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Pharmaceutical composition for preventing and treating ovarian cancer

A composition and a technology for ovarian cancer, applied in the field of medicine, can solve the problems of no literature report on terazosin hydrochloride ovarian cancer, no literature report on terazosin hydrochloride and the like, and achieve significant social and economic significance, tumor-inhibiting activity. Significant, less toxic and side effects

Inactive Publication Date: 2018-04-13
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report that terazosin hydrochloride can be used to fight ovarian cancer, and there is no literature report that the combination of terazosin hydrochloride and cytarabine hydrochloride is used to treat ovarian cancer.

Method used

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  • Pharmaceutical composition for preventing and treating ovarian cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: take by weighing cytarabine hydrochloride 125g, terazosin hydrochloride 50g, starch 200g, microcrystalline cellulose 25g, talcum powder 3g, cytarabine hydrochloride, terazosin hydrochloride cross 120 mesh sieves, starch 1. The microcrystalline cellulose is passed through a 100-mesh sieve, weighed according to the prescribed amount, mixed evenly, granulated, dried, granulated, added with prescribed amount of talcum powder, mixed evenly, and filled to obtain capsules.

Embodiment 2

[0016] Embodiment 2: take by weighing cytarabine hydrochloride 200g, terazosin hydrochloride 50g, starch 200g, microcrystalline cellulose 25g, talcum powder 3g, cytarabine hydrochloride, terazosin hydrochloride cross 120 mesh sieves, starch 1. The microcrystalline cellulose is passed through a 100-mesh sieve, weighed according to the prescribed amount, mixed evenly, granulated, dried, granulated, added with prescribed amount of talcum powder, mixed evenly, and filled to obtain capsules.

Embodiment 3

[0017] Embodiment 3: The combination of terazosin hydrochloride and cytarabine hydrochloride

[0018] 40 SPF grade BALB / c-nu mice, 6 weeks old, weighing 18g-20g. Absorb and discard the medium in the bottle of SKOV3 ovarian cancer cells in the logarithmic growth phase with a confluence of 80% to 90%, wash the cells 2-3 times with phosphate buffer saline, digest with trypsin (0.25%), collect the cells, and again Wash with phosphate buffer, blow and beat to mix, and count; then adjust the concentration with serum-free RPMI-1640, and inoculate 1.0×10 cells subcutaneously on the back of each nude mouse 7 / 0.2mL cell suspension was injected subcutaneously on the back of nude mice. From 7 days after inoculation, small nodules were observed in the subcutaneous area of ​​the tumor cell inoculation site, with a size of about 5mm×5mm; on the 10th day, the size of the tumor was about 7mm×7mm.

[0019] Thirty-five nude mice with tumors were taken and divided into 7 groups by random and b...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating ovarian cancer and an application of the pharmaceutical composition. Active ingredients of the pharmaceutical composition include terazosin hydrochloride and cytosine arabinoside hydrochloride, and preferably in the active ingredients, the weight ratio of the terazosin hydrochloride to the cytosine arabinoside hydrochloride is 1 to (1-5). The pharmaceutical composition for preventing and treating the ovarian cancer provided by the invention is obvious in anti-tumor activity and is low in toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anticancer drug, in particular to a pharmaceutical composition for preventing and treating ovarian cancer and its application. Background technique [0002] Ovarian cancer is one of the common malignant tumors of female reproductive organs, and its incidence rate ranks third after cervical cancer and uterine body cancer. However, the mortality rate of epithelial ovarian cancer ranks first in all types of gynecological tumors, posing a serious threat to women's lives. Due to the complex embryonic development, tissue anatomy and endocrine function of the ovary, and the atypical early symptoms, it is quite difficult to distinguish the tissue type and benign from malignant ovarian tumors before operation. Epithelial carcinoma is the most common ovarian malignancy, followed by malignant germ cell tumors. Only 30% of patients with epithelial ovarian cancer are found t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61K31/517A61P35/00A61P15/00
CPCA61K31/7068A61K31/517A61K2300/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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