127results about How to "Play a therapeutic effect" patented technology

The invention relates to an artificial trachea cannula made of nano materials in the technical field of medical appliance and a preparation method thereof; the artificial trachea cannula comprises a respirator joint, an air supply tube, an inflation tube, an inflation gasbag, a drain pipe and a lubricant coating, wherein, the inflation tube is in the air supply tube, the output end of the air supply tube is connected with the respirator joint; an inserting section of the air supply tube is cuniform; the external wall of the air supply tube is provided with inflation gasbags; the position where the inflation tube is correspondingly arranged is provided with holes; the drain pipe is embedded on the external wall of the air supply tube and is adjacent to the inflation gasbag; the side of the drain pipe close to the inflation gasbag is provided with a liquid outlet, the other side thereof is connected with an injector; the lubricant coating is arranged on the external wall of the inflation gasbag and the air supply tube, the air supply tube and the inflation gasbag are made of modified plastics. With the method of the invention adopted, damage to lumen tissue when the tube is inserted is reduced, pain is reduced, complicating disease is prevented from occurring; in addition, the preparation process is easy and controllable, the cost is low, as a result, the method is applicable to batch production.

The invention discloses a neuromuscular electrical stimulation system with implantable automatic feedback adjustment, which can accurately feedback the executive condition of the implanted parameter, improve the therapeutic effects of the implantable electrode specific parameter, really realize improvement and repairing of the individual functions and improve the reliability, effectiveness and controllability of the implanted device. The invention adopts the technical proposal that an implantable electrical stimulation generator are combined with an in vitro controller which can control the stimulus wave parameters and instructions, thereby the online in vivo parameters can be effectively monitored, feedback and adjusted; the signal transmission in the in vitro controller are completed at the same time. The neuromuscular electrical stimulation system can be used in the neuromuscular electrical stimulation field.

The invention relates to the technical field of medical appliance. Ventilator associated pneumonia results from inhalation of secretion with pathogene, wherein, bacterial pollution of gas circuit of the ventilator is a key factor which causes the ventilator associated pneumonia. The invention aims at providing an artificial trachea cannula with broad-spectrum antibacterium property and controllable slowly-releasing drugs; an air providing tube (2), an air bag (4), an air tube (3) and a liquid discharging tube (5) of the artificial trachea cannula of the invention are coated with nanometre anti-microbial coatings (6) on inner and outer surfaces; the nanometre anti-microbial coatings are mainly blended by macromolecule polymers, nanometre inorganic antimicrobial and slowly-releasing drugs. The artificial trachea cannula with nanometre anti-microbial coatings of the invention not only satisfies traditional functions of artificial trachea in providing air path and maintaining respiratory tract clear, but also has functions of excellent bacteriostasis and slowly releasing of controllable drugs, thereby providing wide application prospect to clinical application of the artificial trachea cannula.

A ferric oxide nucleus-gadolinium oxide shell composite nano particle with the surface modified by polyethylene glycol is 50-300nm in average particle size, and uses ferric oxide as a nucleus and gadolinium oxide as a shell; the surface of a composite nano porous microsphere is modified by polyethylene glycol; the particle is hydrophilic, has better stability in a wide pH (Potential of Hydrogen) scope, and is biocompatible; the surface of the nano particle is regular; a plurality of ducts are formed in a shell wall; and the nano particle has a T1 and T2 dual-mode magnetic resonance imaging function. The ferric oxide nucleus-gadolinium oxide shell composite nano particle with the surface modified by polyethylene glycol has an obvious dual-mode imaging effect; a preparation method is simple, green and environment-friendly; raw materials are cheap; the particle can be inoculated with a target molecule to detect a tumor more accurately; and the particle has high application values and wide application prospects in the fields of materials, biology and medicine. The invention discloses the preparation method of the particle.

The invention provides ginseng and ganoderma lucidum spore powder tablets and a preparation method thereof, belongs to the technical field of health care products and solves the technical problems that real nutrients are not high in content and not easily absorbed by human bodies and the like due to the fact that existing ginseng Ganoderma lucidum spore powder drugs are mixed with too many excipients. According to the ginseng and ganoderma lucidum spore powder tablets, each tablet comprises raw materials of 0.12-0.4 g of ginseng powder and 1-1.4 g of sporoderm-broken ganoderma lucidum spore powder. Different formulas are provided for different ginseng varieties. The invention also provides the preparation method of the ginseng and ganoderma lucidum spore powder tablets. The ginseng and ganoderma lucidum spore powder tablets are pure natural and have no toxic or side effects as no excipients are added, ginseng can reinforce vital energy and enhance the immunity and disease resistance of the human bodies; the ganoderma lucidum spore powder can enhance the body immunity, phagocytose cancer cells and inhibit the cancer cells from transferring or growing; the ginseng and ganoderma lucidum spore powder are combined, and the curative effect is improved; the ginseng and ganoderma lucidum spore powder tablets can be buccal and are absorbed by the human bodies more easily, and a production process of the ginseng and ganoderma lucidum spore powder tablets is simple and is convenient to operate.

The invention relates to antibacterial modified chitosan spray and a preparation method thereof. The preparation method of the antibacterial modified chitosan spray comprises the steps of preparing modified chitosan, preparing gardenia oil, preparing geniposide, preparing spirulina polysaccharide and spirulina polypeptide and preparing chitosan spray. The antibacterial modified chitosan spray is applied to treatment on male and female pruritus vulvae and fungal infection, bacterial infection, folliculitis and vaginitis, also can be used for treating bedsore and long-term skin inflammation, can be widely applied and has antibacterial ability more than 99% on staphylococcus aureus, escherichia coli, streptococcus, candida albicans, pseudomonas aeruginosa or other fungi.

The invention relates to a health-protection cap with functions of magnet therapy and knocking massage. The health-protection cap comprises a cap body. A magnetic knocking hammer is arranged at the position corresponding to the head baihui point of human body, on the cap body. At least one acupuncture-point position except for the position corresponding to the head baihui point of a human body is provided with a static magnet. A gyromagnetic mechanism is also arranged on the cap body. The gyromagnetic mechanism comprises an active magnet and an actuating device used for actuating the active magnet to rotate. When the active magnet rotates, the magnetic-pole positions the two ends of the active magnet are transformed alternately. On the one hand, the magnetic knocking hammer oscillates because of the principle that like poles repel; unlike poles attract and carries out dynamic-magnet acupuncture and the knocking massage on the head baihui point of the human body, on the other hand, the magnetic force lines around the static magnet move up and down because of the principle that like poles repel; unlike poles attract and carry out magnetic force line simulated acupuncture on other corresponding acupuncture points of human head. The health-protection cap has the advantages of simple structure, powerful functions, wide range of treatment, obvious treatment effect, low costs and strong practicability.

Disclosed is a weight-reducing Chinese medicine and disposable weight-reducing dedicated catgut embedding device, wherein the fat-reducing Chinese medicament comprises banksia rose, campeachy wood, Ficus carica, Momordica grosvenori and musk. The surgical catgut wire embedding device comprises a hollow needle head and a wire embedding needle, one end of the hollow needle head is connected with the handle, the other end of the handle is connected with a limiting sleeve.

The invention relates to a visual training device, in particular to a head-mounted visual function training device. The head-mounted visual function training device comprises a shell with an inner cavity. An observation surface contacting with faces is arranged on the outer side of the shell, and is provided with two first through holes corresponding to eyes. The through holes are communicated with the inner side and the outer side of the observation surface. A rotatable imaging device is arranged in the inner cavity of the shell. A 'T'-shaped movement track is arranged in the inner cavity ofthe shell horizontally. The symmetric line of the 'T'-shaped movement track is opposite to the symmetric line of the first through holes. The imaging device can move along the 'T'-shaped movement track. Image reflecting mechanisms, used for reflecting images displayed by the imaging device into the first through holes, are arranged between the large end of the 'T'-shaped movement track and the first through holes. The head-mounted visual function training device has the advantages that visual distances can be well adjusted; the two eyes can be trained at the same time, time is short, and efficiency is high; the device is convenient and safe to wear and has high comfort level.

The invention discloses a conjugate of an anti-human DLL4 humanized antibody and a dolastatin derivative MMAE as well as a preparation method and an application of the conjugate, and relates to the technical field of biological pharmacy. The conjugate of the novel anti-human DLL4 humanized antibody THL4 and the dolastatin derivative MMAE is obtained. The preparation method is characterized in thata small molecular toxin aplysiatoxin derivative MMAE is coupled to an engineered anti-human DLL4 humanized antibody THL4 at a fixed point to synthesize a conjugate, and the conjugate is used in the preparation method. The conjugate HLvM4 is used for promoting the tumor targeting of toxin molecules MMAE, reducing the toxic action on normal cells of a body and achieving a better treatment effect.

The invention relates to functional health-protection beverage with an effect of relieving three highs and a preparation method thereof. The functional health-protection beverage comprises the following raw materials: an achyranthes root extract, a gamma-aminobutyric acid extract, a guarana extract, a siraitia grosvenorii extract, white granulated sugar, acesulfame potassium, aspartame, sodium citrate, taurine, lysine, ethyl maltol, lemon yellow, carmine, citric acid, tartaric acid, mixed fruit essence and purified water; the raw materials are obtained by sugar smelting, extract, acid and pigment adding, water supplementation, essence adding, chemical checking, filtering, sterilizing, cooling and filling; the three-highs symptom can be effectively relieved, and a certain treating effect is achieved; no side effect is caused; meanwhile, nutritional substances essential for a human body can be comprehensively supplemented; the organism energy is enhanced; the immune function of a human body is adjusted; the health of people can be improved.

The invention discloses an epitope-specific antibody screening method, and is used for solving the problem of low screening efficiency of functional antibodies having treatment function in an antibodylibrary screening technology; the method includes the steps of screening of functional epitope peptides and screening of living cells. The invention also provides a fully human anti-PD-1 monoclonal antibody obtained by screening a phage display antibody library by the method; for specific functional epitopes, the fully human anti-PD-1 monoclonal antibody can effectively block the binding of PD-1to a ligand of PD-1, has the characteristics of high affinity and low EC50, and can produce treatment effect on animal models at low dose. The screening efficiency of the functional antibody is greatly improved, and a potential, safer and more economical immunotherapy drug is provided for patients with malignant tumors and immune diseases.

A Chinese medicine for treating beriberi is prepared from 14 Chinese-medicinal materials including tangerine peel, liquorice root, ginger, myrrh, etc through immersing them in liquor for 7-15 days.

The invention provides a picolinamide compound containing a triazole or quinolinone structure and application of the picolinamide compound. According to a technical scheme in the invention, extensiveresearch is conducted on the picolinamide compound, and a plurality of structural sites are modified and transformed, so a series of picolinamide derivatives with novel structures are synthesized. Onsuch a basis, the chemical properties and the biological properties of the derivatives are investigated, and results show that the derivatives have strong c-Met kinase inhibition effect and can achieve a treatment effect on diseases caused by abnormal high expression of c-Met kinase. Thus, the invention determines the use of the compound or its derivatives in the preparation of drugs for treatingproliferative diseases or tumors. Experimental results show that the compound has exact and remarkable inhibition effect on tumor cells, so data support is provided for pharmaceutical application of the compound.

The invention relates to an implanting instrument with bionic micro-thorn attachment structures. The implanting instrument at least comprises an attachment frame, wherein the attachment frame is a self-expanding type support or a ball-expanding type support and comprises a plurality of frameworks and a plurality of bionic micro-thorn attachment structures; the bionic micro-thorn attachment structures are arranged on the outer surfaces of the frameworks; the bionic micro-thorn attachment structures are in the form of bionic plant surface sparse micro-thorns; each bionic micro-thorn attachment structure comprises a thorn root and a micro-thorn; each micro-thorn is composed of a thorn body and a thorn tip; each micro-thorn is linear or J-shaped or the combination of the linear micro-thorn andthe J-shaped micro-thorn; and the thorn bodies and / or the thorn tips of the micro-thorns can touch cavity tissue to achieve an attachment type anchoring function. The implanting instrument is wide inapplication range, free of anchoring damage, firm and high in safety.

The invention relates to the technical field of biological fermentation, and especially relates to a compound enzyme bath composition and a fermentation method and an application thereof; the compoundenzyme bath composition comprises the following substances in parts by weight: 100 parts of a base material, 10-25 parts of a nutrition powder, 0.05-0.15 part of a bacterial strain, 0-15 parts of a Chinese herbal medicine, and 20-40 parts of water. By combination of a traditional enzyme bath with a traditional Chinese medicine fumigation therapy method, heat energy is produced by fermentation, and meanwhile, in the process of fermentation, a large number of enzymes can be produced. A human body is embedded in the enzyme medicated bath, and pores of the body can be opened under the action of the heat energy; and with an absorption principle of the skin, the drug is externally applied, and a body conditioning effect is achieved.

The invention provides a new application of fingolimod and an analogue thereof in preparing medicines for treating cerebral infarction and further shows the mechanism of treatment, effective dose, suitable dosage form and the specific compound of the analogue. Experiments confirm that the fingolimod and the analogue thereof can relieve lymphocyte infiltration caused by cerebral infarction, the relieving effect can be taken as a new target for treating cerebral infraction, furthermore, based on the new properties of the fingolimod and the analogue thereof, the new application of the fingolimod and the analogue thereof in preparing medicines for treating cerebral infraction is confirmed. The clinical applicability of the fingolimod and the analogue thereof is enlarged, the fact that the immune cells involve in cerebral infarction pathological lesion is disclosed, and the medicine prepared by the fingolilmod and the analogue thereof has a remarkable curative effect on cerebral infraction injure, and has prosperous generalization prospect.

The invention relates to the technical field of genetic engineering and biological agents, and particularly discloses a high-stability antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide disclosed by the invention is shown as SEQ ID NO. 1. The antibacterial peptide disclosed by the invention is simple in the synthesis method, the amino acids in the sequence are all natural amino acids, the cost is low, and the peptide sequence has high stability in a simulated in-vivo salt ion environment and a simulated trypsin chymotrypsin environment. The antibacterial peptide shows broad-spectrum antibacterial activity under a neutral pH value, and shows an inhibition effect on strains such as escherichia coli, staphylococcus epidermidis, salmonella and staphylococcus aureus. And under an acidic pH condition, the activity is further enhanced. Meanwhile, the antibacterial peptide has relatively low hemolytic activity and good biocompatibility.

The invention discloses a fat synthetase inhibitor and applications thereof, and belongs to the technical field of medical biology. The inhibitor can significantly inhibit the activity of fatty acid synthetase without affecting normal expression, and can also adjusting the proportion of fatty acid in cells; the inhibitor has good tumor proliferation inhibition effects, and can make the growth period of tumor cells stagnate in interphase, prevent the tumor cells from splitting, inhibit the proliferation of the tumor cells, promote the apoptosis of the tumor cells and achieve treatment effects on tumor; and the inhibitor can be used for drugs for treating tumor and metabolic related diseases, so that the inhibitor has important clinical application prospects.

The invention discloses a drugcoated balloon controllable in drug metabolism and a preparation method of the drugcoated balloon, and relates to the technical field of drugcoated balloons. The drugcoated balloon is prepared through the steps of mixing a drug acceptor protein inhibitor with drugs, water and ethanol to obtain medicinal liquid, spraying the medicinal liquid onto the surface of the balloon back and forth through ultrasonic spraying equipment, and performing drying so as to obtain the drugcoated balloon. The drug acceptor protein inhibitor can also be replaced with a drug metabolismisoenzyme inhibitor, an inducer or a mixture of the drug acceptor protein inhibitor and a drug metabolism isoenzyme inhibitor for preparing the medicinal liquid, and through adjusting the addition quantity of the drug acceptor protein inhibitor and the compounding ratio of the drug acceptor protein inhibitor to drugs further, the drug metabolism period of the drugcoated balloon can be adjusted and controlled. The invention provides the drugcoated balloon controllable in drug metabolism and a simple and efficient preparation method of the drugcoated balloon controllable in drug metabolism, andthe prepared drugcoated balloon has the functions that metabolism can be effectively controllable without destroying the structure of an intima, at the initial stage of using the drugcoated balloon,drug metabolism can be generated to achieve the effect of drug treatment, and the effect period of the drugs can be prolonged through adjusting the formula.

The invention provides a traditional Chinese medicine composition for treatment of superficial gastritis. The traditional Chinese medicine composition comprises active components, by weight, 10-20 parts of rhizome of Chinese atractylode, 12-20 parts of largehead atractylodes rhizome, 12-18 parts of white paeony root, 8-15 parts of Mangnolia officinalis, 10-18 parts of poria cocos, 10-18 parts of fruit of cape jasmine, 5-15 parts of dried tangerine or orange peel and 2-8 parts of licorice root. Compared with the prior art, the traditional Chinese medicine composition has the advantages of being low in toxicity, free of residue and not easy to cause drug resistance. The traditional Chinese medicine composition uses clearing away heat, drying dampness and dispersing stagnated liver qi for regulating stomach as rules of treatment, is capable of remarkably alleviating or effectively eliminating clinical symptoms such as epigastric pain, epigastric discomfort, abdominal distension, early satiety and acid regurgitation due to superficial gastritis, and achieves the treatment effect of treating both manifestation and root cause of disease.

Disclosed is an analgesic ointment. The analgesic ointment is prepared from, by weight, 15-25 parts of crude fructus gardeniae, 16-26 parts of rhizoma paridis, 6-16 parts of konjac, 3-13 parts of herba asari, 3-7 parts of camphor, 3-7 parts of menthol, 25-35 parts of medical vaseline, 2-4 parts of 95% ethanol and 14-24 parts of water. A preparation method comprises the steps that firstly, the crude fructus gardeniae, the rhizoma paridis, the konjac, the herba asari and the camphor are processed and ground; the camphor and the menthol are poured into a container for mixing and grinding, then the 95% ethanol is added to for uniform mixing, and afterwards, a filtering net is adopted for removing impurities; the rhizoma paridis is poured into the medical vaseline, and uniform stirring is carried out; then the water, the konjac flour, the crude fructus gardeniae and a solution are mixed to obtain the ointment. The analgesic ointment takes effect quickly, can achieve radical treatment, has small side effects and achieves the functions of relaxing the tendons, activating blood circulation, strengthening the bones and relieving inflammations.

The invention discloses a pillow for treating cervical spondylosis. The pillow comprises a leaning column, support rods, a propping-up rod, a control structure and a pillowcase, wherein one end of each support rod is connected with the leaning column, and the other end of each support rod is connected with the propping-up rod; the control structure is connected with the support rods; the pillowcase wraps the leaning column, the support rods and the propping-up rod. The pillow disclosed by the invention can be intelligently changed in shape when a patient with the cervical spondylosis lies flat or lies laterally, therefore various different sleeping gestures of the patient with the cervical spondylosis are satisfied; moreover, under each sleeping gesture, the cervical vertebra can be in a reasonable stat, so the patient with the cervical spondylosis has no pain disturbance during sleeping, and a treatment effect is exerted on the cervical spondylosis.

The invention provides an azithromycin granule oral preparation capable of effectively covering up the bitter of azithromycin. The azithromycin granule oral preparation is prepared from the azithromycin, sucrose, carboxymethyl starch sodium, sodium dodecyl sulfate and a novel sweetener Neotame. According to the invention, in the preparing process of azithromycin granules, not only is the novel sweetener introduced, the oral preparation of which the taste and the sweetness are suitable for people to take can be prepared by a small account of the novel sweetener and the compliance of a patient is improved, but also the cost can be reduced; and meanwhile, by regulating the proportion of a formula, the dissolution of the azithromycin granules is greatly improved, and thus, not only can the azithromycin granules be easily accepted by the patient and be particularly easy to take by child patients, but also the improvement of the dissolution ensures the azithromycin easier and faster to adsorb and ensures the curative effects of the azithromycin to be sufficiently taken.

The invention relates to the technical field of biological pharmacy, and specifically discloses a novel humanized anti-CD22 antibody-monomethyl auristatin-E conjugate. According to the invention, the novel humanized anti-CD22 antibody hRFB4 is adopted. The joints and drug composition of vcMMAE is selected; in a conjugation process, antibody semi-reduction is carried out with a phosphine-type reducing agent tris-(2-carboxyethyl)-phosphine hydrochloride (TCEP); conjugation is carried out with vcMMAE; and conjugate purification is carried out. Through the optimization upon the process, the novel anti-CD22 antibody drug conjugate is prepared. The conjugate has good performances in the respects of crucial physical and chemical analysis indicators and biological activity detection indicators. In both in-vitro and in-vivo pharmacodynamic detections, the conjugate performs a highly efficient and specific target cell-killing effector function.

The invention discloses medicine core feed for preventing bacterial diseases of a pig. The medicine core feed comprises a traditional Chinese medicine extract, ultra-fine powder, a biological fermentation product and nucleotide, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 10-30 parts of glycyrrhiza polysaccharide and 10-30 parts of codonopsis pilosula polysaccharide; the ultra-fine powder comprises the following raw materials in parts by weight: 5-10 parts of herba andrographitis, 5-10 parts of honeysuckle and 10-40 parts of tangerine peel; the biological fermentation product comprises the following raw materials in parts by weight: 10-15 parts of probiotics and 10-15 parts of prebiotics; nucleotide comprises 0.5-0.8 part by weight of ATP (Adenosine Triphosphate). The medicine core feed can prevent and treat the diseases, and prevention and treatment effects can be exerted by adjusting a proportion of a medicine core in a feed particle according to actual clinical demands. At the same time, an energy factor is added in a formula of the medicine core, so that the energy is provided for an organism, and the resistance of the organism can be improved.

The invention provides an application of a nano material in preparation of a medicine for treating atherosclerosis. The nano material comprises a core material, the core material comprises a material A, and the material A is a reduced metal oxide semiconductor nano material. The nano material can be excited by near-infrared light or ultrasonic waves to generate heat and active oxygen, atherosclerotic cell apoptosis is inhibited through the heat effect, lipid metabolism in atherosclerotic cells is regulated and controlled through the heat or the active oxygen, and therefore the treatment effect on atherosclerotic plaques is achieved under the condition that obvious cell death is not caused. The nano material can be bound with atherosclerotic cells, has the ability of targeting atherosclerotic plaque cells, and can improve the treatment effect on atherosclerosis.

The invention discloses medicine-core feed resistant to swine viral diseases. The medicine-core feed comprises traditional Chinese medicine extract, superfine powder, biological leavening and nucleotide, wherein the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-30 parts of astragalus polysaccharide and 10-30 parts of codonopsis pilosula polysaccharides; the superfine powder is prepared from the following raw materials in parts by weight: 5-10 parts of coptis chinensis, 5-10 parts of flos lonicerae, 10-40 parts of organge peel,10-40 parts of Chinese angelica; the biological leavening is prepared from the following raw materials in parts by weight: 10-15 parts of probiotics and 10-15 parts of prebiotics; the nucleotide is 0.5-0.8 part of ATP. The medicine-core feed provided by the invention not only can be used for achieving the effect of preventing diseases, but also can be used for achieving a treatment effect. According to the clinical practical needs, the effect of preventing and treating can be achieved by regulating the proportion of the medicine core in the feed particles. Meanwhile, an energy factor is added in the medicine-core formula, so that not only can energy be provided to the swines, but also the immunity of the swines can be improved.

The invention provides a piperacillin-containing composition. The composition contains piperacillin and also contains ampicillin and sulbactam in a certain ratio. The invention also provides a pharmaceutical preparation and application thereof. The composition and the pharmaceutical preparation which are provided by the invention can obviously inhibit drug-resistant acinetobacter baumannii, especially have good treatment effect on infection of the acinetobacter baumannii resistant to carbapenem antibiotics or cefoperazone sulbactam and has obvious clinical advantage.

The invention discloses a production method of polylactic acid coronary stents. The polylactic acid coronary stents is prepared from the following raw materials of polylactic acid, polycaprolactone, polyacrylate, radix astragali, radix ginseng, radix ophiopogonis, radix salviae miltiorrhizae, lignum dalbergiae odoriferae, rhizoma chuanxiong, poria cocos, processed rhizome pinellia, fructus trichosanthis, bulbus allii macrostemi, tangerine peel and radix glycyrrhizae. Compared with the prior art, the polylactic acid coronary stents are compounded by the materials such as medicines and polylactic acid and the like and are prepared into consumable materials of a 3D printing machine; when the stents are produced, suitable coronary stents can be produced by just inputting patterns suitable for patient stents input into a 3D printing device; the polylactic acid coronary stents are simple to produce; the production cost is reduced; meanwhile, the material rich in medicine components is capable of achieving treatment effect; the polylactic acid coronary stents have values of popularization and application.