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Method for preparing valnemulin salt premix

A technology of wernimulin and premix, which can be used in pharmaceutical formulations, devices for making medicines into special physical or ingestible forms, animal feed, etc., which can solve the problem of strong irritation of powder, instability to light, and hygroscopicity. and other issues, to achieve the effect of simple production process

Active Publication Date: 2011-03-16
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The crude drug of vonemulin salt has the disadvantages of hygroscopicity, strong irritant powder, unstable to light, and easy to decompose when in contact with feed, etc.
There is no report on the premix containing warnemulin salt microcapsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of encapsulation fluid

[0025] Use hydroxypropyl methylcellulose with a viscosity of 5mPa·s as the encapsulation material and talc as an anti-sticking agent, dissolve 5g of hydroxypropylmethylcellulose with a viscosity of 5mPa·s in 50ml of purified water, add 3.5g of talc Stir to disperse evenly, and then add purified water until the volume of the dispersed system is 100ml to obtain an encapsulation solution.

[0026] (2) Cyst

[0027] Take 90g of Wernemulin Carbonate and 1.5g of talcum powder as a lubricant and mix them through a 100-mesh sieve to disperse them, then add them to the fluidized bed with an air volume of 75m 3 / h, the inlet air temperature is 72°C, make it fluidized and suspended. A peristaltic pump was used to atomize the encapsulation liquid through a fluidized bed nozzle to encapsulate the vonemulin carbonate. The rotation speed of the peristaltic pump was 10 rpm, and the spray pressure was 2.0 bar. Continue heating for 60 minutes a...

Embodiment 2

[0031] (1) Preparation of encapsulation fluid

[0032] Sodium alginate is used as encapsulation material, talcum powder is used as anti-sticking agent, 47g of sodium alginate is dissolved in 70ml of purified water, 8g of talcum powder is added and stirred to disperse evenly, and then purified water is added until the volume of the dispersion system is 100ml. Obtain cyst fluid.

[0033] (2) Cyst

[0034] Take 35g of warnemulin hydrochloride and 10g of talcum powder as a lubricant, mix them, pass through a 100-mesh sieve to disperse them, and add them to the fluidized bed with an air volume of 65m 3 / h, the air inlet temperature is 75°C, make it fluidized and suspended. A peristaltic pump was used to atomize the encapsulation liquid through a fluidized bed nozzle to encapsulate the warnemulin hydrochloride. The rotational speed of the peristaltic pump was 16 rpm, and the spray pressure was 3.0 bar. Continue drying at 45°C for 30 minutes until 100ml of encapsulation solution i...

Embodiment 3

[0038] (1) Preparation of encapsulation fluid

[0039] Using gelatin as encapsulation material and micropowder silica gel as anti-sticking agent, dissolve 7g of gelatin in 50ml of purified water, add 1.5g of micropowder silica gel and stir to disperse evenly, and then add purified water until the volume of the dispersion is 100ml to obtain encapsulation liquid.

[0040] (2) Cyst

[0041] Take 90g of warnimulin hydrofluoride and 1.5g of micropowdered silica gel as a lubricant, mix them through a 100-mesh sieve to disperse them, and add them to the fluidized bed with an air volume of 70m 3 / h, the inlet air temperature is 70°C, make it fluidized and suspended. A peristaltic pump was used to atomize the encapsulation liquid through a fluidized bed nozzle to encapsulate warnemulin hydrofluoride. The rotational speed of the peristaltic pump was 13 rpm and the spray pressure was 2.5 bar. Continue heating at 42°C for 50 minutes until 100ml of encapsulation liquid is sprayed, then ...

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Abstract

The invention discloses a method for preparing a valnemulin salt premix, which comprises the following steps of: preparing coating liquid by using a coating material, an antisticking agent and water, mixing valnemulin salt with a lubricating agent and fluidizing; then atomizing the coating liquid and injecting into a fluidized bed to coat the valnemulin salt and obtaining microcapsules of the valnemulin salt; and screening the microcapsules and uniformly mixing with a stabilizing agent, a lubricating agent and a diluent so as to prepare the valnemulin salt premix. The preparation process is simple, the prepared premix can effectively overcome the defect that raw material medicaments of the valnemulin salt have humidity, high powder irritation and optical instability, are easy to decompose when contacted with feed and the like, and the premix is convenient for animal administration.

Description

technical field [0001] The invention relates to a preparation method of a special pleuromutilin antibiotic warnemulin salt premix for animals, and belongs to the field of veterinary antibiotic preparations. Background technique [0002] Vernimulin is a new generation of pleuromutilin semi-synthetic antibiotics, which belongs to diterpenes, and belongs to the same class of drugs as tiamulin, and is a special antibiotic for animals. Warnemulin can react with organic and inorganic acids to form organic and inorganic salts of warnemulin, which can change some of its physical properties. [0003] Warney Mutilin was first synthesized in 1984 by BernerH of Sandoz Company using Pleuromutilin as a raw material. Thereafter, the Swiss company Norvatis made it into a premix, and in 1999 under the trade name On the market in Europe, Warnimulin salt is a pleuromutilin semi-synthetic antibiotic approved by the European Union in 1999 for the prevention and treatment of swine dysentery ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/22A61J3/02A61J3/07A61P31/04A61P1/12A61P11/00A61P1/00A23K1/17A23K1/18A23K20/195A23K50/30
Inventor 陈清平汪敦辉王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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