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Anti-breast cancer granules combining metformin hydrochloride and gdc 0941 and a preparation method thereof

A technology of gdc0941 ​​and metformin hydrochloride, which is applied in the direction of medical preparations containing active ingredients, antineoplastic drugs, drug combinations, etc., can solve problems such as difficult anticancer drugs, achieve significant social and economic significance, simple preparation, and effective fast effect

Inactive Publication Date: 2015-12-16
李荣勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing metformin as an anticancer drug, it was found that metformin is difficult to be used as a single anticancer drug at physiological doses.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 The anti-breast cancer granules combined with metformin hydrochloride and gdc0941 ​​are mainly prepared from the following raw materials: 40 g of metformin hydrochloride, 120 g of gdc094, 48 g of starch, 8 g of 10% starch slurry, and 2.4 g of sodium carboxymethyl starch.

[0026] (1) Grind metformin hydrochloride and gdc0941 ​​through a 60-mesh sieve and set aside;

[0027] (2) Mix the pharmaceutical powder prepared in step (1) with starch and sodium carboxymethyl starch, and then add 10% starch slurry to make a soft material that can be lightly held into a ball and dispersed when lightly pressed. The soft material is machined Squeeze through a 20-mesh sieve to obtain wet granules, and then dry them in a normal-pressure oven at 70-80°C. Pass the dry granules through a 16-mesh sieve for granulation, pack them into bags, and obtain granules.

Embodiment 2

[0028] Example 2 The anti-breast cancer granules combined with metformin hydrochloride and gdc0941 ​​are mainly prepared from the following raw materials: metformin hydrochloride 40g, gdc0941120g, starch 48g, 10% starch slurry 8g, sodium carboxymethyl starch 2.4g.

[0029] (1) Grind metformin hydrochloride and gdc0941 ​​through a 100-mesh sieve and set aside;

[0030] (2) Mix the pharmaceutical powder prepared in step (1) with starch and sodium carboxymethyl starch, and then add 10% starch slurry to make a soft material that can be lightly held into a ball and dispersed when lightly pressed. The soft material is machined Squeeze through a 20-mesh sieve to obtain wet granules, and then dry them in a normal-pressure oven at 70-80°C. Pass the dry granules through a 16-mesh sieve for granulation, pack them into bags, and obtain granules.

Embodiment 3

[0031] Example 3 The anti-breast cancer granules combined with metformin hydrochloride and gdc0941 ​​are mainly prepared from the following raw materials: 40 g of metformin hydrochloride, 180 g of gdc094, 48 g of starch, 8 g of 10% starch slurry, and 2.4 g of sodium carboxymethyl starch.

[0032] (1) Grind metformin hydrochloride and gdc0941 ​​through an 80-mesh sieve and set aside;

[0033] (2) Mix the pharmaceutical powder prepared in step (1) with starch and sodium carboxymethyl starch, and then add 10% starch slurry to make a soft material that can be lightly held into a ball and dispersed when lightly pressed. The soft material is machined Squeeze through a 20-mesh sieve to obtain wet granules, and then dry them in a normal-pressure oven at 70-80°C. Pass the dry granules through a 16-mesh sieve for granulation, pack them into bags, and obtain granules.

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Abstract

The invention discloses anti-breast cancer granules combining metformin hydrochloride and gdc 0941. Active components of the anti-breast cancer granules are metformin hydrochloride and gdc 0941. The anti-breast cancer granules further comprise pharmaceutically acceptable auxiliary materials. The anti-breast cancer granules are simple to prepare, easy to operate, lower in cost and economical and practical; the anti-breast cancer granules are portable, dissolve fast, are well absorbable and take effect fast. In-vitro antitumor tests show that anti-cancer activities of the metformin hydrochloride and gdc 0941 are synergistic, the combination of the metformin hydrochloride and gdc 0941 provides high anti-cancer activity, high cost of a single dose can be decreased, and the anti-breast cancer granules are worthy of clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a solid oral preparation with metformin hydrochloride and gdc0941 ​​as active components. Background technique [0002] The discovery of new uses of known drugs is an important direction of new drug research and development. Metformin, the drug of choice for the initial treatment of patients with type 2 diabetes, has the advantages of being cheap, patent-protected, safe and widely used. And its potential in tumor treatment has recently become a hot spot. Many observational studies have reported a reduction in cancer incidence and mortality in diabetic patients treated with metformin. In Evans' report, diabetic patients who received metformin treatment had a 4.3% lower risk of developing cancer than patients who did not receive metformin treatment (a total of 8170 observation objects in the two groups). In the ZODIAC (Zwolle Diabetes Outpatient Integrating Existing Care Progra...

Claims

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Application Information

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IPC IPC(8): A61K31/5377A61K9/16A61P35/00A61K31/155
Inventor 李荣勤
Owner 李荣勤
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