Fat synthetase inhibitor and applications thereof

Abstract

The invention discloses a fat synthetase inhibitor and applications thereof, and belongs to the technical field of medical biology. The inhibitor can significantly inhibit the activity of fatty acid synthetase without affecting normal expression, and can also adjusting the proportion of fatty acid in cells; the inhibitor has good tumor proliferation inhibition effects, and can make the growth period of tumor cells stagnate in interphase, prevent the tumor cells from splitting, inhibit the proliferation of the tumor cells, promote the apoptosis of the tumor cells and achieve treatment effects on tumor; and the inhibitor can be used for drugs for treating tumor and metabolic related diseases, so that the inhibitor has important clinical application prospects.

Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a liposynthase inhibitor and its application. Background technique

[0002] Fatty acids in the human body are directly derived from exogenous fatty acids ingested from the outside world on the one hand, and endogenous fatty acids synthesized by the body itself on the other hand. Fatty acid synthase (FASN) is a key enzyme in the process of endogenous fatty acid synthesis in organisms. It generates long-chain fatty acids by catalyzing acetyl-CoA and malonyl-CoA. FASN includes acetyltransferase (AT), malonyltransferase (MT), β-ketoacyl synthase (KS), β-ketoacyl reductase (KR), β-hydroxyacyl dehydratase (HD ), enoyl reductase (ER) and thioesterase (TE), which can be divided into two subtypes, type I and type II. FASN in bacteria and plants belongs to type II, which is a multi-enzyme system composed of the above seven functional domains as independent enzyme...

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