38 results about "Valnemulin" patented technology

The invention relates to veterinary valnemulin, a novel liposome formulation of the salt thereof and a preparation method thereof, which belongs to the field of veterinary antibiotic preparations. In the preparation, valnemulin and the salt thereof serve as the main components, phospholipid and cholesterol serve as membranes, and the common liposomes, the lung targeting liposomes or the long circulating liposomes of valnemulin or valnemulin salt can be prepared. The valnemulin and the liposomes of the salt thereof have better tissue selectivity compared with the common preparation, are effective to the bacterial and mycoplasma infection in cells, and can reduce the toxic and side effect. The lung targeting liposomes targets the medicine to the lung, and has significant effect to the mycoplasma infection of the lung, bacterial infection and the like, and reduces the toxic and side effect. The long circulating liposomes significantly improves the circulation time of the liposomes in thebody, so that the medicines displays the efficacy for a longer time more effectively, so s to reduce the delivery times and the dosage.

The present invention relates to a pig respiratory tract diseases prevention and treatment drug composition, a premix and a matching material thereof, and belongs to the field of veterinary drugs and premixes. The drug composition of the present invention comprises, by weight, 40-95 parts of a traditional Chinese medicine component, and 10-60 parts of a chemical drug component, wherein the traditional Chinese medicine component is prepared from the fructus arctii, roripa montana and common yam rhizome, and the chemical drug component is selected from florfenicol, tilmicosin, tiamulin, valnemulin, acetylisovaleryltylosin, tylosin, kitasamycin and a salt thereof. The drug compositions of the present invention is suitable for pig respiratory tract diseases prevention and treatment, has characteristics of significant treatment effect, high safety, stable formulation, controllable quality, simple preparation process and the like, is suitable for industrial production, and can further be added to the feed so as to be used for preparation of pig growth promoting feed such as premixes, matching materials and the like.

The invention relates to a drug formula for preventing and treating the chronic PRDC (porcine respiratory disease complex). The drug formula comprises raw materials, namely, valnemulin, enrofloxacin and traditional Chinese medicine powder, wherein the traditional Chinese medicine powder comprises raw materials, namely, codonopsis pilosula, liquorice roots, poria cocos, largehead atractylodes rhizomes, lily bulbs, dwarf lilyturf tubers, purified pinellia tubers, tatarian aster roots, ephedra herbs, thinleaf milkwort roots, common anemarrhena rhizomes, coastal glehnia roots, dried tangerine peels and pumice, the Chinese herbal medicines are distilled with water vapor, an extract is obtained, the extract and fine pumice powder produced through milling by an efficient ball mill are evenly mixed, then dried at the low temperature and packaged in a vacuum manner, and the traditional Chinese medicine powder is prepared. The formula is significant in curative effect on the chronic PRDC, less in traditional Chinese medicine addition amount and good in palatability, takes effect quickly and is high in cure rate according to clinical usage.

The invention relates to a valnemulin oxalate crystal and a crystallization preparation method thereof. According to an X-ray powder diffraction pattern of the crystal, characteristic peaks appear at diffraction angle 2theta of 6.2, 8.0, 10.5, 11.2, 12.5, 13.2, 14.6, 15.0, 17.0, 18.0, 19.7 and 21.1 degrees. According to the invention, valnemulin is dissolved in an ester type solvent, wherein a solution concentration is 0.1-0.4g / mL; oxalic acid is added according to a molar ratio that oxalic acid to valnemulin is 1:1-1:2; under a stirring effect, a reaction is carried out under a temperature of 40-60 DEG C until the solution is clear; the temperature of the solution is reduced to 10-20 DEG C; and filtering, washing, and drying are carried out, such that a valnemulin oxalate crystal product is obtained. The crystallization process has a yield higher than 90%. The valnemulin oxalate product has high crystallinity, high purity, and low fly-off. The valnemulin oxalate product has good stability against light, heating, and moisture.

The invention discloses a preparation method for a valnemulin liposome. The method comprises the following steps: 1) preparation of a NaHCO3 solution; 2) preparation of a citric acid buffer solution; 3) preparation of a blank liposome: a step of dissolving phosphatide and cholesterol in absolute ethyl alcohol in a water bath, allowing ethanol to volatilize and a film to be formed, then adding the citric acid buffer solution, carrying out complete hydration and filtering an obtained liposome solution with a millipore filter to realize whole grain filtering; 4) preparation of valnemulin fluid by dissolving raw valnemulin powder in ethanol; 5) active loading: a step of successively adding the valnemulin fluid and the NaHCO3 solution into the blank liposome and carrying out uniform mixing so as to obtain a crude liposome product; and 6) low temperature high speed centrifugation of the crude product obtained in step 5) so as to prepare the valnemulin liposome. According to the invention, through preparation of the blank liposome and active loading, the valnemulin liposome with a high entrapment rate and good clinical effects is obtained; the method is simple and easily practicable, and solubility of valnemulin in water and effective acting time, stability and targeting of valnemulin are improved.

The invention relates to a drug formula for preventing and treating the chronic PRDC (porcine respiratory disease complex). The drug formula comprises raw materials, namely, valnemulin, enrofloxacin and traditional Chinese medicine powder, wherein the traditional Chinese medicine powder comprises raw materials, namely, codonopsis pilosula, liquorice roots, poria cocos, largehead atractylodes rhizomes, lily bulbs, dwarf lilyturf tubers, purified pinellia tubers, tatarian aster roots, ephedra herbs, thinleaf milkwort roots, common anemarrhena rhizomes, coastal glehnia roots, dried tangerine peels and pumice, the Chinese herbal medicines are distilled with water vapor, an extract is obtained, the extract and fine pumice powder produced through milling by an efficient ball mill are evenly mixed, then dried at the low temperature and packaged in a vacuum manner, and the traditional Chinese medicine powder is prepared. The formula is significant in curative effect on the chronic PRDC, less in traditional Chinese medicine addition amount and good in palatability, takes effect quickly and is high in cure rate according to clinical usage.

The invention discloses a valnemulin artificial antigen and a preparation method and application thereof. The valnemulin artificial antigen is a compound as shown in a formula I, wherein n denotes a natural number from 1 to 25; and K denotes carrier protein. When the artificial antigen is used to immunize a New Zealand white rabbit, an antibody with specific reaction to valnemulin can be obtained. According to ELISA experiments, the titer of the obtained antiserum reaches 1:102400. The invention provides a wide application and development space for the development of detection reagent used inthe enzyme-linked immunoassay method of the valnemulin and the preparation of the enzyme-linked immunoassay reagent kit of the valnemulin. When the antibody obtained by using the artificial antigen is used for the detection of the valnemulin, the operation is simple and convenient, the specificity is good and the accuracy is high. The antibody can be used for the rapid and high-efficiency screening of the valnemulin in animal-based foods and a technical foundation is laid for the rapid detection of the valnemulin. The formula I is as shown is the accompanying drawing.

The invention relates to a novel crystal form of valnemulin hydrogen tartrate and a preparation method thereof. The method comprises the steps of dissolving valnemulin hydrogen tartrate with the purity being over 95% into a mixed solvent of an ester solvent and N,N-dimethylformamide, adding an elution agent after complete dissolution so as to carry out elution crystallization, then, cooling a solution to the temperature of 5-15 DEG C, and washing, filtrating and drying crystal slurry, thereby obtaining a valnemulin hydrogen tartrate product. An X-ray powder diffraction atlas of the crystal has characteristic peaks when a diffraction angle 2[theta] is equal to 2.5, 4.8, 7.4, 7.5, 10.1, 11.2, 11.7, 13.8 or 17.1 degrees. According to the novel crystal form, during crystallization, the yield reaches over 90%, the product purity reaches over 98%, the product is high in crystallinity, good in stability, difficult in moisture absorption and high in solubility, the water solubility at normal temperature reaches 6.5g / 100mL and is increased by about 30% compared with that of the currently marketed products, and the water stability is good, so that the product can be conveniently prepared into a premix.