26 results about "Core shell nanoparticles" patented technology

The invention discloses light-driven toxin-enriched composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises light-driven hydrogel and detection hydrogel, the light-driven hydrogel is agarose hydrogel doped with Au (at) Ag core-shell nano particles; the detection hydrogel is a double strand formed by an okadaic acid aptamer and a complementary sequence cDNA thereof, and a double strand formed by a domoic acid aptamer and a complementary sequence DNAzyme thereof, the hairpin H1 is used for modifying a quenching group BHQ2 at the 3'end, the hairpin H2 is used for modifying a fluorophore Cy3 at the neck part, the hairpin H3 is used for modifying a fluorophore FAM and a quenching group BHQ1 at the two ends respectively, and the metal ion doped agarose hydrogel is used for catalyzing DNAzyme cyclic shearing; and the photo-thermal driving unit is positioned on the detection function unit. According to the present invention, with the composite system of upper layer photo-thermal enrichment and lower layer dual-signal detection, the rapid and high-sensitivity simultaneous detection of the okadaic acid and the domoic acid is achieved through the combination of the photo-thermal transpiration effect and the HCR and DNAzyme cyclic shearing reaction;

A method for preparing a flexible lead-free piezoelectric composite film, in which a rare-earth-doped SrSbxSc2-xTaCl2O8 precursor powder is prepared and coated with a BaTiO3 shell to form core-shell nanoparticles, and the core-shell nanoparticles are dispersed in a polyvinylidene fluoride (PVDF) matrix to obtain the flexible lead-free piezoelectric composite film. An electronic device including such piezoelectric composite film is also provided.

This invention relates to the field of temporary protective materials for glass processing, specifically a high-strength, low-emissivity temporary protective film for glass and its preparation method. The protective film is a core-shell nanoparticle-reinforced waterborne polyurethane composite film with a gradient crosslinking structure, composed of the following components: 100 parts by weight of waterborne polyurethane matrix resin, 10-20 parts by weight of a low-temperature unblocking crosslinking agent, 5-20 parts by weight of core-shell nanoparticles, and 0.5-2 parts by weight of additives. The protective film has a gradient crosslinking structure along its thickness direction, with a higher crosslinking density on the surface near the air side than on the bottom surface near the glass side. This invention significantly improves the film's density through the synergistic reinforcement of the gradient crosslinking structure and core-shell nanoparticles, achieving a surface water contact angle of over 90°. Even after 72 hours in a high-humidity environment, it maintains its integrity and good protective performance, effectively solving the technical problem of traditional water-soluble films easily absorbing moisture and softening.

The invention relates to the field of stiffness-increasing master batches, in particular to a stiffness-increasing master batch special for a degradable tobacco film and a preparation method of the stiffness-increasing master batch. The composite material comprises the following components in percentage by weight: 55-75% of a degradable polymer matrix, 20-35% of a synergistic enhancement system and 3-8% of a functional aid, the degradable polymer matrix is prepared from 40 to 60 percent of polylactic acid and 15 to 25 percent of poly (adipic acid) / butylene terephthalate; the synergistic enhancement system comprises 3%-8% of modified graphene, 12%-22% of degradable core-shell nanoparticles and 5%-10% of a bio-based stiffness increasing agent; the functional auxiliary agent is prepared from 2 to 5 percent of a degradable compatilizer, 0.5 to 1.5 percent of a bio-based antioxidant and 0.5 to 1.5 percent of a biodegradation accelerant. The invention relates to a novel smoke film material which has rigidity and antistatic property superior to those of a traditional BOPP (biaxially-oriented polypropylene) film and can be quickly and completely biodegraded in a natural environment, and unification of high performance and environmental protection property is realized.

The invention provides a preparation method of a high-elasticity wear-resistant fabric, and relates to the technical field of textile fabric preparation, the preparation method comprises the following steps: carrying out melt blending spinning to obtain composite elastic fibers, doubling and twisting the composite elastic fibers and chinlon 66 filaments to form warp yarns, and taking UHMWPE filaments as core yarns, the preparation method comprises the following steps: taking a polyurethane urea elastomer and silicon carbide and graphene core-shell nanoparticles as raw materials, taking composite elastic fibers as fasciated yarns for wrapping to form weft yarns, weaving by a three-dimensional interlacing weave process of the warp yarns and the weft yarns, forming a quincunx locking structure by interweaving points, compounding the polyurethane urea elastomer and the silicon carbide and graphene core-shell nanoparticles to form a coating precursor solution, and immersing the rough fabric blank into the coating precursor solution; the composite elastic fiber has both high elasticity and basic wear resistance, the three-dimensional interlaced weave process can further enhance the synergy of the elasticity and wear resistance of the fabric, a coil is stretched to release elasticity when the quincunx locking structure is stretched, the coil is quickly reset when the quincunx locking structure rebounds, and the wear resistance of the fabric is improved. The coating precursor solution can form a wear-resistant elastic coating which is tightly combined with fibers and structures on the surface of the fabric.

Disclosed is a method of forming a plurality of core / shell nanoparticles comprising spray coating a plurality of ZnO particles with a carbon precursor to form a plurality of clusters having a ZnO-based core and a carbon-containing shell.

This invention relates to a self-triggered demulsification Pickering emulsion cascade catalytic system, its preparation method, and its application. The preparation method includes: preparing Fe3O4 magnetic nanoparticles by co-precipitation; coating their surface with a SiO2 shell using a modified Stöber method to obtain Fe3O4@SiO2 core-shell nanoparticles; simultaneously grafting a triamine silane coupling agent and octyltrimethoxysilane onto the Fe3O4@SiO2 surface using a one-pot method to obtain magnetic amphiphilic nanoparticles; dividing the magnetic amphiphilic nanoparticles into two batches, and immobilizing glucose oxidase and Candida antarcticis lipase B respectively via EDC / NHS-mediated amide coupling reaction to obtain nanoparticle catalysts; using the nanoparticle catalysts as solid emulsifiers in Pickering emulsions to construct an oil-water two-phase cascade catalytic system, realizing a cascade catalytic reaction of glucose oxidation – peracidification – olefin epoxidation; utilizing the accumulation of gluconic acid during the reaction to lower the pH, triggering emulsion demulsification, achieving product separation and magnetic recovery of the nanoparticle catalysts.

The invention discloses a fusion membrane packaged gold-iron core-shell nano diagnosis and treatment preparation as well as a preparation method and application thereof. The preparation takes gold-iron core-shell nanoparticles as a core, and the surface of the gold-iron core-shell nanoparticles is coated with a biomimetic membrane formed by fusion of bacterial outer membrane vesicles and tumor cell membranes. The preparation method comprises the steps of synthesis of the gold-iron nano core, surface functionalization and self-assembly coating of the fusion membrane. The preparation can simultaneously exert photothermal therapy and ferroptosis induction effects under near-infrared light irradiation, effectively initiates tumor cell immunogenicity death, and cooperatively activates dendritic cells and enhances T cell immune response by means of a pathogen related molecular mode carried by the fusion membrane and a tumor related antigen. Experiments show that the preparation can significantly inhibit tumor growth and metastasis, induce long-acting anti-tumor immune memory, and provide a multi-mode synergistic nano platform for tumor immunotherapy.

The invention provides fluorine-containing polymer hollow nanoparticles, a photopolymer type holographic recording medium and application of the photopolymer type holographic recording medium, polystyrene nanospheres are swelled by a solution containing a fluorine-containing monomer, a fluorine-containing cross-linking agent and a photoinitiator, and then polymerization reaction is performed to obtain a core-shell nanoparticle emulsion; tetrahydrofuran is added into the core-shell nanoparticle emulsion, the polystyrene nanosphere template in the core-shell nanoparticle emulsion is completely dissolved and extracted out, the fluorine-containing polymer hollow nanoparticles are obtained, the photopolymer type holographic recording medium containing the fluorine-containing polymer hollow nanoparticles enables the sensitivity of a holographic grating to be larger than 100 cm / mJ, and the photopolymer type holographic recording medium can be applied to the holographic grating. The diffraction efficiency of the recording grating is greater than 95%, the refractive index modulation degree is greater than 0.2, the haze is lower than 1%, and the recording grating has excellent shear strength and tensile strength.

The invention relates to the technical field of biomedical materials, in particular to a gadolinium oxide-based nano preparation as well as a preparation method and application thereof. The preparation method of the preparation comprises the following steps: preparing gadolinium oxide nanoparticles through a hydrothermal method and amination modification, and dissolving the gadolinium oxide nanoparticles in deionized water to obtain a contrast agent solution; dropwise adding the nano-particles into a gold source solution under stirring at a certain temperature to obtain nano-particles with core-shell structures; and finally, slowly adding the synthesized dispersant solution of the water-soluble polymer into the core-shell nanoparticle solution to obtain a gadolinium oxide-based nano preparation solution. And performing post-treatment such as dialysis, freeze drying and the like to obtain the core-shell structure nanoparticles based on the gadolinium oxide nano preparation. The invention relates to a gadolinium oxide-based nano preparation for cancer diagnosis and treatment, gadolinium oxide is used as an MRI contrast agent, and a gold shell is grown on the periphery of the gadolinium oxide as a photo-thermal preparation; the hydrogel has the characteristics of good biocompatibility and the like, and has an important practical prospect in the field of preparation of diagnosis and treatment integrated medicines.

The invention relates to the technical field of medical detection, in particular to a nanoprobe for simultaneously detecting and inhibiting VCAM-1mRNA expression as well as a preparation method and application of the nanoprobe. The nano particle takes a nano Au particle as a core, and p-mercaptocyanophenyl (4-MBN) serving as a Raman signal internal standard molecule is modified on the surface of the Au core; the nano particle takes a gold layer as a shell, and a VCAM-1mRNA targeting recognition sequence segment is fixed on the Au shell; and the tail end of the VCAM-1 mRNA targeted recognition sequence segment is modified with a Raman reporter molecule Cy5. The recognition sequence segment on the nanoprobe can be specifically combined with VCAM-1mRNA to form a rigid double strand, so that Cy5 is far away from the surface of the gold core-shell nanoparticle, the SERS signal strength of Cy5 is weakened, the position of 4-MBN located on a spacing layer is unchanged, and the SERS signal of the 4-MBN is also unchanged. The expression of the VCAM-1 protein can be inhibited by the accompanying mRNA consumption in the detection process, so that the synchronous monitoring and treatment intervention of the atherosclerosis disease closely associated with the expression of the VCAM-1 are realized.

The multi-dimensional plasmonic coupling system based on Ag@PVP and Au@Ag NCs for surface-enhanced Raman spectroscopy (SERS) detection of gentamicin relates to the field of analytical detection, and adopts hydrothermal synthesis to prepare Ag@PVP core-shell nanoparticles and Au@Ag core-shell cubes (Au@Ag NCs). Ag@PVP is induced to agglomerate by gentamicin, and then Au@Ag NCs are introduced to change the electromagnetic field of the nanoparticle agglomeration, so as to change the Raman characteristic peaks of gentamicin and distinguish it from its homologues. Under the optimized experimental conditions, the linear detection range of gentamicin is 10 ‑5 ~10 ‑9 M, the detection limit is 6.23 × 10 ‑10 M, and the relative standard deviation of SERS intensity is less than 10%. The method has the advantages of simple operation, high accuracy and sensitivity, and does not need complex operation technology, and meets the requirements of large quantities and rapid analysis and detection.

The invention discloses a method for quantitatively detecting creatinine in serum by pH-assisted ratio type SERS (Surface Enhanced Raman Scattering), which comprises the following steps: preparing silver-coated gold core-shell nanoparticles Au (at) MPA (at) Ag NPs with internal standard thiohydracrylic acid as an SERS substrate, and normalizing an SERS signal of the creatinine by using an internal standard signal. In addition, the pH of the creatinine is adjusted to enhance the adsorption effect of the creatinine and the nanoparticles, so that a Raman signal is enhanced. The detection method disclosed by the invention has the advantages of effectively eliminating interference of environmental factors, non-uniformity of samples, high dependence on a substrate and the like. Moreover, 2.5 mol / L of creatinine can be detected by the creatinine detection method based on the pH-assisted ratio type SERS technology, the adding standard recovery rate in a serum sample is 98.1%-107.4%, the relative standard deviation is smaller than 5.8%, and the quantitative accuracy of creatinine detection is improved.

The present application belongs to the field of nano-electronic devices and nano-processing technology, and particularly relates to a kind of nanocrystal floating gate memory based on metal core-shell nanoparticle film coated with silicon dioxide and a printing preparation method. First, print the core-shell nanoparticle film, then deposit a silane coupling agent modification layer on the single layer film by chemical vapor deposition, print a polymer intermediate layer and an oriented active layer. The printing preparation technology used in the present application has the advantages of high raw material utilization rate, good controllability and strong repeatability. The core-shell nanoparticle film prepared has low roughness and high particle number density, and can be used as a nanocrystal floating gate / tunneling dielectric composite layer. The organic semiconductor crystal prepared has high crystallinity, obvious orientation and low grain boundary density, and can be used as an active layer. The nanocrystal floating gate memory composed of the above functional layers exhibits excellent electrical performance.

The invention discloses a high-flatness PU adhesive protective film and a preparation method thereof, and relates to the technical field of protective films, the high-flatness PU adhesive protective film comprises the following components by weight: 85-95 parts of a PU adhesive, 2-5 parts of an antistatic agent, and 1-5 parts of a composite leveling agent; the composite leveling agent is prepared from epoxy modified organosiloxane, perfluoropolyether acrylate, cerium-silicon core-shell nanoparticles and hyperbranched polyesteramine according to the mass ratio of 10: 3: 2: 5; an epoxy group in the epoxy modified organosiloxane and a-NH2 group in the PU adhesive are subjected to a ring-opening reaction to form a covalent bond, so that directional fixation of molecules of the leveling agent at the interface of the protective film is realized, and surface tension mutation is eliminated; the cerium-silicon core-shell nanoparticles are of a core-shell structure formed by coating the surface of SiO2 with CeO2 nanocrystals, a rolling effect is generated in a shear force field when the surface of the protective film is coated and leveled, and the radial velocity gradient generated during coating can be compensated, so that the orange peel phenomenon on the surface of the protective film is improved.

The application discloses a kind of medical multifunctional optical probes, belong to tumor operation navigation material technical field.The multifunctional optical probe is the gold nanostar embedding doped Gd 3+ Of magnetic silica, and further modified with polyethylene glycol on the surface of the magnetic silica shell Au@Cu 2‑x Se core-shell nanoparticle modification with near-infrared two-zone plasmonic effect.The medical multifunctional optical probe provided by the application can be applied to tumor operation navigation, and the operation resection can be guided by preoperative MR / SERS imaging and intraoperative SERS using the MATRA probe, which can significantly improve the operation effect.Immunotherapy can further remove local residual microtumor and distant metastatic tumor, thereby effectively inhibiting the recurrence and metastasis of tumor, and significantly improving the anticancer effect of 4T1 breast cancer mouse model.

The invention discloses polyvinyl pyrrolidone grafted magnetic silicon dioxide nanoparticles, a preparation method of the polyvinyl pyrrolidone grafted magnetic silicon dioxide nanoparticles and application of the polyvinyl pyrrolidone grafted magnetic silicon dioxide nanoparticles in beer clarification. The material comprises a Fe3O4 (at) SiO2 core-shell nano particle (silicon dioxide wraps ferroferric oxide nano particles) carrier and a linear polyvinyl pyrrolidone (PVP) polymer grafted on the surface of the carrier. The material can be used for efficiently adsorbing polyphenol substances in beer primary pulp, second-level rapid separation is achieved through an external magnetic field, operation is easy and convenient, good recycling performance is achieved, and a new solution is provided for beer clarification.

Disclosed herein is a core-shell nanoparticle exhibiting aggregation induced emission (AIE) properties. According to the embodiments of the present disclosure, the core-shell nanoparticle comprises a core and a shell layer encapsulating the core, in which the core comprises a polymeric matrix and one or more tetraphenylethane (TPE) embedded in the polymeric matrix. Preferably, the polymeric matrix is made of a hydrophobic polymer, and the shell layer is made of a hydrophilic polymer. Also disclosed herein are methods of producing the core-shell nanoparticle, and methods of detecting an extracellular polymeric substance (EPS) produced by a microorganism via using the core-shell nanoparticle.

This invention belongs to the field of medical polymer materials technology, specifically providing a controllable degradable polylactic acid-based composite material for circumcision suture devices and its preparation method. The composite material uses polylactic acid-polycaprolactone block copolymer as the matrix and adds pH-responsive core-shell nano-hydroxyapatite, compatibilizer, and plasticizer. The core-shell nanoparticles are composed of a zinc-silicon co-doped hydroxyapatite core and a poly(dimethylaminoethyl methacrylate) brush shell. In an acidic degradation environment, the brush shell expands to accelerate the release of zinc ions, thereby achieving intelligent antibacterial properties.

The invention relates to the technical field of chemical preparation technologies, in particular to a modified polyurethane material and a preparation method thereof.The preparation method comprises the following steps that dynamic covalent bond cross-linked polyether polyol and core-shell nanoparticles are dispersed at the high speed at the temperature of 110-130 DEG C; the preparation method has the beneficial effects that the contradiction between self-repairing and mechanical strength is solved through dynamic covalent bond design, optical-electric-magnetic multifunctional integration is achieved through core-shell particle directional arrangement, the structural uniformity is improved by combining gradient catalysis and a spraying process, and finally the light-weight target is achieved through foaming-printing combination. All technical points support each other to form a complete innovative chain from molecular design to macroscopic performance, so that the application boundary of the polyurethane material is obviously expanded.

The application discloses a kind of synergistic toughening and improving glass transition temperature core-shell nanoparticles / dynamic polyimide composite, the formula of the composite includes matrix phase polyimide resin and reinforcing phase polymer core-shell nanoparticles.Preferred raw materials include p-xylylene, triamine crosslinking agent, diamine, polymer core-shell nanoparticles and the like.The preparation route includes: first, polymer core-shell nanoemulsion is phase transferred or directly core-shell nanoparticles are compounded with dynamic polyimide polymer material to modify, the toughness, glass transition temperature and contact angle size of modified dynamic polymer material are significantly improved.The application provides a new means for the composite modification of dynamic polyimide material, and is expected to further broaden and deepen its application in resin matrix, composite and other fields.

The invention provides a preparation process of high-refractive-index optical cement synthesized by polyurethane oligomer, and belongs to the technical field of optical cement preparation. The preparation process of the high-refractive-index optical cement synthesized by the polyurethane oligomer comprises the following steps: step 1, synthesis of a sulfur heterocycle modified polyurethane oligomer; step 2, preparation and modification of core-shell structure high-refractive-index nanoparticles; step 3, composite preparation of the high-refractive-index optical cement; and step 4, curing molding. Through the design of MDI and IPDI mixed diisocyanate, the alicyclic structure of IPDI can reduce the rigidity of a molecular chain, unsaturated double bonds are introduced in combination with a chain extender containing an acrylate group, so that the molecular chain of the polyurethane oligomer has both a rigid segment and a flexible segment, and meanwhile, the dispersion of modified core-shell nanoparticles can further improve the toughness of a system, so that the polyurethane oligomer has good mechanical properties. Finally, the elongation at break of the optical cement reaches 150-200%, and the bonding strength of the optical cement to optical substrates such as glass and PMMA is larger than or equal to 2.5 MPa.

The application relates to a surface scratch-resistant treatment method for a polypropylene composite material for automobile exterior decoration, and belongs to the technical field of automobile polymer material modification. Nano-aluminum oxide is used as a core, is modified on the surface through a silane coupling agent KH-570, and is coated with polymethyl methacrylate to form a core-shell structure nano particle; a base material is modified through blending; the modified polypropylene base material is subjected to degreasing and dust removal treatment; the pretreated base material is placed into a plasma treatment equipment and is subjected to activation treatment; gradient coating deposition is carried out; the deposited base material is subjected to ultraviolet curing or heat curing treatment, and a scratch-resistant polypropylene composite material product for automobile exterior decoration is obtained; the coating layer is formed into a stable crosslinked structure through curing, and the scratch resistance and durability are ensured. Through the synergistic effect of the "core-shell nano particle-hyperbranched fluorosilane blending modified base material" and the "plasma activation-gradient coating deposition", double scratch-resistant protection from the material body to the surface is realized, and excellent mechanical properties and long-term use durability are considered.

A method for preparing a flexible lead-free piezoelectric composite film, in which a rare-earth-doped SrSbxSc2-xTaCl2O8 precursor powder is prepared and coated with a BaTiO3 shell to form core-shell nanoparticles, and the core-shell nanoparticles are dispersed in a polyvinylidene fluoride (PVDF) matrix to obtain the flexible lead-free piezoelectric composite film. An electronic device including such piezoelectric composite film is also provided.

This invention provides a core-shell nanoparticle-modified epoxy resin and its preparation method, relating to the field of functional polymer materials technology. The method includes the following steps: preparing SiO2 nanoparticles using the Stöber method; in-situ polymerization of dopamine on the surface of the obtained SiO2 nanoparticles via molecular self-polymerization to prepare core-shell nanoparticles SiO2@PDA; using TDE-85 type epoxy resin as the matrix and core-shell nanoparticles SiO2@PDA as the modifier, preparing SiO2@PDA / EP modified epoxy resin by solution blending. The core-shell nanoparticles prepared by this invention not only have good interfacial bonding with the epoxy resin matrix but also exhibit a synergistic effect of scattering and absorbing ultraviolet light. The prepared SiO2@PDA / EP modified epoxy resin exhibits superior toughness, higher flexural strength, and excellent ultraviolet shielding performance.