791results about How to "Rapid dissolution" patented technology

Described are nanoparticulate docetaxel or analogue thereof compositions. The compositions, which comprise a nanoparticulate docetaxel or analogue thereof and at least one surface stabilizer, can be used in the treatment of cancer.

The invention relates to a liquid compound biological fertilizer with long shelf life as well as a preparation method and application thereof. The liquid compound biological bacterial fertilizer comprises the following components in parts by weight: 2-5 parts of microbial thalli, 80-130 parts of compound nutrients, 10-30 parts of thalli protective agents and 0.5-3.0 parts of additives, wherein the microbial thalli is metered in terms of the wet weight of deposition obtained after fermentation liquor is centrifugalized, the microbial thalli include bacillus thuringiensis, bacillus megaterium, bacillus mucilaginosus and bacillus amyloliquefaciens, and the total viable count achieves 5*10<8>-5*10<9>/mL. The liquid compound biological bacterial fertilizer disclosed by the invention can be used as a biological pesticide, can be directly applied to the spraying of plant surfaces or applied to seed soaking, root irrigation, and the like, has the effects of insect resistance, phosphate solubilization, potassium solubilization, organic matter solubilization, pest resistance, and the like and is long in shelf life.

The invention relates to a solid dispersion and tablets comprising abiraterone acetate, and preparation methods thereof. The solid dispersion is prepared through the steps that: abiraterone acetate and povidone with a weight ratio of 1:0.5-4 are dissolved in chloroform; and reduced-pressure drying is carried out, such that the solid dispersion is obtained. The tablets comprises 1 part of the abiraterone acetate solid dispersion, 2-8 parts of a filling agent, 0.2-0.8 parts of a disintegrating agent, and 0.05-0.1 parts of a lubricant. According to the invention, a micronization technology and a solid dispersion technology are creatively combined, such that abiraterone acetate water solubility is greatly improved. Therefore, abiraterone acetate can be rapidly dissolved in gastrointestinal tract body fluids.

A helicidium softcapsule is composed of the liquid medicine and shell material, and features that said dliquid medicine is prepared from superfine helicidum particles and medicinal auxiliary.

The invention relates to a drip pills of butylbenzene phthalein and its preparation method and it is characterized by comprising butylbenzene phthalein, base material, dispersing agent and coating materials. PEG4000, PEG6000, PEG20000 and poloxamer are selected as base materials. Dispersing agent is from lightweight aerosol and crospovidone. And coating materials are from hypromellose, hydroxypropyl cellulose, ethyl cellulose and Eudragit E30D.

The secnidazole tablet contains secnidazole 50-90 wt%, microcrystalline cellulose, starch, pre-gelatinized starch and/or lactose 0.5-40 wt%, cross-linked sodium carboxymethyl cellulose and/or cross-linked polyvinyl pyrrolidone 0.5-9 wt%, polyvinyl pyrrolidone or hydroxypropylmethyl cellulose 0.1-2.5 wt%, magnesium stearate 0.5-1 wt%, and talcum powder and/or fine silica gel powder 0.5-1 wt%. The preparation process of the secnidazole tablet includes the steps of mixing the said materials, palletizing and tabletting. The secnidazole tablet has high effective component content, easy swallowing, no bitter taste and fast leaching.

Provided is a tuble vegetable function fertilizer. The tuble vegetable function fertilizer is prepared from, by weight, 25-35 parts of urea, 1-5 parts of ammonium sulfate, 20-35 parts of monoammonium phosphate, 35-45 parts of potassium sulfate, 1-5 parts of organic carbon, 1-5 parts of potassum fulvic acid, 0.5-1 part of calcium superphosphate, 0.1-0.5 part of borax, 0.5-1 part of magnesium sulfate, 1-5 parts of mixed fungicide, 0.1-0.5 part of synergist and 1-5 parts of other additives. A preparation method comprises the steps that the pH value is adjusted for a fermentation waste solution, microelement is added after heating for a complexation reaction, and organic carbon is obtained; the urea, ammonium sulfate, monoammonium phosphate, potassium sulfate, calcium superphosphate, borax, magnesium sulfate, synergist and other additives are prepared into particles; organic carbon and potassum fulvic acid wrap the outer layers of the particles, and finally the tuble vegetable function fertilizer can be obtained by adding the mixed fungicide. According to the tuble vegetable function fertilizer, comprehensiveness of tuble vegetable growth nutrients is effectively guaranteed, soil insect damage is reduced, malformation of tuble crops can be prevented, and the yield is increased.

The invention relates to Chinese medicinal composition granules and a preparation method thereof. The Chinese medicinal composition granules comprise the following ruptured powder in part by weight: 3 to 18 parts of American ginseng ruptured powder, 1 to 24 parts of pseudo-ginseng ruptured powder, 6 to 36 parts of dendrobium ruptured powder, and 9 to 45 parts of root of red-rooted salvia ruptured powder, wherein the granularity D90 of the ruptured powder is between 5 and 75 mu m. The invention also provides a method for preparing the Chinese medicinal composition granules. The method comprises the following steps of: uniformly mixing the American ginseng ruptured powder, pseudo-ginseng ruptured powder, dendrobium ruptured powder, and root of red-rooted salvia ruptured powder of which the D90 is between 5 and 75 mu m; preparing a soft material by adopting aqueous ethanol at the concentration of over 20 vol percent; and after granulating by using a granulator with 10 to 30 meshes, drying and finishing the granules to obtain the Chinese medicinal composition granules. The Chinese medicinal composition granules are applied to preventing and regulating human cardiac-cerebral vascular system diseases and sub-health state such as weak immunity and fatigability, have the obvious advantages of high medical effect, high quality uniformity, convenient carrying and administration, safety, reliability, and the like, and can meet the requirement on modern fast-paced lifestyle.

The invention provides a preparation process of a fish scale collagen protein. With the preparation process, the collagen protein can be extracted from fish scales, so that the fish scales are changed into things of value from waste material and thorough utilization of resources is realized. The preparation process comprises the following steps of pretreating, decalcifying, neutralizing and removing impurity, washing by using water, sol, solid-liquid separating and filtering, hydrolyzing, filtering and separating the collagen protein, filtering and separating the macromolecular protein, desalting, dehydrating, drying and the like to obtain collagen protein powder. The collagen protein powder prepared by the preparation process has the molecular weight of less than 5000 Daltons and can be absorbed by the human body easily.

The present invention belongs to the field of chemical medicine preparing technology, and is especially solid Tacrolimus dispersion as one kind of immunodepressant and its preparation process. The present invention adopts Tacrolimus as active medicine component, and prepares the solid Tacrolimus dispersion through adding carrier material, solvent process, solvent-fusing process and freeze drying process, and the solid Tacrolimus dispersion is further prepared into capasule. The present invention has raised medicine solubility, 5-500 times raised solubility in water compared with Tacrolimus, raised leaching speed and increased absorption of the medicine inside body.

A ticagrelor solid dispersion and preparation method thereof; the solid dispersion is prepared via dispersing the ticagrelor into a carrier material, the carrier material comprising one or more of polyvinylpyrrolidone, copovidone and crospovidone.

The invention belongs to the technical field of medicine, and discloses curcumin nanosuspension and a preparation method of the curcumin nanosuspension. As curcumin is poor in stability, small in solubility and low in oral bioavailability, popularization and use of the curcumin are restricted. The curcumin nanosuspension disclosed by the invention is characterized by containing the curcumin, piperine, and zein, and the mass ratio of the curcumin to the piperine to the zein is 10 to (8-9) to (1-2). The preparation method of the curcumin nanosuspension disclosed by the invention is mild in condition, simple and controllable, and the curcumin achieves high oral bioavailability.

The invention discloses a compound preparation used for joint care and a preparation method thereof. The compound preparation comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, chondroitin sulfate, dimethyl sulfone and collagen, and the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphate or mixture of theglucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, disintegrant, lubricant, bonding agent and wetting agent. The invention has better treatment and prevention functions on arthritis and joint injury; the prepared tablet has good disintegration property, rapid digestion, quick effect taking, strengthened stability andhigh absorption and utilization ratio; and the consumption of the raw materials and the auxiliary materials achieves the optimal proportion.

The invention relates to the technical field of pesticide preparations and specifically relates to a sustained-release pesticide fertilizer granula and a production method thereof. The pesticide fertilizer granula is prepared from a sustained-release coating layer and an inner effective matter, wherein the sustained-release coating layer is prepared from talcum powder, neutral bentonite, hydroxymethyl cellulose and chitosan which are mixed according to the mass ratio of 8 to 5 to 2 to 1; the effective matter is prepared from sustained-release medicine, compound fertilizer, a wetting expandingagent and a filling agent; the sustained-release medicine is a coated systematic type pharmaceutical preparation; the systematic type pharmaceutical preparation and a mesoporous AcF micro powder carrier are mixed and then coated; a coating material is prepared from the following ingredients of polyglycolic acid, talcum powder, mesoporous silica, cyclodextrin, liquid paraffin, polyvinyl alcohol, calcium dodecyl benzene sulfonate and deionized water. The pesticide fertilizer granula is treated by a special coating technology, has the characteristics of quick and stable fertilizer efficiency andslow and durable insect killing pesticide effect and is suitable for synchronous pesticide fertilizer application of flowers and nursery stock plants.

The invention relates to a method for performing ultrasonic alkaline leaching and microwave digestion combined treatment on an electrolytic aluminum waste cathode carbon block, and belongs to the technical field of comprehensive utilization of aluminum electrolysis solid waste resources. The method comprises three processes of crushing and grinding, performing ultrasonic alkaline leaching and performing microwave digestion, the ultrasonic alkaline leaching and the microwave digestion are subjected to combined utilization and are synergistic, a carbon material and fluoride are separated and recycled in an efficient and environment-friendly mode, environmental harm is reduced, remarkable environment-protecting benefit and economic benefit are achieved, harmless treatment and resource utilization of the electrolytic aluminum waste cathode carbon block are realized, and the method is a low-energy-consumption, high-efficiency and high-additional-value process technology for performing harmless treatment and resource utilization on the electrolytic aluminum waste cathode carbon block.

The invention relates to a tablet containing everolimus, and a preparation method thereof. The tablet is prepared by tabletting of everolimus solid dispersion and a pharmaceutically acceptable auxiliary material, wherein the pharmaceutically acceptable auxiliary material comprises a filling material, a disintegrating agent and a lubricant. The everolimus solid dispersion is made of everolimus using a specific carrier material, so that hydrophilicity of everolimus is increased greatly, it is beneficial for rapid dissolving of everolimus in gastrointestinal tract body fluids, and medicine safety is improved.

The invention provides a solid oral preparation without a surfactant. The solid oral preparation comprises the following components in percentage by weight: 5-25% of telmisartan, an alkaline reagent and the balance of pharmaceutically acceptable vectors, wherein the weight of the alkaline reagent is equal to 7-20% of that of telmisartan. The invention also provides a method for preparing the solid oral preparation. The preparation prepared by the method can be quickly and sufficiently released in the psychophysical pH range of gastrointestinal tracts; and compared with the prior art, the preparation method has the advantages that the process is simpler, the quality of the soli oral preparation is more stable, the cost is greatly saved, and the efficiency is improved.

The present invention discloses rivaroxaban-containing tablets, which are prepared from a raw material containing micronized rivaroxaban and an auxiliary material containing a water soluble filler, wherein a weight ratio of the rivaroxaban to the water soluble filler is 1:0.5-50, and the water-soluble filler is one or a plurality of materials selected from lactose, mannitol, sorbitol and sucrose. According to the present invention, the hydrophilicity of the rivaroxaban is significantly improved, the rapid dissolution the rivaroxaban in the gastrointestinal tract body fluid is easily achieved, the preparation process is simple, the operation is convenient, and the method is suitable for industrial large-scale production.

The invention discloses eucommia bark fermented health care vinegar and a preparation method thereof. The preparation method comprises the following steps: (1) preparing a basic fermentation solution: crushing ponkan pulp, extracting juice, conducting coarse filtration, conveying the obtained juice into a cloudy juice tank, adding a folium cortex eucommiae extracting solution, regulating a sugar content and conducting pasteurization, so that the basic fermentation solution is prepared; (2) conducting primary fermentation: inoculating the basic solution with an activated wine-activating yeast, and conducting fermentation at 20-28 DEG C for 5-10 days, so that eucommia bark-ponkan fruit wine is prepared, conducting filtration, and conveying the fruit wine into an acetic acid fermentation tank; and (3) conducting secondary fermentation: adding 8-12% of domesticated acetic acid bacterium liquid to the eucommia bark-ponkan fruit wine; and conducting aerating agitation for 2-3 times every day at 26-33 DEG C for 3-4 days, 1min per time, so that the fruit wine gets into full contact with oxygen, and subsequently, the health care vinegar is obtained. According to the health care vinegar and the preparation method thereof disclosed by the invention, by effectively integrating such technologies as vacuum pulsation enhanced mass transfer, biological fermentation, enzymatic hydrolysis and the like, an optimum effect of preparing the eucommia bark fermented health care vinegar from the folium cortex eucommiae and the ponkan juice is achieved; and the health care vinegar is strong in market competitiveness and broad in application prospect.