Anti-breast cancer powder containing metformin hydrochloride and gdc 0941

A technology of gdc0941 ​​and metformin hydrochloride, which can be used in medical preparations containing active ingredients, antitumor drugs, organic active ingredients, etc., can solve problems such as difficult anticancer drugs, and achieve significant social and economic significance. Prominent, dose-controllable effects

Inactive Publication Date: 2015-12-16
李荣勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing metformin as an anticancer drug, it was found tha

Method used

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  • Anti-breast cancer powder containing metformin hydrochloride and gdc 0941

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 An anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is mainly prepared from the following raw materials: 20 g of metformin hydrochloride, 120 g of gdc094, and 80 g of powdered sugar.

[0022] A preparation method of an anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is:

[0023] (1) Grind metformin hydrochloride, gdc0941, and powdered sugar through a 100-mesh sieve;

[0024] (2) Grind the crushed sugar powder in a mortar, pour out after the mortar is saturated, add crushed metformin hydrochloride and gdc0941 ​​into the mortar, grind well, then add sucrose in equal increments, grind well, divide Pack.

Embodiment 2

[0025] Example 2 An anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is mainly prepared from the following raw materials: 20 g of metformin hydrochloride, 120 g of gdc094 and 80 g of dextrin.

[0026] A preparation method of an anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is:

[0027] (1) Grind metformin hydrochloride, gdc0941, and dextrin respectively through a 150-mesh sieve;

[0028] (2) Grind the crushed dextrin in a mortar, pour it out after the mortar is saturated, add crushed metformin hydrochloride and gdc0941 ​​into the mortar, grind well, then add glucose in equal increments, grind well, divide Pack.

Embodiment 3

[0029] Example 3 An anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is mainly prepared from the following raw materials: 20 g of metformin hydrochloride, 120 g of gdc094, and 40 g of lactose.

[0030] A preparation method of an anti-breast cancer powder containing metformin hydrochloride and gdc0941 ​​is:

[0031] (1) Metformin hydrochloride, gdc0941, and lactose were respectively pulverized through a 120-mesh sieve;

[0032] (2) Grind the crushed lactose in a mortar, pour out after the mortar is saturated, add crushed metformin hydrochloride and gdc0941 ​​into the mortar, grind well, then add lactose in equal increments, grind well, and pack .

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PUM

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Abstract

The invention discloses anti-breast cancer powder containing metformin hydrochloride and gdc0941. Active components of the anti-breast cancer powder are the metformin hydrochloride and gdc 0941. The anti-breast cancer powder further comprises pharmaceutically acceptable auxiliary materials. The anti-breast cancer powder is simple to prepare, easy to operate, lower in cost and economical and practical; the anti-breast cancer powder disperses easily and takes effect fast, and dosage of the powder is easily controllable; in-vitro antitumor tests show that the combination of the metformin hydrochloride and gdc 0941 provides higher anti-cancer activity and the powder is worthy of clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a solid oral preparation with metformin hydrochloride and gdc0941 ​​as active components. Background technique [0002] The discovery of new uses of known drugs is an important direction of new drug research and development. Metformin, the drug of choice for the initial treatment of patients with type 2 diabetes, has the advantages of being cheap, patent-protected, safe and widely used. And its potential in tumor treatment has recently become a hot spot. Many observational studies have reported a reduction in cancer incidence and mortality in diabetic patients treated with metformin. In Evans' report, diabetic patients who received metformin treatment had a 4.3% lower risk of developing cancer than patients who did not receive metformin treatment (a total of 8170 observation objects in the two groups). In the ZODIAC (Zwolle Diabetes Outpatient Integrating Existing Care Progra...

Claims

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Application Information

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IPC IPC(8): A61K31/5377A61K9/14A61P35/00A61K31/155
Inventor 李荣勤
Owner 李荣勤
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