127results about How to "Play a therapeutic effect" patented technology

The invention discloses a neuromuscular electrical stimulation system with implantable automatic feedback adjustment, which can accurately feedback the executive condition of the implanted parameter, improve the therapeutic effects of the implantable electrode specific parameter, really realize improvement and repairing of the individual functions and improve the reliability, effectiveness and controllability of the implanted device. The invention adopts the technical proposal that an implantable electrical stimulation generator are combined with an in vitro controller which can control the stimulus wave parameters and instructions, thereby the online in vivo parameters can be effectively monitored, feedback and adjusted; the signal transmission in the in vitro controller are completed at the same time. The neuromuscular electrical stimulation system can be used in the neuromuscular electrical stimulation field.

A ferric oxide nucleus-gadolinium oxide shell composite nano particle with the surface modified by polyethylene glycol is 50-300nm in average particle size, and uses ferric oxide as a nucleus and gadolinium oxide as a shell; the surface of a composite nano porous microsphere is modified by polyethylene glycol; the particle is hydrophilic, has better stability in a wide pH (Potential of Hydrogen) scope, and is biocompatible; the surface of the nano particle is regular; a plurality of ducts are formed in a shell wall; and the nano particle has a T1 and T2 dual-mode magnetic resonance imaging function. The ferric oxide nucleus-gadolinium oxide shell composite nano particle with the surface modified by polyethylene glycol has an obvious dual-mode imaging effect; a preparation method is simple, green and environment-friendly; raw materials are cheap; the particle can be inoculated with a target molecule to detect a tumor more accurately; and the particle has high application values and wide application prospects in the fields of materials, biology and medicine. The invention discloses the preparation method of the particle.

The invention provides ginseng and ganoderma lucidum spore powder tablets and a preparation method thereof, belongs to the technical field of health care products and solves the technical problems that real nutrients are not high in content and not easily absorbed by human bodies and the like due to the fact that existing ginseng Ganoderma lucidum spore powder drugs are mixed with too many excipients. According to the ginseng and ganoderma lucidum spore powder tablets, each tablet comprises raw materials of 0.12-0.4 g of ginseng powder and 1-1.4 g of sporoderm-broken ganoderma lucidum spore powder. Different formulas are provided for different ginseng varieties. The invention also provides the preparation method of the ginseng and ganoderma lucidum spore powder tablets. The ginseng and ganoderma lucidum spore powder tablets are pure natural and have no toxic or side effects as no excipients are added, ginseng can reinforce vital energy and enhance the immunity and disease resistance of the human bodies; the ganoderma lucidum spore powder can enhance the body immunity, phagocytose cancer cells and inhibit the cancer cells from transferring or growing; the ginseng and ganoderma lucidum spore powder are combined, and the curative effect is improved; the ginseng and ganoderma lucidum spore powder tablets can be buccal and are absorbed by the human bodies more easily, and a production process of the ginseng and ganoderma lucidum spore powder tablets is simple and is convenient to operate.

The invention relates to antibacterial modified chitosan spray and a preparation method thereof. The preparation method of the antibacterial modified chitosan spray comprises the steps of preparing modified chitosan, preparing gardenia oil, preparing geniposide, preparing spirulina polysaccharide and spirulina polypeptide and preparing chitosan spray. The antibacterial modified chitosan spray is applied to treatment on male and female pruritus vulvae and fungal infection, bacterial infection, folliculitis and vaginitis, also can be used for treating bedsore and long-term skin inflammation, can be widely applied and has antibacterial ability more than 99% on staphylococcus aureus, escherichia coli, streptococcus, candida albicans, pseudomonas aeruginosa or other fungi.

The invention relates to a health-protection cap with functions of magnet therapy and knocking massage. The health-protection cap comprises a cap body. A magnetic knocking hammer is arranged at the position corresponding to the head baihui point of human body, on the cap body. At least one acupuncture-point position except for the position corresponding to the head baihui point of a human body is provided with a static magnet. A gyromagnetic mechanism is also arranged on the cap body. The gyromagnetic mechanism comprises an active magnet and an actuating device used for actuating the active magnet to rotate. When the active magnet rotates, the magnetic-pole positions the two ends of the active magnet are transformed alternately. On the one hand, the magnetic knocking hammer oscillates because of the principle that like poles repel; unlike poles attract and carries out dynamic-magnet acupuncture and the knocking massage on the head baihui point of the human body, on the other hand, the magnetic force lines around the static magnet move up and down because of the principle that like poles repel; unlike poles attract and carry out magnetic force line simulated acupuncture on other corresponding acupuncture points of human head. The health-protection cap has the advantages of simple structure, powerful functions, wide range of treatment, obvious treatment effect, low costs and strong practicability.

The invention discloses an epitope-specific antibody screening method, and is used for solving the problem of low screening efficiency of functional antibodies having treatment function in an antibodylibrary screening technology; the method includes the steps of screening of functional epitope peptides and screening of living cells. The invention also provides a fully human anti-PD-1 monoclonal antibody obtained by screening a phage display antibody library by the method; for specific functional epitopes, the fully human anti-PD-1 monoclonal antibody can effectively block the binding of PD-1to a ligand of PD-1, has the characteristics of high affinity and low EC50, and can produce treatment effect on animal models at low dose. The screening efficiency of the functional antibody is greatly improved, and a potential, safer and more economical immunotherapy drug is provided for patients with malignant tumors and immune diseases.

A Chinese medicine for treating beriberi is prepared from 14 Chinese-medicinal materials including tangerine peel, liquorice root, ginger, myrrh, etc through immersing them in liquor for 7-15 days.

The invention provides a picolinamide compound containing a triazole or quinolinone structure and application of the picolinamide compound. According to a technical scheme in the invention, extensiveresearch is conducted on the picolinamide compound, and a plurality of structural sites are modified and transformed, so a series of picolinamide derivatives with novel structures are synthesized. Onsuch a basis, the chemical properties and the biological properties of the derivatives are investigated, and results show that the derivatives have strong c-Met kinase inhibition effect and can achieve a treatment effect on diseases caused by abnormal high expression of c-Met kinase. Thus, the invention determines the use of the compound or its derivatives in the preparation of drugs for treatingproliferative diseases or tumors. Experimental results show that the compound has exact and remarkable inhibition effect on tumor cells, so data support is provided for pharmaceutical application of the compound.

The invention discloses a fat synthetase inhibitor and applications thereof, and belongs to the technical field of medical biology. The inhibitor can significantly inhibit the activity of fatty acid synthetase without affecting normal expression, and can also adjusting the proportion of fatty acid in cells; the inhibitor has good tumor proliferation inhibition effects, and can make the growth period of tumor cells stagnate in interphase, prevent the tumor cells from splitting, inhibit the proliferation of the tumor cells, promote the apoptosis of the tumor cells and achieve treatment effects on tumor; and the inhibitor can be used for drugs for treating tumor and metabolic related diseases, so that the inhibitor has important clinical application prospects.

The invention provides an azithromycin granule oral preparation capable of effectively covering up the bitter of azithromycin. The azithromycin granule oral preparation is prepared from the azithromycin, sucrose, carboxymethyl starch sodium, sodium dodecyl sulfate and a novel sweetener Neotame. According to the invention, in the preparing process of azithromycin granules, not only is the novel sweetener introduced, the oral preparation of which the taste and the sweetness are suitable for people to take can be prepared by a small account of the novel sweetener and the compliance of a patient is improved, but also the cost can be reduced; and meanwhile, by regulating the proportion of a formula, the dissolution of the azithromycin granules is greatly improved, and thus, not only can the azithromycin granules be easily accepted by the patient and be particularly easy to take by child patients, but also the improvement of the dissolution ensures the azithromycin easier and faster to adsorb and ensures the curative effects of the azithromycin to be sufficiently taken.

The invention relates to the technical field of biological pharmacy, and specifically discloses a novel humanized anti-CD22 antibody-monomethyl auristatin-E conjugate. According to the invention, the novel humanized anti-CD22 antibody hRFB4 is adopted. The joints and drug composition of vcMMAE is selected; in a conjugation process, antibody semi-reduction is carried out with a phosphine-type reducing agent tris-(2-carboxyethyl)-phosphine hydrochloride (TCEP); conjugation is carried out with vcMMAE; and conjugate purification is carried out. Through the optimization upon the process, the novel anti-CD22 antibody drug conjugate is prepared. The conjugate has good performances in the respects of crucial physical and chemical analysis indicators and biological activity detection indicators. In both in-vitro and in-vivo pharmacodynamic detections, the conjugate performs a highly efficient and specific target cell-killing effector function.

The invention provides an application of a nano material in preparation of a medicine for treating atherosclerosis. The nano material comprises a core material, the core material comprises a material A, and the material A is a reduced metal oxide semiconductor nano material. The nano material can be excited by near-infrared light or ultrasonic waves to generate heat and active oxygen, atherosclerotic cell apoptosis is inhibited through the heat effect, lipid metabolism in atherosclerotic cells is regulated and controlled through the heat or the active oxygen, and therefore the treatment effect on atherosclerotic plaques is achieved under the condition that obvious cell death is not caused. The nano material can be bound with atherosclerotic cells, has the ability of targeting atherosclerotic plaque cells, and can improve the treatment effect on atherosclerosis.

The invention provides a piperacillin-containing composition. The composition contains piperacillin and also contains ampicillin and sulbactam in a certain ratio. The invention also provides a pharmaceutical preparation and application thereof. The composition and the pharmaceutical preparation which are provided by the invention can obviously inhibit drug-resistant acinetobacter baumannii, especially have good treatment effect on infection of the acinetobacter baumannii resistant to carbapenem antibiotics or cefoperazone sulbactam and has obvious clinical advantage.