Preparation method of tartaric acid valnemulin premixing agent

A technology of warnimulin and tartaric acid, applied in the field of veterinary antibiotic preparations, to achieve the effects of simplifying production equipment, reducing manufacturing costs, and lowering prices

Inactive Publication Date: 2012-12-12
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, warnemulin tartrate is mainly used as a reference substance or a standard substance for drug detection. For example, in the research on the determination of the content of

Method used

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Embodiment Construction

[0014] The present invention will be further described below in conjunction with the examples, but the protection content of the present invention is not limited to the following examples.

[0015] A preparation method of warnemulin tartrate premix is ​​characterized in that comprising the following steps:

[0016] (1) Drying treatment of auxiliary materials: first place the auxiliary materials in the oven and bake for 4-5 hours, and the temperature of the oven is 55-105°C;

[0017] (2) Crush and sieve: Crush the baked excipients, then select 60-80 mesh sieves to screen the excipients, and use 40-80 mesh sieves to screen vornimulin tartrate;

[0018] (3) Mixing of excipients and warnemulin tartrate: Weigh the sieved excipients and warnemulin tartrate, put the two into the mixer, mix and stir evenly to obtain the warnemulin tartrate premix , the percentage by weight of warnemulin tartrate in the warnemulin tartrate premix is ​​0.5%-50%;

[0019] (4) Sampling inspection, packa...

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Abstract

The invention provides a preparation method of a tartaric acid valnemulin premixing agent. According to the invention, tartaric acid valnemulin is directly mixed with accessories to prepare the tartaric acid valnemulin premixing agent. The method comprises four steps of: carrying out dry processing on the accessories; mixing the crushed and screened accessories with tartaric acid valnemulin and performing sampling inspection; packaging; and warehousing. The required tartaric acid valnemulin premixing agent can be obtained conveniently and quickly through the four steps. The tartaric acid valnemulin premixing agent obtained by using the preparation method can well prevent and treat swine dysentery, enzootic pneumoniae, swine colonic spirochetosis, swine hyperplastic enteropathy and other animal diseases, and is simple in processing technique. Not only is production equipment simplified, but also manufacturing cost is reduced, and therefore, the premixing agent can be rapidly popularized in the market at lower price.

Description

technical field [0001] The invention relates to a preparation method of a special pleuromutilin antibiotic premix for animals, in particular a preparation method of a warnemulin tartrate premix, and belongs to the field of veterinary antibiotic preparations. Background technique [0002] Warnemulin hydrochloride was first synthesized by Sandoz Company using pleuromutilin as a raw material in 1984. It belongs to the same class of drugs as tiamulin and is a special antibiotic for animals. Warnemulin hydrochloride is mainly used as a feed premix to prevent swine dysentery, endemic pneumonia, porcine spirochete, porcine proliferative enteropathy, etc. Premix is ​​the main dosage form for oral administration to livestock and poultry. Compared with injection, it is more convenient for administration and saves breeding costs. Although warnemulin hydrochloride has a good anti-mycoplasma effect, the raw material drug has disadvantages such as hygroscopicity, strong powder irritation...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/22A61K47/36A61K47/26A61P31/04A61P1/12A61P11/00A61P1/00
Inventor 王铭宏吴东林
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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