10results about How to "Rapid dissolution" patented technology

The invention discloses metronidazole particles, a preparation containing the metronidazole particles and a preparation method of the metronidazole particles. The metronidazole particle comprises a drug core and a coating layer, wherein the coating layer is coated on the outer surface of the drug core; the medicine core comprises metronidazole; the coating layer comprises a film-forming material, and the film-forming material comprises gastric-soluble acrylic resin and ethyl cellulose. The metronidazole granule has low dissolution rate in water and a medium with high pH (such as pH 6.8), especially the dissolution rate in 15 minutes is less than or equal to 10%, the dissolution rate at low pH (such as pH 1.2-4.5) is consistent with the dissolution rate of commercially available tablets, and the metronidazole granule is rapidly dissolved out.

This invention discloses a white, high-gloss, antibacterial, and flame-retardant composition that inhibits the formation of black spots. It comprises 19.85-22.8 parts by weight of propylene homopolymer A, 30-40 parts by weight of propylene block copolymer B, 8-15 parts by weight of bromobisphenol S derivative flame retardant C, 5-10 parts of synergistic flame retardant D, 15-30 parts of coated zinc oxide E1, 15-30 parts of coated barium salt, and 0.15-1 part of additive F. It is particularly important to note that the additive does not contain organic phosphite antioxidants, inorganic hypophosphite additives, thioester additives, or carbonate additives. This composition achieves a UL94 1.6mm V0 flame retardant rating, while parts made from it have an excellent ceramic-like gloss (60° gloss ≥80%). Surprisingly, without the addition of additional antibacterial agents, the composition itself has an antibacterial efficiency of over 90% against Escherichia coli and imported Staphylococcus aureus. With the addition of additional antibacterial agents, the antibacterial effect against both of these bacteria exceeds 99%. In addition, the number of black spots generated during the preparation process is significantly reduced.

The application provides a pentaethylenehexamine-beta-cyclodextrin grafted folic acid inclusion cannabidiol nanosphere, a preparation method and an application, the method first prepares a pentaethylenehexamine-beta-cyclodextrin grafted folic acid (PEHA-beta-CD-FA) targeting carrier, then cannabidiol (CBD) is mixed with the carrier in an ethanol-water mixed solvent in a certain proportion, a stable inclusion system is formed through ultrasonic-assisted inclusion + room-temperature light-avoiding stirring, and the system is purified through dialysis, freeze-drying or spray-drying, so that the spherical nanoparticles with uniform particle size of about 100 nm are obtained. The application solves the problems that CBD has extremely low water solubility, poor bioavailability and lacks targeted delivery, the obtained nanospheres have folic acid receptor active targeting, pH response drug release, high encapsulation rate and high colloidal stability, can significantly improve the solubility, dissolution rate and in-vivo targeted delivery efficiency of CBD, and are suitable for the fields of anti-inflammatory, neuroprotective and the like drugs, cosmetics and functional foods.

The application provides a sitagliptin and metformin hydrochloride sustained-release pharmaceutical composition and a preparation method and application thereof, and relates to the technical field of sustained-release preparations. The pharmaceutical composition comprises a sustained-release tablet core and a quick-release coating layer; the sustained-release tablet core comprises active ingredients metformin hydrochloride and a sustained-release matrix material hydroxypropyl methyl cellulose, and the sustained-release tablet core does not contain microcrystalline cellulose; the quick-release coating layer comprises active ingredients sitagliptin phosphate; the weight ratio of metformin hydrochloride to hydroxypropyl methyl cellulose in the sustained-release tablet core is 50:(24-27). The composition realizes double-phase release of drugs by using a double-layer structure; by removing the microcrystalline cellulose and limiting the specific ratio of active ingredients to the matrix material, the forming property of the preparation and the ideal dissolution behavior are ensured while the tablet weight is significantly reduced to improve the swallowing compliance, and the technical problem that a high drug loading compound preparation is difficult to maintain the function of the sustained-release matrix under a large amount of weight reduction is successfully solved.

The present application belongs to the technical field of pharmaceutical preparations, and relates to a combined preparation of ezetimibe and atorvastatin calcium, in particular to a preparation containing ezetimibe and atorvastatin calcium and a preparation method thereof. A double-layer tablet is formed by an ezetimibe layer and an atorvastatin calcium layer, the ezetimibe layer is composed of ezetimibe and a first excipient, and the atorvastatin calcium layer is composed of atorvastatin calcium and a second excipient; the second excipient does not contain an alkaline stabilizer, and kaolin is used as a filler in the second excipient. By adding kaolin as a filler, the present application can not only avoid the addition of an alkaline adjusting agent, but also improve the stability of ezetimibe and atorvastatin calcium.

The application discloses white carbon black and a preparation method and application thereof, and the preparation method comprises the following steps: S1, silicon source pretreatment: mixing rice husk ash and a sodium hydroxide solution, reacting under the assistance of microwaves, adding a composite impurity removing agent for deep purification after filtration, and obtaining refined water glass solution; S2, modified precursor preparation: adding a composite modifier into the refined water glass solution, and obtaining a modified precursor solution; S3, high-pressure spray carbonization: atomizing the precursor solution, and reacting with mixed gas of CO2 and N2 in a high-pressure spray reaction tower to generate white carbon black slurry; S4, post-treatment: after washing and grinding, the white carbon black slurry is spray dried to obtain a finished product; and S5, waste liquid circulation: reacting the washing waste liquid with limestone, and recycling the alkali liquor for the step S1. The application realizes the recycling of waste resources; the product has high activation degree and excellent dispersibility, is applied to rubber reinforcement, improves processing performance, significantly enhances mechanical properties such as tensile strength, and has a good industrial application prospect.

This invention belongs to the field of sports nutrition supplements and food ingredient processing technology, and particularly relates to a method for preparing ultrafine creatine with improved solubility and absorption efficiency. Creatine monohydrate is pretreated with low water activity and then ultrafinely pulverized using a low-temperature airflow. Malic acid and citric acid are then enriched and coated onto the surface of the creatine particles under low water activity conditions. The particles are then granulated at low temperature to form porous secondary composite microparticles. These composite microparticles maintain a high crystal form retention rate of creatine monohydrate and a low creatinine production rate in their dry powder state. Upon reconstitution with water, they rapidly disintegrate and form a locally acidic interface environment, improving the wetting, dispersibility, and dissolution efficiency of creatine.

The invention discloses a tigorazan amorphous solid dispersion, a tigorazan-containing tablet core, a tigorazan tablet and a preparation process of the tigorazan amorphous solid dispersion. The invention specifically discloses a tigorasan solid dispersion. The tigorasan solid dispersion comprises tigorasan and a carrier, the tigorasan is one or more of a tigorasan A crystal form, a tigorasan B crystal form and a tigorasan amorphous form; the carrier comprises copovidone and polyethylene glycol; the mass ratio of the copovidone to the polyethylene glycol is 1: (0.5-2). The invention also provides a preparation method of the tigorazan solid dispersion, a tigorazan-containing tablet core and a preparation method thereof, and a tigorazan tablet and a preparation method thereof. According to the method disclosed by the invention, wet granulation is adopted, so that the preparation process is simpler, the product quality is easier to control, the production efficiency is improved, large-scale production is facilitated, and the prepared tigoraz tablets are good in content uniformity and good in stability.

The utility model relates to the technical field of liquid medicine processing, and discloses a liquid medicine extraction device which comprises an extraction mechanism, the extraction mechanism comprises a dipping tank, a mounting hole is formed in the center of the inner bottom wall of the dipping tank, and the front end and the rear end of the inner bottom wall of the dipping tank are each provided with a discharging hole. And a filter separator is fixedly mounted on the outer bottom wall of the impregnating tank and located at the openings of the two discharge holes. The efficient stirring mechanism is arranged in the dipping tank, namely, the stirring paddle is arranged in the dipping tank, the multiple layers of stirring blades are arranged on the outer side of the stirring paddle, and the stirring blades are driven by the motor to stir medicinal materials and solvents at different heights, so that uniform mixing is ensured; the shape and the rotating speed of the stirring blades can be optimally designed according to the size of the dipping tank and the characteristics of medicinal materials.

The invention discloses an efficient resourceful treatment method of firework and firecracker waste residues, which comprises the following steps: S1, sulfur dissolving separation: placing the firework and firecracker waste residues in a sulfur dissolving agent, and carrying out hot filtration separation to obtain a sulfur-containing clear liquid and desulfurized residues; cooling and separating out the sulfur-containing clear liquid, and carrying out solid-liquid separation to obtain sulfur and a sulfur dissolving liquid; s2, slurrying and leaching: adding the desulfurization residues into concentrated sulfuric acid to carry out slurrying reaction, dissolving magnesium and aluminum components, and carbonizing and decomposing lead fibers at the same time; s3, solid-liquid separation and flotation: diluting and cooling the material after the pulpifying reaction, and carrying out solid-liquid separation to obtain a leachate containing magnesium and aluminum ions and residues after leaching; and S4, magnesium aluminate spinel preparation: adjusting the pH value of the leachate to separate out magnesium and aluminum in a precipitation form, filtering, drying filter residues, and calcining to obtain the magnesium aluminate spinel. According to the method, sulfur, magnesium, aluminum and other resources in the waste residues can be safely and efficiently separated and recycled, meanwhile, the final residues are subjected to harmlessness, the amount and volume of the residues are greatly reduced, and the method is suitable for industrial-scale continuous production.