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Antibacterial modified chitosan spray and preparation method thereof

A chitosan and spray technology, applied in the direction of antifungal, antibacterial, aerosol delivery, etc., can solve the problem of no evaluation of antibacterial, antiseptic and fresh-keeping effect, no evaluation of antibacterial effect, and no clear description of the molecular weight of chitosan. and the degree of deacetylation, etc., to achieve the effect of narrow molecular weight distribution and improved antibacterial broad-spectrum performance

Active Publication Date: 2014-09-17
JIANGSU RUIJING TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN102860567A discloses a chitosan fresh-keeping spray, which is made of chitosan, edible gum, glacial acetic acid, citric acid and water, but it does not clearly illustrate the molecular weight and deacetylation degree of chitosan, and does not evaluate Its antibacterial, antiseptic and fresh-keeping effect
CN102524316B discloses a chitosan-based rubber tree antifreeze and antibacterial spray for cut surfaces and a preparation method thereof. The spray contains chitosan, tea tree essential oil, polyvinyl alcohol, plant growth regulator, etc., and it does not clearly state that chitosan Molecular weight and degree of deacetylation, and no evaluation of its antibacterial effect
[0007] The purpose of the present invention is to overcome the shortcoming that exists in the prior art, solve the problems such as lacking pure chitosan environmental protection, high-efficiency antibacterial spray at present, propose a kind of preparation method of antibacterial modified chitosan spray, the spray obtained It has a good spray effect, and the liquid medicine can be evenly distributed on the patient's part, and can be quickly absorbed to play a role. It has a broad spectrum of antibacterial, and can promote the repair and healing of lesion cells. It can be applied to local and systemic treatment of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Embodiment 1: prepare antibacterial modified chitosan spray

[0103] The implementation steps of this embodiment are as follows:

[0104] A, preparation of modified chitosan

[0105] Chitosan sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan has a deacetylation degree of 80% and a molecular weight of 20×10 4 The chitosan of Da, dissolves 5min under the condition of stirring speed 250rpm in 1.6% acetic acid aqueous solution by weight, then adds the di-tert-amyl peroxide that is 1.0 times of chitosan weight, the solution that obtains is in by Changzhou City In the ultrasonic cleaning machine sold by Youda Ultrasonic Equipment Co., Ltd. under the trade name YD1008 Ultrasonic Cleaning Machine, ultrasonic treatment was performed for 35 minutes at an ultrasonic frequency of 22 kHz and an ultrasonic power of 200 W to obtain a low-molecular-weight chitosan complex solution, which was then processed by a recrui...

Embodiment 2

[0115] Embodiment 2: prepare antibacterial modified chitosan spray

[0116] The implementation steps of this embodiment are as follows:

[0117] A, preparation of modified chitosan

[0118] Chitosan sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan has a deacetylation degree of 80% and a molecular weight of 24×10 4The chitosan of Da, dissolves 5min under the condition of stirring speed 320rpm in 3.0% acetic acid aqueous solution by weight, then adds the di-tert-amyl peroxide that is 1.6 times of chitosan weight, the solution that obtains is in by Changzhou City In the ultrasonic cleaning machine sold by Youda Ultrasonic Equipment Co., Ltd. under the trade name YD1008 Ultrasonic Cleaning Machine, ultrasonic treatment was performed for 38 minutes at an ultrasonic frequency of 22 kHz and an ultrasonic power of 200 W to obtain a low-molecular-weight chitosan complex solution, which was then processed by a recruit...

Embodiment 3

[0128] Embodiment 3: prepare antibacterial modified chitosan spray

[0129] The implementation steps of this embodiment are as follows:

[0130] A, preparation of modified chitosan

[0131] Chitosan sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan has a deacetylation degree of 80% and a molecular weight of 24×10 4 The chitosan of Da, dissolves 10min under the condition of stirring velocity 350rpm in 3.0% acetic acid aqueous solution by weight, then adds the di-tert-amyl peroxide that is 2.0 times of chitosan weight, the solution that obtains is in by Changzhou City In the ultrasonic cleaning machine sold by Youda Ultrasonic Equipment Co., Ltd. under the trade name YD1008 Ultrasonic Cleaning Machine, ultrasonic treatment was performed for 40 minutes at an ultrasonic frequency of 22 kHz and an ultrasonic power of 200 W to obtain a low-molecular-weight chitosan complex solution, which was then processed by a re...

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PUM

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Abstract

The invention relates to antibacterial modified chitosan spray and a preparation method thereof. The preparation method of the antibacterial modified chitosan spray comprises the steps of preparing modified chitosan, preparing gardenia oil, preparing geniposide, preparing spirulina polysaccharide and spirulina polypeptide and preparing chitosan spray. The antibacterial modified chitosan spray is applied to treatment on male and female pruritus vulvae and fungal infection, bacterial infection, folliculitis and vaginitis, also can be used for treating bedsore and long-term skin inflammation, can be widely applied and has antibacterial ability more than 99% on staphylococcus aureus, escherichia coli, streptococcus, candida albicans, pseudomonas aeruginosa or other fungi.

Description

【Technical field】 [0001] The invention belongs to the technical field of medical drugs. More specifically, the present invention relates to a kind of antibacterial modified chitosan spray, also relates to the preparation method of described antibacterial modified chitosan spray, 【Background technique】 [0002] Chitosan is a natural alkaline polymer polysaccharide derived from the shells of crustaceans (crabs and shrimps) and bones of arthropods (cockroaches, etc.), with good biocompatibility, biodegradability, antibacterial and antiseptic , Promote the regeneration of endothelial cells, capillaries, cardiomyocytes and nerve axons, hemostasis and promote wound healing and other excellent properties. Studies have shown that low-molecular-weight chitosan has physiological activities such as easy absorption by the human body, activation of lymphocytes, enhancement of immunity, antibacterial and antibacterial, and inhibition of tumor cell growth. In addition, studies have found ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/12A61P31/04A61P31/10A61P15/00A61P17/02A61P17/04A61P17/00A61K31/722
CPCY02A50/30
Inventor 汤瑞明耿在云
Owner JIANGSU RUIJING TECH DEV
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