253 results about "Drug granules" patented technology

Disclosed is a system for delivery of a drug comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a mean diameter of greater than 10 mum to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient. Also disclosed are novel methods, devices and dosage forms for delivering a drug.

A process for coating a polyunsaturated fatty acid (PUFA)-containing carrier particle or a PUFA matrix particle, or a liquid pharmaceutical-containing carrier particle or a liquid pharmaceutical matrix particle. Also disclosed are such particles made by the process of the invention and foods, pharmaceuticals, beverages, nutritional supplements, infant formula, pet food and animal feed with incorporate such particles.

This invention provides an aerosolized inhaler which enables the drug powder to aerosolize within the inhaler by breathing in the air, comprising the main body (11) and the mouthpiece connector (12) connected thereupon, wherein the inhaler the main body (11) has drug holding opening (1), which connects with the vortex passage, and the vortex passage connects with the mouthpiece (9) on the mouthpiece connector (12). It has many obvious advantages as increasing the inhalation rate, pushing more drug granule to reach to the lower respiratory tract and even into the alveolus; and meanwhile, keeping the drug from being blown out of the inhaler when the users breathes out, preventing from cross inflection and minimizing the side effect of the drug to the whole body, and obviously lightening the burden on the users.

The invention relates to a PLA/PLGA shell-core microsphere prepared by solid-in-oil-in-water in the technical field of pharmacy and a preparation method thereof. The microsphere comprises 0.01 to 50 percent of medicine, 20 to 99.99 percent of polylactic acid and/or polylactic acid-glycolic acid, or/and 0 to 30 percent of pharmaceutical excipient (weight percentage). The method comprises the steps of: adding medicine particles into a PLA and/or PLGA organic solution to be emulsified, then selecting a hydrophilic organic solvent to re-emulsify to form unhardened balls, finally hardening in another large oil phase, removing the organic solvent and collecting micropheres. The method overcomes the disadvantages of low envelope rate of the prior W/O and W/O/W, serious burst release of S/O/O, and environmental pollution, controls the grain diameter of the microsphere according to the need, does not pollute the environment, and can be applied to the preparation of slow release or controlled release microspheres of various medicines and adjuvants of vaccines.

A drug formulation is disclosed comprising granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a drug formulation consisting of a tablet core made by mechanical compression, wherein said tablet core comprises granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a dosage form for oral administration of topiramate, comprising a tablet core and an osmotic delivery system. Methods for controlling topiramate release patterns by altering the composition of the topiramate dosage form are also disclosed.

The invention discloses a nanometer medicine particle. The nanometer medicine particle comprises a hydrophobic polymer, a single-layer lipid molecule, an amphipathy macromolecular compound, at least one chemotherapy drug attached to the hydrophobic polymer, and at least one near-infrared photothermal conversion agent, wherein the hydrophobic polymer, the at least one chemotherapy drug attached to the hydrophobic polymer, and the at least one near-infrared photothermal conversion agent form a hydrophobic core; the single-layer lipid molecule surrounds the surface of the hydrophobic core to form an intermediate layer; and the amphipathy macromolecular compound intersperses in the intermediate layer to form a shell. The invention also provides a preparation method of the nanometer medicine particle. The nanometer medicine particle can realize the combined treatment of thermotherapy and chemotherapy and has high biocompatibility; and the preparation method is simple, convenient and easy to carry out.

The invention discloses an intelligent mechanical device, and specifically refers to a device which is used in fields like health-care medicines, medicines and packaging for detecting, identifying, determining and sorting hollow transparent capsule, hollow nontransparent capsule and capsule filled with drug granules. The device comprises a collating unit, a transferring unit, an identifying unit, a separating unit and an intelligent controlling unit. L-type grooves in the collating unit enable capsule to be transferred from an L-type groove at one side to another L-type groove at the other side; on the surface of a circular wheel is provided with an arc-shaped protection screen; capsule in the transferring unit can freely rotate in capsule grooves through the fraction between the transferring unit and a supporting band; the main light source of the identifying unit employs parallel light and the backlight of the identifying unit employs flat source; and the separating unit is provided with a plurality of magnet plungers respectively corresponding to capsule grooves on a linking sheet. The invention has the advantages of high efficiency in separating, improved correct rate of separating, substantial reduction of labor intensity and high automation. The intelligent mechanical device provided in the invention has a wide range of usages in the industries of pharmacy and foodstuff.

Methods are provided for preparing spray-dried, drug-containing particles comprising the steps of: (a) selecting drug, an aqueous solution, and a proton-sequestering agent; (b) adding the drug and the proton-sequestering agent to the solution to form a feed solution; and (c) spray drying the feed solution to form the spray-dried, drug-containing particles, wherein at least a portion of the proton-sequestering agent remains mixed with the drug in the spray-dried, drug containing particles, particles and pharmaceutical formulations comprising the prepared particles as well as methods of use are also provided.

The invention relates to a particles used to shade bad taste of drug, wherein it is formed by corn element with active component and continuous polymer dress; the corn element is formed by active component and acrylic resin at 1:0.5-1:20 mass ratio; the dress is soluble gel slurry; and the drug is soluble in acid solution with bad taste. And the production comprises that: dissolving drug and soluble base material into solvent; using atomizing drier or rotation evaporator to obtain dry particles; then graining them at neutral condition via gel material; forming dress that separates drug and taste bud on the surface of particles; preparing oral agent via general method. The invention can avoid releasing bad taste in mouth but release drug in stomach.

The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.

A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via inhalation. Thus, when an aerosolized drug solution includes surfactant, Marangoni flows cause the drug particles, once deposited in the lungs, to spread over a wider surface area, thereby ensuring greater antimicrobial efficacy. A solution that contains, for example, an antibiotic and tyloxapol or another surfactant providing a similar surface tension to the composition is optimally delivered by the functional combination of a breath-actuated nebulizer and a high-flow compressor.

The invention relates to a nano-drug carrier, reduction response nano-drug granules, a nano-drug granular preparation and a preparation method thereof. The nano-drug carrier comprises a main chain which is formed by polysaccharide and a side chain which is formed by polyethylenimine on the main chain. Because of the characteristics of the nano-drug carrier, when the nano-drug carrier carries drug, the drug is connected with the nano-drug carrier through a disulfide bond (-SS-), and the disulfide bond is disconnected in a cell in the reduction environment so as to well release the drug to a target location.

The invention relates to a cephalosporin ester drug particle in a non-gel state after meeting water, and a preparation method and an application of the drug particle, and belongs to the technical field of pharmaceutical preparations. The drug particle comprises the following raw and auxiliary materials: a cephalosporin ester drug with the bulk density of 0.1-0.3g/ml, and the following auxiliary materials accounting for the mass percentage of the cephalosporin ester drug as follows: 2-4.5% of micropowder silica gel, 2-4.5% of anti-gel adjuvant, and 12-16% of disintegrating agent, wherein the anti-gel adjuvant is a glidant and/or a lubricant with the bulk density greater than 0.50g/ml. According to the cephalosporin ester drug particle in the non-gel state after meeting the water, and the preparation method and the application of the drug particle, the problem that the dissolution rate is relatively low due to the fact that gelatinization is severe when the cephalosporin ester drug is dissolved out in the water in the prior art is solved, the dispersity and the hydrophilicity in a dissolution-out process are good, no gelatinization exists, and the dissolution rate is increased greatly.

The invention discloses a preparation method of sugar-free four-herb Chinese medicine drug granules. The sugar-free four-herb Chinese medicine drug granules are prepared by weighing four medical herbs, namely, 3-10 parts of fewflower lysionotus, 3-10 parts of rhizomes or herbs of purple bergenia, 2-7 parts of giant knotweed rhizomes and 2-7 parts of herbs of denseflower bulbophyllum, eight times of water is added, the medical herbs are decocted three times, decoction lasts for 1 hour each time, after decoction is conducted three times, filtrates are combined and concentrated into a concentrated solution of which the relative density is 1.17, ethyl alcohol is added into the concentrated solution to enable the volume fraction of the ethyl alcohol to be 70%, alcohol precipitation is conducted for 24 hours, and a solution is concentrated into thick paste; after the thick paste, dextrin and soluble starch are mixed, aspartame is added, then, 80% ethyl alcohol is added to conduct wet granulation, and finished products of the sugar-free four-herb granules are obtained. Pharmacodynamics experiments are conducted on the prepared granules, the prepared granules are good in effect, and compared with traditional decoction of Chinese medicine, the prepared granules have the advantages of being convenient to transport, carry, store, take and the like. The sugar-free four-herb Chinese medicine drug granules are good in mouthfeel, can be used by patients suffering from diabetes, obesity and the like, and have very wide development prospects.

The invention discloses a multifunctional medicine box. The multifunctional medicine box comprises a box body, a medicine placing device, a medicine dispensing device, a medicine taking box and a medicine storing box, wherein the medicine placing device comprises a medicine placing tray frame, a medicine tray rotating shaft intermittently rotating is arranged in the center of the medicine placingtray frame, a plurality of area time bins are arranged on the medicine tray rotating shaft, and each area time bin is divided into a plurality of medicine bins by second partition plates; the medicinedispensing device comprises a medicine dispensing plate, the medicine dispensing plate is provided with a medicine leakage groove which corresponds to one area time bin up and down, the drug placingtray frame is rotationally mounted above the medicine dispensing plate, a plurality of medicine placing boxes are arranged on the plurality of medicine bins, liftable medicine box bottom surfaces aredetachably installed at the lower ends of the medicine placing boxes, medicine leakage holes of different numbers are correspondingly formed in the bottom surfaces of the plurality of medicine boxes,a plurality of medicine stopping plates which correspond to the medicine box bottom surfaces one by one are arranged on the medicine dispensing plate with the medicine tray rotating shaft as an axis in an annular array mode, and the intermittent rotating frequency of the medicine blocking plates is twice the rotating frequency of the medicine tray rotating shaft. The box can achieve timing and quantitative delivery of drug particles, and improve the medication experience of old people.

The invention discloses a novel drug-eluting balloon catheter and a preparation method thereof. The drug-eluting balloon catheter consists of a catheter and a drug coating, wherein the drug coating consists of drug particles, an amphiphilic emulsifier and an excipient, and the drug particles wrapped by the amphiphilic emulsifier are uniformly dispersed in the excipient. The drug-eluting balloon catheter has effects of quickly releasing the drug, improving efficiency of transferring the drug into the blood vessel wall in a short time and improving the bioavailability, and has a good applicationprospect in interventional science.