48 results about "Long circulating" patented technology

The invention provides a coordination nano assembly of chiral cyclopeptide and manganese ions as well as a preparation method and application of the coordination nano assembly. According to the method, a manganese superoxide dismutase protein structural domain and a unique tumor microenvironment of melanoma high tyrosinase are combined, and polypeptide sequences L-YD-hL-DD-h, L-YL-HL-DL-H and D-yD-hD-dD-h with different chirality are designed for the first time; the chirality of the polypeptide is regulated and controlled, the in-vivo circulation stability and the cell entry efficiency of the nano assembly are improved, the coordination self-assembly of manganese and different chiral cyclopeptides is realized, and the in-situ oxidation of an in-vivo tumor microenvironment is simulated for photo-thermal therapy and cell membrane coating. The method disclosed by the invention is simple, mild in experimental condition and easy to operate, the prepared cell membrane coated nano assembly not only has long circulation stability and high cell entry efficiency, but also can realize mild photo-thermal therapy through in-situ oxidation, releases manganese ions to activate a CGAS-STING pathway for immunotherapy of tumors, and has a wide application prospect. The potential application value is realized in the field of combined treatment of tumors.

The present invention provides a PEG-modified docetaxel liposome lyophilized powder and a preparation method thereof. The composition of the liposome lyophilized powder according to mass percentage is: 0.01%-10% docetaxel; 10%-45% lipid membrane material; the balance is other excipients; the other excipients are PEG materials, antioxidants and lyophilization protectants, and the amount of PEG material added accounts for 0.01%~10% of the total mass of the lyophilized powder. The present invention can improve the deficiencies of ordinary liposomes and injections and other dosage forms by encapsulating docetaxel through long-circulating liposomes, enhance the solubility and safety of docetaxel, change the distribution of docetaxel in the body, and help to achieve good targeting; polyethylene glycol-modified long-circulating liposomes enhance the stability of docetaxel liposomes in plasma, prolong the retention time in the blood, help to exert the EPR effect, and achieve the purpose of high efficiency and low toxicity.

A gemcitabine liposome pharmaceutical composition, a preparation method therefor and use thereof. According to the preparation method for the liposome, by means of optimization and control of the proportion of phospholipid to cholesterol, the proportion of the total lipid to an optional long circulating functional material, the proportion of the total lipid to a drug, and the type and the concentration of a salt solution in an aqueous interior, a liposome, which has high encapsulation efficiency, good storage stability, and high filtering performance, is not easy to leak, is stable and controllable to release, prolongs the half-life remarkably, improves the therapeutic effect, and reduces toxic and side effects, is prepared. In addition, the provided liposome prescription and preparation process are simple, and scaled-up production and clinical popularization and application are facilitated.

The invention relates to the technical field of biological medicines and vaccines, in particular to a nano-selenium modified liposome as well as a preparation method and application thereof. The nano-selenium modified lipidosome disclosed by the invention comprises a lipidosome and nano-selenium. Wherein the nano-selenium is modified on the surface of the liposome; the liposome is composed of cholesterol, phospholipid, and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000. The nano-selenium modified liposome can be suitable for different treatment scenes, becomes a multifunctional drug delivery platform, has the characteristics of long circulation, good biocompatibility, high drug loading rate, good stability, increase of retention time of a treatment drug in a body and the like, can be directly entrapped with an antigen, can also be cooperatively combined with a drug and a vaccine, and has a wide application prospect. The defects of low bioavailability, poor stability, toxic and side effects and the like of the existing medicinal preparation are overcome, and the immunotherapy effect is remarkably enhanced while the treatment medicine in the liposome is promoted to achieve a remarkable slow release effect.

The invention discloses a novel hydrogen sulfide donor, a preparation method and application of the novel hydrogen sulfide donor in preparation of drugs for treating inflammatory diseases, and belongs to the technical field of biological medicines. The hydrogen sulfide donor comprises hydrogen sulfide synthetase, a drug carrier loaded with the hydrogen sulfide synthetase, and a functional coating coated outside the drug carrier. The drug carrier is a metal organic framework material, a polymer nano material, a liposome material, an exosome material or a hydrogel material, and can provide protection, slow release, enrichment and other functions for biological enzyme according to the characteristics of different inflammatory diseases. The functional coating is a surfactant, a polymer, an edge active agent, a biological membrane or a lipid double layer, and is used for improving the physicochemical properties of the drug carrier, so that the drug carrier is further endowed with special properties such as in-vivo targeting, long circulation, transdermal drug delivery and the like. According to the invention, an accurate, safe and lasting hydrogen sulfide supply means is realized, and the method has a wide application prospect. And a new treatment thought and strategy are expected to be provided for treatment of inflammatory diseases.

The invention provides a lipid nano-carrier, a pharmaceutical preparation, a preparation method and application. The lipid nano-carrier disclosed by the invention comprises lipid nano-particles coupled with endogenous protein, can reduce unexpected liver accumulation and prolong in-vivo long circulation time, has tumor tropism and can realize extrahepatic targeting.

The invention discloses bionic nanoparticles, a composition, a preparation method and application thereof, and relates to the technical field of red blood cell-cancer cell hybrid membrane bionics. The bionic nanoparticles comprise lipidosome and a hybrid membrane coated on the surface of the lipidosome, drugs are coated in the lipidosome, and the drugs are astragaloside and curcumin; the molar ratio of the medicine to the liposome is 1: 15; the hybrid membrane is a hybrid membrane of an erythrocyte membrane and a cancer cell membrane. The erythrocyte-cancer cell hybrid membrane wraps the outer layer of the liposome phospholipid bilayer to construct the nano targeting drug delivery system, the modification of the hybrid cell membrane integrates the advantages of long circulation, immune escape, homologous targeting and the like, and a new treatment mode is developed for immunotherapy of malignant tumors with low response rate. The hybrid membrane can improve the targeting property of the drug, reduce side effects on patients and improve the tolerance of the patients. The medicine can be coated in an aqueous solution layer of the liposome, so that the water solubility of the medicine is improved, and meanwhile, the anti-tumor effect of the medicine can be enhanced.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

To provide long circulating material free (LCMF) poloxamer compositions and uses thereof, in particular, LCMF poloxamer 188 compositions and uses thereof, and to provide supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.SOLUTION: The LCMF poloxamer 188 is a polyoxyethylene / polyoxypropylene copolymer that has the formula HO(CH2CH2O)a'-[CH(CH3)CH2O]b-(CH2CH2O)aH, wherein: each of a and a' is an integer such that the percentage of (C2H4O) is between 60 to 90 wt.% of the total molecular weight of the copolymer; b is an integer such that the molecular weight of (C3H6O) is between 1,300 and 2,300 Da; 1.5% or less of the total components are low molecular weight components and 1.5% or less of the total components are high molecular weight components; the polydispersity value of the LCMF poloxamer is less than 1.07; and the circulating half-life of the LCMF poloxamer is less than 5.0-fold of the predetermined circulating half-life.SELECTED DRAWING: None

The application discloses a naphthalene phthalocyanine copper liposome and a construction method and application thereof, and belongs to the technical field of liposome preparations. The naphthalene phthalocyanine copper liposome can improve the problems of poor water solubility and insufficient stability of existing sonosensitizers by wrapping naphthalene phthalocyanine copper and catalase in the liposome. Meanwhile, the naphthalene phthalocyanine copper liposome has the function of catalyzing the production of O2 by excessive H2O2 in the microenvironment of brain glioma to supply the continuous production of ROS in the sonodynamic therapy (SDT), enhances the sonodynamic performance, improves the treatment effect of brain glioma, has the advantages of good biological safety, low immunogenicity and long circulation in the body, can effectively penetrate the blood-brain barrier and be delivered to the tumor site, solves the problems that drugs are difficult to penetrate the blood-brain barrier and cannot reach an effective concentration in the traditional treatment method of brain glioma, and provides a new strategy for the treatment of brain glioma.

The invention belongs to the technical field of drug delivery and tumor immunotherapy, and particularly relates to an oncolytic virus vesicle as well as a preparation method and application thereof. The preparation method comprises the following steps: co-incubating oncolytic adenovirus and platelets in a buffer system containing prostaglandin E2, and inducing to form an inner membrane encapsulation body; and activating and releasing the vesicles under the conditions of 36-38 DEG C and 4-6% CO2, and carrying out gradient centrifugal collection of 300g, 2000g, 10000g and 100000g. The particle size of the oncolytic virus-loaded vesicle is 50-200nm, the surface of the oncolytic virus-loaded vesicle contains CD41, CD61 and P-selectin, and the oncolytic virus-loaded vesicle can realize long circulation and lung targeting delivery of oncolytic viruses, is suitable for preparing drugs for treating breast cancer and breast cancer lung metastasis, and has a remarkable tumor inhibition effect.

Described herein are novel compositions comprising lipid-poly(ethylene glycol) (lipid-PEG) molecules or lipid-PEG-like molecules, and methods of use thereof, e.g., for sustained delivery of therapeutic agents such as nucleic acids, proteins, and small molecules.

The invention discloses an ergosterol peroxide composite sustained-release agent as well as a preparation method and application thereof, and belongs to the technical field of medical antitumor drug preparations. The invention discloses a preparation method of an ergosterol peroxide composite sustained-release agent, which comprises the following steps: compounding ergosterol peroxide powder and soybean lecithin (Soybean lecithin, SPC, purity gradegt, 90%) through methanol, and sequentially carrying out the steps of normal hexane washing, reduced pressure rotary evaporation, filtration and ultrasonic treatment, so as to obtain the ergosterol peroxide composite sustained-release agent. Compared with the anti-tumor effect of pure ergosterol peroxide, the ergosterol peroxide has the characteristics of long circulation, low toxicity, strong targeting property, better treatment effect and the like.

A fibroblast activation protein (FAP) compound or salt is provided with albumin dual-binding function. It is a new target FAP molecule, comprising a payload group, a linker group and a FAP binding group. The linker group has an architecture selected from four architectures to connect to the payload group and the FAP binding group to form the FAP compound. The target FAP molecule has the biological activity of binding to albumin in blood and that of binding to FAP protein. The present invention is combined with radioactive nuclide Lu-177, Ac-225, Ga-67 or In-111 for long-circulation FAP targeting in the body. Higher accumulation in expressing FAP tumors is achieved, and the accumulation time of inhibitors in tumors is prolonged. The present invention allows radioactivity to act in the tumor for a long time, thereby reducing the radioactivity concentration or reducing the frequency of radioactive inhibitor administration to inhibit tumor growth.

The invention provides a liver function diagnosis and treatment integrated nano preparation and a preparation method thereof. By exploring co-assembly conditions of ICG and small molecule drugs, the prepared nano-preparation is co-assembled under certain conditions (such as a specific mass ratio) through acting forces such as intermolecular hydrogen bonds, hydrophilicity and hydrophobicity, pi-accumulation and the like, and the nano-preparation passively targets the liver through a specific size effect, so that the preparation has a good application prospect. Meanwhile, the nano-particles enhance the uptake of the cells to the medicine, so that the long circulation of the medicine in the body is further caused, and the bioavailability is enhanced. Surprisingly, when the specific small molecule medicine is adopted, the ICG diagnosis window is effectively expanded, and the ICG clearance rate can be increased from 15 min to 60 min. And the error value of clinical operation is effectively reduced. The nano preparation integrating diagnosis and treatment provides a direction for diagnosis and treatment of hepatic fibrosis.

A fibroblast activation protein (FAP) compound or salt is provided with albumin dual-binding function. It is a new target FAP molecule, comprising a payload group, a linker group and a FAP binding group. The linker group has an architecture selected from four architectures to connect to the payload group and the FAP binding group to form the FAP compound. The target FAP molecule has the biological activity of binding to albumin in blood and that of binding to FAP protein. The present invention is combined with radioactive nuclide Lu-177, Ac-225, Ga-67 or In-111 for long-circulation FAP targeting in the body. Higher accumulation in expressing FAP tumors is achieved, and the accumulation time of inhibitors in tumors is prolonged. The present invention allows radioactivity to act in the tumor for a long time, thereby reducing the radioactivity concentration or reducing the frequency of radioactive inhibitor administration to inhibit tumor growth.

The invention belongs to the technical field of separation and purification, and particularly relates to a composition for selectively extracting and purifying a long-circulating antibody from various sample matrixes, a kit and application of the composition and the kit. According to the method, a magnetic nano material with a macroporous structure, a hydrophilic outer surface layer and an FcRn extracellular domain fixed on the surface is used as a magnetic solid phase extraction (MSPE) adsorbent, meanwhile, the operation characteristics of step-by-step combination and elution of the MSPE technology are utilized, the target antibody is accurately extracted from a sample when the pH value is 6.0 + / -0.2, the target antibody is eluted from the surface of the material when the pH value is 7.2 + / -0.2, and the detection result is accurate. Therefore, the long-circulating antibody component in the sample is selectively extracted, but not all antibodies are extracted. Compared with a traditional extraction and purification mode, the method has the advantages that the interference of large-size impurities and hydrophobic impurities in a sample is remarkably reduced, and meanwhile, only the long-circulating antibody can be selectively extracted from various antibody components.

Embodiments of the present disclosure pertain to an active agent carrier that includes a disc-shaped membrane with a plurality of self-assembled amphiphilic block copolymers encased by membrane stabilizing agents, where the amphiphilic block copolymers include hydrophilic blocks and hydrophobic blocks, and where at least one active agent is associated with the disc-shaped membrane. Tunable numbers of targeting agents may also be associated with the disc-shaped membrane. Additional embodiments pertain to methods of delivering one or more active agents to a subject by administering to the subject an active agent carrier of the present disclosure. Further embodiments pertain to methods of making an active agent carrier of the present disclosure.

The invention belongs to the technical field of biological medicines, and discloses a fusion polypeptide of tachyplesin antibacterial peptide and carrier protein and a preparation method of the fusion polypeptide. The fusion polypeptide is formed by sequentially connecting an N-terminal tachyplesin antibacterial peptide, an intermediate microenvironment response type connection module and a C-terminal carrier protein, wherein the connection module is a GFLGVR sequence with both acid sensitivity and MMP-9 cleavability or a chemical equivalent structure of the GFLGVR sequence. Through a bionically designed double-response connection module, the fusion polypeptide is highly stable under physiological conditions, active components are efficiently released in an infected microenvironment, and the therapeutic index is remarkably improved; the in-vivo half-life period of the tachyplesin antibacterial peptide is prolonged from the minute level to the hour level by utilizing the natural long-cycle characteristic of the carrier protein, so that the defect of rapid removal of the tachyplesin antibacterial peptide is overcome; lesion targeted activation is realized by depending on infection microenvironment specific signals, and whole body exposure and potential toxicity are reduced; the preparation process is mature and controllable, is suitable for large-scale production, and lays a foundation for clinical transformation.

The invention belongs to the field of biomedical materials, and particularly relates to a nano-carrier and a preparation method and application thereof.The nano-carrier is prepared from PBAE and DMG-PEG2000, PBAE polymer materials form spherical particles, and the surfaces of the spherical particles are modified with DMG-PEG2000. The preparation method comprises the following steps: preparing a first solution obtained by dissolving PBAE in an organic solvent; preparing a second solution obtained by dissolving DMG-PEG2000 in an organic solvent; mixing and incubating the first solution and the second solution to obtain an oil phase; a micro-fluidic chip is used, and a water phase and an oil phase with the flow rate ratio of (1-4): 1 are mixed to prepare the nano-carrier. The stability of the nanoparticles is improved, aggregation among the nanoparticles is prevented, the DMG-PEG2000 shields the interaction between the nanoparticles and cell membranes through the steric hindrance effect, rapid dissociation can be achieved while in-vivo escape is achieved, and long circulation and passive targeting are achieved.

The invention relates to the field of medicine and health, in particular to a composition with modified gamma-aminobutyric acid and a preparation method thereof.The preparation method comprises the following steps that S1, modified gamma-aminobutyric acid, soybean phosphatidylcholine, cholesterol and modified polyethylene glycol monomethyl ether are added into anhydrous chloroform, the temperature is increased to 30-40 DEG C, the rotating speed is 100-200 rpm, stirring is conducted for 15-25 min, reduced pressure distillation is conducted, and a mixture is obtained; a liposome film is obtained; according to the invention, gamma-aminobutyric acid and L-leucine are chemically bonded to prepare a prodrug, and autonomously synthesized modified polyethylene glycol monomethyl ether 2000 and other materials are utilized to construct a long-circulating liposome to wrap the prodrug, so that the core defects that natural gamma-aminobutyric acid is difficult to penetrate through a blood-brain barrier and the oral bioavailability is low are overcome; the invention provides a new solution for treating anxiety, insomnia and neurodegenerative diseases, and has a wide application prospect.

The invention discloses a preparation method of highly acetylated phospholipid type euphausia superba oil, and belongs to a preparation method of euphausia superba oil phospholipid modification. According to the method, the high acetylated phospholipid type euphausia superba oil is prepared by modifying euphausia superba oil phospholipid with acetic anhydride, and the high acetylated phospholipid type euphausia superba oil is screened under the preparation conditions (reaction temperature, reaction time and acetic anhydride dosage) and can be used as a raw material of lipidosome, so that the high acetylated phospholipid type euphausia superba oil can be used for preparing the high acetylated phospholipid type euphausia superba oil. The preparation method is simple in process, is used for enhancing liposome stability, prolonging circulation time, precisely controlling drug release, reducing toxicity, improving targeted delivery capacity and remarkably optimizing comprehensive performance of a drug delivery system, the preparation process is simple, and the industrial thought of valuable utilization of marine food is developed to a certain extent.

The application discloses star-shaped polyamino acid nanoparticles with long circulation properties and a preparation method and application thereof, and belongs to the technical field of biological medicines.The nanoparticles are of a star-shaped structure with polyamide-amine dendrimers as a core and copolyamino acids as arms;the nanoparticles are prepared through random copolymerization reaction of polyamide-amine as an initiator, first N -carboxylic acid cyclic anhydride and second N -carboxylic acid cyclic anhydride monomers, and the reaction is carried out in an organic solvent; wherein the organic solvent is a mixed solvent of low-polarity halogenated alkane and high-polarity amide or cyclic ether, and the volume ratio of the two is 9:1, and the preparation method is simple and efficient.The application proves that the star-shaped topological structure and glutamic acid / lysine side chains play a key role in realizing long circulation by regulating the types of amino acids, the charge and the topological structure of the nanoparticles, and the nanoparticles have wide application prospects in the field of preparing tumor treatment drugs.

The invention provides a CO release carrier composition, a carrier as well as a preparation method, a release method and application of the CO release carrier composition. The CO release carrier composition comprises a surfactant, inert fluoride liquid and CO gas, the surfactant wraps the inert fluoride liquid; the CO gas is dissolved in the inert fluoride liquid; the surface active agent comprises a surface active agent A and a surface active agent B, and the mass ratio of the surface active agent A to the surface active agent B is 25: (1-50). The prepared CO release carrier has the advantages of being high in loading capacity, controllable in release, long in circulation time, accurate in targeting and the like, and an innovative solution is provided for safe and effective delivery of CO gas.

The present invention discloses a triblock polymer with long circulation and long-acting anti-protein stability, and its preparation and application. The polymer is [PPMA x -b-POPMA y -b-PhGMA z , where x = 15 - 50, y = 15 - 50, and z = 15 - 50. The monomer molecules of this polymer are easy to synthesize, and the polymer blocks are easy to regulate, and can self-assemble to form micelles with different stabilities. The polymer of the present invention can form pH and GSH dual-responsive crosslinked micelles, which can effectively load water-insoluble drugs and have good in vivo circulation ability, drug release performance and good biocompatibility. The micelles of the present invention enhance the stability of the micelles in the physiological environment through block ratio regulation and crosslinking strategy, and have good pH-responsive performance, and can effectively release drugs in the tumor microenvironment, improving the drug delivery efficiency.

The application provides a coordination nanometer assembly of a chiral cyclic peptide and a manganese ion, a preparation method and application thereof, the method of the application combines a manganese superoxide dismutase protein domain with a unique tumor microenvironment of a melanoma high tyrosinase, and first designs polypeptide sequences with different chirality L‑ Y D‑ h L‑ D D‑ h、 L‑ Y L‑ H L‑ D L‑ H and D‑ y D‑ h D‑ d D‑ h, regulates polypeptide chirality, improves in-vivo circulation stability and cell entry efficiency of the nanometer assembly, coordinates self-assembly of manganese and the chiral cyclic peptide, simulates in-situ oxidation of the tumor microenvironment for photothermal therapy, and coats cell membranes. The method of the application is simple, the experimental conditions are mild, and the method is easy to operate, the cell membrane coated nanometer assembly prepared by the method not only has long circulation stability and high cell entry efficiency, but also can realize mild photothermal therapy through in-situ oxidation, release manganese ions to activate the CGAS-STING pathway for tumor immunotherapy, and has potential application value in the field of tumor combination therapy.

The invention discloses the preparation and application of dexamethasone weak base derivatives and preparations thereof, and belongs to the technical field of liposome medicine. The dexamethasone weak base derivatives of the invention are prepared by reacting dexamethasone and a weak base intermediate via ‑COO‑, ‑OOC‑(CH2) n1 ‑S‑(CH2) n2 ‑CO‑ or ‑OOC‑(CH2) n1 ‑S‑S‑(CH2) n2 ‑CO‑connected, and weakly basic intermediates include tetrahydropyrrolyl, piperidinyl, 4‑(1‑piperidinyl)piperidinyl, N‑methylpiperazinyl, morpholinyl or other tertiary amine structures. Weakly basic derivatives of dexamethasone can be prepared as single-loaded liposomes or double-loaded liposomes for combined use with other drugs. The liposome preparation has the characteristics of high encapsulation rate, high drug loading, high stability, etc. Through the modification of PEGylated phospholipids, the preparation can also effectively avoid the uptake of the reticuloendothelial system, thereby achieving the effect of long circulation in the blood.

The application discloses a kind of response type micelles for loading hydrophobic positively charged drug and preparation method thereof, it is related to the field of biomedicine and nanomaterials.This carrier is based on polyethylene glycol and introduces stimulus-responsive disulfide bond and crosslinkable group, and the efficient loading and control release of drug are carried out.Through multi-step organic synthesis "ABA" type triblock structure polymer, four hydroxyl PEG is prepared first, and then coupled and photocrosslinking with undecanethiol undecanoic acid and sulfonated molecule in turn through disulfide bond at four hydroxyl ends, and finally obtain amphiphilic polymer with triblock structure.The polymer can efficiently load hydrophobic drug using its hydrophobic micro area, and promote the loading of positively charged drug by means of its hydrophobic end connected sulfonic group negative group, and realize good water solubility and long cycle by means of the hydrophilicity of PEG segment;The disulfide bond contained therein can be broken under high-concentration glutathione environment in tumor cells, to realize the intelligent control release of drug.

The present invention provides a drug delivery system targeting the blood-brain barrier, and its preparation method and application. The drug delivery system includes a nanocarrier and a drug, wherein the nanocarrier includes a polyamidoamine modified with poloxamer 188. The present invention creatively obtains a nanocarrier by simply modifying the PAMAM-NH2 surface with Pluronic F68, thereby simultaneously endowing the carrier with multiple functions: 1) long circulation; 2) high safety and biocompatibility; 3) inhibition of the passive physical barrier of the BBB and weakening of the active barrier of the BBB; 4) significant increase in cellular drug uptake and good drug sustained-release effect. The nanocarrier has a simple design, low cost, and is more suitable for clinical application, providing new ideas for the design of intelligent nano-drug delivery systems for anti-glioma.

The present invention provides a liposome nanoplatform with inflammation recognition ability, its preparation method and use. The liposome nanoplatform of the present invention takes liposome as the core and loads gold cluster enzymes. The in vitro and in vivo experimental results show that the biomimetic nanoplatform of the present invention not only utilizes the high drug loading capacity of liposomes, but also combines the targeting and long-circulation ability of cell membranes, etc., achieving a good anti-inflammatory effect, providing new ideas for individualized and precise treatment. Moreover, this biomimetic nanoplatform has good biocompatibility and the possibility of large-scale production, with high clinical practical significance, and it may be applicable to the precise treatment of a variety of inflammatory diseases.