228 results about "Drug granules" patented technology

The invention provides a tumor cell exosome, an anti-tumor immune drug delivery system and a preparation method and application of the anti-tumor immune drug delivery system, the tumor cell exosome is derived from starved and stimulated tumor cells, the tumor cell exosome is coated with nano drug particles for delivery, and the exosome has the effects of enhancing immune cell infiltration and remodeling an immune microenvironment; due to the homing effect of the exosome, the medicine and the exosome are more easily accumulated in the tumor, and the targeting property is improved; due to coating and camouflage of the biological membrane of the exosome membrane, the exosome membrane is prevented from being recognized, attacked and removed by an organism, and the biological safety is improved, so that the exosome and the nano-drug act on the tumor together to achieve a synergistic effect.

Various embodiments disclosed relate to polymer encapsulated drug particles and drug release coatings comprising the polymer encapsulated drug particles, as well as drug coated balloon catheters for treating, preventing, or reducing recurrence of body lumen stenosis and methods of use thereof. A drug coated balloon catheter for delivering a therapeutic agent to a body lumen stenosis target site includes an elongated balloon. The balloon catheter includes a coating layer covering the outer surface of the balloon. The coating layer comprises: polymer encapsulated drug particles; or a drug release coating comprising polymer encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

Various embodiments disclosed relate to polymer-encapsulated drug particles and a drug-releasing coating including the same, as well as drug-coated balloon catheters for treating, preventing, or reducing the recurrence of strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes the polymer-encapsulated drug particles; or a drug-releasing coating including the polymer-encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

Pharmaceutical compositions including a pharmaceutical granulation comprising 4-((L-valyl)oxy) butanoic acid and an excipient granulation are disclosed. When the pharmaceutical compositions are combined and mixed with water the excipient granules rapidly dissolve to form a viscous solution with a pharmaceutical granulation suspended in the viscous solution. The pharmaceutical granulations provide palatable oral pharmaceutical compositions.

The invention discloses an administration agent in-vivo release and absorption visualization method based on a CFD-PBM coupling model. The method comprises the following steps: constructing a CFD model of a physiological environment of an injection site; establishing a population balance model (PBM) of the drug particles; the PBM is embedded into a CFD model solver, multi-scale coupling simulation is carried out, and a CFD-PBM coupling model is obtained; the three-dimensional visualization engine dynamically displays drug concentration distribution and particle behaviors; reversely adjusting preparation prescription parameters by using a multi-parameter optimization algorithm; and calibrating model parameters, and generating a key data report. According to the method, the prediction precision and the research and development efficiency can be remarkably improved, and the method is suitable for development of long-acting preparations such as microspheres and implants.

The utility model discloses a solid preparation vortex shaking screen, and belongs to the technical field of pharmacy. A solid preparation vortex oscillation screen comprises a screening bin, a guide plate is fixedly connected in the screening bin, the middle of the guide plate is in an arc shape, the two ends of the guide plate are obliquely bent, one end of the guide plate and the screening bin form a flow dividing channel, a flow dividing plate is arranged in the flow dividing channel and is in a spiral shape, and the other end of the guide plate forms a through hole around the axis of the screening bin. Solid preparations in the discharging process can be buffered, the impact strength of the solid preparations is effectively relieved, the integrity of the solid preparations is protected, the phenomenon that medicine particles are broken is reduced, the solid preparations can be divided and screened, then part of the solid preparations are moved into the through holes, and therefore the solid preparations are prevented from being damaged. And the other part of solid preparations can move into the splitter plate to move, so that a screen in the screening bin can be prevented from being filled, continuous screening and discharging can be achieved, and the screening effect is improved.

The invention relates to the field of medicine screening, in particular to an automatic medicine centrifugal screening machine and a screening method.The screening machine comprises a centrifugal barrel and a separation barrel, a centrifugal mechanism is installed on the centrifugal barrel, and a centrifugal part is installed at the bottom of the centrifugal mechanism and used for achieving centrifugal movement of medicine particles; a backflow part is mounted at the top of the centrifugal part and used for adjusting wind power for blowing medicine particles; an air inlet mechanism is mounted at the bottom of the centrifugal part and is used for conveying external air into the separation barrel; a detection part is mounted on the side surface of the separation cylinder and is used for detecting granularity data of medicines falling into the separation cylinder; by detecting the separation condition of medicine particles in real time and adjusting the wind power and the wind direction for blowing the medicine, automatic multi-stage separation of the medicine is achieved, use of a screen is avoided, the production cost is reduced, continuous and automatic operation is achieved, and the production efficiency is improved.

Excipient granulations containing a viscosifying agent, a disintegrant, and one or more additional excipients are disclosed. An excipient granulation can be combined with a pharmaceutical granulation to provide a pharmaceutical composition. The excipient granulations can be used to increase the viscosity of an aqueous composition such as an oral pharmaceutical composition. When added to an aqueous solution, the excipient granulation can dissolve to provide a suspension of the pharmaceutical granules in a viscous solution. The excipient granulation can be used to improve the palatability of oral pharmaceutical compositions containing a pharmaceutical granulation.

The invention relates to the technical field of medical apparatus and instruments, in particular to an intelligent suture line with electrical stimulation and drug release synergism and a preparation method thereof. The preparation method of the intelligent suture line with synergistic electrical stimulation and drug release comprises the following steps: fully dissolving a high polymer in an organic solvent to obtain a high polymer solution; and mixing the conductive polymer nanoparticles, a stabilizer, a dopant and a micromolecular anti-inflammatory drug to obtain conductive polymer coated drug particles. Uniformly mixing with a high polymer solution to obtain an electrostatic spinning precursor solution; the electrostatic spinning precursor solution and a metal wire are prepared through an electrostatic spinning machine, and then the intelligent suture line is prepared. The prepared intelligent suture line generates inductive charges or alternating current under external stimulation based on a single-electrode mode of a friction nano-generator, realizes control of release of small-molecule drugs and also can generate an alternating electric field to realize electrical stimulation treatment, and can promote rapid healing of wounds under the mutual synergistic effect of the inductive charges and the alternating electric field.

The invention provides an oral cavity soluble film solution based on a nano-carrier and a preparation method of an oral cavity soluble film. According to the method, a nano-carrier technology, microcapsule multilayer coating, a low-temperature electrochemical polymerization method and an ultrasonic dispersion technology are utilized, and uniform distribution and multi-stage slow release of a medicine in an oral instant film are achieved. According to the invention, active pharmaceutical ingredients are firstly wrapped by a nano-carrier, and then a multi-layer composite coating structure is formed by a microcapsule technology, so that drug release effects at different stages are realized. And then, uniformly mixing the microcapsule nano-drug particles with a film-forming substrate, depositing layer by layer to form a film through a low-temperature electrochemical polymerization method, and carrying out low-temperature drying treatment. The soluble film disclosed by the invention has good biocompatibility and mechanical strength, and can be gradually dissolved in an oral cavity, and the medicine is released according to a set stage, so that a long-acting oral care or treatment effect is realized. The method avoids the use of high temperature and organic solvents, is environment-friendly and safe, and is suitable for delivery systems of various oral drugs.

The invention discloses an exosome engineered targeted drug delivery system and a preparation method and application thereof, and belongs to the field of biomedices.The exosome engineered targeted drug delivery system is prepared by mixing and reacting surface modified exosome and pH response type drug controlled release nanoparticles; the pH response type drug controlled release nanoparticles react with the surface modified exosome through a click chemical reaction; the surface of the membrane of which the surface is modified with the exosome is modified with a maleimide group and an azide group; the novel nano-drug has pH responsiveness; the click chemical reaction is thiol-ene click reaction. Bifunctional groups (MAL and N3) are directionally grafted on the surface of an exosome membrane, uniform drug particles are prepared in combination with a micro-fluidic technology, an efficient bimodal targeting drug delivery system is successfully constructed, and remarkable technical advantages are shown in the aspects of improving targeting precision, enhancing antitumor activity, controlling drug release, inhibiting tumor metastasis and the like; and a new technical approach is provided for precise treatment of adenoid cystic carcinoma.

The invention relates to the technical field of pomacea canaliculata trapping, killing and preventing, in particular to an efficient pomacea canaliculata trapping and killing method which comprises the following steps: pre-treating drug particles, specifically preparing drug particles for storing trapping and killing drugs, thickening duckweed dry powder, specifically, coating the drug particles with a duckweed dry powder coating with the thickness of 1mm to obtain inner sphere particles, the mikania micrantha ethanol dry powder thickening treatment means that the mikania micrantha ethanol dry powder tightly and uniformly covers the surface of the duckweed dry powder coating by adopting a spraying process on the outer layer of the inner sphere particles. According to the method, the pomacea canaliculata is actively induced to gather and feed by utilizing the rape straw pith core, and aquatic / terrestrial plant wastes are converted into a biological carrier with gradient inducing-poisoning functions; natural toxic components of mikania micrantha are used for replacing traditional chemical pesticides; the straw pith core is used as a universal skeleton, the duckweed dry powder plays the functions of ecological attraction and nutrition supplement, the mikania micrantha ethanol dry powder provides efficient poisoning ability, and the method is especially suitable for green prevention and control of ampullaria gigas in rice cropping areas of the Yangtze River basin.

The invention provides a cutting woven type stent, and belongs to the technical field of medical instruments for treating vascular diseases. The stent comprises an intravascular stent body, a medicine carrying groove used for containing medicine is formed in the outer surface of the intravascular stent body, sustained-release capsules are fixedly distributed in the medicine carrying groove, each sustained-release capsule is provided with a shell, a containing cavity is formed in the shell, and medicine particles and a shell breaking component are loaded in the containing cavities of part of the sustained-release capsules; the medicine assembly for rapidly treating intracranial vascular stenosis further comprises a driving component, and the driving component is arranged in vitro and used for driving the shell breaking component to rapidly break the shell so as to rapidly release medicine particles in the shell. The drug eluting stent is mainly used for solving the technical problem that a drug eluting stent in the prior art cannot quickly release drugs and cannot quickly generate a treatment effect.

The invention discloses an inhalation administration device and a design method, and mainly relates to the technical field of medical instruments. The device comprises a capsule base, a capsule body, a capsule cabin and a suction nozzle, an inner cavity of the suction nozzle is of an inverted trapezoid structure, and in other words, the diameter of the section is increased by 0.033 mm every time the inner area of the suction nozzle is raised by 1 mm from the bottom end to the top end. According to the design, by optimizing the internal flow field of the suction nozzle, the dispersity of medicine particles can be remarkably improved, wall surface deposition is reduced, and therefore the dispersity of the medicine particles and the lung deposition efficiency are improved. The invention also provides a design method based on lattice Boltzmann method-immersion boundary method-large eddy simulation multi-physics field coupling numerical simulation, and by setting specific performance evaluation parameters, the structure optimization of the inverted trapezoidal suction nozzle can be efficiently and accurately guided. An in-vitro deposition test shows that the performance of the device is superior to or equivalent to that of a commercially available product.

The utility model discloses a medicine particle producing, forming and drying device which comprises a shell, supporting legs are installed at the bottom of the shell, and the medicine particle producing, forming and drying device further comprises a granulating device installed in the shell; the buffer device is arranged below the granulating device; the heating device is mounted below the buffer device; the cleaning devices are arranged on the two sides of the granulating device; wherein the granulating device can scatter medicine raw materials into granules. The utility model relates to the technical field of medicine manufacturing, in particular to a medicine particle producing, forming and drying device which solves the problems that medicine particles are accumulated together and water cannot be volatilized and medicine particle forming is affected due to the fact that traditional processing equipment is not provided with a drying device to scatter medicine raw materials into particles through a heating device. The heating device can be used for heating the medicine particles, and all the medicine particles can be uniformly heated through stirring, so that the forming rate of the medicine particles is improved.

To provide formulations and drug products formed by methods of reducing particle formation.SOLUTION: Biopharmaceutical compositions and drug products disclosed herein exhibit reduced amounts of subvisible particle formation. Compositions and drug products disclosed herein comprise a protein and a surfactant or a stabilizer including high percentage amounts (e.g., at least 97%) of a long-chain fatty acid ester. Also disclosed herein are methods of preparing and storing such compositions and drug products.SELECTED DRAWING: Figure 2

The utility model belongs to the technical field of sewage treatment medicine feeding, and particularly relates to a sewage treatment medicine feeding device which comprises a foot stool, a fixing plate is mounted on the foot stool, a guide frame is mounted on the bottom side of the fixing plate, a weighing hopper is mounted on a sliding block, a first electromagnetic valve is mounted on a discharging pipe, and a second electromagnetic valve is mounted on the discharging pipe. A first lifting block and a second lifting block are assembled in the lifting groove, a first electrode plate is installed on the bottom side of the first lifting block, a second electrode plate is installed on the top side of the second lifting block, medicine particles fall into the weighing hopper from the material guide pipe, the weighing hopper drives the first electrode plate to vertically move downwards, and the first electrode plate is driven to move downwards; when a first electrode plate is in contact with a second electrode plate, an indicator light sends an electric signal to a control panel, and the control panel controls a second electromagnetic valve on a storage box to be closed after receiving the electric signal and controls a first electromagnetic valve on a weighing hopper to be opened at the same time, so that accurate weighing of the medicine is realized, and the accuracy of the feeding amount is improved; and the throwing efficiency can be improved.

The granular medicament screening device comprises a screening net, a plurality of screening holes are formed in the top end of the screening net in an annular array mode, and conical holes are formed in the bottom ends of the multiple screening holes in a communicating mode; a plurality of connecting seats are installed at the top end of the inner wall face of the conical hole in an annular array mode, a shifting plate is integrally formed at the bottom ends of the connecting seats, a deformation notch is formed in the side, close to the inner wall of the conical hole, of the shifting plate, and an arc-shaped touch plate is fixedly installed at the bottom end of the shifting plate and located on the same side of the deformation notch. The screening holes, the conical holes, the stirring plate and the arc-shaped touch plate are arranged; in the swinging process of the stirring plate, the stirring plate can collide and make contact with medicine particles in an inclined posture in real time, the inclined collision direction is always perpendicular to the surface of the stirring plate and points to the inclined lower portion, and therefore inclined downward acting force is always provided for the medicine particles to assist the medicine particles in rapid screening. And the problem that a large number of particles are blocked in the screening process can be avoided.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a pharyngitis adjuvant therapy traditional Chinese medicine formula capable of clearing and nourishing throat and a preparation method thereof, and the pharyngitis adjuvant therapy traditional Chinese medicine formula comprises radix pseudostellariae, poria cocos, Chinese yam, radix scrophulariae, honeysuckle, lily, radix rehmanniae, radix rehmanniae preparata, radix ophiopogonis, folium mori, scutellaria baicalensis, platycodon grandiflorum, coptis chinensis, mint, radix saposhnikoviae, dark plum, pericarpium citri reticulatae, scaphium scaphigerum, rhizoma phragmitis and liquorice. According to the invention, a layer-by-layer self-assembly technology is adopted, a slow-release coating with a multi-layer structure is constructed on the surfaces of drug particles, and the coating can control the release speed of the drug, so that the drug is continuously released at the throat part, the action time of the drug is prolonged, and the bioavailability and the treatment effect of the drug are improved; the structure not only enhances the stability of the coating, but also further controls the release speed of the medicine, so that the medicine is released more stably and lastingly.

The utility model relates to the technical field of therapeutic devices, and discloses a traditional Chinese medicine fumigation therapeutic device which comprises a shell and a steam generator, the shell is communicated with the interior of the steam generator through an air pipe, a fixing plate is fixedly installed on the inner wall of the shell, and a rotating shaft is rotatably installed on the lower surface of the fixing plate. The driving motor drives the rotating shaft to rotate, the rotating shaft drives the stirring rod to rotate, medicine particles in the inner cavity of the shell are stirred through the stirring rod, steam can make full contact with all the medicine particles, and therefore medicine power in the medicine particles is taken away. The medicine efficacy of the medicine can be completely taken away, and the fumigation treatment effect of follow-up steam on the patient is improved.

Excipient granulations containing a viscosifying agent, a disintegrant, and one or more additional excipients are disclosed. An excipient granulation can be combined with a pharmaceutical granulation to provide a pharmaceutical composition. The excipient granulations can be used to increase the viscosity of an aqueous composition such as an oral pharmaceutical composition. When added to an aqueous solution, the excipient granulation can dissolve to provide a suspension of the pharmaceutical granules in a viscous solution. The excipient granulation can be used to improve the palatability of oral pharmaceutical compositions containing a pharmaceutical granulation.

The utility model discloses a composite hollow capsule which comprises a separation inner capsule body, an upper containing cavity, a lower containing cavity, a limiting outer convex ring, a transparent capsule cap, a limiting inner ring groove and a double-face convex transparent structure. Various medicine particles can be simultaneously loaded through the upper accommodating cavity and the lower accommodating cavity which are correspondingly arranged on the upper side and the lower side of the separated inner capsule body, so that the taking quantity of capsules is effectively reduced, comprehensive taking treatment of various medicines is facilitated, and the medicine particles loaded in the upper accommodating cavity and the lower accommodating cavity can be conveniently subjected to perspective observation through the transparent capsule cap; a double-sided convex structure arranged at the top end of the transparent capsule cap is matched with a limiting outer convex ring and a limiting inner ring groove structure to amplify and observe the loaded medicine particles, so that the state of the loaded medicine particles is conveniently confirmed, and the taking safety of the capsule is favorably improved.

Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.

The utility model discloses a kind of ultrasonic cleaning equipment of medicine granule raw material, the utility model relates to ultrasonic cleaning equipment technical field, including cleaning tank, further include: filter screen mechanism, the filter screen mechanism is set to the inside of cleaning tank, for the filter screen processing of pretreated medicine granule raw material, open and close adjusting assembly, set to the inside of cleaning tank, this ultrasonic cleaning equipment of medicine granule raw material is provided with filter screen mechanism, sieve plate in filter screen mechanism can to pretreated medicine granule raw material, accurate filter screen according to different specifications and size, ensure the consistency and uniformity of entering ultrasonic cleaning bin material, improve cleaning effect and medicine production quality.Brushing assembly is rotated by driving motor thread rod, make brush plate move under the limit of limit slot plate and sliding groove, continue to brush sieve plate, prevent medicine granule residual block sieve hole, guarantee filter screen efficiency, reduce artificial cleaning frequency and maintenance cost.

The present invention provides a furosemide solid preparation and a preparation method thereof, relating to the technical field of medicine. The solid preparation described in the present invention comprises the following components: furosemide, microenvironment pH regulator, preparation porosity regulator, diluent, disintegrant, lubricant. The microenvironment pH regulator is sodium bicarbonate, and the preparation porosity regulator is hydrophilic AEROSIL 200Pharma. In the present invention, porous AEROSIL 200Pharma is used to adsorb furosemide, and then sodium bicarbonate, the microenvironment pH regulator, is used to adjust the pH value of the saturated solution around the drug particles, which can improve the solubility of the drug and increase the drug dissolution.

The invention relates to the technical field of drug balloons, in particular to a drug balloon, a drug coating and a preparation method thereof, the drug coating comprises a nano-drug, the nano-drug sequentially comprises drug-loaded nanoparticles, an elastin layer and an adhesion layer from inside to outside, and the adhesion layer comprises a polydopamine coating and a cationic polymer coating. The invention provides the drug particle with excellent adhesion to the target blood vessel, the polydopamine and cationic polymer coating is prepared on the surface of the drug particle, the adhesion can be maintained in a dynamic washing environment, and meanwhile, the elastin with excellent elastic buffering performance is adopted as the middle layer of the drug particle, so that the adhesion of the drug particle can be maintained in a dynamic washing environment. The drug can adapt to periodic expansion, contraction and shear force change of blood vessels, close contact between the drug and blood vessel walls can be kept under blood vessel pulsation and blood flow impact, the adhesion stability of the drug is further enhanced, and the retention rate of the drug in target blood vessels is greatly increased.

The utility model discloses a granular medicine forming device with a drying function, which is characterized in that the upper surface of a shell is fixedly connected with a hydraulic rod, the output end of the hydraulic rod is fixedly connected with an upper extrusion plate, the outer surface of the shell is fixedly connected with a linear motor, and the output end of the linear motor is fixedly connected with a middle template; a lower extrusion plate is detachably connected to the lower bottom wall of the shell, a second collecting opening is formed in the inner wall of the lower extrusion plate, after medicine is extruded, the upper extrusion block and the middle mold plate ascend together, the upper extrusion block can push medicine particles and medicine powder residues in the middle mold plate into the lower extrusion plate, and the middle mold plate is kept clean; the influence of residues on the production of the next batch of medicines can be avoided; the medicine powder residues are sucked into the collecting box through the fan, meanwhile, the medicine can be dried, waste of the medicine powder residues is avoided, the production environment can be kept clean and dry, the stability of the medicine can be improved, the storage life of the medicine can be prolonged, and the medicine quality is ensured.

The present invention provides a nebulizer spacer, comprising a spacer body with a mist outlet provided at the front end of the spacer body. The spacer is characterized in that a rear cover is provided on the inlet provided at the rear end of the spacer body, and a mist inlet, an air inlet, and an air inlet check valve are provided on the rear cover. The air inlet check valve is a spiral air inlet check valve. The main body of the spiral air inlet check valve is annular, with a central opening diameter not less than the diameter of the inner wall of the mist inlet. The spiral air inlet check valve is arranged around the mist inlet, and the thickness of the spiral air inlet check valve gradually decreases from the inner edge to the outer edge. At least three inter-petal openings are provided along the radial direction of the spiral air inlet check valve, forming at least three petals, and each of the petals is provided with a fixing port. The spiral air inlet check valve can reduce the probability of drug mist particles adhering to the inner wall of the spacer, improve drug utilization, refine drug particles, reduce drug diffusion, and increase the delivered dose. Furthermore, the oxygen tube interface provided can achieve simultaneous nebulization while inhaling oxygen, reducing the patient's breath-holding phenomenon.

The invention discloses a preparation method of functionally modified coconut carbon dots, which comprises the following steps: mixing coconut juice, a functional modification reagent and polyethylene glycol, reacting, cooling the reaction liquid, and dialyzing to obtain the functionally modified coconut carbon dots, the functional modification reagent is any one of a metal doped functional modification reagent, a light response functional modification reagent, an amination reagent or a quaternization reagent. According to the functional modified coconut carbon dots prepared by the preparation method, the preparation method is simple and convenient, natural antibacterial components contained in coconut juice are converted into nanoscale medicines with excellent antibacterial characteristics, and the specific surface area of medicine particles is effectively increased, so that the contact area of the medicines is increased, the interaction efficiency between the medicines and bacteria is improved, and the antibacterial activity of the medicines is improved. The antibacterial effect of the product is further enhanced and improved.

The present disclosure provides microneedles and microneedle patches for transdermal drug delivery and methods of making and using the same. The microneedles are comprised of a solid composite material comprising a polymerized / cured biocompatible polymer matrix, drug particles, and a surfactant, wherein drug particles and surfactant are dispersed throughout the polymer matrix forming an interconnected drug network extending to surfaces of the microneedle.