21results about How to "Rapid dissolution" patented technology

The invention provides a preparation process of micromolecular cubilose peptide and a compound tablet thereof, and belongs to the technical field of protein and peptide. The preparation process of the micromolecular cubilose peptide comprises the following steps: freezing and crushing cubilose; and carrying out compound enzyme enzymolysis. The preparation method comprises the following steps: repeatedly freezing and crushing cubilose to prepare cubilose powder, adding the cubilose powder into deionized water, heating and stewing, and adding a compound enzyme formed by mixing neutral protease and flavourzyme for ultrasonic-assisted enzymolysis to obtain the micromolecular cubilose peptide, when the neutral protease and the flavourzyme are mixed according to the mass ratio of 1: (2.8-3.4) to conduct enzymolysis on the cubilose, hydrolysis can be conducted from multiple positions, smaller peptide fragments are formed, the hydrolysis degree is effectively improved, sialic acid originally combined with protein is also released along with hydrolysis of the protein, and therefore the content of sialic acid in the cubilose is increased. Therefore, the content of sialic acid in the prepared micromolecular cubilose peptide can be effectively improved.

The invention discloses a lacidipine film-controlled sustained-release pellet capsule and a preparation method thereof, relates to the technical field of medicines, and aims to solve the problem of release reduction caused by film aging of a lacidipine film-controlled sustained-release pellet prepared by an aqueous dispersion coating. The preparation method comprises the following steps: respectively weighing a lacidipine bulk drug, a polymer carrier material and a plasticizer according to a prescription amount, grinding and uniformly mixing to prepare the lacidipine solid dispersion. A sustained-release coating film of the pellet capsule contains Eurdragit RL30D, a plasticizer triethyl citrate and an anti-sticking agent talcum powder, and a pellet core contains croscarmellose sodium and an excipient. According to the lacidipine solid dispersion solid preparation provided by the invention, lacidipine exists in the carrier material in a microcrystalline state, an amorphous state, a colloidal dispersion state or a molecular dispersion state, so that the lacidipine solid dispersion solid preparation has high dispersity, the dissolution speed of a medicine is accelerated, the absorption of the medicine can be promoted, and the bioavailability is improved.

The invention belongs to the technical field of medicines, and relates to a berberine tannate oral preparation and a preparation method thereof. The oral preparation comprises berberine tannate, a filling agent, a disintegrating agent, an adhesive and a wetting agent, the filling agent is pregelatinized starch, microcrystalline cellulose and colloidal silicon dioxide; the disintegrating agent is one or more of sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone. The auxiliary materials of the berberine tannate oral preparation cooperate with one another, so that the flowability and compressibility of the powder are effectively improved, and the obtained final preparation product is excellent in stability and dissolution property and high in bioavailability; in addition, the oral preparation is simple in preparation process and suitable for large-scale production.

The invention discloses metronidazole particles, a preparation containing the metronidazole particles and a preparation method of the metronidazole particles. The metronidazole particle comprises a drug core and a coating layer, wherein the coating layer is coated on the outer surface of the drug core; the medicine core comprises metronidazole; the coating layer comprises a film-forming material, and the film-forming material comprises gastric-soluble acrylic resin and ethyl cellulose. The metronidazole granule has low dissolution rate in water and a medium with high pH (such as pH 6.8), especially the dissolution rate in 15 minutes is less than or equal to 10%, the dissolution rate at low pH (such as pH 1.2-4.5) is consistent with the dissolution rate of commercially available tablets, and the metronidazole granule is rapidly dissolved out.

This invention discloses a white, high-gloss, antibacterial, and flame-retardant composition that inhibits the formation of black spots. It comprises 19.85-22.8 parts by weight of propylene homopolymer A, 30-40 parts by weight of propylene block copolymer B, 8-15 parts by weight of bromobisphenol S derivative flame retardant C, 5-10 parts of synergistic flame retardant D, 15-30 parts of coated zinc oxide E1, 15-30 parts of coated barium salt, and 0.15-1 part of additive F. It is particularly important to note that the additive does not contain organic phosphite antioxidants, inorganic hypophosphite additives, thioester additives, or carbonate additives. This composition achieves a UL94 1.6mm V0 flame retardant rating, while parts made from it have an excellent ceramic-like gloss (60° gloss ≥80%). Surprisingly, without the addition of additional antibacterial agents, the composition itself has an antibacterial efficiency of over 90% against Escherichia coli and imported Staphylococcus aureus. With the addition of additional antibacterial agents, the antibacterial effect against both of these bacteria exceeds 99%. In addition, the number of black spots generated during the preparation process is significantly reduced.

The invention belongs to the technical field of veterinary drugs, relates to a veterinary albendazole tablet, and provides a preparation method of the preparation. The tablet consists of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable adhesives, disintegrating agents and lubricating agents. The albendazole is fully dispersed by spray-drying a mixed solution of albendazole, trehalose and sodium taurocholate, and the dosage of trehalose and sodium taurocholate is controlled, so that the dissolution and stability of the product are improved.

The application provides a pentaethylenehexamine-beta-cyclodextrin grafted folic acid inclusion cannabidiol nanosphere, a preparation method and an application, the method first prepares a pentaethylenehexamine-beta-cyclodextrin grafted folic acid (PEHA-beta-CD-FA) targeting carrier, then cannabidiol (CBD) is mixed with the carrier in an ethanol-water mixed solvent in a certain proportion, a stable inclusion system is formed through ultrasonic-assisted inclusion + room-temperature light-avoiding stirring, and the system is purified through dialysis, freeze-drying or spray-drying, so that the spherical nanoparticles with uniform particle size of about 100 nm are obtained. The application solves the problems that CBD has extremely low water solubility, poor bioavailability and lacks targeted delivery, the obtained nanospheres have folic acid receptor active targeting, pH response drug release, high encapsulation rate and high colloidal stability, can significantly improve the solubility, dissolution rate and in-vivo targeted delivery efficiency of CBD, and are suitable for the fields of anti-inflammatory, neuroprotective and the like drugs, cosmetics and functional foods.

The application provides a sitagliptin and metformin hydrochloride sustained-release pharmaceutical composition and a preparation method and application thereof, and relates to the technical field of sustained-release preparations. The pharmaceutical composition comprises a sustained-release tablet core and a quick-release coating layer; the sustained-release tablet core comprises active ingredients metformin hydrochloride and a sustained-release matrix material hydroxypropyl methyl cellulose, and the sustained-release tablet core does not contain microcrystalline cellulose; the quick-release coating layer comprises active ingredients sitagliptin phosphate; the weight ratio of metformin hydrochloride to hydroxypropyl methyl cellulose in the sustained-release tablet core is 50:(24-27). The composition realizes double-phase release of drugs by using a double-layer structure; by removing the microcrystalline cellulose and limiting the specific ratio of active ingredients to the matrix material, the forming property of the preparation and the ideal dissolution behavior are ensured while the tablet weight is significantly reduced to improve the swallowing compliance, and the technical problem that a high drug loading compound preparation is difficult to maintain the function of the sustained-release matrix under a large amount of weight reduction is successfully solved.

The invention relates to the technical field of medicine preparation, in particular to a baltefibrate oral-soluble film agent and a preparation method thereof, and the baltefibrate oral-soluble film agent can achieve ideal dissolution speed and bioavailability equivalent to tablets in an oral cavity by controlling particle size distribution of raw material medicines in the baltefibrate oral-soluble film agent and dissolving baltefibrate through polyvinylpyrrolidone aqueous dispersion. According to the invention, the characteristic of good dissolution effect can be realized without additionally adding a pH regulator, and rapid disintegration and dissolution can be realized without additionally adding water in the oral cavity. The preparation method of the Pengfibrate oral soluble film is simple and easy to operate, and is suitable for modern industrial mass production, required production equipment is conventional equipment, the cost is saved, and the production possibility is improved.

The present application belongs to the technical field of pharmaceutical preparations, and relates to a combined preparation of ezetimibe and atorvastatin calcium, in particular to a preparation containing ezetimibe and atorvastatin calcium and a preparation method thereof. A double-layer tablet is formed by an ezetimibe layer and an atorvastatin calcium layer, the ezetimibe layer is composed of ezetimibe and a first excipient, and the atorvastatin calcium layer is composed of atorvastatin calcium and a second excipient; the second excipient does not contain an alkaline stabilizer, and kaolin is used as a filler in the second excipient. By adding kaolin as a filler, the present application can not only avoid the addition of an alkaline adjusting agent, but also improve the stability of ezetimibe and atorvastatin calcium.

The invention discloses a high-drug-loading-capacity celecoxib solid dispersion with solubilizing performance and a preparation method thereof. The solid dispersion is prepared from the following components in percentage by mass: 50% of celecoxib, 40-47% of a carrier material and 3-10% of a crystal inhibitor, the total percentage of all the components is 100%. Wherein the carrier material is polyacrylic resin; the crystal inhibitor is selected from one or more of copovidone VA64, povidone K30, hydroxypropyl methylcellulose E5 and hydroxypropyl methylcellulose E50; the solid dispersion provided by the invention has high dissolution rate and good stability, and can effectively inhibit recrystallization of a drug in a supersaturated solution and maintain the supersaturation degree of the drug in the solution; according to the present invention, the carrier-crystal inhibitor binary polymer combination is adopted to achieve the complete release of the drug, and the new idea is provided for the preparation or the process innovation of the high drug loading capacity celecoxib preparation.

The application discloses white carbon black and a preparation method and application thereof, and the preparation method comprises the following steps: S1, silicon source pretreatment: mixing rice husk ash and a sodium hydroxide solution, reacting under the assistance of microwaves, adding a composite impurity removing agent for deep purification after filtration, and obtaining refined water glass solution; S2, modified precursor preparation: adding a composite modifier into the refined water glass solution, and obtaining a modified precursor solution; S3, high-pressure spray carbonization: atomizing the precursor solution, and reacting with mixed gas of CO2 and N2 in a high-pressure spray reaction tower to generate white carbon black slurry; S4, post-treatment: after washing and grinding, the white carbon black slurry is spray dried to obtain a finished product; and S5, waste liquid circulation: reacting the washing waste liquid with limestone, and recycling the alkali liquor for the step S1. The application realizes the recycling of waste resources; the product has high activation degree and excellent dispersibility, is applied to rubber reinforcement, improves processing performance, significantly enhances mechanical properties such as tensile strength, and has a good industrial application prospect.

This invention belongs to the field of sports nutrition supplements and food ingredient processing technology, and particularly relates to a method for preparing ultrafine creatine with improved solubility and absorption efficiency. Creatine monohydrate is pretreated with low water activity and then ultrafinely pulverized using a low-temperature airflow. Malic acid and citric acid are then enriched and coated onto the surface of the creatine particles under low water activity conditions. The particles are then granulated at low temperature to form porous secondary composite microparticles. These composite microparticles maintain a high crystal form retention rate of creatine monohydrate and a low creatinine production rate in their dry powder state. Upon reconstitution with water, they rapidly disintegrate and form a locally acidic interface environment, improving the wetting, dispersibility, and dissolution efficiency of creatine.

The invention discloses a tigorazan amorphous solid dispersion, a tigorazan-containing tablet core, a tigorazan tablet and a preparation process of the tigorazan amorphous solid dispersion. The invention specifically discloses a tigorasan solid dispersion. The tigorasan solid dispersion comprises tigorasan and a carrier, the tigorasan is one or more of a tigorasan A crystal form, a tigorasan B crystal form and a tigorasan amorphous form; the carrier comprises copovidone and polyethylene glycol; the mass ratio of the copovidone to the polyethylene glycol is 1: (0.5-2). The invention also provides a preparation method of the tigorazan solid dispersion, a tigorazan-containing tablet core and a preparation method thereof, and a tigorazan tablet and a preparation method thereof. According to the method disclosed by the invention, wet granulation is adopted, so that the preparation process is simpler, the product quality is easier to control, the production efficiency is improved, large-scale production is facilitated, and the prepared tigoraz tablets are good in content uniformity and good in stability.

The invention discloses a quick-absorption frovatriptan succinate tablet and a preparation method thereof. In raw materials for preparing the quick-absorption frovatriptan succinate tablet, auxiliary materials comprise lactose and mannitol, and preferably, the weight ratio of the lactose to the mannitol is (3-5): 1. The frovatriptan succinate tablet capable of being rapidly absorbed is high in dissolution speed, stable in dissolution and capable of rapidly releasing drugs in vivo and accelerating drug absorption, so that the onset time of the drugs is shortened. And more medicines can be absorbed to enter blood circulation, so that the bioavailability of the medicines is increased, and the treatment effect is improved.

The utility model relates to the technical field of liquid medicine processing, and discloses a liquid medicine extraction device which comprises an extraction mechanism, the extraction mechanism comprises a dipping tank, a mounting hole is formed in the center of the inner bottom wall of the dipping tank, and the front end and the rear end of the inner bottom wall of the dipping tank are each provided with a discharging hole. And a filter separator is fixedly mounted on the outer bottom wall of the impregnating tank and located at the openings of the two discharge holes. The efficient stirring mechanism is arranged in the dipping tank, namely, the stirring paddle is arranged in the dipping tank, the multiple layers of stirring blades are arranged on the outer side of the stirring paddle, and the stirring blades are driven by the motor to stir medicinal materials and solvents at different heights, so that uniform mixing is ensured; the shape and the rotating speed of the stirring blades can be optimally designed according to the size of the dipping tank and the characteristics of medicinal materials.

The invention discloses an efficient resourceful treatment method of firework and firecracker waste residues, which comprises the following steps: S1, sulfur dissolving separation: placing the firework and firecracker waste residues in a sulfur dissolving agent, and carrying out hot filtration separation to obtain a sulfur-containing clear liquid and desulfurized residues; cooling and separating out the sulfur-containing clear liquid, and carrying out solid-liquid separation to obtain sulfur and a sulfur dissolving liquid; s2, slurrying and leaching: adding the desulfurization residues into concentrated sulfuric acid to carry out slurrying reaction, dissolving magnesium and aluminum components, and carbonizing and decomposing lead fibers at the same time; s3, solid-liquid separation and flotation: diluting and cooling the material after the pulpifying reaction, and carrying out solid-liquid separation to obtain a leachate containing magnesium and aluminum ions and residues after leaching; and S4, magnesium aluminate spinel preparation: adjusting the pH value of the leachate to separate out magnesium and aluminum in a precipitation form, filtering, drying filter residues, and calcining to obtain the magnesium aluminate spinel. According to the method, sulfur, magnesium, aluminum and other resources in the waste residues can be safely and efficiently separated and recycled, meanwhile, the final residues are subjected to harmlessness, the amount and volume of the residues are greatly reduced, and the method is suitable for industrial-scale continuous production.

The invention discloses a method for extracellular preparation of a rice bran protein-emblic leafflower fruit polysaccharide covalent graft, and relates to the technical field of biology. The method comprises the following steps: mixing fresh phyllanthus emblica fruits, rice bran protein and water, carrying out extraction treatment by adopting a flash extractor under the ultrasonic-assisted action, then filtering to obtain filtrate, concentrating the filtrate to obtain a concentrated solution, then carrying out alcohol precipitation treatment to obtain a precipitate, and drying the precipitate to obtain the phyllanthus emblica extract. And freezing and drying to obtain the rice bran protein-emblic leafflower fruit polysaccharide covalent graft. According to the method, the one-step efficient extraction of the emblic leafflower fruit polysaccharide is realized by combining the maximum rotating speed shearing of the flash extractor and the ultrasonic-assisted effect, and the rice bran protein-emblic leafflower fruit polysaccharide covalent graft is formed while the polysaccharide is extracted by controlling the Maillard reaction conditions, so that the yield and the purity of the graft product are remarkably improved, and the cost is reduced. And the stability of the product structure and the maximization of the functionality are ensured.

The invention belongs to the field of pharmaceutical preparations, and discloses a lansoprazole sodium bicarbonate capsule and a preparation process thereof, and the preparation process comprises the following steps: firstly, pressing lansoprazole and auxiliary materials into a tablet core; directly tabletting the hydroxypropyl methylcellulose phthalate, the auxiliary materials and the tablet core again to obtain an enteric-coated layer; and finally, carrying out third-time tabletting on sodium bicarbonate, auxiliary materials and the secondarily-pressed tablet core, and pressing into the micro-tablet which sequentially comprises the lansoprazole tablet core, the enteric-coated layer and the sodium bicarbonate quick-acting layer from inside to outside. According to the lansoprazole sodium bicarbonate capsule prepared through the method, after a patient takes the capsule, the sodium bicarbonate layer in the medicine disintegrates rapidly, the concentration of gastric acid is reduced rapidly, pain of the patient is reduced, then lansoprazole wrapping the enteric layer enters the intestinal tract to be released, the gastric acid releasing capacity of gastric cells is reduced, and the symptoms are treated firstly and then the root causes are treated.

The invention discloses clarified high-anthocyanin aronia instant freeze-dried fruit tea and a preparation method thereof, and relates to the technical field of food processing, the clarified high-anthocyanin aronia instant freeze-dried fruit tea comprises aronia juice, a drying aid, a color fixative, a color fixative and mixed essence, and the mass ratio of the aronia juice to the drying aid to the color fixative to the color fixative is 100: 45: 1: 1. By adopting a vacuum freeze-drying process, the obtained finished product can be directly and quickly dissolved in cold water in the dissolving process, and meanwhile, treatment such as direct heating and hot water brewing is avoided in the preparation process, so that the great loss of functional substances in the fruit tea due to high temperature is avoided; the drying process of vacuum freeze drying can reduce the oxidation degree of the fruit tea in the air in the drying process to the greatest extent, the total anthocyanin content of the instant freeze-dried fruit tea prepared by the method disclosed by the invention reaches 133.87 + / -3.33 mg C3GE / 100g, the total polyphenol content reaches up to 1622.04 + / -2.11 mg GAE / 100g, the total flavone content reaches up to 117.53 + / -4.67 mg CE / 100g, and functional substances in the aronia can be well reserved.

The utility model belongs to the technical field of extraction equipment, and particularly relates to weeding composition production and processing intelligent extraction equipment which comprises a machine frame, foot cups are fixedly installed at the bottom of the machine frame, an installation base is fixed to the top of the machine frame, and a spring column is installed in the middle of the installation base in an embedded mode. A mounting plate is fixedly connected to the top of the spring column through a mounting seat, a vibration motor is fixedly mounted at the center of the bottom of the mounting plate, an extraction tank is fixedly connected to the top of the mounting plate, a solid feeding pipe is arranged at the top of the extraction tank, and a liquid inlet pipe is further arranged at the top of the extraction tank. Through the vibration effect of the vibration motor and the cooperative work of the rotating piece, the rotating plate and the scraping plate on the rotating shaft, materials can be stirred and mixed in an all-dimensional and multi-angle mode, rapid dissolution of effective components is promoted, the extraction efficiency is greatly improved, the equipment can meet the extraction requirements of different types of weeding compositions, and the equipment is suitable for large-scale popularization and application. And the method has wide applicability and flexibility.