5 results about "Extrusion spheronization" patented technology

The utility model discloses an extrusion and round forming device of active ingredient-containing micro-pellets, which comprises a machine body and an extrusion bin, the extrusion bin is arranged on the side surface of the machine body, a discharging chute is connected to the top of the extrusion bin, a round forming groove is arranged on the top of the machine body, the round forming groove is arranged below the discharge port of the extrusion bin, a drying mechanism is arranged in the machine body, and the drying mechanism is connected to the side surface of the round forming groove. The utility model sends high-temperature air into the round forming groove through the drying mechanism, reduces the moisture of the material, avoids the adhesion of the material to the inner wall of the round forming groove, solves the problem that the material is extruded into the round forming machine through the spiral extrusion rod in the background technology, but the material has a certain moisture at this time, is easy to adhere to the inner wall of the round forming machine, and causes the waste of the material.

This utility model discloses an extrusion rounding granulator, including a premixing device and a granulation device. The premixing device includes a mixing tank, a stirring drive component, a clamping assembly, a lead screw, a stirring rod, and a limiting structure. The mixing tank has a mixing chamber and a feed inlet and a liquid inlet communicating with the mixing chamber. The clamping assembly, lead screw, stirring rod, and limiting structure are disposed within the mixing chamber. The lead screw's axial direction is vertical. The clamping assembly is threadedly connected to the lead screw. The limiting structure is arranged along the axial direction of the lead screw, and the clamping assembly is slidably connected to the limiting structure. The stirring drive component is driven to the upper end of the lead screw to drive the lead screw to rotate and drive the clamping assembly to move along the axial direction of the lead screw. The stirring rod is connected to the lower end of the lead screw. The inlet end of the granulation device is connected to the outlet end of the mixing chamber. This utility model can automatically and thoroughly mix materials before granulation, avoiding moisture loss and greatly reducing the labor intensity of workers while ensuring granulation quality.

This invention discloses a traditional Chinese medicine drug for treating atrophic gastritis and its preparation method. The drug is composed of herbs including Salvia miltiorrhiza, chicken gizzard lining, Aucklandia lappa, Amomum villosum, Taraxacum mongolicum, Shenqu (medicated leaven), Citrus aurantium, Corydalis yanhusuo, Coix lacryma-jobi, Viola yedoensis, Angelica sinensis, and Astragalus membranaceus. In preparation, about half of the herbal mixture is pulverized into a fine powder for later use; the remaining herbs are decocted twice with water, and the filtrate is concentrated into a thick paste using vacuum low-temperature concentration technology. The thick paste is mixed with the fine herbal powder, ethanol is added, and wet microcapsules are prepared using an extrusion and spheronization method. The wet microcapsules are finally dried in stages using a fluidized bed and polished to obtain the finished product. This method, by combining extraction with the use of raw powder, and employing key processes such as low-temperature concentration and staged drying, can maximize the retention of water-soluble and heat-sensitive volatile components in the herbs, significantly improving the drug's dissolution rate, active ingredient content, and long-term storage stability, thereby more effectively exerting its comprehensive therapeutic effects of invigorating the spleen and replenishing qi, promoting blood circulation and removing blood stasis, and relieving pain.

This invention belongs to the field of pharmaceutical formulation technology, specifically a microcapsule composition for intestinal targeting and its preparation method. This invention overcomes the problems of poor sustained-release effect and low bioavailability of intestinal-targeted drugs in existing technologies. The microcapsule composition includes a drug-loaded core, an isolation layer, and an enteric coating layer. The drug-loaded core is prepared by extrusion and spheronization of an active drug, cross-linked sodium carboxymethyl cellulose, and povidone. The isolation layer is formed by drop-adding the drug-loaded core into an isolation layer solution. The enteric coating layer is obtained by fluidized bed coating, and the microcapsule composition is obtained by soybean oil treatment. The final targeted microcapsules exhibit excellent sphericity, stable release, and low toxicity, making them suitable for long-term treatment of ulcerative colitis.

The application discloses a kind of millimeter heat storage particles with hollow structure and preparation method thereof, the particle is millimeter size, it has hollow structure in macroscopically, it has micron-nanometer step hole in microcosm, so compared with the millimeter uniform structure particle prepared by traditional extrusion-rounding method has better mass transfer capacity, its reaction rate is obviously promoted.The application is prepared by first preparing core particle that can be completely decomposed in air, then the outer layer of the core particle is coated with a certain thickness of heat storage material, and then the mother core material such as microcrystalline cellulose / polystyrene is removed by calcination to obtain the heat storage particle with hollow shell structure.