8 results about "Metformin hcl" patented technology

The present invention relates to a film coated tablet comprising empagliflozin and metformin hydrochloride, wherein comprising at least one binder which is hydroxypropyl methyl cellulose or hydroxypropyl cellulose or mixtures thereof, the tablet provides pharmacotechnical properties and the desired dissolution profile. The present invention also relates to a simple, rapid, cost effective, time-saving and industrially convenient method of preparing the tablet.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The present invention relates to a film coated tablet comprising empagliflozin and metformin hydrochloride, wherein comprising at least two fillers and the amount of fillers is 10.0% to 60.0% by weight in the total composition, the tablet provides the desired stability and pharmacotechnical properties and the desired dissolution profile. The present invention also relates to a simple, rapid, cost effective, time-saving and industrially convenient method of preparing the tablet.

The application discloses a novel dental nanocomposite material and a preparation method and application thereof, and the nanocomposite material comprises the following preparation raw materials in parts by weight: 15-30 parts of eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate, 10-25 parts of iron nitrate, 5-7 parts of boric acid, 8-12 parts of metformin hydrochloride, 4-6.6 parts of zinc chloride, 40-60 parts of hyaluronic acid and 4-6 parts of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium. The application takes eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate as a core, and through the o-benzenetriol structure of epigallocatechin gallate, a stable metal-phenol / boric acid ester hybrid network inner shell is cooperatively constructed with iron ions and boric acid, and the effect of synergistically improving anti-inflammatory and long-acting promotion of directional differentiation of dental pulp stem cells is achieved.

The present application relates to the technical field of traditional Chinese medicine processing, in particular to a kind of wine stewed fructus corni oligosaccharide and its preparation method and application.The preparation method comprises: after yellow rice wine is used to moisten fructus corni, it is stewed by water separation, total sugar extract is obtained by defatting, water extraction, protein removal and decolorization purification, then alcohol precipitation grading, freeze-drying is carried out, and wine stewed fructus corni oligosaccharide is obtained.Experimental results show that wine stewing process can significantly improve the proportion of oligosaccharide in fructus corni total sugar, and the obtained oligosaccharide can significantly improve the insulin resistance state of IR-HepG2 cells, and the effect is equivalent to that of metformin hydrochloride.The present application also discloses the application of the oligosaccharide in preparing drugs for improving insulin resistance and treating type 2 diabetes.

The utility model relates to the technical field of pharmaceutical production, concretely relates to a production equipment of metformin hydrochloride sustained-release tablet, including stirring mechanism and mixing subassembly, the stirring mechanism includes support frame, and the inner wall fixed connection of support frame has the cylinder, the inner wall fixed connection of support frame has the connecting frame, and the inner wall fixed mounting of connecting frame has the blanking assembly, the blanking assembly includes the blanking seat fixed connection on the connecting frame, and the inside of blanking seat is provided with the circular cavity, the inner wall of circular cavity is provided with feed port and discharge port respectively, the blanking seat is linked together through feed port and cylinder. The utility model overcomes the deficiency of prior art, through setting up blanking assembly between stirring mechanism and mixing subassembly, the cooperation between blanking assembly and motor, conveniently convey the smashing raw materials in the cylinder to the mixing cylinder, the blanking assembly can adjust the rate of raw material delivery, and then avoid the problem that raw materials appear to jam in the process of cylinder blanking.

This invention discloses a metformin empagliflozin tablet technical field, specifically a metformin empagliflozin tablet and its fluidized bed preparation process. First, copovidone is added to purified water to prepare a copovidone aqueous solution. Then, metformin hydrochloride, empagliflozin, and corn starch are added to a mixing device for mixing to obtain a premix. Next, the premix is ​​transferred to a fluidized bed device for fluidization, while the copovidone aqueous solution is sprayed in for granulation, and then dried to the target moisture content to obtain dry granules. The dry granules are then mixed with magnesium stearate and silica to obtain a final mixture. Based on this, this invention, by employing fluidized bed granulation and precisely controlling the process parameters throughout the entire process, including premixing, binder preparation, fluidized bed granulation, final mixing, and coating, achieves a robust and controllable preparation process suitable for large-scale production.

The application relates to the technical field of pharmaceutical preparation, and provides a metformin hydrochloride gastric floating sustained-release microtablet. The component composition of the metformin hydrochloride gastric floating sustained-release microtablet comprises, in percentage by weight, 50%-75% of metformin hydrochloride, 5%-20% of a skeleton material, 9%-18% of a filling agent, 2%-6% of a floating aid, 1%-4% of a lubricant and 1%-3% of a nano modifier. The metformin hydrochloride gastric floating sustained-release microtablet can prolong the residence time of metformin hydrochloride in the stomach and the upper part of the small intestine, and improve the drug utilization.