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A kind of method that the production solid waste of metformin hydrochloride is recycled

A technology of metformin hydrochloride and solid waste, applied in the direction of organic chemistry and the like, can solve the problems of high pollution, high waste, high consumption, etc., and achieve the effects of avoiding environmental pollution, reducing pollution and saving costs

Active Publication Date: 2020-04-24
SHOUGUANG FUKANG PHARMA +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, the existing metformin hydrochloride solid waste treatment technology has the defects of high consumption, high pollution and high waste

Method used

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  • A kind of method that the production solid waste of metformin hydrochloride is recycled
  • A kind of method that the production solid waste of metformin hydrochloride is recycled
  • A kind of method that the production solid waste of metformin hydrochloride is recycled

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 100 g of metformin hydrochloride solid waste, which contains 25 g (0.15 mol) of metformin hydrochloride, 65 g of melamine derivatives, 8 g of water, and 2 g of other salts. Join H 2 O 500g and formic acid 8.28g (0.18mol). Warm up to reflux and react for 5h. After the reaction, cool down to 30°C, add dropwise 72.0g of 30% lye, adjust the pH to 8-10, a large amount of precipitates are formed, stir at 25-35°C for 2 hours, and filter with suction to obtain 90.0g of white solids of melamine derivatives. The solid was placed in a blast oven at 60°C, dried for 12 hours, and weighed to obtain 81.5 g (0.586 mol) of a dry product.

Embodiment 2

[0024] Weigh 200 g of metformin hydrochloride solid waste, which contains 50 g (0.3 mol) of metformin hydrochloride, 130 g of melamine derivatives, 16 g of water, and 4 g of other salts. Join H 2 O 1000 g and formic acid 16.56 g (0.36 mol). Warm up to reflux and react for 5h. After the reaction was completed, the temperature was lowered to 30°C, 145g of 30% lye was added dropwise, the pH was adjusted to 8-10, a large amount of precipitate was formed, stirred at 25-35°C for 2h, and suction filtered to obtain 182g of white solid of melamine derivative. The solid was placed in a blast oven at 60°C, dried for 12 hours, and weighed to obtain 164 g (1.180 mol) of a dry product.

Embodiment 3

[0026] Weigh 100 g of metformin hydrochloride solid waste, which contains 25 g (0.15 mol) of metformin hydrochloride, 65 g of melamine derivatives, 8 g of water, and 2 g of other salts. Join H 2 O 500g and formic acid 9.20g (0.2mol). Warm up to reflux and react for 5h. After the reaction, cool down to 30°C, add 75.0g of 30% lye dropwise, adjust the pH to 8-10, a large amount of precipitates are formed, stir at 25-35°C for 2 hours, and filter with suction to obtain 89.5g of white solid of melamine derivative. The solid was placed in a blast oven at 60°C, dried for 12 hours, and weighed to obtain 81 g (0.583 mol) of a dry product.

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Abstract

The invention relates to a method for recycling solid waste generated in metformin hydrochloride production. The method includes the following steps that firstly, a reaction solvent is added into metformin hydrochloride solid waste, heated, dissolved and reacted with fatty acid; secondly, solid-liquid separation is conducted through cooling, neutralization, sedimentation and suction filtration; thirdly, the solid serves as a melamine derivative and has a good flame-retardant property, filtrate contains a small quantity of pollutants, and pollution-free discharge is achieved basically. Compared with the prior art, recycling of the metformin hydrochloride solid waste can be achieved, emission of odor, waste liquid and liquid residues is reduced, the environment pollution risk is reduced, and clean production is achieved.

Description

technical field [0001] The invention relates to a technology for recycling solid waste in the production process of metformin hydrochloride, in particular to a method for obtaining melamine derivatives by using formic acid to react with metformin hydrochloride in solid waste and realizing waste utilization. Background technique [0002] Metformin hydrochloride is the oldest diabetes treatment drug, which was discovered in the 1920s and widely used in the field of diabetes treatment after the 1950s. At the end of 1994, Bristol-Myers Squibb's Metformin (metformin controlled-release preparation) entered the FDA and quickly grew into a blockbuster. In 2001, the sales volume reached 2.34 billion US dollars. After the patent expired, it was severely impacted by generic drugs, and the market size shrank rapidly. $16 million in 2006. At present, the main market share of metformin is occupied by generic pharmaceutical companies. With low drug prices and a good clinical use foundatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D251/48
CPCC07D251/48
Inventor 宋伟国方浩崔鑫李新建李法辉杨磊何英俊宋成刚杨大伟董良军高东圣杨春程
Owner SHOUGUANG FUKANG PHARMA
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