Novel metformin hydrochloride slow-releasing tablet and preparation method thereof

Abstract

The invention provides a novel metformin hydrochloride slow-releasing tablet and a preparation method thereof. The slow-releasing tablet comprises the following components by weight percent: 66.6%-73.5% of metformin hydrochloride, 30.9%-21.5% chitosan, 2.0%-4.0% of copolymerization and 0.5%-1.0% of superfine silica powder. The dry granulating technique is adopted in the preparation method and the preparation method comprises the following steps: uniformly mixing the metformin hydrochloride, chitosan, copolymerization and superfine silica powder in proportion according to the prescription, granulating by using a dry granulating machine, adding superfine silica powder and uniformly mixing, and then pressing the mixture into tablet, thereby acquiring the novel metformin hydrochloride slow-releasing tablet.

Description

technical field [0001] The invention relates to a sustained-release agent for treating hyperglycemia and a preparation method thereof, in particular to a metformin hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Metformin hydrochloride is a biguanide hypoglycemic drug. Biguanides are internationally recognized as safe and effective oral hypoglycemic drugs, and are currently routinely used in adults with type 2 diabetes. Increase, aerobic metabolism remains unchanged, it concentrates on the intestinal wall, inhibits the absorption of glucose in the intestine, inhibits gluconeogenesis, inhibits the release of glucagon or inhibits the effect of insulin antagonists, and increases insulin sensitivity. Metformin hydrochloride has a hypoglycemic effect on diabetics with normal or lost pancreatic islet function, but has no hypoglycemic effect on normal people, and has nothing to do with normal pancreatic function and islet β c...

AI Technical Summary

Problems solved by technology

Sustained-release tablets prepared by this mechanism use a large amount of skeleton polymer materials, resulting in excessive tablet weight and tablet shape

The tablet weight of "Glucophage XR" product is 1g, and the active drug is 0.5g. When taking it, it needs to be swallowed whole, not crushed, so it is very inconvenient to have to swallow a tablet that is too heavy, especially for Chinese people, the elderly

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