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Azithromycin granules capable of covering up bitter

A technology for masking the bitter taste of azithromycin, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, antibacterial drugs, etc., which can solve the problems that the bitter taste of azithromycin cannot be covered, so as to improve the dissolution rate, reduce the cost and improve the compliance Effect

Inactive Publication Date: 2012-12-19
GUANGXI HELI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it can further improve the taste-masking effect of azithromycin, it still cannot completely cover the bitter taste of azithromycin

Method used

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  • Azithromycin granules capable of covering up bitter
  • Azithromycin granules capable of covering up bitter
  • Azithromycin granules capable of covering up bitter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh raw materials: 10 kg of azithromycin, 90 kg of sucrose, 1 kg of sodium starch glycolate, 100 g of neotame, and 300 g of sodium lauryl sulfate.

[0034] Preparation method: take azithromycin and sucrose, crush them through a 100-mesh sieve, and set aside; take neotame and sodium lauryl sulfate, add appropriate amount of water and stir to dissolve into a solution; mix azithromycin, sucrose and carboxymethyl starch sodium evenly, then add neotame, sodium lauryl sulfate The sodium lauryl sulfate solution is continuously stirred and mixed into a soft material, granulated with a 18-mesh screen, dried at 70°C in a boiling dryer, and granulated with a 16-mesh screen to obtain the product.

Embodiment 2

[0036] Weigh raw materials: 10 kg of azithromycin, 70 kg of sucrose, 2 kg of sodium starch glycolate, 1000 g of neotame, and 300 g of sodium lauryl sulfate.

[0037] Method for making: same example 1.

Embodiment 3

[0039] Weigh raw materials: 10 kg of azithromycin, 50 kg of sucrose, 3 kg of sodium starch glycolate, 2000 g of neotame, and 300 g of sodium lauryl sulfate.

[0040] Preparation method: Same as Example 1.

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Abstract

The invention provides an azithromycin granule oral preparation capable of effectively covering up the bitter of azithromycin. The azithromycin granule oral preparation is prepared from the azithromycin, sucrose, carboxymethyl starch sodium, sodium dodecyl sulfate and a novel sweetener Neotame. According to the invention, in the preparing process of azithromycin granules, not only is the novel sweetener introduced, the oral preparation of which the taste and the sweetness are suitable for people to take can be prepared by a small account of the novel sweetener and the compliance of a patient is improved, but also the cost can be reduced; and meanwhile, by regulating the proportion of a formula, the dissolution of the azithromycin granules is greatly improved, and thus, not only can the azithromycin granules be easily accepted by the patient and be particularly easy to take by child patients, but also the improvement of the dissolution ensures the azithromycin easier and faster to adsorb and ensures the curative effects of the azithromycin to be sufficiently taken.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to azithromycin granules capable of effectively masking bitter taste. Background technique [0002] The main functions of azithromycin are: it has a strong antibacterial effect on G-cocci, G-bacteria and anaerobic bacteria. The antibacterial effect on Brucella catarrhalis, Neisseria gonorrhoeae, Salmonella, Shigella, Klebsiella pneumoniae, Campylobacter, Legionella pneumophila, Clostridium perfringens and anaerobic coccus is also stronger than erythromycin. It also has a significant effect on Pasteurella multocida, Yersinia, Mycoplasma pneumoniae, Chlamydia psittaci, Treponema messelin, Borrelia burgdorferi and histowind amoeba. Azithromycin also has obvious bactericidal effect on some bacteria, for example, it can quickly kill 99.9% of Haemophilus influenzae within 4 hours. [0003] Azithromycin has good curative effect, low toxicity and side effects, and its excellen...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/7052A61K47/18A61P31/04A61P33/02
Inventor 邓厚绪
Owner GUANGXI HELI PHARMA CO LTD
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