Secnidazole tablet and its prepn process
A technology of secnidazole tablets and secnidazole, which is applied in the field of medicine, can solve the problems of large therapeutic dose and low melting point, and achieves the effects of high main drug content, low tablet weight and easy swallowing
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Embodiment 1
[0010] Embodiment 1 per 1000 dosage
[0011] Secnidazole 266g (in C 7 h 11 N 3 o 3 250g in total)
[0012] Microcrystalline Cellulose 62.85g
[0013] Starch 100g
[0014] Lactose 50g
[0015] Cross-linked polyvinylpyrrolidone 37.25g
[0016] Hypromellose 5.3g
[0018] Magnesium stearate 10.6g
[0019] Preparation method: crush secnidazole and pass through a 30-mesh sieve. Take the prescribed amount of secnidazole, microcrystalline cellulose, starch and lactose, and cross-linked polyvinylpyrrolidone (about half the amount) and mix well. Prepare hypromellose with 50% (V / V) ethanol to make a 2 g / L ethanol solution, add the above mixture to make soft material, granulate with 14 mesh sieve, and drum the granules in a constant temperature oven at 40°C to 45°C Air dry for 5 hours. Sieve through a 14-mesh sieve, add cross-linked polyvinylpyrrolidone (the remaining half of the amount), talcum powder, and magnesium stearate, mix evenly, measure the...
Embodiment 2
[0020] Embodiment 2 per 1000 dosage
[0021] Secnidazole 532g (in C 7 h 11 N 3 o 3 500g in total)
[0022] Microcrystalline Cellulose 50g
[0023] 100g pregelatinized starch
[0024] Lactose 65.8g
[0025] Cross-linked polyvinylpyrrolidone 3.8g
[0026] Hypromellose 0.8g
[0027] Micronized silica gel 3.8g
[0028] Magnesium Stearate 3.8g
[0029] Preparation method: crush secnidazole and pass through a 50-mesh sieve. Weigh secnidazole, microcrystalline cellulose, pregelatinized starch, lactose, and cross-linked polyvinylpyrrolidone (about half the amount) and mix well. Prepare hypromellose with 80% (V / V) ethanol to make 1 g / L ethanol solution, add the above mixture to make soft material, granulate with 24 mesh sieve, and drum the granules in a constant temperature oven at 40°C to 45°C Air dry for 4 hours. Sieve through a 24-mesh sieve for granulation, add cross-linked cross-linked polyvinylpyrrolidone (the remaining half), micropowder silica gel, and magnesium st...
Embodiment 3
[0030] Embodiment 3 per 1000 dosage
[0031] Secnidazole 1064g (in C 7 h 11 N 3 o 3 1000g in total)
[0032] Microcrystalline Cellulose 6g
[0033] Croscarmellose Sodium 70.4g
[0034] Polyvinylpyrrolidone (K30) 29.6g
[0035] Talc powder 6g
[0037] Preparation method: crush secnidazole and pass through 80-mesh sieve. Weigh secnidazole, microcrystalline cellulose, and croscarmellose sodium (about half the amount) and mix well. Prepare polyvinylpyrrolidone with 75% (V / V) alcohol to make 20 g / L ethanol solution, add the above mixture to make soft material, granulate with 20 mesh sieve, and dry the granules in a constant temperature oven at 40°C to 45°C 2 hours. Sieve through a 20-mesh sieve, add croscarmellose sodium (the remaining half), mix evenly, measure the content, calculate the weight of the tablet, and compress to obtain the tablet.
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