Artificial trachea cannula with nanometre anti-microbial coating

A nano-antibacterial material and artificial trachea technology, applied in the field of medical devices, can solve the problems of inability to obtain satisfactory antibacterial effects, single antibacterial components, etc., and achieve the effects of simple and controllable manufacturing process, low dosage, and improvement of infection conditions.

Inactive Publication Date: 2009-10-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since only the surface of the fracture is treated, and the antibacterial component is single, it is impossible to obtain a satisfactory antibacterial effect to inhibit and reduce the incidence of ventilator-associated pneumonia

Method used

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  • Artificial trachea cannula with nanometre anti-microbial coating

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An artificial tracheal intubation tube, including a trachea 2, an inflatable tube 3 and an inflatable air bag 4, the trachea body has a connecting end 1 and an insertion end 7, the trachea connection end 1 is connected to a ventilator, and the trachea insertion end 7 It is wedge-shaped for easy insertion into the trachea; the inflatable airbag 4 is set on the outer surface of the insertion end 7 of the trachea, and the edge of the inflatable airbag is airtightly connected with the tube body of the trachea; It communicates with the inflatable airbag and is used to inflate the inflatable airbag 4; the other side of the trachea is embedded with a drain pipe 5, one end of the drain pipe has a liquid discharge port 8 above the inflatable airbag, and the other end can be connected with devices such as syringes , used to regularly suck out the liquid accumulated on the air bag.

[0027] The tracheal intubation is prepared by the extrusion molding process of medical grade polyv...

Embodiment 2

[0029] Polyvinylpyrrolidone (PVP) 5g (Tianjin Boai Xinkaikai Co., Ltd.), moxifloxacin 0.05g (Shenzhen Haibin Pharmaceutical Company), and nanoscale zeolite silver-loaded antibacterial agent 0.15g (Shanghai Bonaweilai New Material Technology Co., Ltd.) Co., Ltd.), 100ml of ethanol, 30ml of dimethylformamide, 30ml of ethyl acetate, mix well, and make a mixed solution for later use;

[0030] Immerse the artificial endotracheal tube prepared above according to the method of Example 1 in the mixed solution for 0.5 minutes, take it out, and dry it at 60-70° C. for about 5-10 minutes to obtain an artificial endotracheal tube with nano-antibacterial material coating. The thickness of the coating was on average 0.3 mm.

Embodiment 3

[0032] With polymer material PVP-vinyl acetate polymer 8.5g (Tianjin Boai Xinkaikai Co., Ltd.), piperacillin / tazobactam composite preparation 0.17g (Dalian Pfizer Company), nanoscale zirconium phosphate silver-loaded antibacterial agent 0.4 g (Shanghai Bona Weilai New Material Technology Co., Ltd.), 100ml of ethanol, 40ml of dimethylformamide, 30ml of ethyl acetate, 10ml of acetone, mix well, and make a solution for later use;

[0033] Immerse the artificial endotracheal tube prepared above according to the method of Example 1 in the mixed solution for 1 minute, take it out, and dry it at 60-70° C. for about 5-10 minutes to obtain an artificial endotracheal tube with nano-antibacterial material coating. The thickness of the coating was on average 0.5 mm.

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Abstract

The invention relates to the technical field of medical appliance. Ventilator associated pneumonia results from inhalation of secretion with pathogene, wherein, bacterial pollution of gas circuit of the ventilator is a key factor which causes the ventilator associated pneumonia. The invention aims at providing an artificial trachea cannula with broad-spectrum antibacterium property and controllable slowly-releasing drugs; an air providing tube (2), an air bag (4), an air tube (3) and a liquid discharging tube (5) of the artificial trachea cannula of the invention are coated with nanometre anti-microbial coatings (6) on inner and outer surfaces; the nanometre anti-microbial coatings are mainly blended by macromolecule polymers, nanometre inorganic antimicrobial and slowly-releasing drugs. The artificial trachea cannula with nanometre anti-microbial coatings of the invention not only satisfies traditional functions of artificial trachea in providing air path and maintaining respiratory tract clear, but also has functions of excellent bacteriostasis and slowly releasing of controllable drugs, thereby providing wide application prospect to clinical application of the artificial trachea cannula.

Description

technical field [0001] The invention relates to the technical field of medical devices, and relates to an artificial tracheal intubation tube coated with nanometer antibacterial materials. Background technique [0002] With the development of science and technology and the improvement of people's health awareness, the application of biomaterials in clinical medicine is becoming more and more extensive. While biomaterials bring convenience to clinical treatment, there are still some problems. It has been found that biomaterials, whether long-term or short-term indwelling in the human body, often cause various bacterial infections. [0003] At present, infectious diseases still account for 1 / 3 of the causes of death among the world's population, and pneumonia ranks first, especially severe pneumonia. Hospital acquired pneumonia (HAP) is the most common nosocomial infection. HAP is the No. 1 nosocomial infection in my country, with a prevalence rate of 1.3% to 3.45%. The most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M16/04A61L2/232A61L2/238A61L101/26A61L101/30A61L101/06A61L101/12A61L101/14A61L101/16A61L101/24A61L101/02A61L101/44A61L101/46A61L101/48
Inventor 李文放林兆奋刘雪峰张强王虑陈德昌
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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