239results about How to "Inhibit enzyme activity" patented technology

The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff in combination with a phytase expressed in yeast wherein the phytase can be selected from the group consisting of AppA1, AppA2 and a site-directed mutant of AppA. The invention also enables reduction of the feed to weight gain ratio and an increase bone mass and mineral content of an animal. A foodstuff and a feed additive comprising AppA2 or a site-directed mutant of AppA are also described.

The present invention discloses an RNA virus inactivation preservation solution. The inactivation preservation solution comprises ammonium salt, 1-ethyl-3-methylimidazolium bisulfate, lithium chloride, ethylenediaminetetraacetic acid, an RNase inhibitor, a surfactant, a reducing agent, a buffer agent and water. The present invention also provides an RNA virus sample inactivation and preservation method and an RNA virus detection method, and the method is conducted by using the inactivation preservation solution. The preservation solution has low cost, inhibits RNase activity, preserves RNA integrity, realizes preservation and transportation of samples at room temperature, can also quickly inactivate pathogens at room temperature, reduces infection risks of medical personnel, and reduces false negatives in detection. At the same time, the inactivation preservation solution can realize a lysis function, does not contain chaotropic reagents and alcohols, is compatible with mainstream nucleic acid extraction kits on the market, greatly saves time of an entire process, and is particularly suitable for 2019 new coronavirus (COVID-19) inactivation and lysis steps after swab sampling.

The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds.

The invention discloses a seabuckthorn fruit juice and a preparing method thereof, and belongs to the field of juice processing. The preparing method includes the following steps of (1) raw seabuckthorn juice preparing; (2) material taking, wherein 40-75 by weight parts of the raw seabuckthorn juice, 10-30 by weight parts of white sugar, 1-5 by weight parts of xanthan gum, 3-8 by weight parts of honey, 0.5-3 by weight parts of gelatin, 1-3 by weight parts of aspartame, 40-100 by weight parts of water and 10-30 by weight parts of raw apple juice are taken; (3) preparing and clarifying; (4) sterilizing, wherein sterile clarified liquid is obtained through high-voltage pulse electric field sterilization; (5) seabuckthorn fruit juice obtaining, wherein the seabuckthorn fruit juice is obtained in a sterile-filling mode. By means of the eabuckthorn fruit juice and the preparing method thereof, nutrient ingredients and flavor substances in seabuckthorn fruits can be effectively reserved.

The invention discloses a moisturizing composition with an anti-allergy repairing efficacy and preparation and application to skincare products. The composition is prepared from xanthan gum, pullulan,polyglutamic acid, hyaluronic acid, trehalose, allantoin, urea and chondroitin sulfate by reasonable compounding. The composition has a function of stereo moisturizing of all skin layers including acorium layer, an epidermal layer, a cuticle layer and a skin surface, the skin moisture content can be increased, and skin moisture loss is reduced. The composition is capable of inhibiting hyaluronidase activity, soothing skin allergy and pruritus and repairing skin barrier. The composition has excellent moisturizing effects and an anti-allergy repairing efficacy in vitro and on human skin, effects are remarkably improved as compared with those of single use of each component, and accordingly synergistic effects are achieved by combination of the components in an appropriate ratio. The composition is solid powder and free of any preservatives, and convenience in long-time storage and transport is achieved. The composition can be applied to all types of skincare and cleansing products.

The invention provides a whitening composition, whitening skin-brightening cream comprising the same and a preparation method thereof. The whitening skin-brightening cream is prepared from the following components in percent by mass: 0.1-20% of the whitening composition, 1-25% of a wetting agent, 1-5% of an emulsifier, 1-20% of skin-moistening grease, 0.1-5% of a skin conditioner, 0.05-3% of a permeation aid, 0.01-1% of a chelating agent, 0.1-1% of a thickener, 0-1% of essence, 0.05-2% of a preservative and the balance deionized water. The whitening composition is prepared from eight traditional Chinese medicinal material extraction solutions: ginseng, cortex mori radicis, angelica sinensis, glycyrrhiza, tea leaves, ganoderma atrum, rhodiola rosea and folium ginkgo as well as conventionalwhitening agents nicotinamide and tranexamic acid, and has the functions of whitening synergically and reducing irritation. The whitening skin-brightening cream moistens the skin and is not greasy, iseasy to absorb, and is obvious in whitening and skin-brightening effect.

The invention relates to full-natural extruded coprinus slices and a production method thereof, belonging to the technical field of agricultural product deep processing. The production method comprises the following the steps that: after slicing and color protection processing, coprinus is put in an air dry oven until the water content of the corpinus is 65-70% of the water content of fresh unopened coprinus; and coprinus slices are placed in a vacuum microwave drying machine to be processed for 3-4min, and then, are returned to be at one air pressure. In the invention, by adopting ozonated water color protection, vacuum microwave drying extrusion, and other technical research and application, during the production process, no any additive is added, processed extruded coprinus slices have beautiful appearances and crisp taste, and are less in nutrition loss, the quality of the product is good, and the full-natural extruded coprinus slices have a wide market development prospect. According to the invention, the defects of fry extrusion and differential pressure extrusion are overcome, and the quick, low-temperature and non-fried extrusion processing of the coprinus slices are realized.

The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.

A proton pump inhibitor containing a compound represented by the formula (I)

wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X₁ and X₂ are each a carbon atom or a nitrogen atom, a ring-constituting atom X₃ is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R¹ is an optionally substituted aryl group or an optionally substituted heteroaryl group, R² is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R³ is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X₁, X₂ and X₃, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing cardiovascular disorders.

The feed additive is characterized by that said feed additive is a mixture of pyruvate and creatine monohydrate, in which the content of pyruvate is 55-75 wt%. The can raise thin-meat rate in animal body obvious, and has no harmful substance, is safe for human body.

The invention discloses a preparing method of a kind of rose collagen peptide powder belonging to the field of food resource development and processing technology, which is characterized in that the coniferous fruit powder and the rose oil are added on the basis of the collagen peptide. The method has following advantages: combination of ingredients of the rose collagen peptide powder is reasonable; synergistic interaction of all ingredients is significant without toxic, side effects and additives; the whitening and anti-wrinkling effect, moisturizing and smoothing effect, anti-acne and dark spots effect, and anti-coarse effect are provided; drinking and carrying are convenient; the production process is simple and safe, operability is strong, the production cycle is short, thereby suitable for industrial production.

The present invention relates to a process for producing cheese, comprising the steps of: providing a first raw material liquid; providing a second raw material liquid; treating the first raw material liquid with a protein crosslinking enzyme to provide an enzyme-treated raw material liquid; mixing the enzyme-treated raw material liquid with the second raw material liquid to provide cheese milk; processing the cheese milk into cheese. The process produces cheese in improved yields while retaining the organoleptic properties of cheese unchanged. The invention further relates to cheese treated with a protein crosslinking enzyme, having the moisture on a fat-free basis of 67% or less and a protein profile of cheese has proteins of molecular weight of less than 66 kDa.

The invention relates to a Streptomyces griseus subsp.griseus trehalose synthetase gene and applications thereof. The gene is cloned from Streptomyces griseus subsp.griseus, and the synthetase gene expressed by the gene is capable of converting maltose into trehalose. The gene has the biggest characteristics of high conversion efficiency and high reaction speed. Under the reaction condition provided by the invention, the content of the trehalose in the reaction product of the trehalose generated by converting the maltose can reach 87 percent, and moreover, only 3.8 percent of glucose is produced, thereby being beneficial to increasing the conversion rate of a substrate and reducing the production cost. Recombinant trehalose synthetase produced by applying the gene can be used for preparing trehalose by using maltose syrup sold in the market or maltose syrup prepared from starch. The trehalose can be applied to the field of food industry, facial cosmetics, pharmaceutical and biological products and the like.

The invention relates to instant natural fruit and vegetable powder. The instant natural fruit and vegetable powder comprises the following components in parts by weight: 95-99 parts of mixed freeze-dried fruit and vegetable powder, 3.5-5.5 parts of konjac powder and 0-1 part of a siraitia grosvenorii extract. The invention aims to provide the instant natural fruit and vegetable powder which is rich in nutrition, unique in flavor, easy to preserve, convenient to carry and simple to brew.

The invention discloses a whitening and moisturizing stock solution and a preparation method thereof. The whitening and moisturizing stock solution is prepared from nonapeptide-1, hexapeptide-2, vitamin C ethyl ether, nicotinamide and the like, the activity of melanoblast is effectively weakened, the output of melanin is reduced, generation of the melanin is inhibited, the melanin conveying meanscan be inhibited, and the effects of skin color equalization and brightening are achieved; the good antioxidant and antibacterial and anti-inflammatory effects are achieved, synthesis with collagen isconducted, the skin cell activity is repaired, and the elasticity and smoothness of the skin are improved. The barrier function of the skin can be improved, the transepidermal water loss is lowered,and the moisturizing effect of the stock solution is improved; facial redness and pigmentation are reduced; the effect of expanding the blood vessel is achieved.

A portable fluorescent probe detector of pesticide residue is composed of optical unit, detection and data processing system as well as power unit. it is featured as forming optical unit by light source, filter, detector and photoelectric tube; setting excitation light filter and photoelectric tube in sequence on light source light path; setting fluorescent filter between excitation light filter and photoelectric tube; setting detector on coaxial after fluorescent filter; connecting detector to amplifier, power to light source and detector; Data processing unit to amplifier and photoelectric tube as well as to display.

The invention discloses a whitening composition and the application thereof in whitening cosmetics. The whitening composition contains the following components in weight percentage: 1-10% of lipid soluble VC derivatives, 0.05-0.2% of Glabridin, 1-5% of nicotinamide, 1-5% of hydrogenated soya lecithin, 0.1-0.5% of a gorgonia extracting solution and 0.5-2% of an amino-acid humectant. According to the whitening composition prepared by the invention, the whitening and speckle removing effects are obvious, the whitening composition can be quickly adsorbed by skin, the irritation to the skin is weak and the obvious moisture-holding, anti-inflammatory and antiallergic effects and effective skin brightening effect are realized.