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Metformin hydrochloride and Glipizide sustained-release pellet and method of preparing the same

A technology of metformin hydrochloride glipizide and metformin hydrochloride, applied in the field of medicine, can solve problems such as lowering blood sugar, and achieve the effects of reducing blood sugar lowering, reducing the frequency of taking medicines, and reducing adverse reactions

Active Publication Date: 2008-10-08
国药控股星鲨制药(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Someone designed to prepare the two drugs into pellets and then fill them into capsules or make tablets, but the glipizide pellets were prepared by the adsorption of the blank core, and the performance of the blank core directly affects the quality of the pellets. Quality, the drug is adsorbed on the surface of the pill core, which is prone to burst release, resulting in a sharp drop in blood sugar

Method used

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  • Metformin hydrochloride and Glipizide sustained-release pellet and method of preparing the same
  • Metformin hydrochloride and Glipizide sustained-release pellet and method of preparing the same
  • Metformin hydrochloride and Glipizide sustained-release pellet and method of preparing the same

Examples

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Embodiment 1

[0033] Preparation of Metformin Hydrochloride Sustained Release Pellets

[0034] The prescription is (per 1000 capsules):

[0035] Metformin Hydrochloride 500g

[0036] Sucrose or lactose 200g

[0037] Microcrystalline Cellulose 300g

[0038] Surelease Water Dispersion (Colorcon) 1000g

[0039] Distilled water 1000g

[0040] Metformin hydrochloride, sucrose or lactose, and microcrystalline cellulose were pulverized respectively, passed through a 100-mesh sieve, mixed evenly, and distilled water was used as a binder, with an amount of 330ml, and the metformin hydrochloride drug-containing pellets were prepared by extrusion spheronization. Among them, the extrusion rate is 30rpm, the spheronization speed is 2500rpm, the spheronization time is 2min, the finished product is dried at 50°C, and the pellets between 700 and 900μm are sieved, which are drug-containing pellets. Add 1000g of distilled water to 1000g of Surelease aqueous dispersion, stir and mix evenly, as a coating ...

Embodiment 2

[0051] Preparation of metformin hydrochloride sustained-release pellets:

[0052] The prescription is (per 1000 capsules):

[0053] Metformin Hydrochloride 500g

[0054] Sucrose or lactose 150g

[0055] Microcrystalline Cellulose 250g

[0056] Surelease Water Dispersion 792g

[0057] Distilled water 792g

[0058] Grind metformin hydrochloride, sucrose or lactose, and microcrystalline cellulose respectively, pass through a 100-mesh sieve, mix well, use distilled water as a binder, and use 275 ml. Metformin hydrochloride drug-containing pellets were prepared by extrusion-spheronization method, wherein the extrusion rate was 35rpm, the spheronization speed was 2500rpm, the spheronization time was 2min, the finished product was dried at 50°C, and the pellets between 700 and 900μm were sieved to obtain the drug-containing pellets . Add 792g of distilled water to 792g of Surelease aqueous dispersion, stir, mix evenly, and use it as a coating solution. Take the drug-containing...

Embodiment 3

[0069] Preparation of metformin hydrochloride sustained-release pellets:

[0070] The prescription is (per 1000 capsules):

[0071] Metformin Hydrochloride 500g

[0072] Sucrose or lactose 100g

[0073] Microcrystalline Cellulose 150g

[0074] Surelease water dispersion 600g

[0075] Distilled water 600g

[0076] Metformin hydrochloride, sucrose or lactose, and microcrystalline cellulose were respectively crushed through a 100-mesh sieve, mixed evenly, and distilled water was used as a binder, and the dosage was 150ml. Metformin hydrochloride drug-containing pellets were prepared by extrusion-spheronization method. The extrusion rate is 25rpm, the spheronization speed is 2200rpm, and the spheronization time is 5min. The finished product is dried at 40°C, and the pellets between 700 and 900μm are sieved, which are drug-containing pellets. Add 600g of distilled water to 600g of Surelease aqueous dispersion, stir, and mix evenly, as a coating solution. The drug-containing ...

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Abstract

The invention discloses a metformin hydrochloride and glipizide sustained-release pellet and a preparation method thereof. In the preparation method, a sustained release coated pellet of the metformin hydrochloride and a sustained release pellet of the glipizide are prepared respectively; and the two pellets are filled in capsules in a proportion of 250g-500g of the metformin hydrochloride and 2.5g-10g of the glipizide in every 1000 capsules; wherein, the coated pellet of the metformin hydrochloride is prepared by pill pericardium sustained release coating membrane; the sustained release pellet of the glipizide is prepared directly by extrusion-spheronization method. In the invention, the two pellets are filled into one capsule, thereby being convenient for quality control; octodecyl alcohol is taken as sustained release material for the sustained-release pellet of the glipizide, which is convenient for the forming of the pellet so as to reduce bursting release effectively. The metformin hydrochloride and the glipizide slowly release a drug within 12 hours, which reduces the frequency of taking medicine, stabilizes blood concentration better and reduces untoward effect, thereby having good marketing prospect.

Description

technical field [0001] The invention relates to metformin hydrochloride glipizide sustained-release pellets and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Diabetes has been considered as the third "killer" that endangers human health after tumors and cardiovascular and cerebrovascular diseases in the world. At present, there are about 150 million diagnosed diabetes patients in the world, and it is predicted that it will reach 300 million by 2025. According to statistics, the incidence rate of diabetes in the world is 3% to 5%, and the average incidence rate of people over 50 years old is 10%. Relevant data show that there are more than 30 million diabetic patients in my country, and 1.5 to 2 million new patients are added every year, of which type II diabetic patients account for more than 90%. According to the latest statistics from the World Health Organization, there are 125 million diabetic patients in the ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/155A61K31/4965A61P3/10
Inventor 平其能范文源肖衍宇吕文莉操峰
Owner 国药控股星鲨制药(厦门)有限公司
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