Preparation method of tartaric acid valnemulin premixing agent

A technology of warnimulin and tartaric acid, which is applied in the field of veterinary antibiotic preparations, can solve the problems that have not been applied in the field of veterinary medicine and have not been seen, and achieve the effects of being convenient for long-term storage, increasing bioavailability, and delaying metabolism

Inactive Publication Date: 2012-12-12
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Abstract
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  • Application Information

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Problems solved by technology

Although coating technology has a long history in the pharmaceutical industry, it has not been applied in the field of vete

Method used

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with embodiment, but content of the present invention is not limited to embodiment.

[0016] In embodiment 1, a kind of preparation method of warnemulin tartrate premix comprises the following steps:

[0017] A preparation method of warnemulin tartrate premix, comprising the following steps:

[0018] (1) Preparation of coating solution: first dissolve 35g of hydroxypropyl methylcellulose with a viscosity of 5mPa·s~lOmPa·s in 50ml of purified water, then add 12g of talc powder and purified water, and stir evenly until the obtained Coating solution, the mass volume ratio of coating material in the coating solution is 35%;

[0019] (2) Coating treatment of warnemulin tartrate: first mix 6 g of warnemulin tartrate with 5.5 g of talc powder, then use a 100-mesh sieve to disperse the two, place them in a fluidized bed, and pass through Air volume is 75m 3 / h, the hot air at a temperature of 75°C makes the...

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Abstract

The invention provides a preparation method of a tartaric acid valnemulin premixing agent, belonging to the field of veterinary antibiotic preparations. The preparation method comprises the following steps of: preparing a coating liquid from a coating material, an anti-sticking agent and purified water; atomizing the coating liquid and spraying the atomized coating liquid into a fluidized bed; coating tartaric acid valnemulin to prepare coated grains; and screening the coated grains and then mixing the screened grains with a diluent, so as to prepare the tartaric acid valnemulin premixing agent. The tartaric acid valnemulin premixing agent prepared by the preparation method is stable in medicine quality, increases the bioavailability of medicines, has outstanding medicine effect, and is mainly used for treating and preventing livestock and poultry diseases.

Description

technical field [0001] The invention relates to a preparation method of special pleuromutilin antibiotics for animals, in particular to a preparation method of warnemulin tartrate premix, belonging to the field of veterinary antibiotic preparations. Background technique [0002] Warnemulin hydrochloride was first synthesized by Sandoz Company using pleuromutilin as a raw material in 1984. It belongs to the same class of drugs as tiamulin and is a special antibiotic for animals. Warnemulin hydrochloride is mainly used as a feed premix to prevent swine dysentery, endemic pneumonia, porcine spirochete, porcine proliferative enteropathy, etc. Premix is ​​the main dosage form for oral administration to livestock and poultry. Compared with injection, it is more convenient for administration and saves breeding costs. Although warnemulin hydrochloride has a good anti-mycoplasma effect, the raw material drug has disadvantages such as hygroscopicity, strong powder irritation, instabi...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/22A61K47/42A61K47/38A61K47/34A61K47/36A61P31/04A61P1/12A61P11/00A61P1/00
CPCY02A40/70
Inventor 吴东林王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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