373results about How to "Reduced release rate" patented technology

Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.

The invention relates to the technical field of the food additive and the microcapsule equipment capable of controlling the release of bioactive substances, in particular to a preparation method of menthol microcapsules. The preparation method uses menthol, wall material, emulsifier, crosslinking agent, pH regulator and water as the raw materials, wherein menthol is used as the core material, chitosan is used as the wall material, monoglyceride and Tween-40 are used as the compound emulsifier, 10% acetic acid is used as the pH regulator. The preparation method comprises the following steps: emusifying the solution under high pressure, adding modified starch to crosslink, finally adopting the spray drying technology to prepare the powdery menthol microcapsule product. The invention aims to provide a menthol microcapsule preparation method with safe and easy technology and low cost, increase the stability and heat resistance of menthol, control the release process and expand the application range.

The invention relates to the technical field of sewage treatment and in particular relates to a solid carbon source as well as a preparation method and application thereof. The solid carbon source is obtained by uniformly mixing at least three substances rich in cellulose, pelletizing and firing. The solid carbon source is placed in an oxygen-poor tank to supply nutrient substances to microorganisms, sewage which is homogenized and averaged sequentially flows through a pre-denitrification tank, an anaerobic tank, an anoxic tank, an aerobic tank and a sedimentation tank to be treated, total nitrogen content of discharged water is equal to or less than 10mg / L, and total phosphorus content is equal to or less than 0.5mg / L. The solid carbon source is made of multiple substances rich in cellulose, fibers of various substances can be easily penetrated and wound, after mixing and firing are carried out, a compact cellulose layer structure can be formed, so that release rate of the solid carbon source is greatly reduced, and a carbon source in the sewage can be stable and sufficient for a long time; besides, the solid carbon source is made of multiple substances, abundant nutrient substances can be supplied to the microorganisms, different functions requirements for metabolism can be met, and utilization ratio of the carbon source is increased.

The invention relates to a coated compound fertilizer, in particular to a totally biodegradable coated compound fertilizer and a preparation method thereof. The coated compound fertilizer consists of a coated layer and a compound fertilizer core. The main body of the coated layer is polylactic acid and / or polybutylene succinate. The coating process adopts fluidized bed spraying-coated technology, and comprises the following steps: dissolving polylactic acid and / or polybutylene succinate in trichloromethane, adding carboxymethylcellulose, urease and / or nitrification inhibitor, organic and / or inorganic conditioner in the solution, spraying and coating the surfaces of the fluidized compound fertilizer granules after uniformly mixing the mixture under the stirring of a stirrer to form the uniform and complete organic polymeric membrane layer. The process has the advantages of easy implementation, and capacity of effectively slowing down the release of the fertilizer nutrient to the outside and the conversion rate of nitrogen in soils, effectively controlling the release and conversion of the fertilizer nutrient in soils, and reducing the pressure on environment caused by the rapid release of nutrient. The coated material can be totally biodegradable, and the degradation products have no secondary pollution to the environment.

The invention discloses a porous inorganic material with insecticidal and mothproof functions and a preparation method thereof. The porous inorganic material with insecticidal and mothproof functions takes porous inorganic material as a carrier, the outer surface of the carrier is grafted with cationization reagent, the inner surface of the duct of the porous inorganic material is grafted with silane coupling agent, and micromolecule mothproof drug is loaded in a pore. The preparation method for the porous inorganic material with insecticidal and mothproof functions comprises the following steps: carrying out covalent modification on the porous inorganic material; grafting a functional group with a cation electric charge on the surface of the porous inorganic material; and loading the micromolecule insecticide into the pore of the porous inorganic material. The porous inorganic material with insecticidal and mothproof functions, which is prepared by using the preparation method disclosed by the invention, has the advantages of excellent insecticidal and mothproof functions, low cost, simple preparation technology and good commercial application prospect and can be used for fields,such as buildings, papermaking, coating, hygiene products and the like.

The invention discloses a preparation method of a controlled release antibacterial film. The method includes the following steps of: (1) dissolving zein and a hydrophobic antibacterial agent into an alcoholic solution; (2) preparing a sodium caseinate aqueous solution; (3) adding the sodium caseinate aqueous solution into the solution obtained in step (1) under stirring; (4) subjecting the solution obtained in step (3) to rotary evaporation and centrifugation, then freeze drying the supernatant, thus obtaining nanoparticle powder; (5) dissolving a film-forming matrix in water, adding the nanoparticle powder and lysozyme to form a mixed solution; and (6) adding glycerin, and conducting film pouring, thus obtaining the film product. The method provided in the invention can simultaneously reduce initial microbial activity and inhibit microbial growth for a long term, and has the advantages of low instrument requirement, and controllable bacterium inhibiting intensity, thus having broad application prospects in food and medical products.

The invention relates to a curing agent of self-hardening furan resin sand, which comprises the following components in portions by weight: 1-300 portions of toluenesulfonic acid, 10-300 portions of xylene monosulfonic acid, 1-170 portions of sulfuric acid, 200-800 portions of phosphoric acid, 1-200 portions of methyl sulfate, 1-50 portions of ethanol, 1-50 portions of methanol, 40-900 portions of water and 0.05-1.0 portion of assistant. The preparation method comprises the following steps: (1) prefabricating the toluenesulfonic acid, the xylene monosulfonic acid and the methyl sulfate; (2) preparing all the raw materials according to the proportion of the curing agent; and (3) synthesizing the curing agent by the following steps: (a) mixing the toluenesulfonic acid, the xylene monosulfonic acid, the methyl sulfate and the sulfuric acid to react for 1.0 hour; (b) cooling to 55 DEG C, adding the mixture of methanol and ethanol to react at 50-70 DEG C for 1.0 hour; (c) adding the phosphoric acid to react at 55-70 DEG C for 1.0 hour; and (d) cooling to 50 DEG C, and adding water and assistant; and discharging after evenly mixing. The curing agent can adapt to the long (super long) use time in the molding process of large castings at high air temperature (above 28 DEG C) and high sand temperature (30-50 DEG C), and solves the problem that the large (super long and large) castings are difficult to produce since the temperature of the reclaimed sand can not drop to the designed value due to various reasons in the foundry corporations.

The invention belongs to the technical field of agricultural films and discloses a multi-layer co-extrusion based biodegradable mulch film and a preparation method thereof. The mulch film adopts a two-layer or three-layer structure, wherein an upper surface layer contains 99wt%-99.9wt% of biodegradable resin A and 0.1wt%-1wt% of auxiliaries; a middle layer is the biodegradable resin A; a lower surface layer contains 70wt%-97wt% of the biodegradable resin A and 3wt%-30wt% of biodegradable herbicide master batches; preparation of the master batches comprises steps as follows: 10wt%-60wt% of herbicide is mixed with 0.5wt%-7wt% of a surfactant A with a hydrophilic-lipophilic balance value being 7-10, and an obtained mixture is subjected to ultrasonic activation; an obtained product is mixed with 25wt%-75wt% of biodegradable resin B and 1wt%-10wt% of a surfactant B with a hydrophilic-lipophilic balance value being 3-6 at a high speed, an obtained mixture is subjected to extrusion pelletization, and the herbicide master batches are obtained. A mass ratio of the surfactant A to the surfactant B is 1:1-1:2.

The invention belongs to the technical field of potato cultivation, and discloses an application of a biodegradable weeding mulching film in potato cultivation. The mulching film comprises the following components in percentage by mass: 70-97% of biodegradable resin A and 3-30% of biodegradable herbicide master batches, wherein the biodegradable herbicide master batches are prepared by a method comprising the following steps: mixing 10-60% of a herbicide with 0.5-7% of a surfactant A, and performing ultrasonic activation; and mixing 25-75% of biodegradable resin B and 1-10% of a surfactant B at a high speed, and performing extrusion and granulation, thereby obtaining the herbicide master batches, wherein the mass ratio of the surfactant A (the hydrophilic-lipophilic balance value is 7-10) to the surfactant B (the hydrophilic-lipophilic balance value is 3-6) is (1:1)-(1:2). As the biodegradable weeding mulching film is used in potato cultivation, the problems that weeds can grow out from furrow surfaces and environment pollution can be caused by common plastics can be effectively prevented, and the labor cost can be lowered.

The invention discloses a preparation method of nanoscale temperature-controlled slow-release fragrant microcapsules. The nanoscale temperature-controlled slow-release aromatic microcapsules are prepared with the method comprising steps as follows: a co-melt is formed from a phase change material as a carrier and perfume and is taken as a core material, a polymer is taken as a wall material, and mixing, emulsifying and emulsion polymerization processes are performed. The nanoscale temperature-controlled slow-release fragrant microcapsules have two slow-release mechanisms: firstly, the phase change material is used as the carrier to realize temperature-controlled slow release; secondly, the dense polymer wall material is used. The product is environmentally friendly, non-toxic, high in mechanical strength and good in heat resistance, and can be used for fragrance enhancement and retaining of textiles, daily necessities and buildings.

The invention discloses a micro-embedded medicament carrier and a preparation method for the carrier. A nano-carrier is embedded in a microcapsule so as to form a medicament carrier of a micro-embedded system, and medicaments are respectively carried in nanoparticles or among different nanoparticles in the microcapsule. The micro-embedded medicament carrier solves the problems of medicament burst effect, single means of adjusting a medicament dissolution rate, insufficient protection of medicament activity and possible medicament cross contamination in medicament combination sustained-release treatment of the conventional medicament sustained-release system, and has the characteristics of simple process, convenient operation, high practicality and wide application prospect.

The invention relates to a carbon release material for purifying groundwater polluted by nitrate nitrogen, which substantially comprises a carbon release agent, an oxygen capture agent, a KH2PO4, trace elements, coarse sand, cement and water, in which the carbon release agent provides carbon for the denitrification degradation process of the microorganism; the oxygen agent is used for capturing and consuming the dissolved oxygen in the groundwater to create an anaerobic environment; the KH2PO4 and the trace elements provide the required nutrient elements for metabolism of the microorganism; the coarse sand is used for promoting permeability of the carbon release material; the cement and the water adhere other components together in the carbon release material. A contrast test of denitrification degradation of nitrate nitrogen in the groundwater proves that the nutrition compound carbon release material in the invention can allow concentration of the dissolved oxygen in the water to decrease from 4.1mg / L to about 0.1mg / L as well as the concentration of the nitrate nitrogen to decrease from 103.4mg / L to 2.5mg / L; the degradation rate is as high as 97.6 percent while the degradation rate of the degradation rate in the contrast text is only up to 50.2 percent.

The invention provides an organic polyurethane foam dressing and a preparation method thereof. An antibacterial component is added into a polyurethane foam synthesis formula to prepare polyurethane foam with an antibacterial function; the obtained polyurethane foam is subjected to low-temperature plasma surface modification treatment; a plasma membrane layer is added on the surface of the antibacterial polyurethane foam material to form a speed limiting barrier. The polyurethane foam dressing prepared by the preparation method disclosed by the invention is high in compliance to a wound and is soft and comfortable; the preparation technology is simple, is convenient to operate and good in treatment effect, has the characteristic of long-time bacteriostat and is suitable for industrial production.

The invention discloses a preparation method of a low aldehyde long-acting slow-release urea formaldehyde fertilizer. The method comprises the following steps: urea aqueous solution and formaldehyde aqueous solution are prepared, then added with an active assistant, after the solution is stable, the PH value of the solution is regulated to 0.9-4.5, after polymerization is finished, the PH value of the solution is regulated to 6.5-7.5, then the solution is added with an aldehyde removing agent, and after the solution is cooled to the room temperature, the suspension is filtrated, the filtrate obtained is collected for recycling, and the low aldehyde long-acting slow-release urea formaldehyde fertilizer is obtained after a filter cake is dried, crushed and prilled. The method has simple process, effectively reduces the release rate of cold water soluble nutrients of the low urea formaldehyde slow-release fertilizer particles by the active assistant and the aldehyde removing agent, reduces the content of free formaldehyde, and increases the active index of the slow-release urea formaldehyde fertilizer, and provides the slow-release urea formaldehyde fertilizer with low formaldehyde content, high activity index and long fertilizer effect for crop growing.

The invention belongs to the field of a magnetic nano-drug / a genetic carrier, in particular to a temperature-sensitive amphiphilic block copolymer / an iron oxide genetic carrier which has the capacity of controlling and relieving drug, a preparation method thereof and application thereof. Polyethyleneimine and polyoxyethylene-polypropylene oxide-polyoxyethylene amphiphilic block copolymer (Pluronic) are decoratively arranged on the surface of iron oxide super paramagnetic nanometer particles. DNA / RNA and the drugs having groups of negative electricity are loaded by the use of groups of positive electricity that are decoratively arranged on the Pluronic; drug loading and released temperature control can be realized by the temperature sensitivity of Pluronic near the body temperature; the amphiphilicity of Pluronic can used for realizing simultaneous loading of hydrophobic / hydrophilic drugs and improving the penetration capability of a drug carrier; the excellent dispersity of the carrier and the long-acting circulation through the body are realized by the biocompatibility of Pluronic; the super paramagnetism of iron oxide kernel is used for realizing targeting delivery of the drug.

The invention discloses a method for preparing a phase-change-adjustable emulsion gel type fat substitute and application and belongs to the field of grease and food processing. The preparation method comprises the following steps: taking an oil-soluble polysaccharide, an oil-soluble micromolecular gel, a water-soluble macromolecular gel and vegetable oil as raw materials, separately dissolving the oil-soluble polysaccharide, the oil-soluble micromolecular gel and the water-soluble macromolecular gel in a heated oil phase and a heated water phase, mixing and emulsifying an oil solution and a water solution to obtain an emulsion, and carrying out stirring and cooling to gelatinize the emulsion, thereby obtaining the emulsion gel type fat substitute. According to the method and the application, the oil-soluble polysaccharide is introduced into a system to reduce the consumption of the oil-soluble micromolecular gel, and the emulsion gel type fat substitute containing zero trans low-saturated fatty acid is prepared to replace the traditional plastic fat; and the whole oil content of emulsion gel is reduced by adding a water phase gelatinized by the water-soluble macromolecular gel, so that the emulsion gel type fat substitute is applicable to different application scenes.

The invention belongs to the technical field of fertilizer production and relates to biological semi-organic fertilizer containing amino acid and a making method thereof. Urea, monoammonium phosphate, potassium sulphate and bentonite are matched reasonably, amino acid mother liquor granules are adopted to form granulation master batch, aminated humic acid, medium trace element compositions, decomposed coal and amino acid mother liquor are blended to form a coating sizing agent used for primary coating of the granulation master batch, then a dusting powder agent is formed by microorganism bacterial liquid and calcium carbonate powder, a coating agent is formed by white oil, molasses and a mixture, and secondary coating is conducted in a coating machine to generate the biological semi-organic fertilizer containing amino acid. The biological semi-organic fertilizer containing amino acid has the efficiency of humic acid, amino acid, biological agents and the like and also has a slow-releasing function, effective constituents can be released slowly and orderly, fertilizer efficiency is remarkable, and production organization is facilitated.

The invention discloses a silk fibroin modified depression structure lactic acid-based polymer drug-carrying microsphere and a method for preparing the same. The method includes (1), dissolving a lactic acid-based polymer in dichloromethane to obtain solution 1; (2), mixing a hydrophobic drug and the solution 1 to obtain solution 2; (3), adding the solution 2 into polyvinyl alcohol aqueous solution under stirring; (4), continuing to stir, centrifuging, removing supernatant, washing with deionized water and carrying out freeze-drying to obtain a lactic acid-based polymer drug-carrying microsphere with depression structure; (5), uniformly mixing silk fibroin aqueous solution and the lactic acid-based polymer drug-carrying microsphere with depression structure to obtain a mixture, centrifuging, removing supernatant, adding glutaraldehyde aqueous solution, carrying out cross-linking, centrifuging, and carrying out freeze-drying. The lactic acid-based polymer drug-carrying microsphere and the method have the advantages that particle size of the lactic acid-based polymer drug-carrying microsphere is uniformly distributed, the method is simple and convenient, the lactic acid-based polymer drug-carrying microsphere is stable in structure, a drug can be slowly released, the hydrophilic properties of the surface of the drug and the structural strength of material can be improved by silk fibroin membrane on the surface of the drug, the release rate can be effectively reduced, and the release time can be prolonged.

The invention relates to a VOC (Volatile Organic Compounds)-inhibited master batch for polypropylene, and a preparation method thereof, and an application thereof. The VOC-inhibited master batch comprises the following mixed components in parts by weight: on the basis of 100 weight parts of polypropylene, 10-60 parts of fully-vulcanized powder silicone rubber, 10-80 parts of cellulose nano crystal, and 5-40 parts of an acid absorption agent. wherein the average particle size of rubber particles in the fully-vulcanized powder silicone rubber is 0.05-1 micrometers, and the gel content is 60wt% or above; surface charge density of the cellulose nano crystal is 0.1-0.4e / nm<2>, length is 90-300 nm, and width is 5-15 nm. The VOC-inhibited master batch for polypropylene can effectively inhibiting generation of VOC in a polypropylene material, the content of a total volatile organic compound (TVOC) in the polypropylene material is lower than 50 [mu]g.C / g, so that the disadvantages in the prior art can be solved. The method has the advantages of simple and reliable operation process, low investment cost, and wide application prospect.

The invention relates to a surface modification method of a cuprous oxide antifouling agent, which comprises the following steps that firstly, chitosan is dissolved in an acetic acid solution; secondly, the chitosan and a liquid mixture formed by dispersing cuprous oxide in a colloidal solution of gum arabic are mixed to obtain a chitosan-gum arabic cuprous oxide suspension; thirdly, the chitosan-gum arabic cuprous oxide suspension is cured to form a microcapsule solution under the action of a curing agent glutaraldehyde; and finally, the microcapsule solution is subjected to centrifugal separation and washing and drying to obtain chitosan-gum arabic cuprous oxide microencapsulated powder, i.e., the surface-modified cuprous oxide antifouling agent. The cuprous oxide antifouling agent prepared by a microencapsulation technology is not easily coagulated during the storage of antifouling paint, and the problem that the untreated cuprous oxide in the antifouling paint is precipitated is solved, therefore the antifouling efficiency is improved and the service life of the antifouling paint is prolonged.

The invention relates to a thermoplastic polymer / clay composite nanomaterial, particularly to a polymer / clay composite nanomaterial for pesticides. The composite nanomaterial is produced by the following steps: intercalating and mixing 2-15 parts of calcium-based or sodium-based montmorillonite clay with a total ion exchange capacity of 80meq-100 meq / 100g, 0.005-0.1 parts of bioactive substances and 0.5-5 parts of quaternary ammonium salt intercalator based on the intercalation method to obtain a uniformly-dispersed blend; mixing 2-15 parts of the uniformly-dispersed blend with 85-98 parts of thermoplastic polymers in molten state; stirring thoroughly; and performing melt-intercalation and extrusion-molding. The thermoplastic polymer / clay composite nanomaterial can reduce the release rate of herbicides and can be further processed into powder, blocks, a drip irrigation device, strips and pipes.

The invention provides a calcium alginate-graphene oxide nanofiber and a preparation method and a drug-carrying calcium alginate-graphene oxide nanofiber and relates to the technical field of nanofibers. The preparation method of the calcium alginate-graphene oxide nanofiber comprises the following step: carrying out microfluidics spinning on a mixed solution of calcium alginate and graphene oxideand a calcium chloride solution, thereby obtaining the calcium alginate-graphene oxide nanofiber. The technical problem that a sudden drug release phenomenon is caused as a conventional calcium alginate nanofiber is good in hygroscopicity and low in mechanical strength is alleviated. By adopting the preparation method provided by the invention, the graphene oxide is put into raw materials, so that the calcium alginate-graphene oxide nanofiber has hydrogen bond interactions with oxygen-containing groups on a graphene oxide sheet and hydroxyl in calcium alginate molecules, the hydrogen bond function of the calcium alginate and water molecules is weakened, the swelling velocity of the calcium alginate is reduced, and the sudden drug release phenomenon can be prevented.

The invention relates to paper for daily use with a mosquito repellent function. The paper for daily use comprises a paper substrate and a mosquito repellent, wherein the mosquito repellent is taken as a capsule core material and is attached on the surface of the paper substrate and / or doped in the paper substrate in the form of microcapsule particles. In comparison with the prior art, through coating the mosquito repellent to the microcapsule particles and attaching the mosquito repellent on the surface and / or interior of the paper substrate, the volatilization speed of the mosquito repellent can be stopped or reduced by a microcapsule wall, so that invalidation of the mosquito repellent function of the paper for daily use due to too quick volatilization of the mosquito repellent can be avoided, thus the paper for daily use, provided by the invention, has a long-acting mosquito repellent function. The invention further relates to a production method of the paper for daily use.

The invention discloses a long-acting sustained-release pellet and a preparation method thereof. The long-acting trimetazidine hydrochloride sustained-release pellet comprises a drug-containing core and a sustained-release coating layer from inside to outside sequentially, wherein an optional isolation coating layer is arranged between the drug-containing core and the sustained-release coating layer; the isolation coating layer accounts for 0-15 percent of the mass of the drug-containing core, and the sustained-release coating layer accounts for 5-30 percent of the mass of the drug-containing core; a gastrointestinal adhesive is contained in the sustained-release coating layer. According to the trimetazidine hydrochloride sustained-release pellet, the prescription is meticulously designed, the drug-containing core is uniformly coated by utilizing the sustained-release coating material, so that slow and uniform drug release of the drug-containing core can be maintained, the active component releasing speed can be reduced, the time for reaching the peak can be postponed, the pellet can be constantly and stably released in 24 hours, the blood concentration stability can be maintained, and the phenomenon of insufficient blood concentration in morning ischemia can be avoided. The administration frequency can be reduced to once a day, and the compliance of patients can be improved.

Production of solid medicaments (A) containing vardenafil hydrochoride (I) in the form of the trihydrate involves using (I) of any water content in the production of (A) and converting (I) into the trihydrate form at an intermediate processing stage or in the final product. An independent claim is included for the medicaments (A) (specifically in coated tablet form) obtained by the process. - ACTIVITY : Vasotropic. - MECHANISM OF ACTION : None given in the source material.

The present invention relates to an encapsulated solid acid, which comprises a capsule core and a capsule wall, wherein the material of the capsule core is nitric acid powder. According to the present invention, the encapsulated solid acid adopted as the additive of a fracturing acidizing liquid can effectively delay the acid release rate; the fracturing acidizing liquid prepared from the encapsulated solid acid can effectively solve the problems of short action time, low acid liquid corrosion efficiency, poor construction effect, difficult filtration loss control, short acid corrosion crack and the like caused by the too rapid acid liquid reaction during the acid fracturing process; and the encapsulated solid acid further has the efficient plugging relieving ability, the solid particles have the temporary plugging and filtration loss reducing functions, and the site construction is simple.

A provided humic-acid-containing modified-starch-coated slow-release fertilizer comprises the following compositions in parts by weight: 75-85 parts of urea, 2-5 parts of potassium superphosphate, 1-3 parts of sodium hydroxide, 3-9 parts of N,N'-methylenebisacrylamide, 1-5 parts of ammonium sulfate, 2-6 parts of ammonium chloride, 1-4 parts of potassium dihydrogen phosphate, 2-6 parts of deionized water, 2-8 parts of microcrystalline wax, 1-5 parts of collophane powder, 2-8 parts of sodium alginate, 6-12 parts of modified starch, 3-9 parts of cellulose derivative, 1-3 parts of humic acid, 2-6 parts of acrylic acid, 3-8 parts of copper potassium pyrophosphate, and 2-6 parts of ammonium polyacrylate. According to the technical scheme, the nutrient release rate of the coated slow-release fertilizer is alleviated, the water retention capability of soil is improved, also the coated slow-release fertilizer is degradable, low in cost, and suitable for large-scale popularization and usage.

The invention relates to the technical field of soil modifying agents and fertilizer synergia, and in particular to a saline-alkali soil modifying agent with a fertilizer synergia effect. The modifying agent is prepared from the raw materials in weight percentage: 0.1 to 1% of urease inhibitor NBPT, 1 to 5% of nitrification inhibitor DCD, 1 to 6% of humic acid, 0.1 to 1% of polyglutamic acid, 10 to 30% of anionic type polyacrylamide, 5 to 15% of cationic polyacrylamide, 10 to 20% of aluminum sulfate and 30 to 40% of filler, wherein the urease inhibitor is NBPT, the nitrification inhibitor is DCD, and the filler is zeolite powder and / or diatomite. The modifying agent can improve saline-alkali soil by adjusting soil acidity, adjusting ion constitution and improving a soil aggregate structure; meanwhile, the modifying agent can improve the fertilizer use rate by adjusting enzymatic activity and microbial activity of soil; the problems that a phosphatic fertilizer is low in effectiveness, the nitrogenous fertilizer easily generates ammonia loss by volatilization, and the normal growth of plants is affected as the saline-alkali soil is much in salinity and high in alkali are solved.

The invention relates to the technical field of agricultural chemistry, in particular to a multi-layer-enveloped controlled-release synergistic weeding pesticidal fertilizer granule and a preparing and using method thereof. The fertilizer granule comprises, by weight, 0.01-1% of a herbicide, 0.1-0.5% of a synergist, 1-15% of an enveloped slow-release layer, 1-10% of an aid and 73.5-97.89% of a fertilizer. By means of the ultra-fine grinding and extruding-granulating process, in a boiling dryer, an advanced ultra-fine spraying device is added, different enveloping slow-release materials are spray-coated layer by layer so that different enveloped thicknesses can be controlled, and the controlled-release synergistic weeding pesticidal fertilizer granule with different releasing rates is prepared to adapt to a complicated variable ecological environment; pesticide effective components and enveloped slow-release materials obtained after ultra-fine grinding or dissolving in a volatile solvent are spray-coated on the surface of the fertilizer granule layer by layer, the slow-releasing of the pesticide and fertilizer is scientifically and reasonably controlled, the granule has the duplex effects after being applied once, and meanwhile the mutual influences (chemical reaction or antagonism) between effective components of the pesticide and fertilizer in a conventional fertilizer are effectively avoided.