Trimetazidine hydrochloride sustained release tablet and preparation method thereof

Abstract

The invention belongs to the field of sustained release medicament preparations, and particularly relates to a trimetazidine hydrochloride sustained release tablet and a preparation method thereof. The trimetazidine hydrochloride sustained release tablet is prepared from 40 to 45 parts of trimetazidine hydrochloride, 100 to 200 parts of polyoxyethylene, 100 to 200 parts of dextrin, 60 to 100 parts of 3-10 percent ethyl cellulose solution and 3 to 5 parts of magnesium stearate through material mixing, soft material preparing, drying, tabletting and other steps. In the trimetazidine hydrochloride sustained release tablet, the polyoxyethylene serves as an auxiliary material, and the sustained release tablet is prepared from the medicaments by a method of direct tabletting or tabletting aftergranulating. The drug dissolution of the trimetazidine hydrochloride sustained release tablet reaches about 90 percent 6 hours later, so the sustained release tablet is only required to be taken twice a day; therefore, the sustained release tablet has the advantages of releasing drug slowly and uniformly to reduce release rate and postpone peak time, reducing the number of administration times per day, improving the compliance of patients to the medicament and the like. Furthermore, the preparation method of the invention is simple and easy to operate.

Description

technical field [0001] The invention belongs to the field of sustained-release pharmaceutical preparations, and in particular relates to a trimetazidine hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Angina is the more common type of ischemic heart disease. According to reports, about 7.2 million people in the United States suffer from angina pectoris, and it is increasing at a rate of 350,000 people per year. 50-75% of the total number of deaths. In my country, with the improvement of people's living standards, the change of lifestyle and the acceleration of the pace of life, the incidence of angina pectoris is increasing year by year. Taking Beijing, where the incidence rate ranks first in the country, as an example, the fatality rate of angina pectoris with complications accounted for 13% of the total population deaths in 2003, and it is still on the rise, approaching the level of European and American countries. ...

AI Technical Summary

Problems solved by technology

After oral administration of these two kinds of coated trimetazidine tablets, trimetazidine is rapidly absorbed, reaching the peak plasma level in less than 2 hours, and the elimination half-life is about 6 hours, taking at least three times a day, the blood drug concentration in the body is easy to appear " "Peak and valley" phenomenon, not only makes the effective blood concentration maintenance time short, but also has large side effects, and the drug effect cannot be exerted smoothly

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