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Novel breast cancer-resistant drug pill

An anti-breast cancer and new drug technology, applied in the field of medicine, can solve the problem of difficult anti-cancer drugs, etc., and achieve the effects of significant social and economic significance, low production cost, and high anti-cancer activity.

Inactive Publication Date: 2015-11-11
李荣勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing metformin as an anticancer drug, it was found that metformin is difficult to be used as a single anticancer drug at physiological doses.

Method used

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  • Novel breast cancer-resistant drug pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 A new anti-breast cancer drug pill, mainly prepared from the following raw materials: 40g of metformin hydrochloride, gdc094120g, 6g of polyvinylpyrrolidone, and a blank pill core.

[0024] (1) Grind metformin hydrochloride and gdc0941 ​​through an 80-mesh sieve, and mix with a mixer;

[0025] (2) Dissolve polyvinylpyrrolidone with absolute ethanol to make a binding solution with a content of 4%, take a blank pellet core and place it in a coating granulator, add the binding solution, and mix the pharmaceutical powder prepared in step (1) with Add it into the granulator at a certain speed, so that the drug powder evenly adheres to the surface of the blank core, and make small pellets, dry them, and pass through a 20-mesh sieve to obtain pills.

Embodiment 2

[0026] Example 2 A new anti-breast cancer drug pill, which is mainly prepared from the following raw materials: 40g of metformin hydrochloride, gdc0941120g, 6g of polyvinylpyrrolidone, and a blank core.

[0027] (1) Grind metformin hydrochloride and gdc0941 ​​through a 120-mesh sieve, and mix with a mixer;

[0028] (2) Dissolve polyvinylpyrrolidone with absolute ethanol to make a binding solution with a content of 4%, take a blank pellet core and place it in a coating granulator, add the binding solution, and mix the pharmaceutical powder prepared in step (1) with Add it into the granulator at a certain speed, so that the drug powder evenly adheres to the surface of the blank core, and make small pellets, dry them, and pass through a 20-mesh sieve to obtain pills.

Embodiment 3

[0029] Example 3 A new anti-breast cancer drug pill, which is mainly prepared from the following raw materials: 40g of metformin hydrochloride, gdc094180g, 6g of polyvinylpyrrolidone, and a blank pill core.

[0030] (1) Grind metformin hydrochloride and gdc0941 ​​through an 80-mesh sieve, and mix with a mixer;

[0031] (2) Dissolve polyvinylpyrrolidone with absolute ethanol to make a binding solution with a content of 4%, take a blank pellet core and place it in a coating granulator, add the binding solution, and mix the pharmaceutical powder prepared in step (1) with Add it into the granulator at a certain speed, so that the drug powder evenly adheres to the surface of the blank core, and make small pellets, dry them, and pass through a 20-mesh sieve to obtain pills.

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Abstract

The invention discloses a novel breast cancer-resistant drug pill. The novel breast cancer-resistant drug pill comprises metformin hydrochloride and gdc0941 as active components and pharmaceutically acceptable accessory materials. The novel breast cancer-resistant drug pill has the advantages of simple preparation process, easy operation and low production cost. An external antineoplastic test proves that metformin hydrochloride and gdc0941 can produce anticancer activity synergism and realize high anticancer activity by combination. The novel breast cancer-resistant drug pill can increase a contact area of a drug and an absorption part, can produce effects fast and has a short treatment course.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a solid oral preparation with metformin hydrochloride and gdc0941 ​​as active components. Background technique [0002] The discovery of new uses of known drugs is an important direction of new drug research and development. Metformin, the drug of choice for the initial treatment of patients with type 2 diabetes, has the advantages of being cheap, patent-protected, safe and widely used. And its potential in tumor treatment has recently become a hot spot. Many observational studies have reported a reduction in cancer incidence and mortality in diabetic patients treated with metformin. In Evans' report, diabetic patients who received metformin treatment had a 4.3% lower risk of developing cancer than patients who did not receive metformin treatment (a total of 8170 observation objects in the two groups). In the ZODIAC (Zwolle Diabetes Outpatient Integrating Existing Care Progra...

Claims

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Application Information

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IPC IPC(8): A61K31/5377A61K9/28A61P35/00A61K31/155
Inventor 李荣勤
Owner 李荣勤
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