Preparation method of fumaric acid valnemulin
A technology of fumaric acid and methyl isobutyl ketone, applied in the field of preparation of medicinal chemicals, can solve the problems of increasing the cost of final products, inaccurate dosage of animal medicines, low storage stability and the like
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Embodiment 1
[0023] Add 7ml of methyl isobutyl ketone into the reaction bottle, conduct a constant temperature water bath, control the temperature at 65-70°C, then add 0.5g of warnemulin, and stir until the solution is clear. Keep the temperature constant, continue to add 1.5ml of absolute ethanol, add 0.13g of fumaric acid under stirring, and control the reaction time for 2 hours. After the end of the reaction, keep warm in an ice bath for 3 hours. Filter, wash with methyl isobutyl ketone, and dry to obtain 0.44 g of warnimulin fumarate.
Embodiment 2
[0025] Add 14ml of methyl isobutyl ketone into the reaction bottle, conduct a constant temperature water bath, and control the temperature at 65-70°C, then add 1g of warnemulin, and stir until the solution is clear. Keep the temperature constant, continue to add 4ml of anhydrous methanol, add fumaric acid 0.27g under stirring, and control the reaction time for 2 hours. After the end of the reaction, keep warm in an ice bath for 3 hours. Filter, wash with methyl isobutyl ketone, and dry to obtain 0.86 g of warnimulin fumarate.
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