Recipe of valnemulin hydrochloride enteric-coated pellet and preparation method thereof

A technology of warnimulin hydrochloride and enteric-coated pellets, which is applied in the direction of medical preparations, pharmaceutical formulations, antibacterial drugs, etc. of non-active ingredients, and can solve gastric mucosal irritation, fine powder, environmental assessment and safety impact and other issues to achieve the effects of reducing costs, improving stability, improving bioavailability and efficacy
CN101874785AInactive Publication Date: 2010-11-03广东大华农动物食品保健品股份有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广东大华农动物食品保健品股份有限公司
Publication Date
2010-11-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a recipe of a valnemulin hydrochloride enteric-coated pellet and a preparation method thereof, wherein, acrylic resin water dispersion is taken as coating liquid, and water is taken as a solvent, thus changing the method that the existing resin coating liquid selects high concentration alcohol as the solvent, lowering cost and overcoming the defect of environmental influence due to evaporation of a large amount of alcohol during the coating process. The preparation method of the valnemulin hydrochloride enteric-coated pellet comprises the steps of preparation of the valnemulin hydrochloride medicine carrying pellet, preparation of the coating liquid and preparation of valnemulin hydrochloride coating. By adopting an extrusion-spheronization process procedure, the preparation method solves the defects of a one-step fluidized bed granulating method such as coarse and loose particles, large particle size range, a large amount of dust; and the pellet prepared by the method has even particle size and narrower distribution range, thus being beneficial to uniform saturation of the coating liquid on the particles, and improving the taste masking effect.
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Description

technical field

[0001] The invention relates to the field of preparation of warnemulin hydrochloride, a special-purpose pleuromutilin antibiotic for animals, in particular to the preparation of warnemulin hydrochloride coated particles. Background technique

[0002] Micropills refer to various pills with a diameter of less than 2.5mm, which can be prepared into sustained-release or controlled-release preparations according to different needs, and can also be further compressed into tablets, capsules, etc. As a new member of multi-unit type drug delivery system, sustained and controlled release pellets have become a hot spot in the research of sustained and controlled release preparations in recent years due to their unique advantages. Compared with a single-unit drug delivery system (such as a tablet), micropills have the following advantages: 1. Small inter-individual differences in body absorption and good reproducibility of absorption kinetics; 2. High bioavailability and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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