New metformin hydrochloride detection method

A technology of metformin hydrochloride and a new method, applied in the direction of electrochemical variables of materials, etc., can solve the problems of high requirements for sample processing, high analysis cost, and wide linear range.

Inactive Publication Date: 2014-04-02
大连杰信生物科技有限公司
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the methods for determining the amount of metformin hydrochloride are mainly based on high-performance liquid chromatography and ultraviolet spectrophotometry, but these methods require complex processing of samples before determination, a...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New metformin hydrochloride detection method
  • New metformin hydrochloride detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be described in detail below in conjunction with the examples, but the following examples are only preferred embodiments of the present invention, and the scope of protection of the present invention is not limited thereto, and any person familiar with the technical field of the present invention is within the technical scope disclosed in the present invention Within the technical scheme of the present invention and its inventive concept, any equivalent replacement or change shall be covered within the protection scope of the present invention.

[0016] Preparation of total ionic strength adjustment buffer solution: Add 20ml of deionized water, 25g of potassium nitrate and 30g of sodium citrate into a 50ml beaker, and stir until completely dissolved. Place the beaker in a cold water bath and slowly add HNO 3 solution, and carefully stirred, and tested with a PHS-2C precision acidity meter (Shanghai Leici Instrument Factory) to make the pH 5. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention provides a new method for determining metformin hydrochloride content by using an ion selective electrode method. According to the present invention, a pCL-1Q9 type chloride ion selective electrode is adopted as a work electrode, a 217 type saturated calomel electrode is adopted as a reference electrode, a stirring rate is 120 rpm/min, a stirring time is 3 min, the pH value is 4-6, a temperature is 18 DEG C, a buffer solvent is a total ionic strength adjustment buffer solution comprising potassium nitrate and sodium citrate, and a standard curve method is adopted as the method for quantitative analysis of the drug metformin hydrochloride effective component content; and compared with the traditional method, the method of the present invention has characteristics of simple experiment equipment, low test cost, simpleness, rapidness, accurate determination result, wide linear range and high sensitivity, and is the easiest and feasible analysis method for determining the metformin hydrochloride content.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, in particular to a potentiometric analysis method for the quantitative analysis of metformin hydrochloride, in particular to a method for determining the content of active ingredients in metformin hydrochloride medicines. Background technique [0002] An ion-selective electrode is an electrode that uses a selective membrane to selectively respond to specific ions to measure or indicate the activity of ions in a solution. The working principle of the ion selective electrode method is as follows: the potential of the indicator electrode (also known as the working electrode, the present invention uses a chloride ion selective electrode) can indicate the change of the measured ion activity (or concentration), and the reference electrode (the present invention uses a saturated The potential of the calomel electrode) is not affected by the change of the test solution composition, and has a relati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N27/26
Inventor 裴红颖李东霞李珂珂杜宇
Owner 大连杰信生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap