical components in an ixeris sonchifolia hance injection based on a UPLC-Q-TOF-MS technology, and aims to take flavonoids, organic acids, amino acids and nucleosides in the ixeris sonchifolia hance injection as research objects to realize quick classification and identification of the chemical components in the ixeris sonchifolia hance injection based on a UPLC-Q-TOF-MS technical platform. The research comprises the following steps: firstly, performing information integration on components of flavonoids, organic acids, amino acids and nucleosides in the ixeris sonchifolia hance injection to discover and summarize a rule for diagnosing fragments and neutral losses of the four types of substances; meanwhile, performing mass spectrographic analysis on reference substances of different types of compounds by adopting the UPLC-Q-TOF-MS technology, and performing verification; and constructing a method for realizing quick classification and identification of chemical components in the ixeris sonchifolia hance injection by using a method for diagnosing fragments and neutral losses as a screening and identifying tool.

Description

[0001] technical field [0002] The invention relates to the identification of chemical components in traditional Chinese medicine injections, that is, the rapid classification and identification of chemical components in Kudiezi injections is realized based on UPLC-Q-TOF-MS technology. Background technique [0003] In the prior art, the Kudiezi injection is Kudiezi, a plant of the genus Kudiezi in the family Asteraceae. Ixeris sonchifolia Hance ] The whole plant is made by extracting and processing. The chemical composition of Kudiezi is relatively complex. According to literature reports, its main components include terpenoids, flavonoids, coumarins, and sterols. Among them, the main active ingredients are affected by factors such as the place of origin, climate and ecological environment, and the ingredients contained in the injections made from Kudiezi from different places of origin are quite surprising. Studies have reported that polysaccharides extracted from various ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62G01N30/02G01N27/626
Inventor 李遇伯袁磊杨彬邹敬韬
Owner TONGHUA HUAXIA PHARMA
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