Piperacillin-containing composition as well as pharmaceutical preparation and application thereof

A technology of piperacillin and pharmaceutical preparations, applied in the directions of medical preparations containing active ingredients, active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve problems such as drug resistance of Acinetobacter baumannii, and achieve significant technical effects and The effect of clinical advantage

Active Publication Date: 2018-04-06
XIANGBEI WELMAN PHARMA CO LTD
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the invention is to solve the problem of drug resistance of Acinetobacter baumannii, especially the problem of drug resistance of Acinetobacter baumannii to cefoperazone sulbactam

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Piperacillin-containing composition as well as pharmaceutical preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 piperacillin composition

[0021] Take piperacillin sodium (1000g as piperacillin acid), ampicillin sodium (0.1g as ampicillin acid) and sulbactam sodium (500g as sulbactam acid), and use a single cone ribbon mixer Thoroughly mix the three materials evenly to obtain a composition. A part of the composition is taken and subpackaged under aseptic conditions to obtain injections in the form of dry powder (sterile powder for injection). Another part of the composition was dissolved with 100 times the amount (ml / g) of 0.9% sodium chloride aqueous solution and subpackaged to obtain an injection in the form of a solution.

Embodiment 2

[0022] The preparation of embodiment 2 piperacillin composition

[0023] Get piperacillin acid 1000g, ampicillin acid 0.3g and sulbactam acid 500g, after dissolving with the aqueous solution that contains 343g sodium bicarbonate, lyophilize, pack, obtain a kind of dry powder form injection (freeze-dried powder) that contains composition Needle).

Embodiment 3-6

[0024] The preparation of embodiment 3-6 piperacillin composition

[0025] The operation of embodiment 3-6 is similar to embodiment 1, and the amount of piperacillin and sulbactam is identical with embodiment 1, and difference is that the consumption of ampicillin increases gradually in each embodiment, is respectively 1g, 3g, 10g and 15g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a piperacillin-containing composition. The composition contains piperacillin and also contains ampicillin and sulbactam in a certain ratio. The invention also provides a pharmaceutical preparation and application thereof. The composition and the pharmaceutical preparation which are provided by the invention can obviously inhibit drug-resistant acinetobacter baumannii, especially have good treatment effect on infection of the acinetobacter baumannii resistant to carbapenem antibiotics or cefoperazone sulbactam and has obvious clinical advantage.

Description

technical field [0001] The invention relates to a composition containing piperacillin and its application. Background technique [0002] Acinetobacter baumannii is an important pathogen that can cause infections in the respiratory, blood, abdominal cavity, central nervous system, urinary and skin soft tissue systems. According to the 2016 report of China Bacterial Resistance Monitoring (CHINET), Acinetobacter baumannii is the pathogen with the highest proportion in respiratory specimens, suggesting that this bacteria has a very important impact on respiratory diseases. Especially for long-term hospitalized critically ill patients, pulmonary infection caused by Acinetobacter baumannii has become an important cause of death. In addition, among all clinical isolates, Acinetobacter baumannii accounted for as high as 10.8%, second only to Escherichia coli and Klebsiella pneumoniae. [0003] For a long time, penem-like carbapenem antibiotics have a good effect on Acinetobacter b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K31/43A61P31/04
CPCA61K31/43A61K31/496A61K2300/00
Inventor 孙天宇
Owner XIANGBEI WELMAN PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap