Metformin hydrochloride slowly released tablet and its preparation method

A technology of metformin hydrochloride and a preparation process, which is applied in metabolic diseases, pharmaceutical formulations, drug combinations and other directions, can solve the problems that ordinary metformin hydrochloride tablets cannot exert the hypoglycemic effect well and are inconvenient to take, and achieve the effect of inhibiting liver and kidney sugars. The effect of xenobiotic effect, reducing the frequency of taking, and simple production process
CN1415288AInactive Publication Date: 2003-05-07NANJING CHANGAO PHARMA SCI & TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING CHANGAO PHARMA SCI & TECH CO LTD
Publication Date
2003-05-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

A slowly-releasing mellitin tablet is prepared from fluamine, excipient, adhesive and lubricant through drying at 40-70 deg.C for 4-6 hrs, pulverizing, sieving by 80-120 meshes, proportionally mixing, mixing with alcohol solution, granularating by 18-mesh sieving, drying at 40-60 deg.C for 2-4 hrs, mixing with lubricant, and tabletting. Its advantages are long half-life (0.9-2.6 hr), low dosage and low by-effect.
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Description

technical field

[0001] The invention relates to a metformin hydrochloride sustained-release tablet and a preparation process thereof. Background technique

[0002] At present, the commonly used diabetes treatment drugs in clinic include: sulfonylureas, biguanides, α-glucosidase inhibitors, insulin sensitizers and Chinese patent medicines. Among them, metformin hydrochloride is the most widely used biguanide drug in clinical practice. Compared with phenformin, it has less lactic acidosis effect and can be completely avoided. It has no hypoglycemic reaction and is effective for both obese and non-obese patients. For those who are ineffective in simple diet therapy, using this product alone can reduce their blood sugar concentration by about 20%. It is the first choice for overweight (obese) NIDDM. This product can be used alone for mild and moderate patients who are unsatisfied with simple diet control, and can also be used in combination with s...

Claims

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