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724 results about "Interphase" patented technology

Interphase is the phase of the cell cycle in which a typical cell spends most of its life. Prophase, however is the longest stage of mitosis. During interphase, the cell copies its DNA in preparation for mitosis. Interphase is the 'daily living' or metabolic phase of the cell, in which the cell obtains nutrients and metabolizes them, grows, reads its DNA, and conducts other "normal" cell functions. This phase was formerly called the resting phase. However, interphase does not describe a cell that is merely resting; rather, the cell is living and preparing for later cell division, so the name was changed. A common misconception is that interphase is the first stage of mitosis, but since mitosis is the division of the nucleus, prophase is actually the first stage.

Continuous liquid interphase printing

A method of forming a three-dimensional object, comprises providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid while concurrently advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof, the gradient of polymerization zone comprising the polymerizable liquid in partially cured form. Apparatus for carrying out the method is also described.
Owner:CARBON INC

Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue

A composite scaffold with a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The multi-layered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition, such as articular cartilage.
Owner:ETHICON INC

Continuous liquid interphase printing

A method of forming a three-dimensional object is carried out by providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid and advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently with the irradiating and / or advancing steps: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof. The gradient of polymerization zone comprises the polymerizable liquid in partially cured form (e.g., so that the formation of fault or cleavage lines between layers of solid polymer in the three-dimensional object is reduced). Apparatus for carrying out the method is also described.
Owner:CARBON INC

Formulations for cell-schedule dependent anticancer agents

The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides a method of treating cancer in a mammal. The present invention also provides a method of blocking, impeding, or otherwise interfering with cell cycle progression at the G1-phase, G1 / S interphase, S-phase, G2 / M interface or M-phase of the cell cycle in a mammal. The methods includes administering to a mammal an effective amount of a flowable composition of the present invention.
Owner:QLT USA INC

Polymer electrolyte, intercalation compounds and electrodes for batteries

Solid battery components are provided. A block copolymeric electrolyte is non-crosslinked and non-glassy through the entire range of typical battery service temperatures, that is, through the entire range of at least from about 0° C. to about 70° C. The chains of which the copolymer is made each include at least one ionically-conductive block and at least one second block immiscible with the ionically-conductive block. The chains form an amorphous association and are arranged in an ordered nanostructure including a continuous matrix of amorphous ionically-conductive domains and amorphous second domains that are immiscible with the ionically-conductive domains. A compound is provided that has a formula of LixMyNzO2. M and N are each metal atoms or a main group elements, and x, y and z are each numbers from about 0 to about 1. y and z are chosen such that a formal charge on the MyNz portion of the compound is (4-x). In certain embodiments, these compounds are used in the cathodes of rechargeable batteries. The present invention also includes methods of predicting the potential utility of metal dichalgogenide compounds for use in lithium intercalation compounds. It also provides methods for processing lithium intercalation oxides with the structure and compositional homogeneity necessary to realize the increased formation energies of said compounds. An article is made of a dimensionally-stable, interpenetrating microstructure of a first phase including a first component and a second phase, immiscible with the first phase, including a second component. The first and second phases define interphase boundaries between them, and at least one particle is positioned between a first phase and a second phase at an interphase boundary. When the first and second phases are electronically-conductive and ionically-conductive polymers, respectively, and the particles are ion host particles, the arrangement is an electrode of a battery.
Owner:MASSACHUSETTS INST OF TECH

Full Karyotype Single Cell Chromosome Analysis

A full set of 24 chromosome-specific probes to analyze single cells or cell organelles to test for abnormalities is described. When used in an assay based on sequential hybridization, the full set is comprised of three subsets of chromosome-specific probes with each set comprised of 8 different probes. Also described are assays using a set of probes to analyze single cells and cellular organelles to accurately determine the number and type of targeted human chromosomes in various types of cells and cell organelles, such as tumor cells, interphase cells and first polar bodies biopsied from non-inseminated oocytes. Methods of selection or generation of suitable probes and hybridization protocols are described, as are preferred probes for frill set of 24 chromosome-specific probes to target all 24 human chromosomes are described in the Tables.
Owner:REPROGENETICS +1

Automated segmentation, classification, and tracking of cell nuclei in time-lapse microscopy

InactiveUS20060127881A1Efficient dynamic cell imaging studyIncrease capacityImage enhancementImage analysisAutomated segmentationInterphase Cell
Methods and apparatus are provided for the automated analysis of images of living cells acquired by time-lapse microscopy. The new methods and apparatus can be used for the segmentation, classification and tracking of individual cells in a cell population, and for the extraction of biologically significant features from the cell images. Based upon certain extracted features, the inventive image analysis methods can characterize a cell as mitotic or interphase and / or can classify a cell into one of the following mitotic phases: prophase, metaphase, arrested metaphase, and anaphase with high accuracy.
Owner:THE BRIGHAM & WOMENS HOSPITAL INC

Automatic electrocardiogram recognition system

The invention discloses an automatic electrocardiogram recognition system. The system comprises an electrocardiogram acquisition device, a wireless / wired network transmission module, an electrocardiogram collection and time domain feature recognizer, an electrocardiogram dominant wave interphase recognizer, an electrocardiogram QRS wave group similarity recognizer and an electrocardiogram queuing recognizer, the electrocardiogram acquisition device inputs acquired data to the electrocardiogram collection and time domain feature recognizer via the transmission module, the electrocardiogram collection and time domain feature recognizer recognizes to obtain positions of peak points of P waves, QRS waves and T waves on a 12-lead, the electrocardiogram dominant wave interphase recognizer recognizes heart rate to obtain normal and abnormal results of the heart rate, the electrocardiogram QRS wave group similarity recognizer recognizes whether an electrocardiogram probably has premature beat or not, and the electrocardiogram queuing recognizer sequences and outputs. The system performs real-time computer-aided analysis of clinically acquired 12-lead electrocardiograms to automatically recognize arrhythmia and premature beat electrocardiograms, and accordingly efficiency of electrocardiogram analysis is improved while a priority processing means is provided for emergency electrocardiograms.
Owner:EAST CHINA NORMAL UNIV

Bi-ventricular ventricular capture management in cardiac resyncronization therapy delivery devices

The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., “CRT”). The invention also provides ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the stimulus captured. If a loss-of-capture (LOC) signal results from the capture management testing, then the applied pacing pulses are modified and the conduction test repeated. If LOC, an alert message can issue. Other aspects include: use of a trend of A-RV / LV and LV-RV timing intervals to monitor changes in the patient's heart conduction properties; bi-ventricular verification test and search—while still pacing BiV by detecting latent sense; single-V pacing threshold search, use of timing of sense in other V chamber to establish capture and LOC windows; (iv) use of a premature V pace rather than short AV interval if VV cannot be discriminated from AV; (v) option to run a threshold search only if the Bi-ventricular verification test fails.
Owner:MEDTRONIC INC

Fiber-reinforced ceramic composite material comprising a matrix with a nanolayered microstructure

A fiber-reinforced ceramic matrix composite material exhibiting increased matrix cracking strength and fracture toughness is produced by sequentially depositing a plurality of 5-500 nanometer-thick layers of a primary ceramic matrix material phase periodically separated by 1-100 nanometer-thick intermediate layers of a secondary matrix material phase onto the reinforcing fibers upon their consolidation. The resultant nanolayered matrix enhances the resistance to the onset of matrix cracking, thus increasing the useful design strength of the ceramic matrix composite material. The nanolayered microstructure of the matrix constituent also provides a unique resistance to matrix crack propagation. Through extensive inter-layer matrix fracture, debonding and slip, internal matrix microcracks are effectively diverted and / or blunted prior to their approach towards the reinforcing fiber, thus increasing the apparent toughness of the matrix constituent. This unique toughening mechanism serves to dampen energetic co-planar macrocrack propagation typically observed in conventionally manufactured ceramic matrix composites wherein matrix cracks are usually deflected at the fiber / matrix interphase region.
Owner:ROLLS ROYCE HIGH TEMPERATURE COMPOSITES INC

Alternating-current brushless generator fault detection method based on exciter exciting current

The invention provides an alternating-current brushless generator fault detection method based on an exciter exciting current. The method comprises the following steps: firstly, measuring the direct-current component and each subharmonic amplitude value of the exciter exciting current of a generator set; and then, detecting whether the generator set generates electrical failures or not with a stator winding turn-to-turn short circuit diagnosis algorithm, a rotor winding turn-to-turn short circuit diagnosis algorithm, an exciter fault diagnosis algorithm and a rotary rectifier fault diagnosis algorithm, wherein the electrical failures comprise stator winding turn-to-turn short circuit, rotor winding turn-to-turn short circuit, exciter rotor winding turn-to-turn short circuit, exciter rotor winding interphase short circuit, open circuit of one diode of the rotary rectifier and short circuit of one diode of the rotary rectifier. According to the LabView development fault diagnosis algorithm, various electrical faults can be detected by measuring the exciter exciting current so as to save measurement points, and various invasive sensors do not need to be installed in the generator. The alternating-current brushless generator fault detection method has good instantaneity, and the on-line detection requirement can be satisfied.
Owner:NAVAL UNIV OF ENG PLA

Classifying cells based on information contained in cell images

Image analysis methods analyze images of cells and place the cells in particular cell cycle phases based upon certain features extracted from the images. The methods can also quantify the total amount of DNA in a cell based on specific features such as fluorescence intensity from fluorescent molecules that bind to DNA. Further, the methods can characterize a cell as mitotic or interphase based on chosen parameters such as the variance in intensity observed in a cell image and / or the size of a region containing DNA. In one example, image analysis methods can classify the cell into one of the following five phases: G1, S, G2, telophase, and an early stage mitotic phase comprised of prophase, metaphase, and anaphase.
Owner:CYTOKINETICS INC

Polymeric core-shell nanoparticles with interphase region

A polymeric nanoparticle composition is provided. The nanoparticle may be of a core / shell configuration with an interphase region connecting the core and the shell. The mean average diameter of the polymer nanoparticles may be less than about 250 nm. The size, composition, and / or configuration of the interphase region may be varied to achieve desired physical and / or chemical properties of the resulting polymeric nanoparticles, and of the compositions into which the nanoparticles are compounded.
Owner:BRIDGESTONE CORP

System and method of AV interval selection in an implantable medical device

An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
Owner:MEDTRONIC INC

Ophthalmic lens comprising a base of polymeric material with a coating having an interferential, Anti-reflective, Anti-iridescent and ir filter multiple layer structure

Ophthalmic lens including a base of polymeric material with a coating having an interferential, anti-reflective, anti-iridescent and infrared filter multiple layer structure. An interphase, a first layer (of 91-169 nm) with a refraction index higher than 1.8, a second layer (of 128-248 nm) with a refraction index lower than 1.65, a third layer (of 73-159 nm) with a refraction index higher than 1.8 and a fourth layer (of 40-138 nm) with a refraction index lower than 1.8. A total thickness of the multiple layer structure is less than 600 nm. The structure can have intermediate layers with intermediate refraction indices, in which case a doublet of two adjacent layers that fulfil the thicknesses above is replaced by a triplet so that the thickness and an optical thickness of the triplet differ from those of the doublet by less than 5%, respectively.
Owner:HORIZONS OPTICAL S L U

Method for pre-lithiating electrode material of lithium ion battery

The invention relates to an electrode material of a lithium ion battery, in particular to a method for pre-lithiating a cathode material. The method comprises the steps that an electrolytic cell cathode cavity is made of the electrode material such as a lithium ion cathode material and arranged in a lithium ion conductive organic electrolyte; an anode cavity is an aqueous solution containing lithium salt or an organic solution; the anode cavity is separated from the cathode cavity by a lithium ion conductor ceramic membrane or a composite membrane of lithium ion conductor ceramic and a high molecular material; an electric potential and current density are controlled by external circuit charge and discharge equipment to allow lithium ions to migrate to a cathode from an anode through the membrane; and an SEI (Solid Electrolyte Interphase) membrane is formed on the surface of the material; or the electrode material is pre-lithiated. According to the method, a cheap and safe lithium ion saline solution serves as a source of the lithium ion; the SEI membrane is generated for the cathode of the lithium ion battery in advance; or lithium is supplemented to the electrode material; the coulombic efficiency and cycling stability of the cathode material can be improved; a formation process in production of the lithium ion battery in the prior art is simplified; the electrode material and cost are saved; and the method is safe and efficient and has a large-scale application prospect.
Owner:赵前永

Nano-composite martensitic steels

Carbon steels of high performance are disclosed that contain dislocated lath structures in which laths of martensite alternate with thin films of austenite, but in which each grain of the dislocated lath structure is limited to a single microstructure variant by orienting all austenite thin films in the same direction. This is achieved by careful control of the grain size to less than ten microns. Further improvement in the performance of the steel is achieved by processing the steel in such a way that the formation of bainite, pearlite, and interphase precipitation is avoided.
Owner:MMFX STEEL CORP OF AMERICA +1

No-ozone cleanable electrostatic dust collector

The present invention relates to a no-ozone cleanable electrostatic dust collector which comprises an ionized region, a dust collecting region, a high-voltage alternating current power supply and a high-voltage direct current power supply. The ionized region is arranged above the dust collecting region; the high-voltage alternating current power supply is connected with the ionized region; the high-voltage direct current power supply is connected with the dust collecting region; adjacent ionized electrode plates are two different electrodes; dust collecting electrode plates are fixed on an outer frame by the block position; and the interphase dust collecting electrode plates are connected by conductive material, so that the adjacent dust collecting electrode plates are two different electrodes. The no-ozone cleanable electrostatic dust collector can collect dust efficiently, no ozone nearly is produced, no static electricity is accumulated, thus being safe and environment protective and having wide application range.
Owner:SHUNDE APOLLO AIR CLEANER

Methods for producing silicon carbide architectural preforms

Methods are disclosed for producing architectural preforms and high-temperature composite structures containing high-strength ceramic fibers with reduced preforming stresses within each fiber, with an in-situ grown coating on each fiber surface, with reduced boron within the bulk of each fiber, and with improved tensile creep and rupture resistance properties for each fiber. The methods include the steps of preparing an original sample of a preform formed from a pre-selected high-strength silicon carbide ceramic fiber type, placing the original sample in a processing furnace under a pre-selected preforming stress state and thermally treating the sample in the processing furnace at a pre-selected processing temperature and hold time in a processing gas having a pre-selected composition, pressure, and flow rate. For the high-temperature composite structures, the method includes additional steps of depositing a thin interphase coating on the surface of each fiber and forming a ceramic or carbon-based matrix within the sample.
Owner:NASA

Method for enhancing electrostatic spinning nanofiber membrane

The invention discloses a method for enhancing an electrostatic spinning nanofiber membrane. The blending electrostatic spinning-hot rolling bonding net fixing technology which can effectively improve the strength of the electrostatic spinning nanofiber membrane is provided. The method for enhancing the electrostatic spinning nanofiber membrane is characterized in that interphase blending electrostatic spinning is conducted through multiple types of thermoplastic high polymers with the fusion point at least 20 DEG C lower than that of other components or low-fusion-point thermoplastic high polymers and non-thermoplastic high polymers, electrostatic spinning jet flows of the components are distributed frontwards and backwards in the moving direction of a receiving device, and fibers are distributed randomly in a staggered mode; after hot rolling is conducted on a blending electrostatic spinning fiber membrane, the blending electrostatic spinning fiber membrane is treated, the hot pressing temperature is slightly higher than the fusion starting temperature of the low-fusion-point thermoplastic high polymers, time ranges from 1min to 10min, the pressure ranges from 1MPa to 20MPa, after hot pressing is conducted, part of the low-fusion-point thermoplastic high polymers is fused, point adhesion is generated on the nanofiber intersection portions, and a hole is not blocked. The method for enhancing the electrostatic spinning nanofiber membrane has the advantages that the strength of the prepared enhanced electrostatic spinning nanofiber membrane is far higher than that of a common electrostatic spinning membrane and original good performance of the electrostatic spinning nanofiber membrane can be kept.
Owner:TIANJIN POLYTECHNIC UNIV

Hydrogenation method for production of hydrogen peroxide by anthraquinone process

The invention discloses a hydrogenation method for production of hydrogen peroxide by the anthraquinone process, belonging to the technical field of chemical industry reaction. The method provided by the invention comprises: dispersing the gaseous phase containing hydrogen into the working solution containing the anthraquinone derivatives to obtain the gas-liquid mixing fluid containing micron bubbles, so that the gas-liquid mixing fluid passes through the pipe reactor filled with the hydrogenation catalyst at the space velocity of 3 to 1000h<-1> to finish the hydrogenation process. In the method provided by the invention, the gas-liquid micro-dispersing process and the static bed catalytic hydrogenation process are directly integrated, so that the interphase mass transfer is strengthened, and the contacts between different reactants and between the reactant and the catalyst are more sufficient and more uniform, thereby enhancing the efficiency and the controllability of the hydrogenation process and improving the economical efficiency and the security of the production of the hydrogen peroxide.
Owner:TSINGHUA UNIV

Well-defined nanosized building blocks for organic/inorganic nanocomposites

Functionalized silsesquioxanes containing from 6 to 24 silicon atoms and minimally about 67 mol percent RSiO3 / 2 moieties where R is a phenyl group bearing a chemically reactive functional group are highly suitable for use as nanoparticles in producing highly ordered nanocomposites of many types, containing a high proportion of interphase. The nanocomposites have unusual physicochemical properties due to the use of uniform, highly functionalized nanoparticles.
Owner:RGT UNIV OF MICHIGAN

Nanofiltration membrane with nanometer hybridized desalination layer

The invention discloses a nanofiltration membrane with a nanometer hybridized desalination layer. The desalination layer formed through interphase hybridization of an inorganic nanoparticle with a particle size of 1 to 1000 nm and polyamide or polyimide is arranged on a porous supporting layer of the membrane. A preparation method for the nanofiltration membrane mainly comprises the following steps: pre-dispersion of the nanoparticle, preparation of a solution A, preparation of a solution B, interfacial polymerization, surface polishing and roller squeezing, rinsing with deionized water, moisture retention with glycerin and drying, wherein air drying and sulfonation can be carried out after surface polishing and roller squeezing. According to the invention, nanometer hybridization effects of a high polymer nano-material in the nanofiltration membrane are made full use of, so hydrophilic performance, antioxidation performance and anti-pollution performance of the nanofiltration membrane are improved, and the nanofiltration membrane has the advantages of low pollution, great flux and a high removal rate. The preparation method is scientific and reasonable, enables the nanometer composite nanofiltration membrane with a specific nanoparticle and polyamide hybridized desalination layer to be prepared and has higher ion selectivity, low pollution capability and temperature stability.
Owner:VONTRON TECH CO LTD

Non-aqueous electrolyte for lithium iron phosphate battery

The invention discloses a non-aqueous electrolyte for a lithium iron phosphate battery. The non-aqueous electrolyte comprises 70 to 85 weight percent of carbonic ester compound, 3 to 20 weight percent of various function additives and 11 to 17 weight percent of lithium hexafluorophosphate, wherein the carbonic ester compound is one of ethylene carbonate, propylene carbonate, butylene carbonate, dimethyl carbonate and diethyl carbonate or a mixture of more of the ethylene carbonate, the propylene carbonate, the butylene carbonate, the dimethyl carbonate and the diethyl carbonate; and the additives comprise one of 0.5 to 10 percent of film-forming additive, 0.5 to 10 percent of high-temperature additive, 0.5 to 10 percent of low-temperature additive, 0.5 to 10 percent of overcharge-preventing additive and 0.001 to 2 percent of stability additive, and a mixture of more of the additives. The non-aqueous electrolyte for the lithium iron phosphate battery has the advantages that the solubility and dissociation of the lithium hexafluorophosphate are improved, and electric conductivity is improved; the low temperature resistance of a solid electrolyte interphase (SEI) is reduced; the overall stability of the battery is improved, the overall service life of the battery is prolonged, the compatibility of an electrolyte and a cathode is improved, circulation of the battery is improved, and the service life is prolonged; and the non-aqueous electrolyte can have high performance at high temperature.
Owner:广东金光高科股份有限公司

Electrotransport devices, methods and drug electrode assemblies

A drug electrode assembly usefully employed in an electrotransport device for the delivery of drugs across a tissue surface includes an electrode, a drug reservoir which stores the drug (including an ionized (e.g., anionic) or neutrally charged drug species), and a liquid impermeable solid-state assist ion conducting barrier layer interposed between the electrode and the drug reservoir. The barrier layer can be a single-ion conductor of a specific (unique) species of ion called the assist ion. During drug delivery, the assist ion moves across the barrier layer into or out of the drug reservoir, and as the assist ion crosses the barrier layer / drug reservoir interphase, the drug species moves to the tissue surface. The assist ion can be, for example, sodium ions (Na+), and the electrode can be an electrode of the assist ion (i.e., a sodium electrode).
Owner:POLYPLUS BATTERY CO INC

Electrocardiosignal data acquisition and processing method and system

The invention provides an electrocardiosignal data acquisition and processing method and system. The electrocardiosignal data acquisition and processing system comprises a data processing unit which comprises a data analysis unit. The data analysis unit comprises an RR interphase preprocessing unit and an instantaneous feature extraction unit. The RR interphase preprocessing unit is used for preprocessing an RR interphase sequence, so that a signal bandwidth of an RR interphase is enabled to fall in a frequency bandwidth requested by the best amplitude frequency features of the Hilbert transform. The instantaneous feature extraction unit is used for extracting instantaneous amplitude features and instantaneous frequency features of the RR interphase sequence. The electrocardiosignal data acquisition and processing system has the advantages that through acquisition and processing of the electrocardiosignals, complexity of data analysis is reduced, and amount of calculation is decreased; the system is simple in design, low in cost and convenient to apply.
Owner:EDAN INSTR
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