Composition containing pioglitazone hydrochloride and metformin hydrochloride and preparation thereof
A technology of pioglitazone hydrochloride and metformin hydrochloride, which is applied in the field of medicine, can solve the problems of slow drug release, poor initial curative effect, and slow drug onset, and achieve the effects of easy portability, definite clinical curative effect, and improved initial dissolution rate
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Embodiment 1
[0040] prescription
[0041] Metformin Hydrochloride 500g
[0042] Pioglitazone Hydrochloride 16.54g
[0043] Microcrystalline Cellulose 70g
[0044] Starch 40g
[0045] Carboxymethyl Starch Sodium 15g
[0046] Copovidone 50g
[0047] 8% povidone K30 aqueous solution appropriate amount
[0048] Magnesium Stearate 3.5g
[0049]
[0050] Makes 1000 pieces
[0051] Preparation Process:
[0052] Metformin hydrochloride, pioglitazone hydrochloride, carboxymethyl starch sodium, copovidone, microcrystalline cellulose, starch and other raw and auxiliary materials were respectively passed through 80 mesh sieves, and an aqueous solution of 8% povidone K30 was prepared at the same time, and set aside.
[0053] Weigh the amounts of raw and auxiliary materials such as metformin hydrochloride, pioglitazone hydrochloride, carboxymethyl starch sodium, copovidone (about 50% of the prescription quantity), microcrystalline cellulose, starch, etc. ,...
Embodiment 2
[0054] Embodiment 2: adopt same material as embodiment 1.
[0055] The raw material of pioglitazone hydrochloride was mechanically crushed (PW177 pulverizer), and the particle size was detected by a particle size analyzer (Mastersizer 2000 laser particle size analyzer). After measurement, 82% of the crushed particle size is between 50 and 75 μm by weight, and the rest is below 50 μm, which is reserved for use;
[0056] Pass raw and auxiliary materials such as metformin hydrochloride, carboxymethyl starch sodium, copovidone, microcrystalline cellulose, and starch through 80 mesh sieves respectively, and prepare an aqueous solution of 8% povidone K30 at the same time for subsequent use;
[0057]Weigh the amounts of raw and auxiliary materials such as metformin hydrochloride, pioglitazone hydrochloride, carboxymethyl starch sodium, copovidone (about 50% of the prescription quantity), microcrystalline cellulose, starch, etc. , copovidone, microcrystalline cellulose, starch and ot...
Embodiment 3
[0058] Embodiment 3: adopt same material as embodiment 1.
[0059] The raw material of pioglitazone hydrochloride is mechanically pulverized (RT-25 airflow ultrafine pulverizer), and the particle size is detected by a particle size analyzer (Mastersizer2000 laser particle size analyzer). After measurement, 81% of the crushed particle size is below 50 μm by weight, and it is ready for use;
[0060] The specific preparation method of the process is the same as in Example 2, and Sample 3 is obtained.
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